Abstract
Anti-idiotype reagents that recognize a common idiotype associated with antibody to hepatitis B surface antigen (anti-HBs) were used to induce anti-HBs in mice. The anti-idiotype-induced anti-HBs was found to recognize the group-specific a determinant of hepatitis B surface antigen and to express an interspecies idiotype. These findings suggest that anti-idiotypes may be useful as vaccines or vaccine primers.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cross Reactions
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Epitopes / immunology
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Hepatitis B Antibodies / biosynthesis*
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Hepatitis B Antibodies / immunology
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Hepatitis B Surface Antigens / classification
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Hepatitis B Surface Antigens / immunology*
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Immunization, Passive
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Immunoglobulin Idiotypes / immunology*
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Mice
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Mice, Inbred BALB C
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Species Specificity
Substances
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Epitopes
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Hepatitis B Antibodies
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Hepatitis B Surface Antigens
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Immunoglobulin Idiotypes