Abstract
Quinolactacins, which inhibit tumor necrosis factor production, contain a quinolone skeleton conjugated with a γ-lactam. The biosynthesis of quinolactacin was investigated by feeding experiments using 13C single-labeled precursors (sodium [1-13C]acetate, DL-[1-13C]isoleucine, L-[methyl-13C]methionine, and sodium [1-13C]anthranilate) and D-[U-13C]glucose.
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Sasaki, T., Takahashi, S., Uchida, K. et al. Biosynthesis of Quinolactacin A, a TNF Production Inhibitor. J Antibiot 59, 418–427 (2006). https://doi.org/10.1038/ja.2006.59
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DOI: https://doi.org/10.1038/ja.2006.59
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