Abstract
Long-term depression (LTD) is a well-known form of synaptic plasticity of principal neurons in the mammalian brain. Whether such changes occur in interneurons is still controversial. CA3 hippocampal interneurons expressing Ca2+-permeable AMPA receptors exhibited LTD after tetanic stimulation of CA3 excitatory inputs. LTD was independent of NMDA receptors and required both Ca2+ influx through postsynaptic AMPA receptors and activation of presynaptic mGluR7-like receptors. These results point to the capability of interneurons to undergo plastic changes of synaptic strength through joint activation of pre- and postsynaptic glutamate receptors.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Calcium / metabolism
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Egtazic Acid / analogs & derivatives
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Egtazic Acid / pharmacology
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Electric Stimulation
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Hippocampus / cytology
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Hippocampus / physiology*
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In Vitro Techniques
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Interneurons / physiology*
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Male
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Neuronal Plasticity*
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Patch-Clamp Techniques
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Pyramidal Cells / physiology
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Rats
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Rats, Sprague-Dawley
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Receptors, AMPA / drug effects
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Receptors, AMPA / metabolism*
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Receptors, Metabotropic Glutamate / drug effects
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Receptors, Metabotropic Glutamate / metabolism*
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Synapses / physiology*
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Synaptic Transmission
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Tetany
Substances
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Receptors, AMPA
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Receptors, Metabotropic Glutamate
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Egtazic Acid
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1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid
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Calcium