Cell-wall biogenesis in bacteria involves multiple intersecting gene networks. A powerful approach that allies synthetic lethality with small-molecule discovery has now been used to probe these networks and has revealed that the pathway for D-alanylation of teichoic acids in Staphylococcus aureus is a viable target for new antibacterials.
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References
Castillo-Hair, S.M., Igoshin, O.A. & Tabor, J.J. Curr. Opin. Microbiol. 24, 113–123 (2015).
Jacob, F., Perrin, D., Sanchez, C. & Monod, J. C. R. Acad. Sci. Paris 250, 1727–1729 (1960).
Le Novère, N. Nat. Rev. Genet. 16, 146–158 (2015).
Pasquina, L. et al. Nat. Chem. Biol. 12, 40–45 (2016).
Percy, M.G. & Gründling, A. Annu. Rev. Microbiol. 68, 81–100 (2014).
Mori, H. et al. Methods Mol. Biol. 1279, 45–65 (2015).
Roemer, T. & Boone, C. Nat. Chem. Biol. 9, 222–231 (2013).
Campbell, J. et al. ACS Chem. Biol. 6, 106–116 (2011).
Lun, S. et al. MBio. 5, e01767–14 (2014).
Godbole, A.A. et al. Biochem. Biophys. Res. Commun. 446, 916–920 (2014).
Gale, R.T. & Brown, E.D. Curr. Opin. Microbiol. 27, 69–77 (2015).
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Hayes, F. Disentangling gene networks. Nat Chem Biol 12, 3–4 (2016). https://doi.org/10.1038/nchembio.1983
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DOI: https://doi.org/10.1038/nchembio.1983
