Abstract
The specific hydrolysis of unactivated esters bearing an R or S enantiomeric alcohol has been achieved by two separate classes of catalytic antibodies induced to bind either the R or S substrates. The antibodies exhibit rate accelerations (10(3) to 10(5] above background hydrolysis that, coupled with their antipodal specificity, provide a novel set of reagents for use in synthesis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Monoclonal* / immunology
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Antibody Specificity
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Antigens / immunology
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Benzyl Alcohols / metabolism
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Catalysis*
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Esters / metabolism
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Haptens
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Hemocyanins / immunology
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Hydrolysis
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Immunization
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Kinetics
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Lipase / metabolism*
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Mice
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Mice, Inbred A
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Molecular Structure
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Organophosphonates / immunology
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Stereoisomerism
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Substrate Specificity
Substances
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Antibodies, Monoclonal
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Antigens
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Benzyl Alcohols
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Esters
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Haptens
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Organophosphonates
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Hemocyanins
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methylphenyl carbinol
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Lipase
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keyhole-limpet hemocyanin