Research PaperNeutralization Takes Precedence Over IgG or IgA Isotype-related Functions in Mucosal HIV-1 Antibody-mediated Protection
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Abbreviations
ADCC
Antibody-dependent cell-mediated cytotoxicity
ARV
Anti-retroviral
AZT
Zidovudine
bnAb
Broadly neutralizing antibody
CD4bs
CD4 binding site
dIgA
Dimeric IgA
FcRn
Neonatal Fc receptor
GalCer
Galactosyl ceramide
GI
Gastrointestinal
GU
Genitourinary
IDV
Indinivir
IMC
Infectious molecular clone
LED
Lowest effective dose
mAb
Monoclonal antibody
mIgA
Monomeric IgA
MPER
Membrane-proximal external region
nnAb
Non-neutralizing antibody
pIgR
Polymeric IgA receptor
SC
Secretory component
snLuc
Secreted nanoluciferase
sIgA
Secretory IgA
T/F
Transmitted/founder
Keywords
Antibodies
Neutralizing antibodies
HIV-1
Mucosal immunology
Non-human primate rectal challenge model
Vaginal explants
IgA
IgG
Cited by (0)
- 1
These authors contributed equally to this work.
- 2
Current address: College of Life Science and Technology, Jinan University Guangzhou, China
- 3
These authors also contributed equally to this work.
© 2016 The Authors. Published by Elsevier B.V.