Abstract
There is a long-standing controversy regarding the mechanisms that generate the functional subdivisions of the cerebral neocortex. One model proposes that thalamic axonal input specifies these subdivisions; the competing model postulates that patterning mechanisms intrinsic to the dorsal telencephalon generate neocortical regions. Gbx-2 mutant mice, whose thalamic differentiation is disrupted, were investigated. Despite the lack of cortical innervation by thalamic axons, neocortical region-specific gene expression (Cadherin-6, EphA-7, Id-2, and RZR-beta) developed normally. This provides evidence that patterning mechanisms intrinsic to the neocortex specify the basic organization of its functional subdivisions.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Axons / chemistry
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Axons / physiology*
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Cadherins / genetics
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Calbindin 2
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Carbocyanines
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DNA-Binding Proteins / genetics
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Gene Expression
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Homeodomain Proteins / genetics
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Homeodomain Proteins / physiology
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Immunohistochemistry
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In Situ Hybridization
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Inhibitor of Differentiation Proteins
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Lymphoid Enhancer-Binding Factor 1
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Mice
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Mutation
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Neocortex / anatomy & histology
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Neocortex / embryology*
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Neocortex / growth & development
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Neocortex / metabolism
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Nerve Fibers / physiology
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Nerve Fibers / ultrastructure
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Proteins / genetics
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Receptors, Cell Surface / genetics
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Receptors, Cytoplasmic and Nuclear / genetics
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Receptors, Melatonin
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S100 Calcium Binding Protein G / analysis
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Steroid 17-alpha-Hydroxylase / analysis
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Telencephalon / embryology
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Telencephalon / growth & development
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Telencephalon / physiology
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Thalamus / anatomy & histology
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Thalamus / embryology*
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Thalamus / growth & development
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Thalamus / metabolism
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Transcription Factors / genetics
Substances
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Cadherins
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Calbindin 2
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Carbocyanines
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DNA-Binding Proteins
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Gbx2 protein, mouse
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Homeodomain Proteins
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Idb4 protein, mouse
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Inhibitor of Differentiation Proteins
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Lymphoid Enhancer-Binding Factor 1
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Proteins
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Receptors, Cell Surface
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Receptors, Cytoplasmic and Nuclear
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Receptors, Melatonin
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S100 Calcium Binding Protein G
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Transcription Factors
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3,3'-dioctadecylindocarbocyanine
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Steroid 17-alpha-Hydroxylase
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K cadherin