The need to use environmentally friendly substances in agriculture for pest control has become increasingly urgent in recent years. This was generated by humanity’s awareness of the harmful effects of chemicals with increased persistence, which accumulated in nature and harmed living beings. Essential oils are among the most important biopesticides and could significantly contribute to the expansion of ecological agriculture, replacing traditional methods. However, for judicious use, it is necessary to have a thorough knowledge of the mechanisms by which these oils act on both harmful and useful insects. An important step in transitioning from theory to practice is adapting essential oil application technologies for open fields, overcoming the difficulties created by their high volatility and low remanence, which results in a rapid reduction in the toxic effect. The review proposes an in-depth, up-to-date analysis of the existing literature on these subjects, aiming to provide researchers with some potential future study directions and practitioners with a solid base of information regarding the interaction between insects and essential oils. Full article

This paper provides insights into the use of Proton Beam Therapy (PBT) in pediatric patients with non-rhabdomyosarcoma soft tissue sarcomas (NRSTS). NRSTS are a heterogeneous group of rare and aggressive mesenchymal extraskeletal tumors, presenting complex and challenging clinical management scenarios. The overall survival rate for patients with NRSTS is around 70%, but the outcome is strictly related to the presence of various variables, such as the histological subtype, grade of malignancy and tumor stage at diagnosis. Multimodal therapy is typically considered the preferred treatment for high-grade NRSTS. Radiotherapy plays a key role in the treatment of children and adolescents with NRSTS. However, the potential for radiation-induced side effects partially limits its use. Therefore, PBT represents a very suitable therapeutic option for these patients. The unique depth-dose characteristics of protons can be leveraged to minimize doses to healthy tissue significantly, potentially allowing for increased tumor doses and enhanced preservation of surrounding tissues. These benefits suggest that PBT may improve local control while reducing toxicity and improving quality of life. While clear evidence of therapeutic superiority of PBT over other modern photon techniques in NRSTS is still lacking—partly due to the limited data available—PBT can be an excellent treatment option for young patients with these tumors. A dedicated international comprehensive collaborative approach is essential to better define its role within the multidisciplinary management of NRSTS. Shared guidelines for PBT indications—based on the patient’s age, estimated outcome, and tumor location—and centralization in high-level referral centers are needed to optimize the use of resources, since access to PBT remains a challenge due to the limited number of available proton therapy facilities. Full article

Managing Multi-Processor Systems-on-Chip (MPSoCs) is becoming increasingly complex as demands for advanced capabilities rise. This complexity is due to the involvement of more processing elements and resources, leading to a higher degree of heterogeneity throughout the system. Over time, management schemes have evolved from simple to autonomous systems with continuous control and monitoring of various parameters such as power distribution, thermal events, fault tolerance, and system security. Autonomous management integrates self-awareness into the system, making it aware of its environment, behavior, and objectives. Self-Aware Cyber-Physical Systems-on-Chip (SA-CPSoCs) have emerged as a concept to achieve highly autonomous management. Communication infrastructure is also vital to SoCs, and Software-Defined Networks-on-Chip (SDNoCs) can serve as a base structure for self-aware systems-on-chip. This paper presents a survey of the evolution of MPSoC management over the last two decades, categorizing research works according to their objectives and improvements. It also discusses the characteristics and properties of SA-CPSoCs and explains why SDNoCs are crucial for these systems. Full article

This study explores the impact of artificial intelligence (AI) on customer perceptions and behavior in restaurants, airline companies, and hotel sectors within the hospitality industry of Iran. The primary objective is to analyze how AI affects customer trust, brand engagement, electronic word-of-mouth (eWOM), and tourists’ readiness to use AI technologies. Using a comparative analysis approach and surveys, this research tests hypotheses about the effects of artificial intelligence on various dimensions of customer interaction. The findings highlight significant relationships between the quality of artificial intelligence and customer engagement metrics, such as trust and brand loyalty, which are crucial for understanding and predicting customer behavior in response to technological advancements. This study lays the groundwork for theoretical assumptions about sustainability in these sectors in developing countries, providing a basis for future empirical research that could validate these assumptions and explore broader implications of AI integration in enhancing sustainable practices within the hospitality industry. Full article

The seed of Citrullus lanatus mucosospermus, known as egusi, is versatile and explored for its oil and flour functionality. Raw flour can be used as a raw material in a nutritional program due to its oil-rich, remarkably high protein content, and richness in omega-6 fatty acids. There is a need to explore eco-friendly defatting methods using the supercritical CO₂ extraction method (SFECO₂) to preserve this seed’s generic richness and to control the flour–oil ratio in processing formulations. The supercritical fluid extraction method uses temperature, pressure, and CO₂ flow rate to determine the best yield and extraction parameters. Defatted egusi flour (DEF) was extracted using three runs. Firstly, at 60 °C, 30 g/h, and 450 bar (DEF1); secondly, at 55 °C, 30 g/h, and 600 bar (DEF2); and thirdly, extraction was performed at 75 °C, 30 g/h and 600 bar (DEF3). Trace and major elements were analysed using Agilent 7700 quadruple ICP-MS (Agilent Technologies Network, Palo Alto, CA, USA) and Thermo Cap 6200 ICP-AES (Thermo Scientific, Waltham, MA, USA), respectively. The sugar was separated on a gas chromatograph coupled to a Mass Selective Detector (MSD). The fundamental pasting property measurements were performed using a Rapid Visco Analyser RVA 4500 Perten instrument Sin 214 31208-45 Australia. Data analysis was conducted using IBM SPSS version 29 software (v. 2022). The protein content of defatted egusi flour ranged from 48.4 for DEF2 to 60.4% w/w for DEF1 and differed significantly, with a rich amino acid high in glutamine ranging from 9.8 to 12.9 g/100 g). DEF2 (512.0 cP) showed the highest peak viscosity and was the most viscous among the samples. Defatted flour with lower temperature and lower pressure (60 °C and 450 bar) offered the best nutritional properties, proffering defatted egusi flour from SFECO_2, a novel flour for dietary programs. Full article

The Alaska Native Tribal Health Consortium (ANTHC) participated in the United States Centers for Disease Control and Prevention Colorectal Cancer Control Program (CRCCP) from 2009 to 2015. We conducted a descriptive evaluation of ANTHC CRCCP demographics, quality measures, and clinical outcomes, including screening methods employed within the program and screening outcomes. There were 6981 program screenings completed, with the majority (81.3%) of people screened in the 50–75 year age group. Colonoscopy was the primary screening test used, accounting for 6704 (96.9%) of the screening tests. Quality of colonoscopy was high: adequate bowel preparation was reported in 98.2% of colonoscopies, cecal intubation rate was 98.9%, and the adenoma detection rate was 38.9%. A high proportion (58.9%) of colonoscopies had an initial finding of polyps or lesions suspicious for cancer; 41.2% of all colonoscopies had histological confirmation of either adenomatous polyps (40.6%) or cancer (0.5%). The ANTHC CRCCP successfully increased CRC screening among American Indian and Alaska Native peoples living in Alaska; this was achieved primarily through high-quality colonoscopy metrics. These data support a continued focus by the Alaska Native Tribal Health Consortium and its tribal health partners on increasing CRC screening and reducing cancer mortality among Alaska Native peoples. Full article

Tetra-n-butylammonium Bromide (TBAB) finds extensive use in diverse applications. An in-depth investigation into the effects of the formation conditions on TBAB hydrate is necessary to optimize the application process. This work focuses on examining the influence of the mass concentration of TBAB solution and the cooling rate on TBAB hydrate formation through optical microscopy and Raman spectroscopy. The TBAB hydrate formation process occurs in a confined space created by an optical sheet with a 0.03 mm deep groove. Four TBAB solutions of 13. 8 wt%, 18 wt%, 32 wt%, and 40 wt% are investigated, and the supercooling required for hydrate nucleation increases with concentration at a cooling rate of 0.5 K/min. Notably, Type A TBAB hydrate preferentially forms in all of the solutions, although type B hydrate is thermodynamically stable in the two dilute solutions. At a larger cooling rate of 2 K/min, two distinct crystal growth patterns are observed: one controlled by mass transfer and the other regulated by heat transfer. Increasing the cooling rate not only alters the optical morphology, but also reduces the supercooling due to a decrease in the Gibbs free energy barrier caused by a larger temperature gradient. This is beneficial for practical applications as it helps to alleviate the supercooling degree. Full article

This paper presents the results of a study on the non-isothermal laminar flow and heat transfer of oil with Newtonian and viscoplastic rheologies. Heat exchange with the surrounding environment leads to the formation of a near-wall zone of viscoplastic fluid. As the flow proceeds, the transformation of a Newtonian fluid to a viscoplastic state occurs. The rheology of the Shvedoff–Bingham fluid as a function of temperature is represented by the effective molecular viscosity apparatus. A numerical solution to the system of equations of motion and heat transfer was obtained using the Semi-Implicit Method for Pressure-Linked Equations (SIMPLE) algorithm. The calculated data are obtained at Reynolds number Re from 523 to 1046, Bingham number Bn from 8.51 to 411.16, and Prandl number Pr = 45. The calculations’ novelty lies in the appearance of a “stagnation zone” in the near-wall zone and the pipe cross-section narrowing. The near-wall “stagnation zone” is along the pipe’s radius from r/R = 0.475 to r/R = 1 at Re = 523, Bn = 411.16, Pr = 45, u₁ = 0.10 m/s, t₁ = 25 °C, and t_w = 0 °C. The influence of the heat of phase transition of paraffinic oil on the development of flow and heat transfer characteristics along the pipe length is demonstrated. Full article

A two-dimensional porous silica nanomesh (VMT-SiO₂) was used as a carrier to prepare MgO-CuO-based catalysts and tested for one-step ethanol conversion to 1, 3-butadiene. The effects of catalyst composition and different calcination temperatures on the reaction performances of the catalysts were mainly investigated. Combining various characterization techniques, such as HRTEM, XRD, FT-IR, and TPD, it was found that the dispersion state of MgO and CuO on the catalyst surface was related to the calcination temperature, which further induced changes in the acid–base properties. A small number of acidic centers and a proper proportion of medium–strong alkaline centers maintained a subtle balance, affecting catalytic performance. A lower total acid/base ratio is more conducive to ethanol conversion and 1, 3-butadiene formation. At the same time, the synergistic effect of CuO and MgO promotes the transformation of the intermediate acetaldehyde product, which is the key to ensuring the subsequent aldol condensation and then 1, 3-butadiene formation. Among the investigated samples, the CuO/MgO-VMT-SiO₂ catalyst calcined at 500 °C exhibited the best catalytic performance, with an impressive ethanol conversion of 47.8% and 1, 3-butadiene formation (42.6% selectivity and a space-time yield of 182.0 g_C4H6·kg_cat⁻¹·h⁻¹). Full article

The implementation effectiveness of ship emission control area (ECA) policies can be effectively evaluated using econometric models. However, existing studies mainly focus on changes in SO₂ concentrations in the air. In order to comprehensively assess the impact of ECA policies on air quality, this study takes Ningbo Port in China as an example and uses a regression discontinuity (RD) model to analyze the influence of ship emissions around the wharf on concentrations of SO₂, NO₂, and particulate matter (PM) in the air. The results indicate that individual ships’ activities within the monitoring area (within 300 m) make a relatively small contribution to the concentration of SO₂ in the air and do not form a significant breakpoint. However, there is a noticeable breakpoint in the concentration of NO₂ around the monitoring point as the ship approaches. At the same time, the variation range of PM_2.5 is significantly greater than that of PM₁₀, which aligns with the characteristics of PM emitted by ships. The experimental results have passed three robustness tests, demonstrating that the current policy on ship ECAs has a positive limiting effect on SO₂ emissions and, to some extent, reduces PM emissions. However, further reductions in ship emissions may require more restrictions in nitrogen oxide emissions. Full article

Duck hepatitis B virus (DHBV) is widely prevalent in global ducks and has been identified in Chinese geese with a high prevalence; the available detection techniques are time-consuming and require sophisticated equipment. In this study, an assay combining multienzyme isothermal rapid amplification (MIRA) and lateral flow dipstick (LFD) was developed for the efficient and rapid detection of DHBV. The primary reaction condition of the MIRA assay for DHBV detection was 10 min at 38 °C without a temperature cycler. Combined with the LFD assay, the complete procedure of the newly developed MIRA assay for DHBV detection required only 15 min, which is about one-fourth of the reaction time for routine polymerase chain reaction assay. And electrophoresis and gel imaging equipment were not required for detection and to read the results. Furthermore, the detection limit of MIRA was 45.6 copies per reaction, which is approximately 10 times lower than that of a routine polymerase chain reaction assay. The primer set and probe had much simpler designs than loop-mediated isothermal amplification, and they were only specific to DHBV, with no cross-reactivity with duck hepatitis A virus subtype 1 and duck hepatitis A virus subtype 3, goose parvovirus, duck enteritis virus, duck circovirus, or Riemerella anatipestifer. In this study, we offer a simple, fast, and accurate assay method to identify DHBV in clinical serum samples of ducks and geese, which would be suitable for widespread application in field clinics. Full article

Deformation along a subway rail network is related to the safe operation of the subway and the stability of construction facilities on the surface, making long-term deformation monitoring imperative. Long-term monitoring of surface deformation along the subway network and statistical analysis of the overall deformation situation are lacking in China. Therefore, targeting 35 Chinese cities whose subway mileage exceeds 50 km, we extracted their surface deformation along subway networks between 2018 and 2022, using spaceborne synthetic aperture radar (SAR) interferometry (InSAR) technology and Sentinel-1 satellite data. We verified the results with the continuous global navigation satellite system (GNSS) stations’ data and found that the root mean square error (RMSE) of the InSAR results was 3.75 mm/year. Statistical analysis showed that ground subsidence along the subways was more prominent in Beijing, Tianjin, and other areas in the North China Plain, namely Kunming (which is dominated by karst landforms), as well as Shanghai, Guangzhou, Qingdao, and other coastal cities. In addition, an analysis revealed that the severity of surface subsidence correlated positively with a city’s gross domestic product (GDP) with a Pearson correlation of 0.787, since the higher the GDP, the more frequent the construction and maintenance of subway, and the more commuters there are, which in turn exacerbates the disturbance to the surface. Additionally, the type of land cover also affects the ground deformation. Our findings provide a reference for constructing, operating, and maintaining the urban subway systems in China. Full article

Lunar mare basalt is recognized as an important in situ resource on the lunar surface. However, the significant compositional variability of lunar mare basalts introduces uncertainties concerning the potential for their use in fabricating fibers and composite materials. This study investigates the impact of different components on the fiber-forming capabilities of mare basalts by simulating the compositions of basalts collected from several well-known lunar missions and then preparing simulated lunar mare basalt fibers. Raman spectroscopy is primarily employed for analysis and characterization, using “peak area normalization” to explore the impact of compositional fluctuations in the simulated lunar mare basalts on the glass network structure. The findings indicate that an increase in the Fe content raises the likelihood of basalt fibers crystallizing. Additionally, Fe³⁺ is shown to substitute for Si and Al in constructing bridging oxygen bonds in the network structure, albeit reducing the overall polymerization of the network. Meanwhile, Fe²⁺ acts as a network modifier to enhance the mechanical properties of the fibers. Full article

Zinc (Zn) deficiency in soils not only reduces the productivity of forage crops, but also results in inadequate dietary zinc intake for livestock. The objective of this study was to evaluate the impact of different rates and methods of applying ZnSO₄ to both soil and foliage on the yield and quality of fodder maize grown in a sandy loam soil testing low in DTPA-extractable Zn. A 2-year field experiment was conducted with six treatments including control, foliar application of 0.3% ZnSO₄ at 30 days after sowing (DAS) (F₁), foliar application of 0.3% ZnSO₄ at 30 and 40 DAS (F₂), soil application of 16 kg ha⁻¹ ZnSO₄ (S₁₆) and a combination of both soil and foliar ZnSO₄ application (S₁₆ + F₁ and S₁₆ + F₂). Increase in green herbage yield by 25%, dry matter yield by 47% and Zn content by 79% was observed under S₁₆ + F₂ treatment over the control. Zinc application improved N, K, Cu and crude protein content of herbage significantly over the control. Thus, the study shows that significant improvement in growth parameters, herbage yield and quality of maize can be achieved with soil Zn application + two foliar sprays of ZnSO₄ at 30 and 40 DAS, thereby ensuring availability of improved fodder Zn to the livestock. Full article

Background: Gene rearrangements affecting KMT2A are frequent in acute myeloid leukemia (AML) and are often associated with a poor prognosis. KMT2A gene fusions are often detected by chromosome banding analysis and confirmed by fluorescence in situ hybridization. However, small intragenic insertions, termed KMT2A partial tandem duplication (KMT2A-PTD), are particularly challenging to detect using standard molecular and cytogenetic approaches. Methods: We have validated the use of a custom hybrid-capture-based next-generation sequencing (NGS) panel for comprehensive profiling of AML patients seen at our institution. This NGS panel targets the entire consensus coding DNA sequence of KMT2A. To deduce the presence of a KMT2A-PTD, we used the relative ratio of KMT2A exons coverage. We sought to corroborate the KMT2A-PTD NGS results using (1) multiplex-ligation probe amplification (MLPA) and (2) optical genome mapping (OGM). Results: We analyzed 932 AML cases and identified 41 individuals harboring a KMT2A-PTD. MLPA, NGS, and OGM confirmed the presence of a KMT2A-PTD in 22 of the cases analyzed where orthogonal testing was possible. The two false-positive KMT2A-PTD calls by NGS could be explained by the presence of cryptic structural variants impacting KMT2A and interfering with KMT2A-PTD analysis. OGM revealed the nature of these previously undetected gene rearrangements in KMT2A, while MLPA yielded inconclusive results. MLPA analysis for KMT2A-PTD is limited to exon 4, whereas NGS and OGM resolved KMT2A-PTD sizes and copy number levels. Conclusions: KMT2A-PTDs are complex gene rearrangements that cannot be fully ascertained using a single genomic platform. MLPA, NGS panels, and OGM are complementary technologies applied in standard-of-care testing for AML patients. MLPA and NGS panels are designed for targeted copy number analysis; however, our results showed that integration of concurrent genomic alterations is needed for accurate KMT2A-PTD identification. Unbalanced chromosomal rearrangements overlapping with KMT2A can interfere with the diagnostic sensitivity and specificity of copy-number-based KMT2A-PTD detection methodologies. Full article

This study presents a biosensor fabricated based on integrated passive device (IPD) technology to measure microbial growth on solid media in real-time. Yeast (Pichia pastoris, strain GS115) is used as a model organism to demonstrate biosensor performance. The biosensor comprises an interdigital capacitor in the center with a helical inductive structure surrounding it. Additionally, 12 air bridges are added to the capacitor to increase the strength of the electric field radiated by the biosensor at the same height. Feasibility is verified by using a capacitive biosensor, and the change in capacitance values during the capacitance detection process with the growth of yeast indicates that the growth of yeast can induce changes in electrical parameters. The proposed IPD-based biosensor is used to measure yeast drop-added on a 3 mm medium for 100 h at an operating frequency of 1.84 GHz. The resonant amplitude of the biosensor varies continuously from 24 to 72 h due to the change in colony height during vertical growth of the yeast, with a maximum change of 0.21 dB. The overall measurement results also fit well with the Gompertz curve. The change in resonant amplitude between 24 and 72 h is then analyzed and reveals a linear relationship with time with a coefficient of determination of 0.9844, indicating that the biosensor is suitable for monitoring yeast growth. Thus, the proposed biosensor is proved to have potential in the field of microbial proliferation detection. Full article

Fiber–particle-reinforced silica aerogels are widely applied in thermal insulation. Knowing their effective thermal conductivity (ETC) and radiative characteristics under high temperatures is necessary to improve their performance. This article first analyzes the radiation characteristics of silica aerogels doped with opacifier particles and reinforced fibers, and then a universal model is established to predict the ETC. Furthermore, the impacts of different parameters of opacifier particles and reinforced fibers on the thermal insulation performance of silica aerogels are investigated. The results indicate that SiC exhibits comparatively strong absorption characteristics, making it a good alternative for opacifiers to improve thermal insulation performance under high temperatures. For the given type and volume fraction of opacifier particles, there exists an optimal diameter and volume fraction to achieve the best insulation performance of silica aerogel under a certain temperature. Considering that SiO₂ fibers exhibit a limited extinction capability and higher conductive thermal conductivity under high temperatures, for fiber–particle-reinforced silica aerogels, it is beneficial for their insulation performance to reduce the fiber volume fraction when the required mechanical properties are satisfied. Full article

Background: Up to 34% of patients with schizophrenia are resistant to several treatment trials. Lack of continuous and adequate treatment is associated with relapse, rehospitalization, a lower effect of antipsychotic therapy, and higher risk of side effects. Long-acting injectables antipsychotics (LAI APs) enhance compliance and improve clinical outcomes and quality of life in patients with schizophrenia, and thus it may be advisable to administer two LAI APs at the same time in cases of treatment-resistant schizophrenia. The purpose of this review is to summarize the available literature regarding the combined use of two LAI APs in patients with schizophrenia or other psychotic spectrum disorders. Methods: An extensive literature search for relevant articles regarding any combination of two long-acting injectable antipsychotics has been performed from inception up to 9 February 2024, on PubMed, Scopus and APA PsycInfo, according to the PRISMA statement. Only studies reporting combination of two LAI APs and its clinical outcome in patients with schizophrenia and related disorders were selected. Results: After the selection process, nine case reports, four case series and two observational retrospective studies were included in the final analysis. All patients treated with dual LAI APs reported a good response, and no new or unexpected adverse effects due to the combination of two LAIs were reported. Different drug combinations were used, and the most frequent association resulted in aripiprazole monohydrate + paliperidone palmitate once monthly (32 times). Conclusions: Our review highlights that the treatment regimen with two concurrent LAI APs is already widely used in clinical practice and is recognized as providing a promising, effective, and relatively safe therapeutic strategy for treating the schizophrenia spectrum disorders. Full article

In response to the global megatrends of digitalization and transportation automation, Turku University of Applied Sciences has developed a test platform to advance autonomous maritime operations. This platform includes the unmanned surface vessel eM/S Salama and a remote operations center, both of which are detailed in this article. The article highlights the importance of collecting and annotating multi-modal sensor data from the vessel. These data are vital for developing deep learning algorithms that enhance situational awareness and guide autonomous navigation. By securing relevant data from maritime environments, we aim to enhance the autonomous features of unmanned surface vessels using deep learning techniques. The annotated sensor data will be made available for further research through open access. An image dataset, which includes synthetically generated weather conditions, is published alongside this article. While existing maritime datasets predominantly rely on RGB cameras, our work underscores the need for multi-modal data to advance autonomous capabilities in maritime applications. Full article

Introduction: Psychological vulnerability is a relevant component of polycystic ovarian syndrome (PCOS), but it is still under-explored, especially during adolescence. The aim of this study was to describe a selection of psychometric characteristics in a clinical sample of Italian adolescents with PCOS. Moreover, we reported the associations of body image, eating attitudes, and mood with metabolic features. Methods: Our sample included 128 adolescent girls (age range: 14–19 years) with PCOS. Validated psychometric questionnaires were administered: State Anxiety Inventory (STAI), Beck Depression Inventory (BDI), Body Attitude Test (BAT), Bulimia Investigation Test (BITE), Eating Attitudes Test (EAT), and Perceived Stress Scale (PSS). Results: Anxiety was the most prevalent mood disorder (63.1% trait anxiety and 57% state anxiety). Our cohort also showed a high prevalence of depression (39.1%), body image dissatisfaction (49.2%), disordered eating (11.7%), and bulimic risk (41.4%). PCOS adolescents with obesity and insulin resistance (IR) had statistically significant higher body image distress compared to those with normal weight and without IR (p < 0.001). The Sobel test for mediation showed that body image dissatisfaction mediates the relationship between state anxiety and bulimic risk (Z = 3.42, p < 0.001) and between depression and bulimic risk (Z = 4.59, p < 0.001). Conclusions: A considerable number of patients with PCOS experience psychological disorders during adolescence. IR and obesity play a role in the distress associated with body image, further contributing to psychological vulnerability, especially in the bulimic domain. A comprehensive biopsychosocial approach in adolescents with PCOS represents the basis for effectively managing and preventing complications arising from both psychological and biological disorders in adulthood. Full article

This study investigated the bactericidal effects of ultraviolet (UV) radiation, a high-voltage electric field (HVEF), and their combination on Escherichia coli. The results indicated that UV and combined disinfection were more effective with longer exposure, leading to significant reductions in microbial activity. Specifically, the single UV disinfection alone reduced activity by 3.3 log after 5 min, while combined disinfection achieved a 4.2 log reduction. In contrast, short-term HVEF treatment did not exhibit significant bactericidal effects, only achieving a reduction of 0.17 log in 5 min. Furthermore, prolonged exposure to both UV disinfection and an HVEF was found to damage cell membranes, ultimately causing cell death, while shorter durations did not. Despite rapid cell count decreases, flow cytometry did not detect apoptotic or necrotic cells, likely due to rapid cell rupture. This study suggests that combining UV radiation and an HVEF could be a promising approach for inhibiting bacterial reproduction, with HVEF enhancing UV effects. These findings provide insights for using combined HVEF and UV disinfection in food safety and preservation. Full article

Myocardial ischemia is the leading cause of health loss from cardiovascular disease worldwide. Myocardial ischemia and hypoxia during exercise trigger the risk of sudden exercise death which, in severe cases, will further lead to myocardial infarction. The Nrf2 transcription factor is an important antioxidant regulator that is extensively engaged in biological processes such as oxidative stress, inflammatory response, apoptosis, and mitochondrial malfunction. It has a significant role in the prevention and treatment of several cardiovascular illnesses, since it can control not only the expression of several antioxidant genes, but also the target genes of associated pathological processes. Therefore, targeting Nrf2 will have great potential in the treatment of myocardial ischemic injury. Natural products are widely used to treat myocardial ischemic diseases because of their few side effects. A large number of studies have shown that the Nrf2 transcription factor can be used as an important way for natural products to alleviate myocardial ischemia. However, the specific role and related mechanism of Nrf2 in mediating natural products in the treatment of myocardial ischemia is still unclear. Therefore, this review combs the key role and possible mechanism of Nrf2 in myocardial ischemic injury, and emphatically summarizes the significant role of natural products in treating myocardial ischemic symptoms, thus providing a broad foundation for clinical transformation. Full article