Metabolism of propachlor by the germfree rat

Science. 1980 Oct;210(4468):433-5. doi: 10.1126/science.7433983.

Abstract

Three major metabolites of propachlor were isolated from the excreta of germfree rats given 14C-labeled propachlor orally. In contrast, 11 urinary metabolites, six of which were 2-methylsulfonylacetanilides not present in excreta of germfree rats, were isolated from control rats given 14C-labeled propachlor orally. Enterohepatic circulation and microbial metabolism in the intestine were necessary for production of the methylsulfonyl-containing and other metabolites of propachlor in the conventional rat.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetanilides / metabolism*
  • Animals
  • Enterohepatic Circulation
  • Germ-Free Life*
  • Glutathione / metabolism
  • Intestinal Mucosa / metabolism
  • Intestines / microbiology*
  • Liver / metabolism
  • Oxidation-Reduction
  • Rats

Substances

  • Acetanilides
  • propachlor
  • Glutathione