Abstract
In mice deficient in either lymphotoxin-alpha (LT-alpha) or the type I tumor necrosis factor (TNF) receptor, but not the type II TNF receptor, germinal centers failed to develop in peripheral lymphoid organs. Germinal center formation was restored in LT-alpha-deficient mice by transplantation of normal bone marrow, indicating that the LT-alpha-expressing cells required to establish this lymphoid structure are derived from bone marrow.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Bone Marrow Cells
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Bone Marrow Transplantation
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Gene Targeting
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Germinal Center / cytology
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Germinal Center / immunology
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Germinal Center / physiology*
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Immunization
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Lymphotoxin-alpha / genetics
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Lymphotoxin-alpha / physiology*
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Mice
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Receptors, Tumor Necrosis Factor / genetics
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Receptors, Tumor Necrosis Factor / physiology*
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Spleen / anatomy & histology
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Spleen / immunology*
Substances
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Lymphotoxin-alpha
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Receptors, Tumor Necrosis Factor