Under extreme conditions such as high speed and heavy load, 18Cr2Ni4WA steel cannot meet the service requirements even after carburizing and quenching processes. In order to obtain better surface mechanical properties and tribological property, a hollow cathode ion source diffusion strengthening device was used to nitride the traditional carburizing and quenching samples. Unlike traditional ion carbonitriding technology, the low-temperature ion carbonitriding technology used in this article can increase the surface hardness of the material by 50% after 3 h of treatment, from the original 600 HV_0.1 to 900 HV_0.1, while the core hardness only decreases by less than 20%. The effect of post-ion carbonitriding treatment on mechanical properties and tribological properties of the carburized and quenched 18Cr2Ni4WA steel was investigated. Samples in different treatment are characterized using optical microscopy (OM), scanning electron microscopy (SEM), optimal SRV-4 high temperature tribotester, as well as Vickers hardness tester. Under two conditions of 6N light load and 60 N heavy load, compared with untreated samples, the wear rate of ion carbonitriding samples decreased by more than 99%, while the friction coefficient remained basically unchanged. Furthermore, the careful selection of ion nitrocarburizing and carburizing tempering temperatures in this study has been shown to significantly enhance surface hardness and wear resistance, while preserving the overall hardness of the carburized sample. The present study demonstrates the potential of ion carbonitriding technology as a viable post-treatment method for carburized gears. Full article

Artificial enhancement and release activity is an important method in the restoration of fishery resources. In order to understand the possible genetic effect of hatchery-released populations on wild populations during the artificial enhancement and release activities of Sebastiscus marmoratus in Zhoushan waters, we utilized mitochondrial DNA control region sequences to examine the genetic diversity in four S. marmoratus populations, including one farmed population, one released population and two wild populations. A total of 68 haplotypes from 123 individuals were detected, including 3 shared haplotypes. Haplotype diversity ranged from 0.944 to 0.980, with a mean of 0.966. The nucleotide diversity ranged from 0.020 to 0.025, with a mean of 0.022. Analysis of Molecular Variance (AMOVA) indicated that the primary genetic variation occurs within populations and the index of genetic differentiation between populations (F_ST) among the four populations showed no differentiation. The results indicate that the current artificial enhancement and release has not impacted the S. marmoratus population in Zhoushan waters. Continued long-term monitoring is essential to protect the high-quality germplasm resources of S. marmoratus. Full article

(1) Background: The combination of CAR-T with ASCT has been observed to enhance the efficacy of CAR-T cell therapy. However, the impact of this combination on adverse reactions is still uncertain. (2) Methods: Between January 2019 and February 2023, 292 patients diagnosed with r/r B-cell lymphoma received either CAR-T therapy alone or in combination with ASCT at our institution. We evaluated the incidence of CRS and CRES and utilized a logistic regression model to identify factors contributing to severe CRS (grade 3–4) and CRES (grade 3–4). (3) Results: The overall incidence of CRS and CRES was 78.9% and 8.2% in 147 patients receiving CAR-T alone, and 95.9% and 15.2% in 145 patients receiving CAR-T combined with ASCT, respectively. The incidence of overall CRS (p < 0.0001) and mild CRS (grade 1–2) (p = 0.021) was elevated in the ASCT combined with CAR-T group. No significant difference was observed in severe CRS and CRES between the groups. Among the 26 cases of lymphoma involving the central nervous system (CNS), 96.2% (25/26) developed CRS (15.4% grade 3–4), and 34.6% (9/26) manifested CRES (7.7% grade 3–4). Female patients had a lower incidence of severe CRS but a higher incidence of severe CRES. Lymphomas with CNS involvement demonstrated a higher risk of CRES compared to those without central involvement. (4) Conclusions: The combination of ASCT with CAR-T demonstrated a preferable option in r/r B-cell lymphoma without an increased incidence of severe CRS and CRES. Full article

Background: The time from submission to publication can significantly impact the speed of knowledge dissemination and is influenced by multiple factors. This research aims to investigate the time from submission to publication of journals of primary health care and to explore the factors that influence this duration. Methods: We selected journals of primary health care and extracted their impact factors, annual publication frequencies, and open access status. The time from submission to acceptance (SA lag), acceptance to publication (AP lag), and submission to publication (SP lag) were calculated. Additionally, we conducted statistical analyses to determine whether impact factors, annual publication frequencies, and journal open access status had an influence on publication time. Results: This study revealed the average SP lag was 243.4 days (interquartile range, IQR 159–306), the average SA lag was 177.8 days (IQR 99–229.3), and the average AP lag was 65.6 days (IQR 14–101). Variations were observed in SP lag, SA lag, and AP lag among different journals. SP lag generally decreased with higher impact factors. Journals with open access had longer SA lag but shorter AP lag. There was a general trend of decreasing SP lag and SA lag with an increasing number of annual publications, but no clear trend was observed for AP lag. Conclusions: Improvements are needed in reducing the duration from submission to publication for primary health care journals. Significant variation exists among journals. Additionally, factors such as the impact factor, open access status, and the number of annual publications may influence publication speed. Full article

The autonomous navigation system of feed-pushing robots is one of the key technologies for the intelligent breeding of dairy cows, and its accuracy has a significant influence on the quality of feed-pushing operations. Currently, the navigation methods of feed-pushing robots in the complex environment of cattle barns mainly include visual, LiDAR, and geomagnetic navigation, but there are still problems relating to low navigation accuracy. An autonomous navigation system based on ultra-wideband (UWB) positioning utilizing the dynamic forward-looking distance pure pursuit algorithm is proposed in this paper. First, six anchor nodes were arranged in the corners and central feeding aisle of a 30 × 86 m rectangular standard barn to form a rectangular positioning area. Then, utilizing the 9ITL-650 feed-pushing robot as a platform and integrating UWB wireless positioning technology, a global coordinate system for the cattle barn was established, and the expected path was planned. Finally, the pure pursuit model was improved based on the robot’s two-wheel differential kinematics model, and a dynamic forward-looking distance pure pursuit controller based on PID regulation was designed to construct a comprehensive autonomous navigation control system. Subsequently, field experiments were conducted in the cattle barn. The experimental results show that the static positioning accuracy of the UWB system for the feed-pushing robot was less than 16 cm under no-line-of-sight conditions in the cattle barn. At low speeds, the robot was subjected to linear tracking comparative experiments with forward-looking distances of 50, 100, 150, and 200 cm. The minimum upper-line distance of the dynamic forward-looking distance model was 205.43 cm. In the steady-state phase, the average lateral deviation was 3.31 cm, with an average standard deviation of 2.58 cm and the average root mean square error (RMSE) of 4.22 cm. Compared with the fixed forward-looking distance model, the average lateral deviation, the standard deviation, and the RMSE were reduced by 42.83%, 37.07%, and 42.90%, respectively. The autonomous navigation experiments conducted on the feed-pushing robot at travel speeds of 6, 8, and 10 m/min demonstrated that the maximum average lateral deviation was 7.58 cm, the maximum standard deviation was 8.22 cm, and the maximum RMSE was 11.07 cm, meeting the autonomous navigation requirements for feed-pushing operations in complex barn environments. This study provides support for achieving high-precision autonomous navigation control technology in complex environments. Full article

Plant roots exert hydrotropism in response to moisture gradients to avoid drought stress. The regulatory mechanism underlying hydrotropism involves novel regulators such as MIZ1 and GNOM/MIZ2 as well as abscisic acid (ABA), reactive oxygen species (ROS), and Ca²⁺ signaling. ABA, ROS, and Ca²⁺ signaling are also involved in plant responses to drought stress. Although the mechanism of moisture gradient perception remains largely unknown, the sensory apparatus has been reported to reside in the root elongation zone rather than in the root cap. In Arabidopsis roots, hydrotropism is mediated by the action of MIZ1 and ABA in the cortex of the elongation zone, the accumulation of ROS at the root curvature, and the variation in the cytosolic Ca²⁺ concentration in the entire root tip including the root cap and stele of the elongation zone. Moreover, root exposure to moisture gradients has been proposed to cause asymmetric ABA distribution or Ca²⁺ signaling, leading to the induction of the hydrotropic response. A comprehensive and detailed analysis of hydrotropism regulators and their signaling network in relation to the tissues required for their function is apparently crucial for understanding the mechanisms unique to root hydrotropism. Here, referring to studies on plant responses to drought stress, we summarize the recent findings relating to the role of ABA, ROS, and Ca²⁺ signaling in hydrotropism, discuss their functional sites and plausible networks, and raise some questions that need to be answered in future studies. Full article

High-tech greenhouse horticulture offers efficient crop cultivation that is unaffected by outdoor climate. However, compared to conventional cultivation systems, energy requirements, such as greenhouse heating and control, are larger, and concerns about the associated increase in CO₂ emissions exist. Although several previous studies have analyzed CO₂ emissions from high-tech greenhouse horticulture, few have covered the entire life cycle. This study aimed to analyze CO₂ emissions from high-tech greenhouse horticulture for tomatoes in Japan across the entire life cycle. A hybrid method combining process and input–output analyses was used to estimate life cycle CO₂ (LC-CO₂) emissions. The emission reduction potential of replacing liquefied petroleum gas (LPG) for greenhouse heating with wood chips was also examined. The results show that LC-CO₂ emissions were estimated to be 3.67 kg-CO₂ per 1 kg of tomato, 55.6% of which came from the production and combustion of LPG for greenhouse heating. The substitution of LPG with wood chips has the potential to reduce LC-CO₂ emissions by up to 49.1%. However, the improved LC-CO₂ emissions are still higher than those of conventional cultivation systems; thus, implementing additional measures to reduce LC-CO₂ emissions is crucial. Full article

The quality of grouting in pre-stressed pipelines plays a critical role in ensuring the safety and durability of pre-stressed concrete bridges. In this study, the transmission wave method was proposed as a means to assess the quality of grouting in pre-stressed pipelines. The ABAQUS finite element simulation (FE simulation) method was used to study the propagation of hammer stress waves in pre-stressed pipes. A full-scale test was conducted to verify the numerical simulation using the AGI-BWG instrument system developed to detect the quality of grouting. The results show that the propagation speed of transmitted waves increases and the frequency shifts towards higher frequencies with an increase in void length within pre-stressed pipelines. This research suggests that the propagation velocity of elastic waves in pre-stressed pipelines serves as a key indicator of grouting quality. The transmission wave method, based on hammer signals, proves to be an effective tool for detecting the quality of grouting in pre-stressed pipelines. Full article

This study highlights the disproportionate number of fatal and non-fatal accidents in general aviation (GA) compared to airline carriers, emphasizing the need to investigate the contributing factors to these incidents. It identifies poor decision-making and a lack of situational awareness as key issues and presents a systematic literature review using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) method to analyze preflight information used by GA pilots. The findings underscore the significance of operational factors in ensuring a successful flight and suggest modifications to pilot license renewal processes, with an emphasis on the adoption of digital preflight tools. A new theoretical framework based on the operational factors identified is also introduced, which could serve as a foundation for future studies and interventions aimed at enhancing safety in general aviation. Full article

In this study, the release of proteins and other biomolecules into an aqueous media from two red macroalgae (Sphaerococcus coronopifolius and Gelidium spinosum) was studied using eight different cell disruption techniques. The contents of carbohydrates, pigments, and phenolic compounds coextracted with proteins were quantified. In addition, morphological changes at the cellular level in response to the different pretreatment methods were observed by an optical microscope. Finally, the antioxidant capacity of obtained protein extracts was evaluated using three in vitro tests. For both S. coronopifolius and G. spinosum, ultrasonication for 60 min proved to be the most effective technique for protein extraction, yielding values of 3.46 ± 0.06 mg/g DW and 9.73 ± 0.41 mg/g DW, respectively. Furthermore, the highest total contents of phenolic compounds, flavonoids, and carbohydrates were also recorded with the same method. However, the highest pigment contents were found with ultrasonication for 15 min. Interestingly, relatively high antioxidant activities like radical scavenging activity (31.57–65.16%), reducing power (0.51–1.70, OD at 700 nm), and ferrous iron-chelating activity (28.76–61.37%) were exerted by the different protein extracts whatever the pretreatment method applied. This antioxidant potency could be attributed to the presence of polyphenolic compounds, pigments, and/or other bioactive substances in these extracts. Among all the used techniques, ultrasonication pretreatment for 60 min appears to be the most efficient method in terms of destroying the macroalgae cell wall and extracting the molecules of interest, especially proteins. The protein fractions derived from the two red macroalgae under these conditions were precipitated with ammonium sulfate, lyophilized, and their molecular weight distribution was determined using SDS-PAGE. Our results showed that the major protein bands were observed between 25 kDa and 60 kDa for S. coronopifolius and ranged from 20 kDa to 150 kDa for G. spinosum. These findings indicated that ultrasonication for 60 min could be sufficient to disrupt the algae cells for obtaining protein-rich extracts with promising biological properties, especially antioxidant activity. Full article

The current trend in distributed electric aircraft propulsion systems is to utilize the DC bus system at higher voltage levels than conventional aircraft systems. With Boeing and Airbus utilizing the +/−270 V bipolar DC bus system, the research on high-voltage systems is increasing gradually, with voltage levels ranging from 1 to 10 kV systems or +/−0.5 to +/−5 kV DC bus systems. These voltage levels present considerable challenges to the distributed electric aircraft propulsion systems. In addition to partial discharge effects, there are other challenges, particularly the challenge associated with effectively limiting short-circuit fault currents due to the low cable impedance of the distribution system. The cable impedance is a significant factor that determines the fault current during fault conditions. Due to the low impedance, there is a sharp increase in fault current, necessitating an enhanced protection strategy, which ensures that the system is adequately protected. This paper introduces a coordinated protection strategy specifically designed for distributed electric aircraft propulsion systems to mitigate or prevent short-circuit faults. The proposed algorithm utilizes an I²t-based strategy and the current-limiting-based strategy to protect the system from short-circuit faults and overload conditions. Redundant backup protection is also included in the algorithm in case the circuit breaker fails to operate. Full article

Land surface deformation, including subsidence and uplift, has significant impacts on human life and the natural environment. In recent years, the city of Wuxi, China has experienced large-scale surface deformation following the implementation of a groundwater abstraction ban policy in 2005. To accurately measure the regional impacts and understand the underlying mechanisms, we investigated the spatiotemporal characteristics of surface deformation in Wuxi from 2015 to 2023 using 100 Sentinel-1A SAR images and the Persistent Scatterer InSAR (PS-InSAR) technique. The results revealed that surface deformation in Wuxi exhibited significant spatial and temporal variations, with some areas experiencing alternating trends of subsidence and uplift rather than consistent unidirectional change. To uncover the factors influencing this volatility, we conducted a comprehensive analysis focusing on groundwater, precipitation, and soil geology. This study found strong correlations between the groundwater level changes and surface deformation, with the soft soil geology of the area, characterized by alternating layers of sand and clay, further increasing the surface volatility. Moreover, we innovatively applied the Generalized Autoregressive Conditional Heteroskedasticity (GARCH) model, typically used in financial analyses, to analyze the subsidence displacement time series in Wuxi. Based on this model, we propose a new “Amplitude Factor” index to evaluate overall surface deformation volatility in the city. Our qualitative assessment of surface stability based on the Amplitude Factor was consistent with research findings, demonstrating the accuracy and effectiveness of the proposed model. These results provide valuable insights for urban planning, construction, and safety control, highlighting the importance of continuous monitoring and analysis of surface deformation volatility for the city’s future development and safety. Full article

Glioblastoma multiforme (GBM) is the deadliest, most heterogeneous, and most common brain cancer in adults. Not only is there an urgent need to identify efficacious therapeutics, but there is also a great need to pair these therapeutics with biomarkers that can help tailor treatment to the right patient populations. We built patient drug response models by integrating patient tumor transcriptome data with high-throughput cell line drug screening data as well as Bayesian networks to infer relationships between patient gene expression and drug response. Through these discovery pipelines, we identified agents of interest for GBM to be effective across five independent patient cohorts and in a mouse avatar model: among them are a number of MEK inhibitors (MEKis). We also predicted phosphoglycerate dehydrogenase enzyme (PHGDH) gene expression levels to be causally associated with MEKi efficacy, where knockdown of this gene increased tumor sensitivity to MEKi and overexpression led to MEKi resistance. Overall, our work demonstrated the power of integrating computational approaches. In doing so, we quickly nominated several drugs with varying known mechanisms of action that can efficaciously target GBM. By simultaneously identifying biomarkers with these drugs, we also provide tools to select the right patient populations for subsequent evaluation. Full article

People spend more than 90% of their time indoors, and, as such, improving indoor lighting quality can enhance their quality of life by positively influencing both physiological and psychological aspects. Numerous studies suggest that perceptions of a space vary depending on a number of lighting attributes present. Significant effort has been made across various fields to identify the spatial lighting conditions and attributes that impact human perception, although we lack studies that explore the impact of these conditions in tandem. This paper investigates how interior lighting conditions influence human impressions of room ambiance. The study examines 16 different interior scenes, considering factors such as sky condition (sunny vs. overcast), shading blinds position (open vs. closed), presence or absence of electric light (on vs. off), and Correlated Color Temperature (CCT) (2700 K, 4000 K, and 6500 K). The evaluation is conducted within an office environment at Carnegie Mellon University, using a combination of objective lighting metrics and subjective assessments. In total, 26 participants, consisting of 11 females, 14 males, and one undisclosed, aged between 18 and 50, evaluated the office ambiance under various lighting conditions using semantic differential scales. The analysis showed that the variation of blinds and CCT levels significantly influenced the participants’ impression of light. The study also identified statistically significant interactions between “blinds and CCT” and “blinds and sky” conditions, highlighting the combined influence of these variables on shaping indoor light impressions. This research offers valuable insights into the complex interplay of different lighting factors in shaping human perceptions, and underscores the importance of optimizing indoor lighting conditions for creating healthy and sustainable indoor environments. Full article

The high levels of musculoskeletal pain, in conjunction with the low levels of functional capacity, may negatively affect workers’ health, efficiency, and productivity. This randomized controlled study investigated the efficacy of a 6-month comprehensive workplace exercise program on musculoskeletal pain and functional capacity in office workers. Seventy male and female office workers with musculoskeletal pain in any body area were randomly assigned to either an intervention (IG; n = 35) or a control group (CG; n = 35). The IG participated every working day (during working hours) in a 6-month supervised combined (flexibility, strength, and balance) exercise program (120 training sessions; five times/week) for the total body. The CG did not participate in any intervention. Musculoskeletal pains in nine body areas and functional capacity (flexibility, balance, and strength) of the lower and upper body were measured before and following the intervention. The IG significantly reduced duration and intensity of pain (43.1–70%; p = 0.000) as well as days of work absenteeism (84.6%; p = 0.000), while improving work capacity (87.1%; p = 0.000). Furthermore, the IG significantly increased cervical, handgrip, back, and leg maximal strength (10.3–27.1%; p = 0.000) and flexibility and balance (12.3–73.7%; p = 0.000). In CG, all musculoskeletal pain and functional capacity indices remained unchanged. In conclusion, this program may be effectively used to reduce musculoskeletal pain and improve functional capacity. Full article

The research aimed to observe the influence of the storage conditions of silver colloidal solutions prepared by biological (green) and chemical methods on their long-term stability. Green methods for reducing and stabilizing silver nanoparticles (AgNPs) use natural substances. The rosemary leaf extract was used for AgNPs synthesis, and prepared nanoparticles were spherical (average size of 12 nm). In the chemical method, commercial chemicals (NaBH₄, TSC, PVP, and H₂O₂) were used, and two colloids were prepared; the first contained spherical nanoparticles with an average size of 8 nm, and the second triangular prisms with an average size of 35 nm. The prepared colloids were stored under four conditions: at room temperature in the light and the dark, and at a temperature of 5 °C (refrigerator) in the light and the dark. The results confirmed the influence of storage conditions on the stability of nanoparticles. Colloids stored at 5 °C in the dark show the best stability. However, differences in stability dependent on the shape of nanoparticles prepared by chemical method were also observed; triangular nanoparticles showed the least stability. Methods such as UV–vis spectrophotometry, TEM, and EDX were used to analyze the nanoparticles before and after storage. Full article

To investigate the ameliorative effects and mechanism of Lycium barbarum polysaccharide (LBP) on growth performance, oxidative stress, and lipid deposition in common carp (Cyprinus carpio) fed with high-fat diets, fish with an initial weight of 5.29 ± 0.12 g were divided into five experimental groups—including normal-fat diets, high-fat diets, and high-fat diets—supplemented with LBP (0.5, 1.0, and 2.0 g/kg) for 8 weeks. The results showed that high-fat diets resulted in significant decreases in final body weight, weight gain rate, and specific growth rate of fish, as well as causing a significant decrease in hepatic total antioxidant capacity, catalase, and glutathione peroxidase activities. These changes were accompanied by a significant decrease in lipase activity and ATP level and a significant increase in malondialdehyde content. The expression levels of lipid metabolism-related genes (acetyl coenzyme A carboxylase 1, stearoyl coenzyme A desaturase 1, fat synthase, peroxisome proliferator-activated receptor-γ, fructofuranose bisphosphatase, and glucose-6-phosphatase) were also markedly elevated by high-fat diets. Supplementation with 0.5–2.0 g/kg LBP in high-fat diets improved the reduced growth performance, increased hepatic total antioxidant enzymes, catalase, and glutathione peroxidase activities, and lowered malondialdehyde level in fish fed with high-fat diets. Additionally, dietary supplementation with LBP significantly downregulated hepatic gene expression levels of acetyl coenzyme A carboxylase 1, stearoyl coenzyme A desaturase 1, fat synthase, sterol regulatory element-binding protein 1, peroxisome proliferator-activated receptor-γ, fructofuranose bisphosphatase, and glucose-6-phosphatase. In conclusion, fish fed with high-fat diets demonstrated impaired growth performance, antioxidant capacity, and lipid metabolism, and dietary supplementation with 0.5–2.0 g/kg LBP ameliorated the impairments induced by high-fat diets. Full article

Regularly, large parts of the agricultural areas of the Great Hungarian Plain are inundated due to excessive rainfall and insufficient evaporation and infiltration. Climate change is expected to lead to increasingly extreme weather conditions, which may even increase the frequency and extent of these inundations. Shallow “floods”, also defined as inland excess water, are phenomena that occur due to a complex set of interrelated factors. Our research presents a workflow based on active and passive satellite data from Sentinel-1 and -2, combined with a large auxiliary data set to detect and predict these floods. The workflow uses convolutional neural networks to classify water bodies based on Sentinel-1 and Sentinel-2 satellite data. The inundation data were complimented with meteorological, soil, land use, and GIS data to form 24 features that were used to train an XGBoost model and a deep neural network to predict future inundations, with a daily interval. The best prediction was reached with the XGBoost model, with an overall accuracy of 86%, a Kappa value of 0.71, and an F1 score of 0.86. The SHAP explainable AI method showed that the most important input features were the amount of water detected in the satellite imagery during the week before the forecast and during the period two weeks earlier, the number of water pixels in the surroundings on the day before the forecast, and the potential evapotranspiration on the day of the forecast. The resulting inland excess water inundation time series can be used for operational action, planning, and prevention. Full article

Background: Popular movement-based injury risk screens were shown to lack predictive precision, leading to interest in multifactorial models. Furthermore, there is a lack of research regarding injury risk assessment for those currently or planning to be recreationally active. This study aims to provide injury risk insights by analyzing multifactorial injury risk models and associated clinical measures in the U.S. population. Methods: Data related to injury, inflammatory markers, physical functioning, body composition, physical activity, and other variables from 21,033 respondents were extracted from NHANES. Odds ratios for self-reported injury were calculated for single predictors and risk models. Case–control and principal component analyses (PCA) were conducted to elucidate confounders and identify risk factor clusters, respectively. Receiver operating characteristic analysis was used to test the precision of a risk factor cluster to identify pain points and functional difficulties. Results: Sociodemographic, individual, and lifestyle factors were strongly associated with higher odds of injury. Increases in fibrinogen and C-reactive protein were significantly associated with all risk groups. Membership to the high-risk group (age over 40, obesity, no muscle-strengthening activities, sedentary lifestyle, and low back pain) predicted at least one functional difficulty with 67.4% sensitivity and 87.2% specificity. In the injury group, bone turnover markers were higher, yet confounded by age, and there was a significantly higher prevalence of self-reported osteoporosis compared to the control. In males, low testosterone was associated with injury, and high estradiol was associated with pain and functional difficulties. In females, high follicle-stimulating hormone was associated with functional difficulties. PCA revealed four high-risk profiles, with markers and activities showing distinct loadings. Conclusions: A comprehensive approach to injury risk assessment should consider the nexus of aging, lifestyle, and chronic disease to enhance tailored injury prevention strategies, fostering safe and effective physical activity participation and reducing the burden of musculoskeletal disorders. Full article

Electrochromic glazing alters its optical properties in the absence/presence of an electrical charge, varying from clear to dark to control daylighting and solar heat gains. This study aims to evaluate the impact of an electrochromic glazing, with indoor glare or temperature control, on the energy performance and thermal and visual comfort of an office room under three European climates, using a calibrated simulation model. The novelty of the paper lies in its combined performance assessment, using different standards and metrics. The results showed reduced climatization energy requirements with temperature control, but significantly increased artificial lighting energy use. Glare control achieved useful illuminance levels during 74–80% of working hours. Concerning temperature control, working hours within thermal comfort increased (21–43%) under a free-float regime. Moreover, the performance of this glazing was compared to that of a clear glazing with/without a reflective film and a thermochromic glazing for different solar orientations. The electrochromic glazing with glare control showed the highest energy savings (14–36%) for a western orientation, and the lowest negative impact on daylighting for a northern orientation. The best glare reduction was achieved with the reflective film. Considering the free-float regime, the electrochromic glazing, with temperature control, showed the highest increase in working hours within thermal comfort (6–9%) for a western orientation. Full article

In recent years, there has been an increasing amount of research analyzing open government initiatives that enable access to the information held by public bodies, promoting accountability and the fight against corruption. As there are few studies on intermediate governments to date, this research focuses on this level of government in Spain, one of the most decentralized countries in the world. The autonomous communities in Spain manage over 35% of consolidated public spending and are responsible for providing most social services, including health, education, and social services. To achieve this goal, the perceptions of the seventeen heads of open government in Spain’s autonomous communities were collected through a questionnaire. This approach fills a research gap as individuals outside of public administration have made the previous assessments. By allowing for a comparison with the conclusions reached by prior research, this study contributes to the creation of new knowledge. The study’s results are consistent with previous research and suggest that the open government in Spain is positively regarded, not falling below the European or global averages, and has a promising future despite significant obstacles, such as a resistance to change. Transparency is the most developed aspect of open government, while citizen collaboration ranks last. The autonomous communities of the Basque Country, Aragon, Castile Leon, and Catalonia have been identified as the most advanced in terms of open government. The analysis did not reveal any gender-based differences in opinion. Still, it did show variations based on age, the size of the autonomous community, or membership to the most developed group. Therefore, it is evident that promoting open government in the autonomous communities of Spain should continue. Full article

Countries face challenges in paying for new drugs. High prices are driven in part by exploding drug development costs, which, in turn, are driven by essential but excessive regulation. Burdensome regulation also delays drug development, and this can translate into thousands of life-years lost. We need system-wide reform that will enable less expensive, faster drug development. The speed with which COVID-19 vaccines and AIDS therapies were developed indicates this is possible if governments prioritize it. Countries also differ in how they value drugs, and generally, those willing to pay more have better, faster access. Canada is used as an example to illustrate how “incremental cost-effectiveness ratios” (ICERs) based on measures such as gains in “quality-adjusted life-years” (QALYs) may be used to determine a drug’s value but are often problematic, imprecise assessments. Generally, ICER/QALY estimates inadequately consider the impact of patient crossover or long post-progression survival, therapy benefits in distinct subpopulations, positive impacts of the therapy on other healthcare or societal costs, how much governments willingly might pay for other things, etc. Furthermore, a QALY value should be higher for a lethal or uncommon disease than for a common, nonlethal disease. Compared to international comparators, Canada is particularly ineffective in initiating public funding for essential new medications. Addressing these disparities demands urgent reform. Full article