Auditory intensity discrimination after selective loss of cochlear outer hair cells

Science. 1981 Jun 12;212(4500):1286-8. doi: 10.1126/science.7233219.

Abstract

The contributions of the inner and outer hair cells of the mammalian cochlea to auditory intensity discrimination were evaluated in a combined behavioral-anatomical study of the guinea pig. Intensity difference thresholds were unchanged from baseline values after selective destruction of outer hair cells, suggesting that those cells are unnecessary for normal intensity discrimination.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acoustic Stimulation
  • Animals
  • Auditory Threshold* / drug effects
  • Guinea Pigs
  • Hair Cells, Auditory / physiology*
  • Hair Cells, Auditory, Inner / drug effects
  • Hair Cells, Auditory, Inner / physiology
  • Hearing* / drug effects
  • Kanamycin / pharmacology
  • Male

Substances

  • Kanamycin