Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cell fate

Transition loses its invasive edge

Two studies provide evidence that epithelial tumour cells do not need to transition to a mesenchymal-cell state to form metastases, but that this process does contribute to drug resistance. See Article p.472 & Letter p.525

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Metastatic potential.

Notes

  1. See all news & views

References

  1. Thiery, J. P., Acloque, H., Huang, R. Y. & Nieto, M. A. Cell 139, 871–890 (2009).

    Article  CAS  Google Scholar 

  2. Ye, X. & Weinberg, R. A. Trends Cell Biol. 25, 675–686 (2015).

    Article  CAS  Google Scholar 

  3. Fischer, K. R. et al. Nature 527, 472–476 (2015).

    Article  ADS  CAS  Google Scholar 

  4. Zheng, X. et al. Nature 527, 525–530 (2015).

    Article  ADS  CAS  Google Scholar 

  5. Yu, M. et al. Science 339, 580–584 (2013).

    Article  ADS  CAS  Google Scholar 

  6. Singh, A. & Settleman, J. E Oncogene 29, 4741–4751 (2010).

    Article  CAS  Google Scholar 

  7. Peinado, H., Olmeda, D. & Cano, A. Nature Rev. Cancer 7, 415–428 (2007).

    Article  CAS  Google Scholar 

  8. Puisieux, A., Brabletz, T. & Caramel, J. Nature Cell Biol. 16, 488–494 (2014).

    Article  CAS  Google Scholar 

  9. Clark, A. G. & Vignjevic, D. M. Curr. Opin. Cell Biol. 36, 13–22 (2015).

    Article  CAS  Google Scholar 

  10. Aceto, N. et al. Cell 158, 1110–1122 (2014).

    Article  CAS  Google Scholar 

  11. Rumman, M., Dhawan, J. & Kassem, M. Stem Cells 33, 2903–2912 (2015).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Shyamala Maheswaran or Daniel A. Haber.

Related links

Related links

Related links in Nature Research

Cancer: The to and fro of tumour spread

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Maheswaran, S., Haber, D. Transition loses its invasive edge. Nature 527, 452–453 (2015). https://doi.org/10.1038/nature16313

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature16313

This article is cited by

Search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer