The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Salfredins, New Aldose Reductase Inhibitors Produced by Crucibulum sp. RF-3817
I. Fermentation, Isolation and Structures of Salfredins
KOICHI MATSUMOTO, KAZUO NAGASHIMA, TOSHIYUKI KAMIGAUCHI, YOSHIMI KAWAMURA, YUKIO YASUDA, KIKUO ISHII, NOBUO UOTANI, TOMOHIRO SATO, HIROSHI NAKAI, YOSHIHIRO TERUI, JUNKO KIKUCHI, YUJI IKENISI, TADASHI YOSHIDA, TOSHIYUKI KATO, HIROSHI ITAZAKI
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1995 Volume 48 Issue 6 Pages 439-446

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Abstract

New inhibitors of aldose reductase, designated salfredins A3, A4, A7, C1, C2, C3 and B11, were isolated from the fermentation broth of Crucibulum sp. RF-3817 by successive purification procedures of solvent extraction, silica gel column chromatographies and reverse-phase HPLC. Their structures were established by spectroseopic methods, including UV, SI-MS and NMR. The structures of salfredins A4 and B11 were confirmed by X-ray crystallographic analysis.

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The Journal of Antibiotics, Series A

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