The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
THE BIOSYNTHESIS OF THE MACROLIDE ANTIBIOTIC LUCENSOMYCIN
D. G. MANWARING, R. W. RICKARDS, G. GAUDIANO, V. NICOLELLA
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1969 Volume 22 Issue 11 Pages 545-550

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Abstract

The biosynthesis of lucensomycin in cultures of Streptomyces lucensis has been studied using 14C-labelled precursors. The aglycone arises from two propionate and twelve acetate units. One propionate unit provides the chain-initiating unit, whilst the second, involved in chain-extension, undergoes oxidation of its methyl group to form the free carboxyl function of the aglycone.

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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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