Abstract
There is a growing interest in the development of submicron optochemical sensing devices. Miniaturization of sensors to nano-dimensions decreases their typical response time down to the millisecond time scale. Their penetration volume is reduced to a few cubic micrometers and they exhibit a spatial resolution at the nanometer scale. In this review the fabrication of submicron optical fiber fluorescent sensors and particle-based fluorescent nanosensors is described. The functional characteristics of these exciting miniaturized fluorescent sensors and their applications for quantitative measurement of intracellular analytes are demonstrated.
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Received: 7 October 1999 / Revised: 11 January 2000 / Accepted: 19 January 2000
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Lu, J., Rosenzweig, Z. Nanoscale fluorescent sensors for intracellular analysis. Fresenius J Anal Chem 366, 569–575 (2000). https://doi.org/10.1007/s002160051552
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DOI: https://doi.org/10.1007/s002160051552