Background and Objectives: This retrospective cohort study analyzes mechanical complications in hip fracture surgery using the Trochanteric Fixation Nail-Advanced (TFNA) implant. It investigates the correlation of these complications with demographic, intraoperative, and radiological factors, aiming to identify associated risk factors and suggest improvements in clinical surveillance and treatment strategies. Materials and Methods: We enrolled 253 patients diagnosed with pertrochanteric hip fractures treated between 2017 and 2021, with 126 meeting the criteria for a minimum 6-month follow-up. Data on demographics, American Anesthesia Association Classification (ASA), comorbidities, AO/OTA [AO (Arbeitsgemeinschaft für Osteosynthesefragen)/OTA (Orthopedic Trauma Association)] fracture classification, procedural details, and time to failure were collected. Radiographs were evaluated for reduction quality, the tip–apex distance (TAD), progressive varus deviation, and identification of mechanical complications. Statistical analysis was performed using SPSS software. Results: The predominant AO/OTA fracture classification was 31A2 in 67 cases (52.7%). Reduction quality was deemed good or acceptable in 123 cases (97.6%). The mean time to failure was 4.5 months (range: 2.2–6). The average TAD was 18 mm (range: 1.2–36), with a mean progressive varus deviation of 2.44° (range: 1.30–4.14). A good or acceptable reduction quality was observed in 97.6% of cases. Mechanical complications occurred in 21.4% of patients, with significant associations found with the lateral cortex fracture, use of a TFNA implant with a 130° angle, open reduction, and absence of prior osteoporosis treatment. Conclusions: The study provides insights into mechanical complications in proximal femur fractures treated with the TFNA nail, emphasizing the need for enhanced clinical and radiographic surveillance, especially in patients without osteoporosis treatment. Our findings support the necessity for further clinical studies comparing these outcomes with other implant designs and underscore the importance of personalized treatment strategies to reduce complication rates.  Full article

Percutaneous closure of the patent foramen ovale (PFO) is generally regarded as a safe and effective procedure, indicated in patients with a prior PFO-associated stroke. While it is highly safe, rarely, it could be accompanied by a migration of the device, mainly caused by the interplay of a specific PFO morphology and inappropriate device sizing. Herein, we outline a seldom-observed complication of an unintentional detachment of the PFO closure device during implantation, leading to its migration into the abdominal aorta, and a unique management approach. Due to the inability to recapture the occluder with a snare, which is considered to be a mainstay of endovascular retrieval methods, two coronary guidewires were maneuvered through the mesh of the occluder and then captured with a snare proximally to the occluder. This innovative dual-wire–snare system was carefully pulled to the common femoral artery, a position deemed suitable for surgical extraction via arteriotomy, which was achieved successfully. Full article

Background and objectives: Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide and is caused by multiple factors. To explore novel targets for HCC treatment, we comprehensively analyzed the expression of HomeoboxB13 (HOXB13) and its role in HCC. Materials and Methods: The clinical significance of HCC was investigated using open gene expression databases, such as TIMER, UALCAN, KM, OSlihc, and LinkedOmics, and immunohistochemistry analysis. We also analyzed cell invasion and migration in HCC cell lines transfected with HOXB13-siRNA and their association with MMP9, E2F1, and MEIS1. Results: HOXB13 expression was higher in fibrolamellar carcinoma than in other histological subtypes. Its expression was associated with lymph node metastasis, histological stage, and tumor grade. It was positively correlated with immune cell infiltration of B cells (R = 0.246), macrophages (R = 0.182), myeloid dendritic cells (R = 0.247), neutrophils (R = 0.117), and CD4+ T cells (R = 0.258) and negatively correlated with immune cell infiltration of CD8+ T cells (R = −0.107). A positive correlation was observed between HOXB13, MMP9 (R = 0.176), E2F1 (R = 0.241), and MEIS1 (R = 0.189) expression (p < 0.001). The expression level of HOXB13 was significantly downregulated in both HepG2 and PLC/PFR/5 cell lines transfected with HOXB13-siRNA compared to that in cells transfected with NC siRNA (p < 0.05). Additionally, HOXB13 significantly affected cell viability and wound healing. Conclusions: HOXB13 overexpression may lead to poor prognosis in patients with HCC. Additional in vivo studies are required to improve our understanding of the biological role and the exact mechanism of action of HOXB13 in HCC. Full article

Introduction: Vitamin B1 deficiency poses a significant risk of impaired consciousness, with manifestations ranging from anorexia and fatigue to severe neurological and cardiovascular disturbances. Wernicke’s encephalopathy, a neurological disorder stemming from vitamin B1 deficiency, presents as the triad of ophthalmoplegia, altered mental state, and cerebellar ataxia. However, these symptoms are not consistently present, complicating the diagnosis. In addition, subclinical vitamin B1 deficiency can progress unnoticed until severe complications arise. Studies indicate a high rate of undiagnosed cases, emphasizing the need for early detection and intervention. Case presentation: We present the case of a 65-year-old man in whom hyperlactatemia was incidentally detected, leading to the diagnosis of vitamin B1 deficiency. The patient, presenting with vertigo and vomiting, had been eating boxed lunches bought from convenience stores following the death of his wife 3 years earlier. Vertigo gradually improved with rest, but the persistence of hyperlactatemia prompted further investigation, revealing low vitamin B1 levels and high pyruvate levels. Treatment with dietary adjustments and supplements significantly improved his symptoms. Discussion: In this case, hyperlactatemia was found in a vertigo patient, revealing asymptomatic vitamin B1 deficiency. Elevated lactate is often linked with conditions like sepsis but can also stem from overlooked factors such as low vitamin B1 levels due to poor diet habits like consuming fried foods. Conclusion: This case highlights the importance of considering vitamin B1 deficiency in patients with unexplained hyperlactatemia, even in high-income countries. Early detection can prevent progression to the severe complications associated with Wernicke’s encephalopathy. Proactive measurement of lactate levels in at-risk populations may facilitate early diagnosis and intervention, ultimately improving patient outcomes. Full article

The occurrence of the pseudoaneurysm of visceral arteries in the field of chronic pancreatitis is a very rare complication that represents a life-threatening condition. The higher frequency of this complication is in the necrotic form of pancreatic inflammation, especially in patients with formed peripancreatic necrotic collections. The degradation of the arterial wall leads to bleeding and transforms these necrotic collections into a pseudoaneurysm. Urgent endovascular angioembolization is the first choice in the therapeutic approach as a valid minimally invasive solution with very satisfactory immediate and long-term outcomes. This successfully avoids open surgery, which is associated with a high mortality rate in these patients, especially in acute-on-chronic pancreatitis. Full article

Background and Objectives: Despite the fact that biologic drugs have transformed inflammatory bowel disease (IBD) treatment, addressing fibrosis-related strictures remains a research gap. This study explored the roles of cytokines, macrophages, and Krüppel-like factors (KLFs), specifically KLF4, in intestinal fibrosis, as well as the interplay of KLF4 with various gut components. Materials and Methods: This study examined macrophage subtypes, their KLF4 expression, and the effects of KLF4 knockdown on macrophage polarization and cytokine expression using THP-1 monocyte models. Co-culture experiments with stromal myofibroblasts and a conditioned medium from macrophage subtype cultures were conducted to study the role of these cells in intestinal fibrosis. Human-induced pluripotent stem cell-derived small intestinal organoids were used to confirm inflammatory and fibrotic responses in the human small intestinal epithelium. Results: Each macrophage subtype exhibited distinct phenotypes and KLF4 expression. Knockdown of KLF4 induced inflammatory cytokine expression in M0, M2a, and M2c cells. M2b exerted anti-fibrotic effects via interleukin (IL)-10. M0 and M2b cells showed a high migratory capacity toward activated stromal myofibroblasts. M0 cells interacting with activated stromal myofibroblasts transformed into inflammatory macrophages, thereby increasing pro-inflammatory cytokine expression. The expression of IL-36α, linked to fibrosis, was upregulated. Conclusions: This study elucidated the role of KLF4 in macrophage polarization and the intricate interactions between macrophages, stromal myofibroblasts, and cytokines in experimental in vitro models of intestinal fibrosis. The obtained results may suggest the mechanism of fibrosis formation in clinical IBD. Full article

There is a need for increased renewable energy to meet net-zero targets and decarbonise the economy. Harnessing the predictable power of the tides with tidal stream turbines can contribute to this. Tidal energy is a nascent technology with higher costs at present. However, cost reductions have been observed with an increased deployment in other renewable energy technologies that have received financial support, and it is postulated that similar will happen with tidal energy. The first tidal stream projects have been awarded market support in the UK through the Contracts for Difference (CfD) scheme, with almost 100 MW expected to be commissioned by 2028. This work uses learning rates to investigate how much investment in ongoing market support might be needed to achieve cost reductions through subsidised deployment alongside research and innovation. Using a range of informed `what if?’ scenarios, it shows sensitivity to key inputs. The results show that the support needed is most sensitive to the learning rate, reducing it from 15% to 12.5% or 10% doubles or more than quadruples the investment required, respectively. The support is also highly dependent on the starting cost from which learning occurs, taken as the CfD Strike Price in 2025. Varying this between 156 and 220 GBP/MWh results in total investment of GBP 6.7 and 22.3 bn, respectively. Most importantly, a balance is needed between subsidising deployment to drive down costs through learning and funding innovation to maintain a high learning rate. Full article

Fastener screws are critical components of rail fasteners. For the fastener screw maintenance robot, an image-based fast fastener screw detection method is urgently needed. In this paper, we propose a light-weight model named FSS-YOLO based on YOLOv5n for rail fastener screw detection. The C3Fast module is presented to replace the C3 module in the backbone and neck to reduce Params and FLOPs. Then, the SIoU loss is introduced to enhance the convergence speed and recognition accuracy. Finally, for the enhancement of the screw detail feature fusion, the shuffle attention (SA) is incorporated into the bottom-up process in the neck part. Experiment results concerning CIoU and DIoU for loss, MobileNetv3 and GhostNet for light-weight improvement, simple attention mechanism (SimAM), and squeeze-and-excitation (SE) attention for the attention module, and YOLO series methods for performance comparison are listed, demonstrating that the proposed FSS-YOLO significantly improves the performance, with higher accuracy and lower computation cost. It is demonstrated that the FSS-YOLO is 7.3% faster than the baseline model in FPS, 17.4% and 19.5% lower in Params and FLOPs, respectively, and the P, mAP@50, Recall, and F1 scores are increased by 10.6% and 6.4, 13.4%, and 12.2%, respectively. Full article

This study offers a comprehensive examination, both theoretically and experimentally, of the potential of methanol (M) as a sustainable aviation fuel (SAF) assessed in combination with kerosene (Ke—Jet-A aviation fuel + 5% Aeroshell oil). Different blends of methanol and kerosene (10%, 20%, and 30% vol. of (M) was added to Ke) were tested in an aviation micro turbo-engine under various operating regimes, such as idle, cruise, and maximum. Key engine parameters, including combustion temperature, fuel consumption, and thrust, were closely monitored during these trials. Essential performance indicators such as combustion efficiency, thermal efficiency, and specific consumption for all fuel blends under maximum operating conditions are also presented. Physical and chemical characteristics, such as viscosity, density, calorific value and flash point, were determined for each blend. Moreover, elemental analysis and FTIR spectroscopy were utilized to evaluate the chemical composition of the fuels. This study further investigated the air requirements for stoichiometric combustion and computed the resulting CO₂ and H₂O emissions. Experimental tests were conducted on the Jet Cat P80^® micro turbo-engine, covering assessments of starting procedures, acceleration, deceleration, and pollutant emissions (CO and SO₂) during various engine operating conditions. The results suggest that the examined fuel blends demonstrate stable engine performance at concentrations of 10% and 20% methanol. However, observations indicate that with an increase in methanol concentration, particularly at 30%, the stability of the engine at idle and, notably, at maximum speed decreases significantly. Specifically, at a 30% methanol concentration, the engine no longer operates stably, exhibiting significant rpm fluctuations, leading to the decision not to explore higher concentrations. Full article

To weaken or avoid the impact of dynamic threats such as wind and extreme weather on the real-time path of a UAV swarm, a path-planning method based on improved long short-term memory (LSTM) network prediction parameters was constructed. First, models were constructed for wind, static threats, and dynamic threats during the flight of the drone. Then, it was found that atmospheric parameters are typical time series data with spatial correlation. The LSTM network was optimized and used to process time series parameters to construct a network for predicting atmospheric parameters. The state of the drone was adjusted in real time based on the prediction results to mitigate the impact of wind or avoid the threat of extreme weather. Finally, a path optimization method based on an improved LSTM network was constructed. Through simulation, it can be seen that compared to the path that does not consider atmospheric effects, the optimized path has significantly improved flightability and safety. Full article

In the present research, we consider a biological model of serum hepatitis disease. We carry out a detailed analysis of the mentioned model along with a class with asymptomatic carriers to explore its theoretical and numerical aspects. We initiate the study by using the piecewise fractal–fractional derivative (FFD) by which the crossover effects within the model are examined. We split the time interval into subintervals. In one subinterval, FFD with a power law kernel is taken, while in the second one, FFD with an exponential decay kernel of the proposed model is considered. This model is then studied for its disease-free equilibrium point, existence, and Hyers–Ulam (H-U) stability results. For numerical results of the model and a visual presentation, we apply the Lagrange interpolation method and an extended Adams–Bashforth–Moulton (ABM) method, respectively. Full article

The formation of a rigid, tough interface based on a nacre-like structure in carbon fiber (CF) composites is a promising way to eliminate low delamination resistance. An effective method of coating CFs is electrophoretic deposition (EPD), which, in the case of dissimilar components like graphene oxide (GO) and polymeric glue, usually requires chemical bonding/strong interactions. In this work, we focus on chitin nanocrystals (ChNCs), leading to an excellent mechanical performance of artificial nacre, where favorable interactions and bonding with GO are controlled by degrees of deacetylation (5, 15, and 30%). We prepared coatings based on GO/ChNC adducts with 95/5, 90/10, 50/50, and 25/75 ratios using optimized EPD conditions (pH, concentration, voltage, and time). The prepared materials were characterized using FTIR, TEM, XPS, SEM, DLS, and XRD. SEM evaluation indicates the formation of a homogeneous interlayer, which has a fair potential for chemical bonding with the epoxy matrix. Short-beam testing of epoxy matrix composites indicates that the coating does not decrease stiffness and has a relatively low dependence on composition. Therefore, all coatings are promising for a detailed study of delamination resistance using laminate samples. Moreover, facile EPD from the water solution/suspension has a fair potential for industrial applications. Full article

Aim and background: Periapical lesions, which occur due to the infection and necrosis of dental pulp, are a significant dental pathology that poses risks to oral and systemic health. These lesions often require interventions such as root canal treatment or periapical surgery. Recent research has focused on the effectiveness of biocompatible materials, including mineral trioxide aggregate, bioceramics, and leukocyte-platelet-rich fibrin (L’PRF), in improving healing outcomes. This report presents the application of leukocyte-platelet-rich fibrin (L’PRF) derived from the patient’s autologous blood to enhance bone healing. Case description: A 61-year-old woman with well-controlled hypertension and good oral hygiene visited the dental clinic due to a painless swelling near her upper left central incisor. After examination, it was determined that she had a periapical granuloma. The patient underwent successful root canal retreatment and apical surgery, during which leukocyte-platelet-rich fibrin was applied. After 30 months, she experienced significant improvement with no symptoms and substantial bone regeneration. Conclusion: Clinical evidence and this case study indicate that leukocyte-platelet-rich fibrin (L’PRF) may enhance healing post periapical surgery. Further research, including more extensive and longer-term randomized trials, must confirm L’PRF’s effectiveness and refine treatment protocols. Clinical significance: L’PRF enhances bone healing post periapical surgery. Clinicians should consider integrating L’PRF in periapical surgeries, ensure diligent follow-up, and inform patients of its long-term advantages. Further randomized trials are needed to refine L’PRF clinical guidelines. Full article

The use of tag devices in marine environments has become indispensable in attaining a better understanding of marine life and contributing to conservation efforts. However, the successful deployment and operation of underwater tags both depend significantly on their hydrodynamic characteristics, particularly their resistance to motion and stability in various environmental conditions. Herein, a comprehensive study on the hydrodynamic characteristics and optimization of an underwater tag designed for monitoring blue sharks is presented. Firstly, a validation process is conducted by comparing the computational fluid dynamics (CFD) results with the experimental data from Myring’s study, focusing on the resistance characteristics of the tag’s body and the impact of various operational conditions. Subsequently, the validated CFD model is applied to assess the hydrodynamic performance of the tag under different flow conditions, velocities, and angles of attack. Through iterative simulations, including mesh independence studies and boundary condition adjustments, the study identifies key parameters influencing the tag’s resistance and stability. Furthermore, the paper proposes and implements design modifications, including the incorporation of stabilizing fins, aimed at minimizing resistance and improving the tag’s equilibrium position. The effectiveness of these design enhancements is demonstrated through a comparative analysis of resistance and pitching moments for both preliminary and optimized tag configurations. Overall, the study provides valuable insights into the hydrodynamic behavior of underwater tags and offers practical recommendations for optimizing their design to minimize interference with the movement of tagged marine animals. Full article

This paper explores two routes along which a pragmatic philosophical approach can contribute to reflections on agnosticism. The first of these approaches is developed in dialogue with William James, and it is oriented towards the needs and obligations of individuals and the extent to which agnosticism affects our abilities to lead strenuous lives. The second is developed in dialogue with Richard Rorty. It is oriented towards how agnosticisms can be adopted within particular vocabularies vis-a-vis other vocabularies as a pragmatically helpful strategy or skill. I discuss the extent to which these can contribute to philosophical reflection on agnosticism and propose that they show that the agnosticism debate would benefit from a broadened focus where epistemic and pragmatic considerations are better integrated than presently. This would enable us to discuss different types of agnosticism that come to the fore in various contexts and whether they prevent us or allow us to better handle concrete problems in our interactions with the world. Full article

This essay uses Freudian–Lacanian psychoanalytic theory to interpret Hassan Blasim’s short story “The Nightmares of Carlos Fuentes”. Blasim’s story depicts the psychological struggles of an Iraqi emigrant relating to his embattled sense of belonging in a Dutch society due to the recurrent nightmares of his “traumatic” past. It challenges his assimilationist fantasies. I develop Lacan’s idea of ontological lack as a structural susceptibility that is exacerbated by actual experiences of trauma to underline how racialized refugees from the war-torn global South are doubly vulnerable to experiencing subjective dehiscence between their efforts to forget past war traumas and the challenges of assimilating into (white) host nations. This essay uses Blasim’s story to illustrate a serious psychological issue experienced by racialized minority subjects in white/European host countries. Full article

This study presents a responsive analysis of the role of artificial intelligence (AI) in risk management, contrasting traditional approaches with those augmented by AI and highlighting the challenges and opportunities that emerge. AI, intense learning methodologies such as convolutional neural networks (CNNs), have been identified as pivotal in extracting meaningful insights from image data, a form of analysis that holds significant potential in identifying and managing risks across various industries. The research methodology involves a strategic selection and processing of images for analysis and introduces three case studies that serve as benchmarks for evaluation. These case studies showcase the application of AI, in place of image processing capabilities, to identify hazards, evaluate risks, and suggest control measures. The comparative evaluation focuses on the accuracy, relevance, and practicality of the AI-generated findings alongside the system’s response time and comprehensive understanding of the context. Results reveal that AI can significantly enhance risk assessment processes, offering rapid and detailed insights. However, the study also recognises the intrinsic limitations of AI in contextual interpretation, advocating for a synergy between technological and domain-specific expertise. The conclusion underscores the transformative potential of AI in risk management, supporting continued research to further integrate AI effectively into risk assessment frameworks. Full article

The present work delineates the tailoring of the thermal effusivity and diffusivity of the novel class of heat transfer fluids—ionanofluids—by the incorporation of nanocarbons like diesel soot (DS), camphor soot (CS), carbon nanotubes (CN), and graphene (GR). When the thermal diffusivity delivers information on the thermal energy propagation, the thermal effusivity concerns the energy exchange at the interface, enabling energy-efficient thermal system design. The nanocarbons are subjected to morphological characterisation by field emission scanning electron microscopy. Fourier-transform infrared and Raman spectroscopic analyses confirm functional groups and vibrational bands. The microcrystalline size and graphiticity are also understood from the Raman spectrum. Ionanofluids prepared by dispersing nanocarbons into an ionic liquid base 1-Butyl-3-methylimidazolium methyl sulfate (BMMS) are analysed by nondestructive photopyroelectric calorimetry (PPE). The PPE analysis of ionanofluids demonstrates that nanocarbons influence thermal parameters in the base fluid, with soot ionanofluids exhibiting increased thermal effusivity and diffusivity due to their various carbon allotropic composition. This study underscores the importance of selecting the appropriate carbon allotrope for tailoring ionanofluids’ thermal properties, providing insights into manipulating these properties for enhanced performance across various industrial applications. Full article

This study presents the development of a sandwich ELISA method for gluten detection in foods, using recombinant Fab antibody fragments against gliadin. The Fabs were chemically biotinylated and immobilized on streptavidin-coated plates as capture antibodies, while alkaline phosphatase-conjugated Fabs were used as detection antibodies. Four different gliadin-binding Fabs were tested and the Fab pair Fab8E-4 and Fab-C showed the best compatibility. An indirect sandwich immunoassay, using unmodified Fab8E-4 for capture and Fab-C as the detection antibody, achieved a detection limit of 26 ng/mL of gliadin, corresponding to 10 mg/kg of gluten in foods. No cross-reactivity was observed against 60 gluten-free species commonly used in the food industry. Analysis of 50 commercial products demonstrated consistent results compared to the standard method for gluten detection. The complete lack of cross-reactivity of the developed immunoassay with oat products potentially provides an advantage over other gluten detection systems. Full article

The low solubility and stability of fat-soluble curcumin in water limit its application in active packaging. This study explored the use of a pH-driven method to investigate the preparation and enhancement of the performance of films loaded with curcumin in a matrix of sodium alginate (Alg) and egg white protein (EWP). In this study, the EWP, Alg, and curcumin primarily bind through hydrogen bonding, electrostatic interactions, and hydrophobic interactions. Compared to EWP films, the films loaded with curcumin through the pH-driven method exhibited enhanced extensibility and water resistance, with an elongation at break (EB) of 103.56 ± 3.13% and a water vapor permeability (WVP) of 1.67 ± 0.03 × 10⁻¹⁰ g·m/m²·Pa·s. The addition of Alg improved the encapsulation efficiency and thermal stability of curcumin, thereby enhancing the antioxidant activity of the film through the addition of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radicals, which resulted in 106.95 ± 2.61 μg TE/g and 144.44 ± 8.89 μg TE/g, respectively. It is noteworthy that the detrimental effect of Alg on the color responsiveness of films containing curcumin has also been observed. This study provides a potential strategy and consideration for the loading of low water-soluble active substances and the preparation of active packaging. Full article

Knowledge communication in cultural heritage and digital humanities currently faces two challenges, which this paper addresses: On the one hand, data-driven storytelling in these fields has mainly focused on human protagonists, while other essential entities (such as artworks and artifacts, institutions, or places) have been neglected. On the other hand, storytelling tools rarely support the larger chains of data practices, which are required to generate and shape the data and visualizations needed for such stories. This paper introduces the InTaVia platform, which has been developed to bridge these gaps. It supports the practices of data retrieval, creation, curation, analysis, and communication with coherent visualization support for multiple types of entities. We illustrate the added value of this open platform for storytelling with four case studies, focusing on (a) the life of Albrecht Dürer (person biography), (b) the Saliera salt cellar by Benvenuto Cellini (object biography), (c) the artist community of Lake Tuusula (group biography), and (d) the history of the Hofburg building complex in Vienna (place biography). Numerous suggestions for future research arise from this undertaking. Full article