Abstract
The influx of K+ into swollen mitochondria in the presence of valinomycin results in the synthesis of adenosine triphosphate in which approximately one H+ disappears per adenosine triphosphate synthesized. The synthesis is blocked by atractyloside but is insensitive to oligomycin and relatively insensitive to uncouplers.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adenosine Triphosphate / biosynthesis*
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Animals
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Antimycin A / pharmacology
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Atractyloside / pharmacology
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Cyanides / pharmacology
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Ion Channels / physiology
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Mitochondria / metabolism*
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Mitochondrial Swelling
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Phosphorylation
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Potassium / metabolism*
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Rotenone / pharmacology
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Uncoupling Agents / pharmacology
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Valinomycin / pharmacology
Substances
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Cyanides
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Ion Channels
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Uncoupling Agents
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Rotenone
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Atractyloside
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Valinomycin
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Antimycin A
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Adenosine Triphosphate
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Potassium