Abstract
Veratridine-stimulated uptake of sodium-22 in brain synaptosomes was significantly reduced by ionizing radiation over a dose range of 10 to 1000 rads. The response was dose-dependent and involved a decrease in the maximum effect of veratridine on uptake. The central nervous system may be more sensitive to ionizing radiation than generally thought, perhaps through a loss of the ability of the sodium channel to respond properly to stimulation.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Brain / drug effects
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Brain / radiation effects*
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Dose-Response Relationship, Drug
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Dose-Response Relationship, Radiation
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Ion Channels / drug effects
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Ion Channels / radiation effects
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Male
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Rats
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Rats, Inbred Strains
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Sodium / metabolism*
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Synaptosomes / drug effects
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Synaptosomes / radiation effects*
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Veratridine / pharmacology*
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Veratrine / analogs & derivatives*
Substances
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Ion Channels
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Veratridine
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Sodium
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Veratrine