Abstract
Calicheamicin gamma 1I is a recently discovered diyne-ene-containing antitumor antibiotic that cleaves DNA in a double-stranded fashion, a rarity among drugs, at specific sequences. It is proposed that the cutting specificity is due to a combination of the complementarity of the diyne-ene portion of the aglycone with DNA secondary structures and stabilization by association of the thiobenzoate-carbohydrate tail with the minor groove.
MeSH terms
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Aminoglycosides*
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Animals
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Anti-Bacterial Agents / metabolism*
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Antibiotics, Antineoplastic
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Base Sequence
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Benzoates
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Binding Sites
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Carbohydrates
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Cattle
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Computer Simulation
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DNA / metabolism*
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Enediynes
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Models, Molecular
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Molecular Structure
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Nucleic Acid Conformation
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Structure-Activity Relationship
Substances
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Aminoglycosides
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Anti-Bacterial Agents
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Antibiotics, Antineoplastic
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Benzoates
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Carbohydrates
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Enediynes
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calicheamicin gamma(1)I
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DNA