As the number of electronic gadgets in our daily lives is increasing and most of them require some kind of human interaction, this demands innovative, convenient input methods. There are limitations to state-of-the-art (SotA) ultrasound-based hand gesture recognition (HGR) systems in terms of robustness and accuracy. This research presents a novel machine learning (ML)-based end-to-end solution for hand gesture recognition with low-cost micro-electromechanical (MEMS) system ultrasonic transducers. In contrast to prior methods, our ML model processes the raw echo samples directly instead of using pre-processed data. Consequently, the processing flow presented in this work leaves it to the ML model to extract the important information from the echo data. The success of this approach is demonstrated as follows. Four MEMS ultrasonic transducers are placed in three different geometrical arrangements. For each arrangement, different types of ML models are optimized and benchmarked on datasets acquired with the presented custom hardware (HW): convolutional neural networks (CNNs), gated recurrent units (GRUs), long short-term memory (LSTM), vision transformer (ViT), and cross-attention multi-scale vision transformer (CrossViT). The three last-mentioned ML models reached more than 88% accuracy. The most important innovation described in this research paper is that we were able to demonstrate that little pre-processing is necessary to obtain high accuracy in ultrasonic HGR for several arrangements of cost-effective and low-power MEMS ultrasonic transducer arrays. Even the computationally intensive Fourier transform can be omitted. The presented approach is further compared to HGR systems using other sensor types such as vision, WiFi, radar, and state-of-the-art ultrasound-based HGR systems. Direct processing of the sensor signals by a compact model makes ultrasonic hand gesture recognition a true low-cost and power-efficient input method. Full article

Synanthropic flora (weeds, i.e., spontaneously developed plants) are plants that accompany humans, appearing as a result of anthropopressure as well as after its cessation. The potential of synanthropic flora in shaping green areas usually brings many measurable benefits that depend on land management in cities. This study aimed to determine the preferences and attitudes of adults towards synanthropic flora in settlement units. This article presents survey results from 447 city residents. The obtained results were statistically analyzed using the k-means clustering method to identify segments of respondents with similar attitudes and preferences toward synanthropic flora. Mann–Whitney U tests were employed to determine statistical differences in the demographic variables among the analyzed clusters of respondents. Additionally, multiple regression analysis was performed to identify the opinions and attitudes towards synanthropic flora that may influence their greater acceptance in the vicinity of residential areas. The results obtained in the multiple regression analysis indicate that the respondent’s evaluation of the level of support for the introduction of more synanthropic vegetation into urban greenery (Yw) grows with the increase in the acceptance of synanthropic plants’ occurrence in the surroundings. Residents’ acceptance of synanthropic flora in green areas is at a relatively high level. Full article

This article presents the verification of the hypothesis on using certain approximation curves in the evaluation of used lubricating oil. These curves are plotted for fresh lubricating oil to approximate the parameters of lubricating oil diluted with diesel oil. To confirm the hypothesis, an experiment is conducted to determine the flash point, initial boiling point, density at 15 °C, kinematic viscosity at 40 °C and 100 °C, and viscosity index. The analysis covers fresh oil and used SAE 30 grade Marinol CB-30 RG1230 oil taken from the circulating lubrication system of a supercharged, trunk-piston, 4-stroke ZUT Zgoda Sulzer 5 BAH 22 engine that is located in the Marine Power Plant Laboratory of the Maritime University of Szczecin. Undiluted lubricating oils (both fresh and used) and mixtures of lubricating oils with diesel oil are examined for diesel oil concentrations in the mixture equal to 1, 2, 5, 10, 15, and 20% m/m. Orlen Efecta Diesel Biodiesel is used to prepare the mixtures. The functions approximating the parameters for fresh oil are determined and adapted to describe the variation of the same parameters for the used lubricating oil. For each case, the coefficient of determination, the maximum relative error of the model fitting to the experimental results, and the root mean square error (RMSE) are determined. In the experiment, the variation in the parameters of the used lubricating oil remained the same as for fresh oil parameters. Thus, the research hypothesis is confirmed. Full article

Antifreeze peptides have become effective antifreeze agents for frozen products, but their low quantity of active ingredients and high cost limit large-scale application. This study used the glycosylation of fish collagen peptides with glucosamine hydrochloride catalyzed by transglutaminase to obtain a transglutaminase-catalyzed glycosylation product (TGP) and investigate its antifreeze effect on tilapia. Compared with the blank group, the freshness (pH value of 6.31, TVB-N value of 21.7 mg/100 g, whiteness of 46.28), textural properties (especially hardness and elasticity), and rheological properties of the TGP groups were significantly improved. In addition, the protein structures of the samples were investigated using UV absorption and fluorescence spectroscopy. The results showed that the tertiary structure of the TGP groups changed to form a dense polymer. Therefore, this approach can reduce the denaturation and decomposition of muscle fibers and proteins in fish meat more effectively and has a better protective effect on muscle structure and protein aggregation, improving the stability of fish meat. This study reveals an innovative method for generating antifreeze peptides by enzymatic glycosylation, and glycosylated fish collagen peptide products can be used as new and effective green antifreeze agents in frozen foods. Full article

Micro-ROS is widely used to bridge the performance gap between resource-constrained microcontrollers and powerful computing devices in ROS-based robotic applications. After modeling the callback scheduling module and the communication module in micro-ROS, we found that there are some design flaws that significantly impact the real-time performance of micro-ROS. To improve the timing predictability and run-time efficiency of micro-ROS, we design and implement a priority-driven chain-aware scheduling system (PoDS) based on the existing micro-ROS architecture. The experimental results demonstrate that our proposed PoDS exhibits significantly improved real-time performance compared to the default micro-ROS. Full article

A novel rare mutation in the pore region of Nav1.5 channels (p.L889V) has been found in three unrelated Spanish families that produces quite diverse phenotypic manifestations (Brugada syndrome, conduction disease, dilated cardiomyopathy, sinus node dysfunction, etc.) with variable penetrance among families. We clinically characterized the carriers and recorded the Na⁺ current (I_Na) generated by p.L889V and native (WT) Nav1.5 channels, alone or in combination, to obtain further insight into the genotypic–phenotypic relationships in patients carrying SCN5A mutations and in the molecular determinants of the Nav1.5 channel function. The variant produced a strong dominant negative effect (DNE) since the peak I_Na generated by p.L889V channels expressed in Chinese hamster ovary cells, either alone (−69.4 ± 9.0 pA/pF) or in combination with WT (−62.2 ± 14.6 pA/pF), was significantly (n ≥ 17, p < 0.05) reduced compared to that generated by WT channels alone (−199.1 ± 44.1 pA/pF). The mutation shifted the voltage dependence of channel activation and inactivation to depolarized potentials, did not modify the density of the late component of I_Na, slightly decreased the peak window current, accelerated the recovery from fast and slow inactivation, and slowed the induction kinetics of slow inactivation, decreasing the fraction of channels entering this inactivated state. The membrane expression of p.L889V channels was low, and in silico molecular experiments demonstrated profound alterations in the disposition of the pore region of the mutated channels. Despite the mutation producing a marked DNE and reduction in the I_Na and being located in a critical domain of the channel, its penetrance and expressivity are quite variable among the carriers. Our results reinforce the argument that the incomplete penetrance and phenotypic variability of SCN5A loss-of-function mutations are the result of a combination of multiple factors, making it difficult to predict their expressivity in the carriers despite the combination of clinical, genetic, and functional studies. Full article

Ceramic sherds from approximately 20 samples of lead-glazed tableware, recovered from diverse archaeological sites, including three repurposed storage pits transformed into dumpsters within the medieval city of Santarém (13th–14th century), underwent a meticulous examination. This investigation utilised techniques such as micro-Raman, ground-state diffuse reflectance absorption, and X-ray fluorescence spectroscopies, in addition to X-ray diffraction and stereomicroscopy. A parallel study was conducted on contemporaneous European ceramics (glazed sherds) sourced from archaeological sites dating back to the 13th–15th centuries in Saintonge (France), Ardenne, Zomergem, and Bruges (Belgium), as well as Surrey–Hampshire, Kingston, and Cheam (England). The first premise for comparing the Santarem samples with European production locations was their frequent commercial relations with Portugal and the frequency of these productions being found in Portugal. The colour of the ceramic bodies is predominantly white or whitish, with a few exhibiting a vivid red hue. Analyses of the fabric, mineralogical, and elemental composition of the sherds suggest that the majority of Santarém’s glazed ceramics were locally or regionally produced, potentially derived from a Pliocene kaolin-rich sand formation. However, this conclusion is not supported by the absence of discovered lead glaze kilns or workshops in Santarém for the late Middle Ages. Full article

Esophageal squamous cell carcinoma (ESCC) is a deadly consequence of radiation exposure to the esophagus. ESCC arises from esophageal epithelial cells that undergo malignant transformation and features a perturbed squamous cell differentiation program. Understanding the dose- and radiation quality-dependence of the esophageal epithelium response to radiation may provide insights into the ability of radiation to promote ESCC. We have explored factors that may play a role in esophageal epithelial radiosensitivity and their potential relationship to ESCC risk. We have utilized a murine three-dimensional (3D) organoid model that recapitulates the morphology and functions of the stratified squamous epithelium of the esophagus to study persistent dose- and radiation quality-dependent changes. Interestingly, although high-linear energy transfer (LET) Fe ion exposure induced a more intense and persistent alteration of squamous differentiation and 53BP1 DNA damage foci levels as compared to Cs, the MAPK/SAPK stress pathway signaling showed similar altered levels for most phospho-proteins with both radiation qualities. In addition, the lower dose of high-LET exposure also revealed nearly the same degree of morphological changes, even though only ~36% of the cells were predicted to be hit at the lower 0.1 Gy dose, suggesting that a bystander effect may be induced. Although p38 and ERK/MAPK revealed the highest levels following high-LET exposure, the findings reveal that even a low dose (0.1 Gy) of both radiation qualities can elicit a persistent stress signaling response that may critically impact the differentiation gradient of the esophageal epithelium, providing novel insights into the pathogenesis of radiation-induced esophageal injury and early stage esophageal carcinogenesis. Full article

In visible light communication (VLC), the precise latency evaluation of wireless access networks and the efficient forwarding strategy of core networks are the crux for end-to-end reliability provisioning. Leveraging martingale theory, an elegant latency-bounded reliability analysis framework is studied for the VLC network. Considering the characteristic that VLC links are easy to block, the martingale of the service process is constructed. Based on the time shift features, the martingale process related to latency is proposed for the VLC system, which models the influence of entanglement between aggregate arrivals and random service on latency. A stopping time event about latency is defined. Renting the stopping time theory, a tight upper bound of the unreliability with regard to latency is derived. In the core network, a dynamic forward backhaul framework is proposed, which uses the relay selection algorithm based on back-pressure theory to improve data transmission quality. The theoretical latency-bounded reliability matches the simulation results well, which verifies the effectiveness of the proposed analysis framework, and the proposed relay selection algorithm can also improve network performance under data-intensive transmission. Full article

Our increasingly connected world continues to face an ever-growing number of network-based attacks. An Intrusion Detection System (IDS) is an essential security technology used for detecting these attacks. Although numerous Machine Learning-based IDSs have been proposed for the detection of malicious network traffic, the majority have difficulty properly detecting and classifying the more uncommon attack types. In this paper, we implement a novel hybrid technique using synthetic data produced by a Generative Adversarial Network (GAN) to use as input for training a Deep Reinforcement Learning (DRL) model. Our GAN model is trained on the NSL-KDD dataset, a publicly available collection of labeled network traffic data specifically designed to support the evaluation and benchmarking of IDSs. Ultimately, our findings demonstrate that training the DRL model on synthetic datasets generated by specific GAN models can result in better performance in correctly classifying minority classes over training on the true imbalanced dataset. Full article

Androgen receptor (AR) is a transcription factor expressed in various normal tissues and is a therapeutic target for prostate and possibly other cancers. A TMA containing 18,234 samples from 141 different tumor types/subtypes and 608 samples of 76 different normal tissue types was analyzed by immunohistochemistry. AR positivity was found in 116 tumor types including 66 tumor types (46.8%) with ≥1 strongly positive tumor. Moderate/strong AR positivity was detected in testicular sex cord-stromal tumors (93.3–100%) and neoplasms of the prostate (79.3–98.7%), breast (25.0–75.5%), other gynecological tumors (0.9–100%), kidney (5.0–44.1%), and urinary bladder (5.4–24.2%). Low AR staining was associated with advanced tumor stage (pTa versus pT2-4; p < 0.0001) in urothelial carcinoma; advanced pT (p < 0.0001), high tumor grade (p < 0.0001), nodal metastasis (p < 0.0001), and reduced survival (p = 0.0024) in invasive breast carcinoma; high pT (p < 0.0001) and grade (p < 0.0001) in clear cell renal cell carcinoma (RCC); and high pT (p = 0.0055) as well as high grade (p < 0.05) in papillary RCC. AR staining was unrelated to histopathological/clinical features in 157 endometrial carcinomas and in 221 ovarian carcinomas. Our data suggest a limited role of AR immunohistochemistry for tumor distinction and a prognostic role in breast and clear cell RCC and highlight tumor entities that might benefit from AR-targeted therapy. Full article

This study examined the impact of patient-centered care, satisfaction with the hospital environment, and maternal information-seeking on maternal healthcare satisfaction in Tanzania. A total of 707 mothers who delivered at Chanika Hospital in Tanzania were surveyed using a structured questionnaire. Multiple regression analyses were conducted to identify factors related to maternal satisfaction. Only 9.9% of the participants reported that they “usually” or “always” felt involved in treatment decisions. High levels of satisfaction were found for hospital cleanliness (93.6%) and safety (94.9%). However, there was a significant gap in satisfaction regarding the adequacy of water quality for medical services, with only 8.1% expressing satisfaction. Limited use of digital platforms was observed in terms of information-seeking behavior for fetal development, with only 19.5% of the participants using the internet and 14.3% using mobile apps. Patient-centered experiences with healthcare providers, especially midwives, had a significant positive impact on maternal satisfaction (β = 0.11, p = 0.021). Other significant variables were satisfaction with the hospital environment (β = 0.25, p < 0.001) and satisfaction with hospital water (β = 0.13, p < 0.001). It is recommended that healthcare improvements focus on patient-centered experiences and water quality for drinking and medical services to improve patient satisfaction. Full article

This proposal outlines the development of a comprehensive solution to address hydration challenges through the creation of a Smart Water ATM with Arduino integration, RFID authentication, and dynamic dispensing capabilities. Traditional water dispensers often fall short in monitoring water intake and promoting optimal hydration practices. In response, our project aims to revolutionize hydration practices by integrating Arduino Mega and Uno boards into a Smart Water ATM with a Bottle Dispenser. This innovative system is designed to dispense specific water quantities based on user preferences, encourage the use of personal water bottles, display water temperature, and operate independently without the need for a water line connection. Prior to prototype fabrication, an extensive literature review and survey were conducted to understand existing water dispenser shortcomings and gather public perspectives in Singapore. The Smart Water ATM addresses identified issues by incorporating sensors to monitor water levels, dispense specific quantities, and measure water temperatures. The prototype fabrication involves designing a stainless-steel housing, 3D printing the Smart Water dispenser unit, and installing tanks, tubing, and electronic components. To enhance user interaction, the Smart Water ATM requires RFID authentication through Identity Cards, tracking daily water consumption. An LCD screen displays the dispensed water volume over the ATM’s lifespan, motivating users to be mindful of their water consumption and minimize wastage. Adjustments will be made for deployment in public spaces, such as train stations, where access to permanent water dispensers is limited. This proposal presents an innovative solution to promote enhanced hydration practices, encouraging users to adopt mindful water consumption habits. Full article

Glyceraldehyde (GA) is a three-carbon monosaccharide that can be present in cells as a by-product of fructose metabolism. Bruno Mendel and Otto Warburg showed that the application of GA to cancer cells inhibits glycolysis and their growth. However, the molecular mechanism by which this occurred was not clarified. We describe a novel multi-modal mechanism by which the L-isomer of GA (L-GA) inhibits neuroblastoma cell growth. L-GA induces significant changes in the metabolic profile, promotes oxidative stress and hinders nucleotide biosynthesis. GC-MS and ¹³C-labeling was employed to measure the flow of carbon through glycolytic intermediates under L-GA treatment. It was found that L-GA is a potent inhibitor of glycolysis due to its proposed targeting of NAD(H)-dependent reactions. This results in growth inhibition, apoptosis and a redox crisis in neuroblastoma cells. It was confirmed that the redox mechanisms were modulated via L-GA by proteomic analysis. Analysis of nucleotide pools in L-GA-treated cells depicted a previously unreported observation, in which nucleotide biosynthesis is significantly inhibited. The inhibitory action of L-GA was partially relieved with the co-application of the antioxidant N-acetyl-cysteine. We present novel evidence for a simple sugar that inhibits cancer cell proliferation via dysregulating its fragile homeostatic environment. Full article

To maintain an optimal body content of phosphorus throughout postnatal life, variable phosphate absorption from food must be finely matched with urinary excretion. This amazing feat is accomplished through synchronised phosphate transport by myriads of ciliated cells lining the renal proximal tubules. These respond in real time to changes in phosphate and composition of the renal filtrate and to hormonal instructions. How they do this has stimulated decades of research. New analytical techniques, coupled with incredible advances in computer technology, have opened new avenues for investigation at a sub-cellular level. There has been a surge of research into different aspects of the process. These have verified long-held beliefs and are also dramatically extending our vision of the intense, integrated, intracellular activity which mediates phosphate absorption. Already, some have indicated new approaches for pharmacological intervention to regulate phosphate in common conditions, including chronic renal failure and osteoporosis, as well as rare inherited biochemical disorders. It is a rapidly evolving field. The aim here is to provide an overview of our current knowledge, to show where it is leading, and where there are uncertainties. Hopefully, this will raise questions and stimulate new ideas for further research. Full article

Input noise causes inescapable bias to the weight vectors of the adaptive filters during the adaptation processes. Moreover, the impulse noise at the output of the unknown systems can prevent bias compensation from converging. This paper presents a robust bias compensation method for a sparse normalized quasi-Newton least-mean (BC-SNQNLM) adaptive filtering algorithm to address these issues. We have mathematically derived the biased-compensation terms in an impulse noisy environment. Inspired by the convex combination of adaptive filters’ step sizes, we propose a novel variable mixing-norm method, BC-SNQNLM-VMN, to accelerate the convergence of our BC-SNQNLM algorithm. Simulation results confirm that the proposed method significantly outperforms other comparative works regarding normalized mean-squared deviation (NMSD) in the steady state. Full article

The multimodal and dispersive character of ultrasonic guided waves (UGW) offers the potential for non-destructive evaluation of fiber-reinforced composite (FRC) materials. In this study, a methodology for in situ stiffness assessment of FRCs using UGWs is introduced. The proposed methodology involves a comparison between measured wave speeds of the fundamental symmetric and antisymmetric guided wave modes with a pre-established dataset of UGW speeds and translation of them to corresponding stiffness properties, i.e., $ABD$-components, in an inverse manner. The dispersion relations of guided waves have been calculated using the semi-analytical finite element method. First, the performance of the proposed methodology has been assessed numerically. It has been demonstrated that each of the independent $ABD$-components of the considered laminate can be approximated with an error lower than 10.4% compared to its actual value. The extensional and bending stiffness properties can be approximated within an average error of 3.6% and 9.0%, respectively. Secondly, the performance of the proposed methodology has been assessed experimentally. This experimental assessment has been performed on a glass fiber-reinforced composite plate and the results were compared to mechanical tensile and four-point bending tests on coupons cut from the plate. Larger differences between the estimated $ABD$-components according to UGW and mechanical testing were observed. These differences were partly attributed to the variation in material properties across the test plate and the averaging of properties over the measurement area. Full article

The development of solid-state zinc–air batteries (SZABs) has stimulated significant interest. However, the practical use of SZABs still encounters difficulties due to the complicated preparation process and low-performance air cathode. In this study, we developed a free-standing CoNi/graphene composite cathode without current collectors and binders. The simplified cathode structure decreased the preparation process, and the self-assembled conductive matrix increased charge transfer, which holds promise for facile preparation and high-performance SZABs. Specifically, a free-standing CoNi/graphene film was fabricated by a simple composition method. The CoNi/graphene electrocatalyst exhibited comparable oxygen reduction reaction (ORR) catalytic activity to that of Pt/C. Furthermore, the CoNi/graphene film could be directly used as a cathode, which showed an open-circuit voltage of 1.41 V and a power density of 210 mW cm⁻² in alkaline liquid ZABs, as well as an open-circuit voltage of 1.43 V and a power density of 40 mW cm⁻² in alkaline SZABs. This facile preparation and excellent performance offer substantial potential for practical SZAB applications. Full article

This study is based on the research results of frazil ice evolution in recent years and proposes an improved frazil ice evolution mathematical model. Based on the NSGA-II genetic algorithm, seven key parameters were used as optimization design variables, the minimum average difference between the number of frazil ice, the mean and the standard deviation of particle diameter of the simulation results, and the observed data were used as the optimization objective, the Pareto optimal solution set was optimized, and the importance of each objective function was analyzed and discussed. The results show that compared to previous models, the improved model has better agreement between simulation results and experimental results. The optimal parameters obtained by the optimization model reduces the difference rate of water temperature process by 5.75%, the difference rate of quantity process by 39.13%, the difference rate of mean particle size process by 47.64%, and the difference rate of standard deviation process by 56.84% during the period of intense evolution corresponding to the initial parameter group. The results prove the validity of the optimization model of frazil ice evolution parameters. Full article

Adenomyosis is a benign condition commonly encountered in patients with infertility. While the definitive surgical management is hysterectomy, conservative surgical management is gaining attention in patients desiring future fertility. This review explores whether the surgical treatment of adenomyosis affects fertility outcomes for patients trying to conceive. The PubMed and Medline databases were searched using the keywords: “adenomyosis”, “surgery”, “radiofrequency”, “infertility”, “pregnancy”, “sterility”, “conception”, “miscarriage”, and “endometrial receptivity”. Abstracts were screened, and relevant articles were selected for review. This review reveals that surgery appears to improve fertility outcomes with or without medical therapy; however, the risk of uterine rupture remains high and the best technique to reduce this risk is still not known. More studies are needed to formulate the best surgical approach for preserving fertility in treating adenomyosis and to establish standardized guidelines. Full article

This paper proposes a concept based on field plate (FP) integration inside printed circuit board (PCB)-embedded power modules. The goal is to reduce the electric field at their surface and thus increase the partial discharge inception voltage (PDIV). Electrostatic simulations are first carried out to analyze the electric field reduction induced by the use of FPs. Then, dedicated experiments are proposed to demonstrate that the actual PDIV increases in AC sinus 50 Hz when FPs are implemented. More specifically, it is observed that an optimal FP length exists. Several analyses based on simulations and experiments are thus proposed to explain this phenomenon. Finally, an assessment of PD activity and PD location is presented to support the analysis. AC sinus 50 Hz characterizations indicate that PDIV can be increased by 178% compared to PCBs without FPs with a proper definition of equipotential prolongation and PCB length. Full article

The hectic pace of modern life often leads to quick solutions, both in lifestyle and the choice of food we consume. The importance of the gut microbiome and its balance is being increasingly researched, with the prebiotic concept itself becoming a topic of scientific investigation. The aim of this paper is to analyze scientific studies on the understanding of prebiotics conducted between 2019 and 2024 in order to see what new knowledge, new sources, new ways of use, and newly established effects on certain disease states have been discovered during this period. The question that the authors are trying to answer is how specific prebiotics affect the growth and activity of selected probiotic strains in the human gut (have impact on gut microbiome) and what the implications of these interactions are. Four databases were searched: Pubmed/MEDLINE, Springerlink, Google Scholar, and Scopus. The keywords used were prebiotics, functional food, probiotics, gut microbiome, and trends. A systematic review of 30 scientific studies on the topic of prebiotics revealed significant advances in understanding and application. Research particularly indicates how prebiotics stimulate the growth of beneficial probiotic strains, such as Lacticaseibacillus rhamnosus, Lactiplantibacillus plantarum, and Bifidobacterium. In addition, innovative approaches in food production, including pasta rich in prebiotic fibers, chocolate with inulin and stevia, and the use of fruit by-products, show promising results in creating “healthier” food options. Although the papers had differing objectives and research methodologies, certain similarities were found. All papers emphasized the importance of using prebiotics, although it depended on the type they come from and their impact on the gut microbiome, i.e., the stimulation of probiotic action within the gut microbiome, which consequently has benefits on health. This review serves as a springboard for further research in this exciting field, with the ultimate goal of harnessing the power of prebiotics to improve health outcomes. Full article