SFX by Ex Libris Inc.

Title:	The impact of target site accessibility on the design of effective siRNAs
Source:	Nature Biotechnology [1087-0156] Tafer, Hakim yr:2008

Basic

Full text

Full text available via Nature

Year:

Volume:

Issue:

Start Page:

Document delivery

Request document via Library/Bibliothek

Users interested in this article also expressed an interest in the following:
description	1.	de Almeida, R. "Structure and sequence motifs of siRNA linked with in vitro down-regulation of morbillivirus gene expression." Antiviral research 79.1 (2008): 37-48.
description	2.	Elbashir, S M M. "Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells." Nature 411.6836 (2001): 494-498.
description	3.	Richter, J.D. D. "Think you know how miRNAs work? Think again." Nature structural & molecular biology 15.4 (2008): 334-336.
description	4.	Akinc, A. "A combinatorial library of lipid-like materials for delivery of RNAi therapeutics." Nature biotechnology 26.5 (2008): 561-9.
description	5.	Agrawal, S. "Antisense and siRNA as agonists of Toll-like receptors." Nature biotechnology 22.12 (2004): 1533-1537.
description	6.	Hannon, G. "RNA interference." Nature 418.6894 (2002): 244-251.
description	7.	Elbashir, S M M. "RNA interference is mediated by 21- and 22-nucleotide RNAs." Genes & development 15.2: 188-200.
description	8.	fire, A. "potent and specific genetic interference by double-stranded RNA in caenorhabditis elegans." Nature 391.6669: 806-811.
description	9.	Bradác, I. "siRNA selection criteria--Statistical analyses of applicability and significance." Biochemical and biophysical research communications 359.1 (2007): 83-87.
description	10.	Zamore, P D D. "RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals." Cell 101.1 (2000): 25-33.
description	11.	Dorsett, Y. "siRNAs: applications in functional genomics and potential as therapeutics." Nature reviews. Drug discovery 3.4 (2004): 318-29.
description	12.	Anderson, Akin G. "Development of Lipidoid-siRNA Formulations for Systemic Delivery to the Liver." Molecular therapy 17.5 (2009): 872-879.
description	13.	Green, J. "A combinatorial polymer library approach yields insight into nonviral gene delivery." Accounts of chemical research 41.6 (2008): 749-759.
description	14.	Makeyev, T. "Multilevel regulation of gene expression by microRNAs." Science 319.5871 (2008): 1789-90.
description	15.	Patzel, V. "Design of siRNAs producing unstructured guide-RNAs results in improved RNA interference efficiency." Nature biotechnology 23.11 (2005): 1440-4.
description	16.	Green, Jordan J. J. "Combinatorial modification of degradable polymers enables transfection of human cells comparable to adenovirus." Advanced materials 19.19 (2007): 2836-2842.
description	17.	Ying, S. "The MicroRNA (miRNA): Overview of the RNA genes that modulate gene function." Molecular Biotechnology 38.3 (2007): 129-268.
description	18.	Wang, Y. "A window onto siRNA delivery." Nature biotechnology 31.7 (2013): 611-612.
description	19.	Delhase, M. "Signalling pathways: Kinase regulation in inflammatory response." Nature 406.6794 (2000): 367-368.
description	20.	Lu, J. "The birth and death of microRNA genes in Drosophila." Nature genetics 40.3 (2008): 351-355.