ISOLATION AND STRUCTURE OF NOVEL AUTOREGULATORS FROM STREPTOMYCES GRISEUS

U. GRÄFE; G. REINHARDT; W. SCHADE; D. KREBS; I. ERITT; W. F. FLECK; E. HEINRICH

doi:10.7164/antibiotics.35.609

ISOLATION AND STRUCTURE OF NOVEL AUTOREGULATORS FROM STREPTOMYCES GRISEUS

U. GRÄFE, G. REINHARDT, W. SCHADE, D. KREBS, I. ERITT, W. F. FLECK, E. HEINRICH

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JOURNAL FREE ACCESS

1982 Volume 35 Issue 5 Pages 609-614

DOI https://doi.org/10.7164/antibiotics.35.609

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Abstract

Two novel autoregulators affecting the cyto-differentiation of anthracycline-producing Streptomyces griseus have been isolated from cultures of aerial mycelium-forming progenitor strains and blocked mutants. By spectral (IR, CD, MS, ^1H and ¹³C NMR) methods, the autoregulators are shown to be the diastereomers of 4, 5-dihydroxydecanoic acid-4-lactone. Two novel autoregulators affecting the cyto-differentiation of anthracycline-producing Streptomyces griseus have been isolated from cultures of aerial mycelium-forming progenitor strains and blocked mutants. By spectral (IR, CD, MS, ^1H and ¹³C NMR) methods, the autoregulators are shown to be the diastereomers of 4, 5-dihydroxydecanoic acid-4-lactone.

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