How does neuronal activity affect the development of neural circuits? Work on the retina shows that blocking activity at the synapses between neurons reduces local synapse assembly without affecting global cellular structure.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Cline, H. & Haas, K. J. Physiol. (Lond.) 586, 1509–1517 (2008).
Tian, N. J. Physiol. (Lond.) 586, 4347–4355 (2008).
Kerschensteiner, D. et al. Nature 460, 1016–1020 (2009).
Wässle, H. Nature Rev. Neurosci. 5, 747–757 (2004).
Schiavo, G. et al. Nature 359, 832–835 (1992).
Bodnarenko, S. R. & Chalupa, L. M. Nature 364, 144–146 (1993).
Blankenship, A. G. et al. Neuron 62, 230–241 (2009).
Nevin, L. M., Taylor, M. R. & Baier, H. Neural Dev. 3, 36 (2008).
Sanes, J. R. & Yamagata, M. Annu. Rev. Cell Dev. Biol. doi:10.1146/annurev.cellbio.24.110707.175402 (2009).
Sanes, J. R. & Lichtman, J. W. Annu. Rev. Neurosci. 22, 389–442 (1999).
Bosman, L. W. & Konnerth, A. Neuroscience 162, 612–623 (2009).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Demb, J., Feller, M. Activity acts locally. Nature 460, 961–963 (2009). https://doi.org/10.1038/460961a
Published:
Issue Date:
DOI: https://doi.org/10.1038/460961a