Abstract
An investigation of the efficacy of astatine-211--tellurium colloid for the treatment of experimental malignant ascites in mice reveals that this alpha-emitting radiocolloid can be curative without causing undue toxicity to normal tissue. By comparison, negatron-emitting phosphorus-32 as colloidal chromic phosphate had no antineoplastic activity. The most compelling explanation for this striking difference is the dense ionization and short range of action associated with alpha-emission. These results have important implications for the development and use of alpha-emitters as radiocolloid therapy for the treatment of human tumors.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alpha Particles
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Animals
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Ascites / radiotherapy*
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Astatine / therapeutic use*
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Cell Survival / radiation effects
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Chromium / therapeutic use
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Chromium Compounds*
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Colloids
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Female
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Mice
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Neoplasm Transplantation
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Neoplasms, Experimental / radiotherapy*
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Ovarian Neoplasms
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Phosphates / therapeutic use
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Phosphorus Radioisotopes / therapeutic use
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Radioisotopes / therapeutic use*
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Tellurium / therapeutic use*
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Transplantation, Homologous
Substances
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Chromium Compounds
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Colloids
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Phosphates
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Phosphorus Radioisotopes
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Radioisotopes
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Chromium
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chromic phosphate
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Tellurium
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Astatine