The 2023 MDPI Annual Report has
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20 pages, 4120 KiB  
Article
Life Cycle Cost Assessment of Electric, Hybrid, and Conventional Vehicles in Bangladesh: A Comparative Analysis
by Md. Sarowar Khaled, Abdalla M. Abdalla, Pg Emeroylariffion Abas, Juntakan Taweekun, Md. Sumon Reza and Abul K. Azad
World Electr. Veh. J. 2024, 15(5), 183; https://doi.org/10.3390/wevj15050183 - 26 Apr 2024
Abstract
The automobile industry is shifting from internal combustion engine vehicles (ICEVs) to hybrid electric vehicles (HEVs) or electric vehicles (EVs) extremely fast. Our calculation regarding the most popular private car brand in Bangladesh, Toyota, shows that the life cycle cost (LCC) of a [...] Read more.
The automobile industry is shifting from internal combustion engine vehicles (ICEVs) to hybrid electric vehicles (HEVs) or electric vehicles (EVs) extremely fast. Our calculation regarding the most popular private car brand in Bangladesh, Toyota, shows that the life cycle cost (LCC) of a Toyota BZ3 (EV), USD 43,409, is more expensive than a Toyota Aqua (HEV) and Toyota Prius (HEV), but cheaper than a Toyota Axio (ICEV) and Toyota Allion (ICEV). It has been found that about a 25% reduction in the acquisition cost of a Toyota BZ3 would lower its LCC to below others. EVs can be a good choice for those who travel a lot. Changes in electricity prices have little effect upon the LCC of EVs. With the expected decline in the annual price for batteries, which is between 6 and 9%, and the improvement of their capacities, EVs will be more competitive with other vehicles by 2030 or even earlier. EVs will dominate the market since demand for alternative fuel-powered vehicles is growing due to their environmental and economic advantages. Full article
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17 pages, 7329 KiB  
Article
Integrating Real-Time Meteorological Conditions into a Novel Fire Spread Model for Grasslands
by Yakun Zhang, Huimin Yu, Wenjiang Huang, Tiecheng Huang, Meng Fan and Kun Wang
Fire 2024, 7(5), 154; https://doi.org/10.3390/fire7050154 - 26 Apr 2024
Abstract
Accurate comprehension of grassland fires is imperative for maintaining ecological stability. In this study, we propose a novel fire model that incorporates real-time meteorological conditions. Our methodology integrates key meteorological factors including relative humidity, temperature, degree of solidification of combustible materials, and wind [...] Read more.
Accurate comprehension of grassland fires is imperative for maintaining ecological stability. In this study, we propose a novel fire model that incorporates real-time meteorological conditions. Our methodology integrates key meteorological factors including relative humidity, temperature, degree of solidification of combustible materials, and wind speed. These factors are embedded into a comprehensive function that determines both the downwind and upwind spreading speeds of the fire. Additionally, the model accommodates fire spread in the absence of wind by incorporating the direction perpendicular to the wind, with wind speed set to zero. By precisely determining wind speed, the model enables real-time calculation of fire spread speeds in all directions. Under stable wind conditions, the fire spread area typically adopts an elliptical shape. Leveraging ellipse properties, we define the aspect ratio as a function related to wind speed. Consequently, with knowledge of the fire duration, the model accurately estimates the area of fire spread. Our findings demonstrate the effectiveness of this model in predicting and evaluating fires in the Hulunbuir Grassland. The model offers an innovative method for quantifying grassland fires, contributing significantly to the understanding and management of grassland ecosystems. Full article
(This article belongs to the Special Issue Fire Numerical Simulation)
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13 pages, 1111 KiB  
Article
Dynamics and Complexity Analysis of Fractional-Order Inventory Management System Model
by Tengfei Lei, Rita Yi Man Li, Jirawan Deeprasert and Haiyan Fu
Fractal Fract. 2024, 8(5), 258; https://doi.org/10.3390/fractalfract8050258 - 26 Apr 2024
Abstract
To accurately depict inventory management over time, this paper introduces a fractional inventory management model that builds upon the existing classical inventory management framework. According to the definition of fractional difference equation, the numerical solution and phase diagram of an inventory management system [...] Read more.
To accurately depict inventory management over time, this paper introduces a fractional inventory management model that builds upon the existing classical inventory management framework. According to the definition of fractional difference equation, the numerical solution and phase diagram of an inventory management system are obtained by MATLAB simulation. The influence of parameters on the nonlinear behavior of the system is analyzed by a bifurcation diagram and largest Lyapunov exponent (LLE). Combined with the related indexes of time series, the complex characteristics of a quantization system are analyzed using spectral entropy and C0. This study concluded that the changing law of system complexity is consistent with the LLE of the system. By analyzing the influence of order on the system, it is found that the inventory changes will be periodic in some areas when the system is fractional, which is close to the actual conditions of the company’s inventory situation. The research results of this paper provide useful information for inventory managers to implement inventory and facility management strategies. Full article
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17 pages, 339 KiB  
Article
Some Properties of Normalized Tails of Maclaurin Power Series Expansions of Sine and Cosine
by Tao Zhang, Zhen-Hang Yang, Feng Qi and Wei-Shih Du
Fractal Fract. 2024, 8(5), 257; https://doi.org/10.3390/fractalfract8050257 - 26 Apr 2024
Abstract
In the paper, the authors introduce two notions, the normalized remainders, or say, the normalized tails, of the Maclaurin power series expansions of the sine and cosine functions, derive two integral representations of the normalized tails, prove the nonnegativity, positivity, decreasing property, and [...] Read more.
In the paper, the authors introduce two notions, the normalized remainders, or say, the normalized tails, of the Maclaurin power series expansions of the sine and cosine functions, derive two integral representations of the normalized tails, prove the nonnegativity, positivity, decreasing property, and concavity of the normalized tails, compute several special values of the Young function, the Lommel function, and a generalized hypergeometric function, recover two inequalities for the tails of the Maclaurin power series expansions of the sine and cosine functions, propose three open problems about the nonnegativity, positivity, decreasing property, and concavity of a newly introduced function which is a generalization of the normalized tails of the Maclaurin power series expansions of the sine and cosine functions. These results are related to the Riemann–Liouville fractional integrals. Full article
(This article belongs to the Section General Mathematics, Analysis)
18 pages, 2967 KiB  
Article
Metabolite Profiling and Molecular Network Shows Kinkeloids as Promoting of Collagen Synthesis from Combretum micranthum
by Souhila Messaili, Doha Haggouch, Mikaela Bignard, Pierre-Eric Campos, Emilie Destandau and Eldra Delannay
Separations 2024, 11(5), 132; https://doi.org/10.3390/separations11050132 - 26 Apr 2024
Abstract
Combretum micranthum, a plant native to Africa, has a well-documented traditional use in the treatment of various ailments such as fever, diabetes, and malaria. Its pharmaceutical benefits include nephroprotective, anti-inflammatory, antioxidant, and antimicrobial properties, which were proven. In addition, its potential for [...] Read more.
Combretum micranthum, a plant native to Africa, has a well-documented traditional use in the treatment of various ailments such as fever, diabetes, and malaria. Its pharmaceutical benefits include nephroprotective, anti-inflammatory, antioxidant, and antimicrobial properties, which were proven. In addition, its potential for cosmetic applications is being explored due to its depigmenting, anti-inflammatory, and UV-damage-repairing properties. This article investigates the molecular composition and new cosmetically relevant biological activity of C. micranthum and enriched fractions to begin the establishment of the structure–activity relationship. Firstly, an extract of C. micranthum was prepared and selected for its overall biological response and then fractionated to obtain simplified molecular fractions. One fraction was particularly enriched in kinkeloids, a specific family of compounds to this species. All the fractions and the crude extract were then tested on biological targets to evaluate and compare their cosmetic activities. Molecular networks were constructed from the UHPLC-MS/HRMS data to better characterize the extract and fractions and to highlight structure–activity relationships. This study highlights the metabolic profiling of a butylene glycol extract of C. micranthum, showing its main chemical families and revealing that the kinkeloids, identified by HRMS and NMR, promote an increase in collagen I synthesis, an interesting cosmetic activity neither previously described for these compounds and neither for C. micranthum extract. Full article
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18 pages, 1311 KiB  
Review
Digital Twins for Discrete Manufacturing Lines: A Review
by Xianqun Feng and Jiafu Wan
Big Data Cogn. Comput. 2024, 8(5), 45; https://doi.org/10.3390/bdcc8050045 - 26 Apr 2024
Abstract
Along with the development of new-generation information technology, digital twins (DTs) have become the most promising enabling technology for smart manufacturing. This article presents a statistical analysis of the literature related to the applications of DTs for discrete manufacturing lines, researches their development [...] Read more.
Along with the development of new-generation information technology, digital twins (DTs) have become the most promising enabling technology for smart manufacturing. This article presents a statistical analysis of the literature related to the applications of DTs for discrete manufacturing lines, researches their development status in the areas of the design and improvement of manufacturing lines, the scheduling and control of manufacturing line, and predicting faults in critical equipment. The deployment frameworks of DTs in different applications are summarized. In addition, this article discusses the three key technologies of high-fidelity modeling, real-time information interaction methods, and iterative optimization algorithms. The current issues, such as fine-grained sculpting of twin models, the adaptivity of the models, delay issues, and the development of efficient modeling tools are raised. This study provides a reference for the design, modification, and optimization of discrete manufacturing lines. Full article
15 pages, 847 KiB  
Article
Precision Agriculture: Computer Vision-Enabled Sugarcane Plant Counting in the Tillering Phase
by Muhammad Talha Ubaid and Sameena Javaid
J. Imaging 2024, 10(5), 102; https://doi.org/10.3390/jimaging10050102 - 26 Apr 2024
Abstract
The world’s most significant yield by production quantity is sugarcane. It is the primary source for sugar, ethanol, chipboards, paper, barrages, and confectionery. Many people are affiliated with sugarcane production and their products around the globe. The sugarcane industries make an agreement with [...] Read more.
The world’s most significant yield by production quantity is sugarcane. It is the primary source for sugar, ethanol, chipboards, paper, barrages, and confectionery. Many people are affiliated with sugarcane production and their products around the globe. The sugarcane industries make an agreement with farmers before the tillering phase of plants. Industries are keen on knowing the sugarcane field’s pre-harvest estimation for planning their production and purchases. The proposed research contribution is twofold: by publishing our newly developed dataset, we also present a methodology to estimate the number of sugarcane plants in the tillering phase. The dataset has been obtained from sugarcane fields in the fall season. In this work, a modified architecture of Faster R-CNN with feature extraction using VGG-16 with Inception-v3 modules and sigmoid threshold function has been proposed for the detection and classification of sugarcane plants. Significantly promising results with 82.10% accuracy have been obtained with the proposed architecture, showing the viability of the developed methodology. Full article
(This article belongs to the Special Issue Imaging Applications in Agriculture)
18 pages, 8706 KiB  
Article
Separation and Analysis of Connected, Micrometer-Sized, High-Frequency Damage on Glass Plates due to Laser-Accelerated Material Fragments in Vacuum
by Sabrina Pietzsch, Sebastian Wollny and Paul Grimm
J. Imaging 2024, 10(5), 101; https://doi.org/10.3390/jimaging10050101 - 26 Apr 2024
Abstract
In this paper, we present a new processing method, called MOSES—Impacts, for the detection of micrometer-sized damage on glass plate surfaces. It extends existing methods by a separation of damaged areas, called impacts, to support state-of-the-art recycling systems in optimizing their parameters. These [...] Read more.
In this paper, we present a new processing method, called MOSES—Impacts, for the detection of micrometer-sized damage on glass plate surfaces. It extends existing methods by a separation of damaged areas, called impacts, to support state-of-the-art recycling systems in optimizing their parameters. These recycling systems are used to repair process-related damages on glass plate surfaces, caused by accelerated material fragments, which arise during a laser–matter interaction in a vacuum. Due to a high number of impacts, the presented MOSES—Impacts algorithm focuses on the separation of connected impacts in two-dimensional images. This separation is crucial for the extraction of relevant features such as centers of gravity and radii of impacts, which are used as recycling parameters. The results show that the MOSES—Impacts algorithm effectively separates impacts, achieves a mean agreement with human users of (82.0 ± 2.0)%, and improves the recycling of glass plate surfaces by identifying around 7% of glass plate surface area as being not in need of repair compared to existing methods. Full article
(This article belongs to the Section Computer Vision and Pattern Recognition)
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18 pages, 3120 KiB  
Article
Recycling of Egyptian Shammi Corn Stalks for Maintaining Sustainable Cement Industry: Scoring on Sustainable Development Goals
by Fajr Qasem, Mahmoud Sharaan, Manabu Fujii and Mahmoud Nasr
Recycling 2024, 9(3), 34; https://doi.org/10.3390/recycling9030034 - 26 Apr 2024
Abstract
This study focuses on recycling Shammi corn stalks in the cement industries, further avoiding air and soil pollution caused by their improper disposal. This crop residue was thermally treated at 700 °C for 2 h under an oxygen-rich environment to produce Shammi corn [...] Read more.
This study focuses on recycling Shammi corn stalks in the cement industries, further avoiding air and soil pollution caused by their improper disposal. This crop residue was thermally treated at 700 °C for 2 h under an oxygen-rich environment to produce Shammi corn stalk ash (SCSA). This SCSA was used as a cement replacement material (2–10%, w/w), whereas the control sample included only cement. The compressive strength values for the 4% (w/w) replacement ratio at 2-, 7-, and 28-day ages were greater than those for the control by 26.5%, 15.8%, and 11.4%, respectively. This 4% (w/w) also maintained a better flexural strength than other mixtures, with proper initial and final setting times (135 and 190 min), workability (18.5 cm), and water consistency (27.5%). These mechanical/physical properties were integrated with socio-enviro-economic data collected from experts through a pairwise comparison questionnaire, forming the inputs of a multi-criteria decision-making (MCDM) model. Recycling SCSA in the cement-manufacturing process attained positive scores in the achievement of the three pillars of sustainable development, revealing an overall score greater than the control. Hence, the study outcomes could be essential in developing green concrete, cement blocks, and mortar, based on the sustainable development goals (SDGs) agenda. Full article
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22 pages, 4136 KiB  
Article
DepthCrackNet: A Deep Learning Model for Automatic Pavement Crack Detection
by Alireza Saberironaghi and Jing Ren
J. Imaging 2024, 10(5), 100; https://doi.org/10.3390/jimaging10050100 - 26 Apr 2024
Abstract
Detecting cracks in the pavement is a vital component of ensuring road safety. Since manual identification of these cracks can be time-consuming, an automated method is needed to speed up this process. However, creating such a system is challenging due to factors including [...] Read more.
Detecting cracks in the pavement is a vital component of ensuring road safety. Since manual identification of these cracks can be time-consuming, an automated method is needed to speed up this process. However, creating such a system is challenging due to factors including crack variability, variations in pavement materials, and the occurrence of miscellaneous objects and anomalies on the pavement. Motivated by the latest progress in deep learning applied to computer vision, we propose an effective U-Net-shaped model named DepthCrackNet. Our model employs the Double Convolution Encoder (DCE), composed of a sequence of convolution layers, for robust feature extraction while keeping parameters optimally efficient. We have incorporated the TriInput Multi-Head Spatial Attention (TMSA) module into our model; in this module, each head operates independently, capturing various spatial relationships and boosting the extraction of rich contextual information. Furthermore, DepthCrackNet employs the Spatial Depth Enhancer (SDE) module, specifically designed to augment the feature extraction capabilities of our segmentation model. The performance of the DepthCrackNet was evaluated on two public crack datasets: Crack500 and DeepCrack. In our experimental studies, the network achieved mIoU scores of 77.0% and 83.9% with the Crack500 and DeepCrack datasets, respectively. Full article
(This article belongs to the Special Issue Deep Learning in Image Analysis: Progress and Challenges)
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25 pages, 16623 KiB  
Article
Using Mutation Breeding to Improve the Eating Characteristics of the Fusarium Wilt-Resistant Banana Variety, ‘Goldfinger’ (AAAB)
by Katelyn Robertson, Sharon Hamill, Carole Wright, Massimo Bianco, Ashley Balsom, Simoné Moller, Ishita Pramanik, Philippa Lyons and Jeff Daniells
Horticulturae 2024, 10(5), 444; https://doi.org/10.3390/horticulturae10050444 - 26 Apr 2024
Abstract
Banana production in Australia is under threat from Fusarium wilt Tropical Race 4 (TR4), and the option of growing a disease-resistant variety is sought after by many farmers. Goldfinger is one such alternative; however, it was previously rejected by Australian consumers. In Phase [...] Read more.
Banana production in Australia is under threat from Fusarium wilt Tropical Race 4 (TR4), and the option of growing a disease-resistant variety is sought after by many farmers. Goldfinger is one such alternative; however, it was previously rejected by Australian consumers. In Phase I of this investigation, mutagenesis was employed as a practical method to generate large numbers of novel variants. In Phase II, 631 variants were established in a field trial where agronomic and postharvest assessments, including taste-testing, identified 20 improved selections. Phase III involved a replicated field evaluation of the selections with favourable mutations, where further taste-testing revealed five selections with the most promising eating characteristics. In Phase IV, the five selections underwent large-scale consumer and sensory evaluations where four of them performed as well as the industry standard controls ‘Williams’ Cavendish and Lady Finger. The sensory analysis revealed differences in the fruit flavour profile and textural attributes, and these features will play a key role in bringing a new banana variety to market and for promotion to consumers. Screening of the variants’ resistance to yellow Sigatoka was integrated into the project, but further work is needed to ensure these four selections have retained their TR4 resistance. Full article
(This article belongs to the Special Issue Developments in the Genetics and Breeding of Banana Species)
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15 pages, 2747 KiB  
Article
Production of Polyclonal Antibodies and Development of Competitive ELISA for Quantification of the Lantibiotic Paenibacillin
by Ahmed G. Abdelhamid, Macdonald Wick and Ahmed E. Yousef
Fermentation 2024, 10(5), 232; https://doi.org/10.3390/fermentation10050232 - 26 Apr 2024
Abstract
The discovery and biotechnological application of new antimicrobial peptides are impeded by a lack of sensitive methods for peptide quantification. Paenibacillin is an emerging antimicrobial lantibiotic that was discovered in Paenibacillus polymyxa OSY-DF ATCC PTA-7852, isolated from the fermented vegetable Kimchee. This lantibiotic [...] Read more.
The discovery and biotechnological application of new antimicrobial peptides are impeded by a lack of sensitive methods for peptide quantification. Paenibacillin is an emerging antimicrobial lantibiotic that was discovered in Paenibacillus polymyxa OSY-DF ATCC PTA-7852, isolated from the fermented vegetable Kimchee. This lantibiotic has potency against many foodborne pathogenic and spoilage bacteria. To advance the research and application of paenibacillin, a rapid, specific, and sensitive detection and quantification immunoassay was developed. After anti-paenibacillin polyclonal antibodies (pAbs) were generated and purified, a competitive enzyme-linked immunosorbent assay (cELISA) was developed and optimized for paenibacillin quantification. The dynamic range of the cELISA was determined by using a three-parameter nonlinear regression model, achieving a correlation (R2) value of 0.95. The cELISA displayed high sensitivity, with the ability to detect paenibacillin at levels as low as 15.6 ng/mL, which is significantly lower than the limit of detection of the conventional antimicrobial assay (20 µg/mL paenibacillin). The cELISA successfully differentiated paenibacillin concentrations in cell-free crude supernatants of P. polymyxa wild type and its mutant strain when grown at 30 °C and 37 °C; higher paenibacillin levels were found in the mutant (0.248–0.276 µg/mL) than in the wild type (0.122–0.212 µg/mL) culture. These findings were validated by the transcriptional analysis of 11 paenibacillin biosynthetic genes, which were significantly upregulated (≥2-fold increase) in the mutant compared with the wild strain. Additionally, the cELISA exhibited high sensitivity by recovery of paenibacillin titers spiked at 2.5 and 10 µg/mL in de Man, Rogosa, and Sharpe (MRS) broth and diluted skim milk. These results suggest that the anti-paenibacillin pAbs and the developed cELISA could be valuable in quantifying paenibacillin in complex matrices and in aiding the discovery of paenibacillin-producing natural microbiota. Full article
(This article belongs to the Special Issue Green Synthesis of Antimicrobials and Its Applications)
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28 pages, 1375 KiB  
Review
Microbial Preservation and Contamination Control in the Baking Industry
by Alane Beatriz Vermelho, Jean Vinícius Moreira, Athayde Neves Junior, Claudia Ramos da Silva, Veronica da Silva Cardoso and Ingrid Teixeira Akamine
Fermentation 2024, 10(5), 231; https://doi.org/10.3390/fermentation10050231 - 26 Apr 2024
Abstract
The required processes and steps for making bread include technological and innovative concepts. The current trend is the use of less toxic compounds and green methods. Besides lactic acid bacteria and yeast, other microorganisms with unique properties, such as enzymes, new aromas and [...] Read more.
The required processes and steps for making bread include technological and innovative concepts. The current trend is the use of less toxic compounds and green methods. Besides lactic acid bacteria and yeast, other microorganisms with unique properties, such as enzymes, new aromas and flavors, exopolysaccharides, and vitamins, among other compounds with beneficial properties, could be added to bread manufacture, improving bread quality and health effects for the consumers. The preservation of microbial cultures and starters is crucial in bread-making. New encapsulation methods, cryoprotectants, spray-drying, fluidized bed drying, and vacuum drying are employed for microorganism cultures that will be used as starters or biological additives in fermentation. A development is observed in the antimicrobial methods used as bread preservatives, and studies with plant extracts and essential oils have been proposed and introduced, replacing chemical agents, such as propionate, within the clean-label bread formulations concept. Baking science is a growing research line that incorporates innovative methods, biological additives, new methods, and processes focusing on microbiological protection. Full article
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15 pages, 3944 KiB  
Article
Functional Study of Different Lignocellulases from Trichoderma guizhouence NJAU4742 in the Synergistic Degradation of Natural Straw
by Tuo Li, Ronghua Pei, Jiaguo Wang, Yihao Zhou and Dongyang Liu
Fermentation 2024, 10(5), 230; https://doi.org/10.3390/fermentation10050230 - 26 Apr 2024
Abstract
The enzyme-based degradation of lignocellulose for bioenergy production is an eco-friendly and sustainable approach. This study aimed to elucidate the enzymatic characteristics of endoglucanase (EGL), β-glucosidase (BGL), and xylanase (XYN) from Trichoderma guizhouence NJAU4742, and to explore the potential mechanisms underlying their synergistic [...] Read more.
The enzyme-based degradation of lignocellulose for bioenergy production is an eco-friendly and sustainable approach. This study aimed to elucidate the enzymatic characteristics of endoglucanase (EGL), β-glucosidase (BGL), and xylanase (XYN) from Trichoderma guizhouence NJAU4742, and to explore the potential mechanisms underlying their synergistic degradation of different natural substrates. The results demonstrated that the three enzymes possessed remarkable high-temperature catalytic activity, broad pH adaptability, and responsiveness to different metal ions. The functional group absorption peaks of different substrates were shifted and altered after the synergistic action, particularly for C=O and O-H. Simultaneously, the crystallinity index of wheat straw, soybean straw, rice straw, and corn straw decreased by 7.40%, 2.37%, 20.60%, and 7.67%, respectively, compared to CK (natural straw). Additionally, the dense structure of different substrates was destroyed, and the inner parenchyma began to be exposed after the synergistic action, as observed by SEM. These findings offer valuable theoretical guidance for the development of lignocellulase applications. Full article
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19 pages, 737 KiB  
Article
Machine Learning to Enhance the Detection of Terrorist Financing and Suspicious Transactions in Migrant Remittances
by Stanley Munamato Mbiva and Fabio Mathias Correa
J. Risk Financial Manag. 2024, 17(5), 181; https://doi.org/10.3390/jrfm17050181 - 26 Apr 2024
Abstract
Migrant remittances have become significant in poverty alleviation and microeconomic development in low-income countries. However, the ease of conducting global migrant remittance transfers has also introduced the risk of misuse by terrorist organizations to quickly move and conceal operational funds, facilitating terrorism financing. [...] Read more.
Migrant remittances have become significant in poverty alleviation and microeconomic development in low-income countries. However, the ease of conducting global migrant remittance transfers has also introduced the risk of misuse by terrorist organizations to quickly move and conceal operational funds, facilitating terrorism financing. This study aims to develop an unsupervised machine learning algorithm capable of detecting suspicious financial transactions associated with terrorist financing in migrant remittances. To achieve this goal, a structural equation model (SEM) and an outlier detection algorithm were developed to analyze and identify suspicious transactions among the financial activities of migrants residing in Belgium. The results show that the SEM model classifies a significantly high number of transactions as suspicious, making it prone to detecting false positives. Finally, the study developed an ensemble outlier detection algorithm that comprises an isolation forest (IF) and a local outlier factor (LOF) to detect suspicious transactions in the same dataset. The model performed exceptionally well, being able to detect over 90% of suspicious transactions. Full article
(This article belongs to the Section Mathematics and Finance)
40 pages, 844 KiB  
Review
Equine Musculoskeletal Pathologies: Clinical Approaches and Therapeutical Perspectives—A Review
by Inês L. Reis, Bruna Lopes, Patrícia Sousa, Ana C. Sousa, Ana R. Caseiro, Carla M. Mendonça, Jorge M. Santos, Luís M. Atayde, Rui D. Alvites and Ana C. Maurício
Vet. Sci. 2024, 11(5), 190; https://doi.org/10.3390/vetsci11050190 - 26 Apr 2024
Abstract
Musculoskeletal injuries such as equine osteoarthritis, osteoarticular defects, tendonitis/desmitis, and muscular disorders are prevalent among sport horses, with a fair prognosis for returning to exercise or previous performance levels. The field of equine medicine has witnessed rapid and fruitful development, resulting in a [...] Read more.
Musculoskeletal injuries such as equine osteoarthritis, osteoarticular defects, tendonitis/desmitis, and muscular disorders are prevalent among sport horses, with a fair prognosis for returning to exercise or previous performance levels. The field of equine medicine has witnessed rapid and fruitful development, resulting in a diverse range of therapeutic options for musculoskeletal problems. Staying abreast of these advancements can be challenging, prompting the need for a comprehensive review of commonly used and recent treatments. The aim is to compile current therapeutic options for managing these injuries, spanning from simple to complex physiotherapy techniques, conservative treatments including steroidal and non-steroidal anti-inflammatory drugs, hyaluronic acid, polysulfated glycosaminoglycans, pentosan polysulfate, and polyacrylamides, to promising regenerative therapies such as hemoderivatives and stem cell-based therapies. Each therapeutic modality is scrutinized for its benefits, limitations, and potential synergistic actions to facilitate their most effective application for the intended healing/regeneration of the injured tissue/organ and subsequent patient recovery. While stem cell-based therapies have emerged as particularly promising for equine musculoskeletal injuries, a multidisciplinary approach is underscored throughout the discussion, emphasizing the importance of considering various therapeutic modalities in tandem. Full article
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12 pages, 787 KiB  
Article
Retrospective Study of Clinicopathological Changes and Prediction Model for Canine Vascular Neoplasms
by Jidapa Suphonkhan, Chananchida Klaymongkol, Wijittra Khomsiri, Jedsada Wanprom, Saharuetai Jeamsripong, Narisara Chimnakboon, Anudep Rungsipipat and Araya Radtanakatikanon
Vet. Sci. 2024, 11(5), 189; https://doi.org/10.3390/vetsci11050189 - 26 Apr 2024
Abstract
Vascular neoplasms, including hemangiosarcoma (HSA) and hemangioma (HMA), are more common in dogs than other domestic animal species; however, comprehensive laboratory screening tests for early diagnosis are currently limited. The aims of this study were to investigate general signalments, anatomic locations, and clinicopathological [...] Read more.
Vascular neoplasms, including hemangiosarcoma (HSA) and hemangioma (HMA), are more common in dogs than other domestic animal species; however, comprehensive laboratory screening tests for early diagnosis are currently limited. The aims of this study were to investigate general signalments, anatomic locations, and clinicopathological abnormalities of dogs diagnosed with vascular neoplasms and to determine the diagnostic significance of these abnormalities. Retrospective data of dogs with HMA, HSA, and healthy dogs were analyzed. Dogs with HMA and HSA were seniors, with mixed breeds being most affected. HMA affected predominantly non-visceral sites, while HSA was more common in visceral sites, particularly the spleen. In multivariate model analyses, the odds of HMA diagnosis were 5.5 times higher in anemic dogs and 33.0 times higher in lymphopenic dogs compared to dogs without the abnormalities. The odds of HSA diagnosis were 42.5 times higher in anemic dogs, 343 times higher in lymphopenic dogs and 92.7 times higher in dogs with hyperfibrinogenemia compared to dogs without the abnormalities. The study suggested that these identified abnormalities were nonspecific and commonly observed in various chronic diseases, and hence their combination with clinical information, such as diagnostic imaging and histopathology, is important to facilitate a more precise diagnosis of canine vascular neoplasms. Full article
(This article belongs to the Section Anatomy, Histology and Pathology)
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17 pages, 7424 KiB  
Article
Automatic Estimation of the Interference Subspace Dimension Threshold in the Subspace Projection Algorithms of Magnetoencephalography Based on Evoked State Data
by Ruochen Zhao, Ruonan Wang, Yang Gao and Xiaolin Ning
Bioengineering 2024, 11(5), 428; https://doi.org/10.3390/bioengineering11050428 - 26 Apr 2024
Abstract
A class of algorithms based on subspace projection is widely used in the denoising of magnetoencephalography (MEG) signals. Setting the dimension of the interference (external) subspace matrix of these algorithms is the key to balancing the denoising effect and the degree of signal [...] Read more.
A class of algorithms based on subspace projection is widely used in the denoising of magnetoencephalography (MEG) signals. Setting the dimension of the interference (external) subspace matrix of these algorithms is the key to balancing the denoising effect and the degree of signal distortion. However, most current methods for estimating the dimension threshold rely on experience, such as observing the signal waveforms and spectrum, which may render the results too subjective and lacking in quantitative accuracy. Therefore, this study proposes a method to automatically estimate a suitable threshold. Time–frequency transformations are performed on the evoked state data to obtain the neural signal of interest and the noise signal in a specific time–frequency band, which are then used to construct the objective function describing the degree of noise suppression and signal distortion. The optimal value of the threshold in the selected range is obtained using the weighted-sum method. Our method was tested on two classical subspace projection algorithms using simulation and two sensory stimulation experiments. The thresholds estimated by the proposed method enabled the algorithms to achieve the best waveform recovery and source location error. Therefore, the threshold selected in this method enables subspace projection algorithms to achieve the best balance between noise removal and neural signal preservation in subsequent MEG analyses. Full article
(This article belongs to the Special Issue 10th Anniversary of Bioengineering: Biosignal Processing)
13 pages, 851 KiB  
Article
Temporal Trend of Serum Perfluorooctanoic Acid and Perfluorooctane Sulfonic Acid among U.S. Adults with or without Comorbidities in NHANES 1999–2018
by Jinhua Pan, Changping Ouyang, Shengze Zhou, Xuemei Wang, Heming Liu, Jia Zhang, Xiao Wang, Xiaoru Shi, Aimin Yang and Xiaobin Hu
Toxics 2024, 12(5), 314; https://doi.org/10.3390/toxics12050314 - 26 Apr 2024
Abstract
Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are associated with adverse health effects. This study examined the trend of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) levels in individuals with and without pre-existing comorbidities. We analyzed the characteristics of 13,887 participants across nine U.S. [...] Read more.
Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are associated with adverse health effects. This study examined the trend of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) levels in individuals with and without pre-existing comorbidities. We analyzed the characteristics of 13,887 participants across nine U.S. NHANES cycles (1999–2000 to 2017–2018) and calculated the geometric mean (GM) of PFOA and PFOS levels, standardized by sex and age. A joinpoint regression model was used to analyze the temporal trends of serum PFOA and PFOS levels. We observed declining PFOA and PFOS serum levels among adults in NHANES from 1999–2000 to 2017–2018. Serum PFOA and PFOS concentrations were higher in men, smokers, and individuals with pre-existing diabetes, CKD, hyperlipidemia, CVD, and cancer. We observed faster decline rates in PFOA levels among individuals with diabetes and CKD and faster decline rates in PFOS levels among individuals with diabetes and those without CKD. This study provided evidence of varying levels and changing trends of PFOA and PFOS between groups with and without established chronic disease, highlighting the role of environmental chemicals in the onset and development of chronic diseases. Full article
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16 pages, 1001 KiB  
Article
Sustainable Utilization of Mushroom By-Products Processed with a Combined Osmotic Dehydration Pretreatment and a Hot-Air-Drying Step
by Natalia A. Stavropoulou, Andriana E. Lazou and Maria C. Giannakourou
Foods 2024, 13(9), 1339; https://doi.org/10.3390/foods13091339 - 26 Apr 2024
Abstract
Mushroom production and consumption are gaining increased interest due to their unique flavor and nutritional value. However, in the mushroom industry, large amounts of by-products are generated, which have a high negative environmental and economic impact. In this study, an osmotic dehydration process [...] Read more.
Mushroom production and consumption are gaining increased interest due to their unique flavor and nutritional value. However, in the mushroom industry, large amounts of by-products are generated, which have a high negative environmental and economic impact. In this study, an osmotic dehydration process followed by hot-air-drying was applied to mushroom stems to produce dried mushrooms as the end product. The osmotic dehydration conditions (concentration of hypertonic solution, specifically, 10–30% maltodextrin and 20–40% oligofructose; a treatment time of 40–80 min; and a temperature range of 30–50 °C) were optimized using response surface methodology (RSM). The results showed that a four-factor three-level Box–Behnken experimental design was effectively implemented to evaluate the effect of the process parameters and identify the optimal osmotic dehydration conditions for producing osmotically dehydrated mushrooms. The main factor affecting mass transfer was the osmosis temperature, and the optimal conditions were found to be 38 °C, 40% oligofructose and 19.3% maltodextrin as the osmotic agents, and 80 min of immersion time. Moreover, the results showed that osmotic pretreatment, in the optimal conditions, significantly reduced the required drying time of the by-products compared to traditional hot-air-drying, especially at milder drying temperatures. Consequently, the required energy was also reduced by at least 40% at 50 °C. Full article
18 pages, 5337 KiB  
Article
Enhancement of Nutritional Substance, Trace Elements, and Pigments in Waxy Maize Grains through Foliar Application of Selenite
by Boyu Lu, Haoyuan An, Xinli Song, Bosen Yang, Zhuqing Jian, Fuzhu Cui, Jianfu Xue, Zhiqiang Gao and Tianqing Du
Foods 2024, 13(9), 1337; https://doi.org/10.3390/foods13091337 - 26 Apr 2024
Abstract
Selenium (Se) is a micronutrient known for its essential role in human health and plant metabolism. Waxy maize (Zea mays L. sinensis kulesh)—known for its high nutritional quality and distinctive flavor—holds significant consumer appeal. Therefore, this study aims to assess the [...] Read more.
Selenium (Se) is a micronutrient known for its essential role in human health and plant metabolism. Waxy maize (Zea mays L. sinensis kulesh)—known for its high nutritional quality and distinctive flavor—holds significant consumer appeal. Therefore, this study aims to assess the effects of foliar Se spraying on the nutritional quality of waxy maize grains, with a focus on identifying varietal differences and determining optimal Se dosage levels for maximizing nutritional benefits. We employed a two-factor split-plot design to assess the nutritional quality, trace elements, and pigment content of jinnuo20 (J20) and caitiannuo1965 (C1965) at the milk stage after being subjected to varying Se doses sprayed on five leaves. Our findings indicate superior nutrient content in J20 compared to C1965, with both varieties exhibiting optimal quality under Se3 treatment, falling within the safe range of Se-enriched agricultural products. JS3 (0.793) demonstrated the highest overall quality, followed by JS2 (0.606), JS4 (0.411), and JS1 (0.265), while CS0 had the lowest (−0.894). These results underscore the potential of foliar biofortification to enhance the functional component contents of waxy maize grains. Full article
(This article belongs to the Section Grain)
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17 pages, 3983 KiB  
Article
Research of Processing Technology of Longjing Tea with ‘Baiye 1’ Based on Non-Targeted Aroma Metabolomics
by Ruimin Teng, Cun Ao, Haitao Huang, Daliang Shi, Yuxiao Mao, Xuxia Zheng and Yun Zhao
Foods 2024, 13(9), 1338; https://doi.org/10.3390/foods13091338 - 26 Apr 2024
Abstract
Longjing tea is favored by consumers due to its refreshing and delicate aroma, as well as its fresh and sweet flavor. In order to study the processing technology of Longjing tea with ‘Baiye 1’ tea varieties, solid phase microextraction and gas chromatography–mass spectrometry [...] Read more.
Longjing tea is favored by consumers due to its refreshing and delicate aroma, as well as its fresh and sweet flavor. In order to study the processing technology of Longjing tea with ‘Baiye 1’ tea varieties, solid phase microextraction and gas chromatography–mass spectrometry were used to analyze the volatile components of Longjing tea in different process stages. The results revealed the identification of 275 aroma metabolites in the processing samples of Longjing tea. The sensory evaluation and principal component analysis revealed that the leaves of fresh (XY) and spreading (TF) were different from the leaves of first panning (YQ), second panning (EQ), final panning (HG), and fragrance enhancing (TX). The relative contents of geraniol (1199.95 and 1134.51), linalool (745.93 and 793.98), methyl salicylate (485.22 and 314.67), phenylethyl alcohol (280.14 and 393.98), 2-methylfuran (872.28 and 517.96), 2-butenal (56.01 and 154.60), and 2-hexenal (46.22 and 42.24), refreshing and floral substances in the XY and TF stages, were higher than other stages. The aroma contents of 2-methylfuran, furfural, 2-methyl-1-penten-3-one, 3-hexen-2-one, dodecane, hexanoyl hexanoate, 2,5-dimethyl-pyrazine, and methyl-pyrazine were found to be significantly positively correlated with the intensity of chestnut aroma. In conclusion, this study contributes to a better understanding of the composition and formation mechanism of chestnut-like aroma and provides new insights into the processing technology to improve the quality of albino green tea. Full article
(This article belongs to the Section Foodomics)
17 pages, 4837 KiB  
Article
Gut Microbiota-Derived Tryptophan Metabolites Alleviate Allergic Asthma Inflammation in Ovalbumin-Induced Mice
by Hongchao Wang, Yuan He, Danting Dang, Yurong Zhao, Jianxin Zhao and Wenwei Lu
Foods 2024, 13(9), 1336; https://doi.org/10.3390/foods13091336 - 26 Apr 2024
Abstract
Asthma is a prevalent respiratory disease. The present study is designed to determine whether gut microbiota-derived tryptophan metabolites alleviate allergic asthma inflammation in ovalbumin (OVA)-induced mice and explore the effect and potential mechanism therein. Asthma model mice were constructed by OVA treatment, and [...] Read more.
Asthma is a prevalent respiratory disease. The present study is designed to determine whether gut microbiota-derived tryptophan metabolites alleviate allergic asthma inflammation in ovalbumin (OVA)-induced mice and explore the effect and potential mechanism therein. Asthma model mice were constructed by OVA treatment, and kynurenine (KYN), indole-3-lactic acid (ILA), in-dole-3-carbaldehyde (I3C), and indole acetic acid (IAA) were administered by intraperitoneal injection. The percent survival, weight and asthma symptom score of mice were recorded. The total immunoglobulin E and OVA-specific (s)IgE in the serum and the inflammatory cytokines in the bronchoalveolar lavage fluid (BALF) were detected by the corresponding ELISA kits. The composition of the gut microbiota and tryptophan-targeted metabolism in mouse feces were analyzed using 16S rRNA gene sequencing and targeted metabolomics, respectively. The four tryptophan metabolites improved the percent survival, weight and asthma symptoms of mice, and reduced the inflammatory cells in lung tissues, especially I3C. I3C and IAA significantly (p < 0.05) downregulated the levels of OVA-IgE and inflammatory cytokines. KYN was observed to help restore gut microbiota diversity. Additionally, I3C, KYN, and ILA increased the relative abundance of Anaeroplasma, Akkermansia, and Ruminococcus_1, respectively, which were connected with tryptophan metabolic pathways. IAA also enhanced capability of tryptophan metabolism by the gut microbiota, restoring tryptophan metabolism and increasing production of other tryptophan metabolites. These findings suggest that tryptophan metabolites may modulate asthma through the gut microbiota, offering potential benefits for clinical asthma management. Full article
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