Abstract
More than 3 percent of the protein sequences inferred from the Caenorhabditis elegans genome contain sequence motifs characteristic of zinc-binding structural domains, and of these more than half are believed to be sequence-specific DNA-binding proteins. The distribution of these zinc-binding domains among the genomes of various organisms offers insights into the role of zinc-binding proteins in evolution. In addition, the complete genome sequence of C. elegans provides an opportunity to analyze, and perhaps predict, pathways of transcriptional regulation.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Animals
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Binding Sites
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Caenorhabditis elegans / chemistry*
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Caenorhabditis elegans / genetics
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Caenorhabditis elegans / metabolism
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Caenorhabditis elegans Proteins*
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DNA-Binding Proteins / chemistry
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism
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Evolution, Molecular
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GATA Transcription Factors
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Gene Expression Regulation
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Helminth Proteins / chemistry*
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Helminth Proteins / genetics
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Helminth Proteins / metabolism
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Membrane Proteins / chemistry
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Membrane Proteins / genetics
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Membrane Proteins / metabolism
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Receptors, Cell Surface / chemistry
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Receptors, Cell Surface / genetics
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Trans-Activators / chemistry
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Trans-Activators / genetics
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Trans-Activators / metabolism
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Transcription Factors / chemistry
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Transcription Factors / genetics
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Transcription Factors / metabolism
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Zinc Fingers*
Substances
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Caenorhabditis elegans Proteins
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DNA-Binding Proteins
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ELT-1 protein, C elegans
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GATA Transcription Factors
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Helminth Proteins
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Membrane Proteins
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Receptors, Cell Surface
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Trans-Activators
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Transcription Factors
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tra-1 protein, C elegans