NEW OLEANDOMYCIN 9-OXIMES SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY

GORJANA LAZAREVSKI; GABRIJELA KOBREHEL; SLOBODAN DOKIC; LIDIJA KOLACNY-BABIC; BISERKA KOJIC-PRODIC; DRAGAN JANKOVIC; VITOMIR PUNTAREC

doi:10.7164/antibiotics.47.349

GORJANA LAZAREVSKI, GABRIJELA KOBREHEL, SLOBODAN DOKIC, LIDIJA KOLACNY-BABIC, BISERKA KOJIC-PRODIC, DRAGAN JANKOVIC, VITOMIR PUNTAREC

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JOURNAL FREE ACCESS

1994 Volume 47 Issue 3 Pages 349-356

DOI https://doi.org/10.7164/antibiotics.47.349

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Abstract

A series of the novel oleandomycin 9-oximes has been prepared and characterized by spectroscopic data and X-ray analysis. The antibacterial in vitro activities of the oximes (6-10) were compared with that of oleandomycin (1). Among the novel derivatives the most active compound was 8(R)-rriethyloleandomycin-9-oxime (9) in contrast to its 8(S)-isomer (10) which possessed only low potency. Some preliminary pharmacokinetic data of 9 confirmed its activity. Compound 9 has been advanced to further biological study.

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