The 2023 MDPI Annual Report has
been released!
 
20 pages, 1230 KiB  
Review
Interactions between Cytokines and the Pathogenesis of Prion Diseases: Insights and Implications
by Gabriela Assis-de-Lemos, Rayanne Moura-do-Nascimento, Manuela Amaral-do-Nascimento, Ana C. Miceli and Tuane C. R. G. Vieira
Brain Sci. 2024, 14(5), 413; https://doi.org/10.3390/brainsci14050413 (registering DOI) - 23 Apr 2024
Abstract
Transmissible Spongiform Encephalopathies (TSEs), including prion diseases such as Bovine Spongiform Encephalopathy (Mad Cow Disease) and variant Creutzfeldt–Jakob Disease, pose unique challenges to the scientific and medical communities due to their infectious nature, neurodegenerative effects, and the absence of a cure. Central to [...] Read more.
Transmissible Spongiform Encephalopathies (TSEs), including prion diseases such as Bovine Spongiform Encephalopathy (Mad Cow Disease) and variant Creutzfeldt–Jakob Disease, pose unique challenges to the scientific and medical communities due to their infectious nature, neurodegenerative effects, and the absence of a cure. Central to the progression of TSEs is the conversion of the normal cellular prion protein (PrPC) into its infectious scrapie form (PrPSc), leading to neurodegeneration through a complex interplay involving the immune system. This review elucidates the current understanding of the immune response in prion diseases, emphasizing the dual role of the immune system in both propagating and mitigating the disease through mechanisms such as glial activation, cytokine release, and blood–brain barrier dynamics. We highlight the differential cytokine profiles associated with various prion strains and stages of disease, pointing towards the potential for cytokines as biomarkers and therapeutic targets. Immunomodulatory strategies are discussed as promising avenues for mitigating neuroinflammation and delaying disease progression. This comprehensive examination of the immune response in TSEs not only advances our understanding of these enigmatic diseases but also sheds light on broader neuroinflammatory processes, offering hope for future therapeutic interventions. Full article
(This article belongs to the Special Issue Immune Responses to Viruses in the Central Nervous System)
16 pages, 3335 KiB  
Article
Intelligent Tire Prototype in Longitudinal Slip Operating Conditions
by Jennifer Bastiaan, Abhishek Chawan, Wookjin Eum, Khalil Alipour, Foroogh Rouhollahi, Mohammad Behroozi and Javad Baqersad
Sensors 2024, 24(9), 2681; https://doi.org/10.3390/s24092681 (registering DOI) - 23 Apr 2024
Abstract
With the recent advances in autonomous vehicles, there is an increasing need for sensors that can help monitor tire–road conditions and the forces that are applied to the tire. The footprint area of a tire that makes direct contact with the road surface, [...] Read more.
With the recent advances in autonomous vehicles, there is an increasing need for sensors that can help monitor tire–road conditions and the forces that are applied to the tire. The footprint area of a tire that makes direct contact with the road surface, known as the contact patch, is a key parameter for determining a vehicle’s effectiveness in accelerating, braking, and steering at various velocities. Road unevenness from features such as potholes and cracks results in large fluctuations in the contact patch surface area. Such conditions can eventually require the driver to perform driving maneuvers unorthodox to normal traffic patterns, such as excessive pedal depressions or large steering inputs, which can escalate to hazards such as the loss of control or impact. The integration of sensors into the inner liner of a tire has proven to be a promising method for extracting real-time tire-to-road contact patch interface data. In this research, a tire model is developed using Abaqus/CAE and analyzed using Abaqus/Explicit to study the nonlinear behavior of a rolling tire. Strain variations are investigated at the contact patch in three major longitudinal slip driving scenarios, including acceleration, braking, and free-rolling. Multiple vertical loading conditions on the tire are applied and studied. An intelligent tire prototype called KU-iTire is developed and tested to validate the strain results obtained from the simulations. Similar operating and loading conditions are applied to the physical prototype and the simulation model such that valid comparisons can be made. The experimental investigation focuses on the effectiveness of providing usable and reliable tire-to-road contact patch strain variation data under several longitudinal slip operating conditions. In this research, a correlation between FEA and experimental testing was observed between strain shape for free-rolling, acceleration, and braking conditions. A relationship between peak longitudinal strain and vertical load in free-rolling driving conditions was also observed and a correlation was observed between FEA and physical testing. Full article
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17 pages, 632 KiB  
Review
Valorization of Agro-Industrial Orange Peel By-Products through Fermentation Strategies
by Teresa Gervasi and Giuseppina Mandalari
Fermentation 2024, 10(5), 224; https://doi.org/10.3390/fermentation10050224 (registering DOI) - 23 Apr 2024
Abstract
The use of whole-cell biocatalysts in microbial cell factories is of great interest to produce added-value compounds. Through large-scale fermentative processes, which use secondary raw materials as substrates, it is possible to recycle and upgrade agro-industrial by-products. This review addresses the main fermentative [...] Read more.
The use of whole-cell biocatalysts in microbial cell factories is of great interest to produce added-value compounds. Through large-scale fermentative processes, which use secondary raw materials as substrates, it is possible to recycle and upgrade agro-industrial by-products. This review addresses the main fermentative processes and bioreactors currently used for the valorization of orange peel, a by-product of the Citrus processing industry. Among the main added-value products, bioethanol, organic acids, enzymes, single cell proteins (SCPs), dyes and aromatic compounds have been industrially produced using orange peel via solid state fermentation and submerged fermentation. This approach fits within the circular economy goals in terms of clean technology and renewable energy, valorization and recycling, upgrade of industrial by-products and sustainability. Full article
(This article belongs to the Special Issue Microbial Biotechnology and Agro-Industrial By-Products Fermentation)
22 pages, 5825 KiB  
Article
Valproic Acid Treatment after Traumatic Brain Injury in Mice Alleviates Neuronal Death and Inflammation in Association with Increased Plasma Lysophosphatidylcholines
by Regina Hummel, Erika Dorochow, Sonja Zander, Katharina Ritter, Lisa Hahnefeld, Robert Gurke, Irmgard Tegeder and Michael K. E. Schäfer
Cells 2024, 13(9), 734; https://doi.org/10.3390/cells13090734 (registering DOI) - 23 Apr 2024
Abstract
The histone deacetylase inhibitor (HDACi) valproic acid (VPA) has neuroprotective and anti-inflammatory effects in experimental traumatic brain injury (TBI), which have been partially attributed to the epigenetic disinhibition of the transcription repressor RE1-Silencing Transcription Factor/Neuron-Restrictive Silencer Factor (REST/NRSF). Additionally, VPA changes post-traumatic brain [...] Read more.
The histone deacetylase inhibitor (HDACi) valproic acid (VPA) has neuroprotective and anti-inflammatory effects in experimental traumatic brain injury (TBI), which have been partially attributed to the epigenetic disinhibition of the transcription repressor RE1-Silencing Transcription Factor/Neuron-Restrictive Silencer Factor (REST/NRSF). Additionally, VPA changes post-traumatic brain injury (TBI) brain metabolism to create a neuroprotective environment. To address the interconnection of neuroprotection, metabolism, inflammation and REST/NRSF after TBI, we subjected C57BL/6N mice to experimental TBI and intraperitoneal VPA administration or vehicle solution at 15 min, 1, 2, and 3 days post-injury (dpi). At 7 dpi, TBI-induced an up-regulation of REST/NRSF gene expression and HDACi function of VPA on histone H3 acetylation were confirmed. Neurological deficits, brain lesion size, blood–brain barrier permeability, or astrogliosis were not affected, and REST/NRSF target genes were only marginally influenced by VPA. However, VPA attenuated structural damage in the hippocampus, microgliosis and expression of the pro-inflammatory marker genes. Analyses of plasma lipidomic and polar metabolomic patterns revealed that VPA treatment increased lysophosphatidylcholines (LPCs), which were inversely associated with interleukin 1 beta (Il1b) and tumor necrosis factor (Tnf) gene expression in the brain. The results show that VPA has mild neuroprotective and anti-inflammatory effects likely originating from favorable systemic metabolic changes resulting in increased plasma LPCs that are known to be actively taken up by the brain and function as carriers for neuroprotective polyunsaturated fatty acids. Full article
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43 pages, 1509 KiB  
Review
The Benzoylpiperidine Fragment as a Privileged Structure in Medicinal Chemistry: A Comprehensive Review
by Giulia Bononi, Chiara Lonzi, Tiziano Tuccinardi, Filippo Minutolo and Carlotta Granchi
Molecules 2024, 29(9), 1930; https://doi.org/10.3390/molecules29091930 (registering DOI) - 23 Apr 2024
Abstract
The phenyl(piperidin-4-yl)methanone fragment (here referred to as the benzoylpiperidine fragment) is a privileged structure in the development of new drugs considering its presence in many bioactive small molecules with both therapeutic (such as anti-cancer, anti-psychotic, anti-thrombotic, anti-arrhythmic, anti-tubercular, anti-parasitic, anti-diabetic, and neuroprotective agents) [...] Read more.
The phenyl(piperidin-4-yl)methanone fragment (here referred to as the benzoylpiperidine fragment) is a privileged structure in the development of new drugs considering its presence in many bioactive small molecules with both therapeutic (such as anti-cancer, anti-psychotic, anti-thrombotic, anti-arrhythmic, anti-tubercular, anti-parasitic, anti-diabetic, and neuroprotective agents) and diagnostic properties. The benzoylpiperidine fragment is metabolically stable, and it is also considered a potential bioisostere of the piperazine ring, thus making it a feasible and reliable chemical frame to be exploited in drug design. Herein, we discuss the main therapeutic and diagnostic agents presenting the benzoylpiperidine motif in their structure, covering articles reported in the literature since 2000. A specific section is focused on the synthetic strategies adopted to obtain this versatile chemical portion. Full article
(This article belongs to the Special Issue Recent Advances in Development of Small Molecules to Fight Cancer)
10 pages, 913 KiB  
Communication
A Multi-Drug Concentration Gradient Mixing Chip: A Novel Platform for High-Throughput Drug Combination Screening
by Jiahao Fu, Yibo Feng, Yu Sun, Ruiya Yi, Jing Tian, Wei Zhao, Dan Sun and Ce Zhang
Biosensors 2024, 14(5), 212; https://doi.org/10.3390/bios14050212 (registering DOI) - 23 Apr 2024
Abstract
Combinatorial drug therapy has emerged as a critically important strategy in medical research and patient treatment and involves the use of multiple drugs in concert to achieve a synergistic effect. This approach can enhance therapeutic efficacy while simultaneously mitigating adverse side effects. However, [...] Read more.
Combinatorial drug therapy has emerged as a critically important strategy in medical research and patient treatment and involves the use of multiple drugs in concert to achieve a synergistic effect. This approach can enhance therapeutic efficacy while simultaneously mitigating adverse side effects. However, the process of identifying optimal drug combinations, including their compositions and dosages, is often a complex, costly, and time-intensive endeavor. To surmount these hurdles, we propose a novel microfluidic device capable of simultaneously generating multiple drug concentration gradients across an interlinked array of culture chambers. This innovative setup allows for the real-time monitoring of live cell responses. With minimal effort, researchers can now explore the concentration-dependent effects of single-agent and combination drug therapies. Taking neural stem cells (NSCs) as a case study, we examined the impacts of various growth factors—epithelial growth factor (EGF), platelet-derived growth factor (PDGF), and fibroblast growth factor (FGF)—on the differentiation of NSCs. Our findings indicate that an overdose of any single growth factor leads to an upsurge in the proportion of differentiated NSCs. Interestingly, the regulatory effects of these growth factors can be modulated by the introduction of additional growth factors, whether singly or in combination. Notably, a reduced concentration of these additional factors resulted in a decreased number of differentiated NSCs. Our results affirm that the successful application of this microfluidic device for the generation of multi-drug concentration gradients has substantial potential to revolutionize drug combination screening. This advancement promises to streamline the process and accelerate the discovery of effective therapeutic drug combinations. Full article
(This article belongs to the Special Issue Application of Microfluidics in Cell Manipulation and Biosensing)
24 pages, 3656 KiB  
Article
Visual Field Restriction in the Recognition of Basic Facial Expressions: A Combined Eye Tracking and Gaze Contingency Study
by Melina Boratto Urtado, Rafael Delalibera Rodrigues and Sergio Sheiji Fukusima
Behav. Sci. 2024, 14(5), 355; https://doi.org/10.3390/bs14050355 (registering DOI) - 23 Apr 2024
Abstract
Uncertainties and discrepant results in identifying crucial areas for emotional facial expression recognition may stem from the eye tracking data analysis methods used. Many studies employ parameters of analysis that predominantly prioritize the examination of the foveal vision angle, ignoring the potential influences [...] Read more.
Uncertainties and discrepant results in identifying crucial areas for emotional facial expression recognition may stem from the eye tracking data analysis methods used. Many studies employ parameters of analysis that predominantly prioritize the examination of the foveal vision angle, ignoring the potential influences of simultaneous parafoveal and peripheral information. To explore the possible underlying causes of these discrepancies, we investigated the role of the visual field aperture in emotional facial expression recognition with 163 volunteers randomly assigned to three groups: no visual restriction (NVR), parafoveal and foveal vision (PFFV), and foveal vision (FV). Employing eye tracking and gaze contingency, we collected visual inspection and judgment data over 30 frontal face images, equally distributed among five emotions. Raw eye tracking data underwent Eye Movements Metrics and Visualizations (EyeMMV) processing. Accordingly, the visual inspection time, number of fixations, and fixation duration increased with the visual field restriction. Nevertheless, the accuracy showed significant differences among the NVR/FV and PFFV/FV groups, despite there being no difference in NVR/PFFV. The findings underscore the impact of specific visual field areas on facial expression recognition, highlighting the importance of parafoveal vision. The results suggest that eye tracking data analysis methods should incorporate projection angles extending to at least the parafoveal level. Full article
(This article belongs to the Section Cognition)
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16 pages, 858 KiB  
Review
An Overview of Demand Analysis and Forecasting Algorithms for the Flow of Checked Baggage among Departing Passengers
by Bo Jiang, Guofu Ding, Jianlin Fu, Jian Zhang and Yong Zhang
Algorithms 2024, 17(5), 173; https://doi.org/10.3390/a17050173 (registering DOI) - 23 Apr 2024
Abstract
The research on baggage flow plays a pivotal role in achieving the efficient and intelligent allocation and scheduling of airport service resources, as well as serving as a fundamental element in determining the design, development, and process optimization of airport baggage handling systems. [...] Read more.
The research on baggage flow plays a pivotal role in achieving the efficient and intelligent allocation and scheduling of airport service resources, as well as serving as a fundamental element in determining the design, development, and process optimization of airport baggage handling systems. This paper examines baggage checked in by departing passengers at airports. The crrent state of the research on baggage flow demand is first reviewed and analyzed. Then, using examples of objective data, it is concluded that while there is a significant correlation between airport passenger flow and baggage flow, an increase in passenger flow does not necessarily result in a proportional increase in baggage flow. According to the existing research results on the influencing factors of baggage flow sorting and classification, the main influencing factors of baggage flow are divided into two categories: macro-influencing factors and micro-influencing factors. When studying the relationship between the economy and baggage flow, it is recommended to use a comprehensive analysis that includes multiple economic indicators, rather than relying solely on GDP. This paper provides a brief overview of prevalent transportation flow prediction methods, categorizing algorithmic models into three groups: based on mathematical and statistical models, intelligent algorithmic-based models, and combined algorithmic models utilizing artificial neural networks. The structures, strengths, and weaknesses of various transportation flow prediction algorithms are analyzed, as well as their application scenarios. The potential advantages of using artificial neural network-based combined prediction models for baggage flow forecasting are explained. It concludes with an outlook on research regarding the demand for baggage flow. This review may provide further research assistance to scholars in airport management and baggage handling system development. Full article
18 pages, 316 KiB  
Article
A One-Parameter Family of Methods with a Higher Order of Convergence for Equations in a Banach Space
by Ramandeep Behl, Ioannis K. Argyros and Sattam Alharbi
Mathematics 2024, 12(9), 1278; https://doi.org/10.3390/math12091278 (registering DOI) - 23 Apr 2024
Abstract
The conventional approach of the local convergence analysis of an iterative method on Rm, with m a natural number, depends on Taylor series expansion. This technique often requires the calculation of high-order derivatives. However, those derivatives may not be part of [...] Read more.
The conventional approach of the local convergence analysis of an iterative method on Rm, with m a natural number, depends on Taylor series expansion. This technique often requires the calculation of high-order derivatives. However, those derivatives may not be part of the proposed method(s). In this way, the method(s) can face several limitations, particularly the use of higher-order derivatives and a lack of information about a priori computable error bounds on the solution distance or uniqueness. In this paper, we address these drawbacks by conducting the local convergence analysis within the broader framework of a Banach space. We have selected an important family of high convergence order methods to demonstrate our technique as an example. However, due to its generality, our technique can be used on any other iterative method using inverses of linear operators along the same line. Our analysis not only extends in Rm spaces but also provides convergence conditions based on the operators used in the method, which offer the applicability of the method in a broader area. Additionally, we introduce a novel semilocal convergence analysis not presented before in such studies. Both forms of convergence analysis depend on the concept of generalized continuity and provide a deeper understanding of convergence properties. Our methodology not only enhances the applicability of the suggested method(s) but also provides suitability for applied science problems. The computational results also support the theoretical aspects. Full article
(This article belongs to the Special Issue Numerical Analysis and Modeling)
11 pages, 1230 KiB  
Article
A Comparison of the Mechanisms and Activation Barriers for Ammonia Synthesis on Metal Nitrides (Ta3N5, Mn6N5, Fe3Mo3N, Co3Mo3N)
by Constantinos D. Zeinalipour-Yazdi
Crystals 2024, 14(5), 392; https://doi.org/10.3390/cryst14050392 (registering DOI) - 23 Apr 2024
Abstract
In this study we perform a comparison of the reaction mechanism and the activation barrier for the rate-determining step in various metal nitrides (Ta3N5, Mn6N5, Fe3Mo3N, Co3Mo3N) [...] Read more.
In this study we perform a comparison of the reaction mechanism and the activation barrier for the rate-determining step in various metal nitrides (Ta3N5, Mn6N5, Fe3Mo3N, Co3Mo3N) for the ammonia synthesis reaction. The reactions are explained with simplified schematics and the energy profiles for the various reaction mechanisms are given in order to screen the catalytic activity of the catalysts for the ammonia synthesis reaction. We find that the catalytic activity ranks in the following order: Co3Mo3N > Fe3Mo3N > Ta3N5 > Mn6N5. We also find that the reaction mechanism proceeds either by a Langmuir–Hinshelwood and an Eley–Rideal/Mars–van Krevelen mechanism. This is an overview of about 10 years of computational research conducted to provide an overview of the progress established in this field of study. Full article
(This article belongs to the Special Issue Synthesis and Characterization of Ammonia Synthesis Catalysts)
17 pages, 566 KiB  
Article
Efficient Feature Learning Model of Motor Imagery EEG Signals with L1-Norm and Weighted Fusion
by Xiangzeng Kong, Cailin Wu, Shimiao Chen, Tao Wu and Junfeng Han
Biosensors 2024, 14(5), 211; https://doi.org/10.3390/bios14050211 (registering DOI) - 23 Apr 2024
Abstract
Brain–computer interface (BCI) for motor imagery is an advanced technology used in the field of medical rehabilitation. However, due to the poor accuracy of electroencephalogram feature classification, BCI systems often misrecognize user commands. Although many state-of-the-art feature selection methods aim to enhance classification [...] Read more.
Brain–computer interface (BCI) for motor imagery is an advanced technology used in the field of medical rehabilitation. However, due to the poor accuracy of electroencephalogram feature classification, BCI systems often misrecognize user commands. Although many state-of-the-art feature selection methods aim to enhance classification accuracy, they usually overlook the interrelationships between individual features, indirectly impacting the accuracy of feature classification. To overcome this issue, we propose an adaptive feature learning model that employs a Riemannian geometric approach to generate a feature matrix from electroencephalogram signals, serving as the model’s input. By integrating the enhanced adaptive L1 penalty and weighted fusion penalty into the sparse learning model, we select the most informative features from the matrix. Specifically, we measure the importance of features using mutual information and introduce an adaptive weight construction strategy to penalize regression coefficients corresponding to each variable adaptively. Moreover, the weighted fusion penalty balances weight differences among correlated variables, reducing the model’s overreliance on specific variables and enhancing accuracy. The performance of the proposed method was validated on BCI Competition IV datasets IIa and IIb using the support vector machine. Experimental results demonstrate the effectiveness and superiority of the proposed model compared to the existing models. Full article
17 pages, 1111 KiB  
Article
Screening of a Saccharomyces cerevisiae Strain with High 3-Methylthio-1-Propanol Yield and Optimization of Its Fermentation Conditions
by Qi Sun, Jinghao Ma, Rana Abdul Basit, Zhilei Fu, Xiaoyan Liu and Guangsen Fan
Foods 2024, 13(9), 1296; https://doi.org/10.3390/foods13091296 (registering DOI) - 23 Apr 2024
Abstract
3-Methylthio-1-propanol (3-Met) is an important flavor compound in various alcoholic beverages such as Baijiu and Huangjiu. To maintain the content of 3-Met in these alcoholic beverages, it is necessary to screen a micro-organism with high yield of 3-Met from the brewing environment. [...] Read more.
3-Methylthio-1-propanol (3-Met) is an important flavor compound in various alcoholic beverages such as Baijiu and Huangjiu. To maintain the content of 3-Met in these alcoholic beverages, it is necessary to screen a micro-organism with high yield of 3-Met from the brewing environment. In this study, the ability of yeast strains from the Baijiu brewing to produce 3-Met was analyzed, aiming to obtain yeast with high-yield 3-Met, and its fermentation conditions were optimized. Firstly, 39 yeast strains were screened using 3-Met conversion medium. The results showed that the majority of the strains from Baijiu brewing sources could produce 3-Met, and nearly half of the strains produced more than 0.5 g/L of 3-Met. Among these, yeast F10404, Y03401, and Y8#01, produced more than 1.0 g/L of 3-Met, with yeast Y03401 producing the highest amount at 1.30 g/L. Through morphological observation, physiological and biochemical analysis, and molecular biological identification, it was confirmed that yeast Y03401 was a Saccharomyces cerevisiae. Subsequently, the optimal fermentation conditions for 3-Met production by this yeast were obtained through single-factor designs, Plackett–Burman test, steepest ascent path design and response surface methodology. When the glucose concentration was 60 g/L, yeast extract concentration was 0.8 g/L, L-methionine concentration was 3.8 g/L, initial pH was 4, incubation time was 63 h, inoculum size was 1.6%, shaking speed was 150 rpm, loading volume was 50 mL/250 mL, and temperature was 26 °C, the content of 3-Met produced by S. cerevisiae Y03401 reached a high level of 3.66 g/L. It was also noteworthy that, in contrast to other study findings, this yeast was able to create substantial amounts of 3-Met even in the absence of L-methionine precursor. Based on the clear genome of S. cerevisiae and its characteristics in 3-Met production, S. cerevisiae Y03401 had broad prospects for application in alcoholic beverages such as Baijiu. Full article
23 pages, 1347 KiB  
Review
Carbon Monoxide Poisoning: From Occupational Health to Emergency Medicine
by Gabriele Savioli, Nicole Gri, Iride Francesca Ceresa, Andrea Piccioni, Christian Zanza, Yaroslava Longhitano, Giovanni Ricevuti, Maurizio Daccò, Ciro Esposito and Stefano M. Candura
J. Clin. Med. 2024, 13(9), 2466; https://doi.org/10.3390/jcm13092466 (registering DOI) - 23 Apr 2024
Abstract
Carbon monoxide poisoning remains a leading cause of accidental poisoning worldwide (both at home and at work), and it is also a cause of suicidal poisoning. Such poisoning can arise following prolonged exposure to low levels of CO or following brief exposure to [...] Read more.
Carbon monoxide poisoning remains a leading cause of accidental poisoning worldwide (both at home and at work), and it is also a cause of suicidal poisoning. Such poisoning can arise following prolonged exposure to low levels of CO or following brief exposure to high concentrations of the gas. In fact, despite exposure limits, high safety standards, and the availability of CO alarms, nearly 50,000 people in the United States visit the emergency department each year due to poisoning. Additionally, CO poisoning in the United States causes up to 500 deaths each year. Despite the widespread nature of this form of poisoning, known about for centuries and whose damage mechanisms have been recognized (or rather hypothesized about) since the 1800s, early recognition, especially of late complications, and treatment remain a medical challenge. A well-designed therapeutic diagnostic process is necessary so that indication for hyperbaric or normobaric therapy is correctly made and so that patients are followed up even after acute exposure to diagnose late complications early. Furthermore, it is necessary to consider that in the setting of emergency medicine, CO poisoning can be part of a differential diagnosis along with other more frequent conditions, making its recognition difficult. The last thirty years have been marked by a significant increase in knowledge regarding the toxicity of CO, as well as its functioning and its importance at physiological concentrations in mammalian systems. This review, taking into account the significant progress made in recent years, aims to reconsider the pathogenicity of CO, which is not trivially just poisonous to tissues. A revision of the paradigm, especially as regards treatment and sequelae, appears necessary, and new studies should focus on this new point of view. Full article
(This article belongs to the Section Emergency Medicine)
23 pages, 2281 KiB  
Article
A Generative Deep Learning Approach for Improving the Mechanical Performance of Structural Components
by Nurullah Yüksel and Hüseyin Rıza Börklü
Appl. Sci. 2024, 14(9), 3564; https://doi.org/10.3390/app14093564 (registering DOI) - 23 Apr 2024
Abstract
This study aimed to improve the mechanical properties of 3D concept designs by combining the design capability of a generative adversarial network with finite element analysis. This approach offers an innovative perspective on the conditioning of generative models while improving design properties and [...] Read more.
This study aimed to improve the mechanical properties of 3D concept designs by combining the design capability of a generative adversarial network with finite element analysis. This approach offers an innovative perspective on the conditioning of generative models while improving design properties and automation. A new design and evaluation framework has been developed for GAN models to generate 3D models with improved mechanical properties. The framework is an iterative process that includes dataset generation, GAN training, and finite element analysis. A “joint” component used in the aerospace industry is considered to demonstrate the proposed method’s effectiveness. Over six iterations, an increase of 20% is recorded in the average safety factor of the designs, and the variety of designs produced is narrowed in the desired direction. These findings suggest that the direct generation of structural components with generative models can expand the potential of deep learning in engineering design. Another innovative aspect of this study is that it provides a new option for the conditioning of data-dependent generative design models. Full article
(This article belongs to the Section Computing and Artificial Intelligence)
15 pages, 1519 KiB  
Article
The Contribution of Genetic Testing in Optimizing Therapy for Patients with Recurrent Depressive Disorder
by Rita Ioana Platona, Florica Voiță-Mekeres, Cristina Tudoran, Mariana Tudoran and Virgil Radu Enătescu
Clin. Pract. 2024, 14(3), 703-717; https://doi.org/10.3390/clinpract14030056 - 23 Apr 2024
Abstract
(1) Background: The aim of this study was to analyze the impact of pharmacogenetic-guided antidepressant therapy on the 12-month evolution of the intensity of depressive symptoms in patients with recurrent depressive disorder (RDD) in comparison to a control group of depressive subjects who [...] Read more.
(1) Background: The aim of this study was to analyze the impact of pharmacogenetic-guided antidepressant therapy on the 12-month evolution of the intensity of depressive symptoms in patients with recurrent depressive disorder (RDD) in comparison to a control group of depressive subjects who were treated conventionally. (2) Methods: This prospective longitudinal study was conducted between 2019 and 2022, and the patients were evaluated by employing the Hamilton Depression Rating Scale (HAM-D), Hamilton Anxiety Rating Scale (HAM-A) and the Clinical Global Impressions Scale: Severity and Improvement. We followed them up at 1, 3, 6, and 12 months. (3) Results: Of the 76 patients with RDD, 37 were tested genetically (Group A) and 39 were not (Group B). Although the patients from Group A had statistically significantly more severe MDD at baseline than those from Group B (p < 0.001), by adjusting their therapy according to the genetic testing, they had a progressive and more substantial reduction in the severity of RDD symptoms [F = 74.334; η2 = 0.674; p < 0.001], indicating a substantial association with the results provided by the genetic testing (67.4%). (4) Conclusions: In patients with RDD and a poor response to antidepressant therapy, pharmacogenetic testing allows for treatment adjustment, resulting in a constant and superior reduction in the intensity of depression and anxiety symptoms. Full article
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19 pages, 4730 KiB  
Article
Exchangeable Quantities and Power Laws: Τhe Case of Pores in Solids
by Antigoni G. Margellou and Philippos J. Pomonis
Foundations 2024, 4(2), 156-174; https://doi.org/10.3390/foundations4020012 - 23 Apr 2024
Abstract
In this work we suggest that the common cause for the development of various power laws is the existence of a suitable exchangeable quantity between the agents of a set. Examples of such exchangeable quantities, leading to eponymous power laws, include money (Pareto’s [...] Read more.
In this work we suggest that the common cause for the development of various power laws is the existence of a suitable exchangeable quantity between the agents of a set. Examples of such exchangeable quantities, leading to eponymous power laws, include money (Pareto’s Law), scientific knowledge (Lotka’s Law), people (Auerbach’s Law), and written or verbal information (Zipf’s Law), as well as less common cases like bullets during deadly conflicts, recognition in social networks, heat between the atmosphere and sea-ice floes, and, finally, mass of water vapors between pores in solids. This last case is examined closely in the present article based on extensive experimental data. It is shown that the transferred mass between pores, which eventually grow towards a power law distribution, may be expressed using different parameters, either transferred surface area, or transferred volume, or transferred pore length or transferred pore anisotropy. These distinctions lead to different power laws of variable strength as reflected by the corresponding exponent. The exponents depend quantitatively on the spread of frequency distribution of the examined parameter and tend to zero as the spread of distribution tends to a single order of magnitude. A comparison between the energy and the entropy of different kinds of pore distributions reveals that these two statistical parameters are linearly related, implying that the system poise at a critical state and the exchangeable quantities are the most convenient operations helping to keep this balance. Full article
(This article belongs to the Section Chemical Sciences)
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17 pages, 27418 KiB  
Article
Landsat 8 and 9 Underfly International Surface Reflectance Validation Collaboration
by Joshua Mann, Emily Maddox, Mahesh Shrestha, Jeffrey Irwin, Jeffrey Czapla-Myers, Aaron Gerace, Eon Rehman, Nina Raqueno, Craig Coburn, Guy Byrne, Mark Broomhall and Andrew Walsh
Remote Sens. 2024, 16(9), 1492; https://doi.org/10.3390/rs16091492 (registering DOI) - 23 Apr 2024
Abstract
During the launch and path to its final orbit, the Landsat 9 satellite performed a once in a mission lifetime maneuver as it passed beneath Landsat 8, resulting in near coincident data collection. This maneuver provided ground validation teams from across the globe [...] Read more.
During the launch and path to its final orbit, the Landsat 9 satellite performed a once in a mission lifetime maneuver as it passed beneath Landsat 8, resulting in near coincident data collection. This maneuver provided ground validation teams from across the globe the opportunity of collecting surface in situ data to compare directly to Landsat 8 and Landsat 9 data. Ground validation teams identified surface targets that would yield reflectance and/or thermal values that could be used in Landsat Level 2 product validation and set out to collect at these locations using surface validation methodologies the teams developed. The values were collected from each team and compared directly with each other across each of the different bands of both Landsat 8 and 9. The results proved consistency across the Landsat 8 and 9 platforms and also agreed well in surface reflectance underestimation of the Coastal Aerosol, Blue, and SWIR2 bands. Full article
17 pages, 554 KiB  
Article
12-Month Trajectories of Health-Related Quality of Life Following Hospitalization in German Cancer Centers—A Secondary Data Analysis
by Martin Eichler, Klaus Hönig, Corinna Bergelt, Hermann Faller, Imad Maatouk, Beate Hornemann, Barbara Stein, Martin Teufel, Ute Goerling, Yesim Erim, Franziska Geiser, Alexander Niecke, Bianca Senf and Joachim Weis
Curr. Oncol. 2024, 31(5), 2376-2392; https://doi.org/10.3390/curroncol31050177 - 23 Apr 2024
Abstract
Patient-reported outcomes (PROs) offer a diverse array of potential applications within medical research and clinical practice. In comparative research, they can serve as tools for delineating the trajectories of health-related quality of life (HRQoL) across various cancer types. We undertook a secondary data [...] Read more.
Patient-reported outcomes (PROs) offer a diverse array of potential applications within medical research and clinical practice. In comparative research, they can serve as tools for delineating the trajectories of health-related quality of life (HRQoL) across various cancer types. We undertook a secondary data analysis of a cohort of 1498 hospitalized cancer patients from 13 German cancer centers. We assessed the Physical and Mental Component Scores (PCS and MCS) of the 12-Item Short-Form Health Survey at baseline (t0), 6 (t1), and 12 months (t2), using multivariable generalized linear regression models. At baseline, the mean PCS and MCS values for all cancer patients were 37.1 and 44.3 points, respectively. We observed a significant improvement in PCS at t2 and in MCS at t1. The most substantial and significant improvements were noted among patients with gynecological cancers. We found a number of significant differences between cancer types at baseline, t1, and t2, with skin cancer patients performing best across all time points and lung cancer patients performing the worst. MCS trajectories showed less pronounced changes and differences between cancer types. Comparative analyses of HRQoL scores across different cancer types may serve as a valuable tool for enhancing health literacy, both among the general public and among cancer patients themselves. Full article
11 pages, 363 KiB  
Article
Effectiveness of Mentorship Using Cognitive Behavior Therapy to Reduce Burnout and Turnover among Nurses: Intervention Impact on Mentees
by Takashi Ohue and Masaru Menta
Nurs. Rep. 2024, 14(2), 1026-1036; https://doi.org/10.3390/nursrep14020077 - 23 Apr 2024
Abstract
Objective: Mentoring programs can improve nurses’ mental health. This study examined the effects of a staff training program based on cognitive behavior therapy for burnout in which mentors provided intervention to their mentees. Methods: The principal investigator served as a facilitator and conducted [...] Read more.
Objective: Mentoring programs can improve nurses’ mental health. This study examined the effects of a staff training program based on cognitive behavior therapy for burnout in which mentors provided intervention to their mentees. Methods: The principal investigator served as a facilitator and conducted staff training in cognitive behavior therapy. An original cognitive behavior therapy manual was presented to trained nurses (mentors), and lectures were provided on using the manual, ways of implementing cognitive behavior therapy, and other important points. The study participants included 35 mid-career nurses (mentors) and 34 young nurses in their first to third year (mentees) working in acute care hospitals. Groups of five mentees were formed in which two mentors provided cognitive behavior therapy based on the manual. Changes in mentees’ stress, burnout, and turnover intention at pre-intervention, post-intervention, and follow-up (3 months after the intervention) were objectively evaluated using an evaluation index. Results: The intervention significantly reduced the following evaluation indicators: total strain, conflict with other nursing staff, nursing role conflict, qualitative workload, quantitative workload, conflict with patients, problem avoidance due to irrational beliefs, escape-avoidance, emotional exhaustion of burnout, desire to change hospitals or departments, and turnover intention. Conclusion: Implementation of cognitive behavior therapy by mentors effectively reduced mentees’ stress, burnout, and turnover. Full article
(This article belongs to the Special Issue Burnout and Nursing Care)
17 pages, 387 KiB  
Article
Key Challenges of Cloud Computing Resource Allocation in Small and Medium Enterprises
by Abdulghafour Mohammad and Yasir Abbas
Digital 2024, 4(2), 372-388; https://doi.org/10.3390/digital4020018 - 23 Apr 2024
Abstract
Although cloud computing offers many benefits, such as flexibility, scalability, and profitability, some small and medium enterprises (SMEs) are still unable to fully utilize cloud resources, such as memory, computing power, storage, and network bandwidth. This reduces their productivity and increases their expenses. [...] Read more.
Although cloud computing offers many benefits, such as flexibility, scalability, and profitability, some small and medium enterprises (SMEs) are still unable to fully utilize cloud resources, such as memory, computing power, storage, and network bandwidth. This reduces their productivity and increases their expenses. Therefore, the central objective of this paper was to examine the key challenges related to the allocation of cloud computing resources in small and medium enterprises. The method used for this study is based upon qualitative research using 12 interviews with 12 owners, managers, and experts in cloud computing in four countries: the United States of America, the United Kingdom, India, and Pakistan. Our results, based on our empirical data, show 11 key barriers to resource allocation in cloud computing that are classified based on the technology, organization, and environment (TOE) framework. Theoretically, this research contributes to the body of knowledge concerning cloud computing technology and offers valuable understanding of the cloud computing resource allocation approaches employed by small and medium enterprises (SMEs). In practice, this research is useful to aid SMEs in implementing successful and sustainable strategies for allocating cloud computing resources. Full article
23 pages, 959 KiB  
Systematic Review
Enhancing Chronic Non-Cancer Pain Management: A Systematic Review of Mindfulness Therapies and Guided Imagery Interventions
by Beatriz Manarte Pinto, Isaura Tavares and Daniel Humberto Pozza
Medicina 2024, 60(5), 686; https://doi.org/10.3390/medicina60050686 - 23 Apr 2024
Abstract
Background and Objectives: There has been an increasing interest in the use of non-pharmacological approaches for the multidimensional treatment of chronic pain. The aim of this systematic review was to assess the effectiveness of mindfulness-based therapies and Guided Imagery (GI) interventions in [...] Read more.
Background and Objectives: There has been an increasing interest in the use of non-pharmacological approaches for the multidimensional treatment of chronic pain. The aim of this systematic review was to assess the effectiveness of mindfulness-based therapies and Guided Imagery (GI) interventions in managing chronic non-cancer pain and related outcomes. Materials and Methods: Searching three electronic databases (Web of Science, PubMed, and Scopus) and following the PRISMA guidelines, a systematic review was performed on Randomized Controlled Trials (RCTs) and pilot RCTs investigating mindfulness or GI interventions in adult patients with chronic non-cancer pain. The Cochrane Risk of Bias Tool was utilized to assess the quality of the evidence, with outcomes encompassing pain intensity, opioid consumption, and non-sensorial dimensions of pain. Results: Twenty-six trials met the inclusion criteria, with most of them exhibiting a moderate to high risk of bias. A wide diversity of chronic pain types were under analysis. Amongst the mindfulness interventions, and besides the classical programs, Mindfulness-Oriented Recovery Enhancement (MORE) emerges as an approach that improves interoception. Six trials demonstrated that mindfulness techniques resulted in a significant reduction in pain intensity, and three trials also reported significant outcomes with GI. Evidence supports a significant improvement in non-sensory dimensions of pain in ten trials using mindfulness and in two trials involving GI. Significant effects on opioid consumption were reported in four mindfulness-based trials, whereas one study involving GI found a small effect with that variable. Conclusions: This study supports the evidence of benefits of both mindfulness techniques and GI interventions in the management of chronic non-cancer pain. Regarding the various mindfulness interventions, a specific emphasis on the positive results of MORE should be highlighted. Future studies should focus on specific pain types, explore different durations of the mindfulness and GI interventions, and evaluate emotion-related outcomes. Full article
(This article belongs to the Section Psychiatry)
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32 pages, 22322 KiB  
Article
Enhanced Energy Absorption with Bioinspired Composite Triply Periodic Minimal Surface Gyroid Lattices Fabricated via Fused Filament Fabrication (FFF)
by Dawit Bogale Alemayehu and Masahiro Todoh
J. Manuf. Mater. Process. 2024, 8(3), 86; https://doi.org/10.3390/jmmp8030086 - 23 Apr 2024
Abstract
Bio-inspired gyroid triply periodic minimum surface (TPMS) lattice structures have been the focus of research in automotive engineering because they can absorb a lot of energy and have wider plateau ranges. The main challenge is determining the optimal energy absorption capacity and accurately [...] Read more.
Bio-inspired gyroid triply periodic minimum surface (TPMS) lattice structures have been the focus of research in automotive engineering because they can absorb a lot of energy and have wider plateau ranges. The main challenge is determining the optimal energy absorption capacity and accurately capturing plastic plateau areas using finite element analysis (FEA). Using nTop’s Boolean subtraction method, this study combined walled TPMS gyroid structures with a normal TPMS gyroid lattice. This made a composite TPMS gyroid lattice (CTG) with relative densities ranging from 14% to 54%. Using ideaMaker 4.2.3 (3DRaise Pro 2) software and the fused deposition modeling (FDM) Raise3D Pro 2 3D printer to print polylactic acid (PLA) bioplastics in 1.75 mm filament made it possible to slice computer-aided design (CAD) models and fabricate 36 lattice samples precisely using a layer-by-layer technique. Shimadzu 100 kN testing equipment was utilized for the mechanical compression experiments. The finite element approach validates the results of mechanical compression testing. Further, a composite CTG was examined using a field emission scanning electron microscope (FE-SEM) before and after compression testing. The composite TPMS gyroid lattice showed potential as shock absorbers for vehicles with relative densities of 33%, 38%, and 54%. The Gibson–Ashby model showed that the composite TPMS gyroid lattice deformed mainly by bending, and the size effect was seen when the relative densities were less than 15%. The lattice’s relative density had a significant impact on its ability to absorb energy. The research also explored the use of these innovative foam-like composite TPMS gyroid lattices in high-speed crash box scenarios to potentially enhance vehicle safety and performance. The structures have tremendous potential to improve vehicle safety by acting as advanced shock absorbers, which are particularly effective at higher relative densities. Full article
(This article belongs to the Special Issue Lattice Structure and Metamaterial Design for Additive Manufacturing)
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14 pages, 1059 KiB  
Article
Triple Attention Mechanism with YOLOv5s for Fish Detection
by Wei Long, Yawen Wang, Lingxi Hu, Jintao Zhang, Chen Zhang, Linhua Jiang and Lihong Xu
Fishes 2024, 9(5), 151; https://doi.org/10.3390/fishes9050151 - 23 Apr 2024
Abstract
Traditional fish farming methods suffer from backward production, low efficiency, low yield, and environmental pollution. As a result of thorough research using deep learning technology, the industrial aquaculture model has experienced gradual maturation. A variety of complex factors makes it difficult to extract [...] Read more.
Traditional fish farming methods suffer from backward production, low efficiency, low yield, and environmental pollution. As a result of thorough research using deep learning technology, the industrial aquaculture model has experienced gradual maturation. A variety of complex factors makes it difficult to extract effective features, which results in less-than-good model performance. This paper proposes a fish detection method that combines a triple attention mechanism with a You Only Look Once (TAM-YOLO)model. In order to enhance the speed of model training, the process of data encapsulation incorporates positive sample matching. An exponential moving average (EMA) is incorporated into the training process to make the model more robust, and coordinate attention (CA) and a convolutional block attention module are integrated into the YOLOv5s backbone to enhance the feature extraction of channels and spatial locations. The extracted feature maps are input to the PANet path aggregation network, and the underlying information is stacked with the feature maps. The method improves the detection accuracy of underwater blurred and distorted fish images. Experimental results show that the proposed TAM-YOLO model outperforms YOLOv3, YOLOv4, YOLOv5s, YOLOv5m, and SSD, with a mAP value of 95.88%, thus providing a new strategy for fish detection. Full article

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