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most exciting work published in the various research areas of the journal.
Cold stress occurs in late winter and early spring threatens greatly the nectarine industry. In this study, the semi-lethal low temperature (LT50) and thirteen cold resistance related parameters of five nectarine cultivars, including ‘Nonglehong little princess’ (LP), ‘Luyou No. 5’ (LY),
[...] Read more.
Cold stress occurs in late winter and early spring threatens greatly the nectarine industry. In this study, the semi-lethal low temperature (LT50) and thirteen cold resistance related parameters of five nectarine cultivars, including ‘Nonglehong little princess’ (LP), ‘Luyou No. 5’ (LY), ‘Nonglehong No. 6’ (NL), ‘Zhongyou No. 20’ (ZY) and ‘Qiuhongzhu’ (QH), were determined. Based on these parameters, they were categorized into high—(HR, including NL and LP), moderate—(MR, including QH) and low-cold resistant (LR, including ZY and LY) groups. The relative water (RW), proline (PRO), soluble sucrose (SS) and soluble protein (SP) contents, and superoxide dismutase (SOD) and peroxidase (POD) activities of HR cultivars were higher while their relative electronic conductivity (RE), malondialdehyde (MDA) and gibberellin acid (GA3) contents and catalase (CAT) activity were lower than other cultivars during natural overwintering. Redundancy analysis revealed that the lowest temperature in a day (LT) and LT50 significantly explains 69.8% and 10.9% of these physiological variables, respectively. Moreover, GA3 and indoleacetic acid (IAA) contents and CAT activity were positively correlated, while PRO, SS, ABA and RW contents were negatively correlated with both LT and LT50. Our study will be helpful in understanding the cold resistance variations of nectarine germplasm resources.
Full article
The precise placement of antennas is essential to ensure effective coverage, service quality, and network capacity in wireless communications, particularly given the exponential growth of mobile connectivity. The antenna positioning problem (APP) has evolved from theoretical approaches to practical solutions employing advanced algorithms,
[...] Read more.
The precise placement of antennas is essential to ensure effective coverage, service quality, and network capacity in wireless communications, particularly given the exponential growth of mobile connectivity. The antenna positioning problem (APP) has evolved from theoretical approaches to practical solutions employing advanced algorithms, such as evolutionary algorithms. This study focuses on developing innovative web tools harnessing genetic algorithms to optimize antenna positioning, starting from propagation loss calculations. To achieve this, seven empirical models were reviewed and integrated into an antenna positioning web tool. Results demonstrate that, with minimal configuration and careful model selection, a detailed analysis of antenna positioning in any area is feasible. The tool was developed using Java 17 and TypeScript 5.1.6, utilizing the JMetal framework to apply genetic algorithms, and features a React-based web interface facilitating application integration. For future research, consideration is given to implementing a server capable of analyzing the environment based on specific area selection, thereby enhancing the precision and objectivity of antenna positioning analysis.
Full article
Forest canopy fuel moisture content (FMC) is a critical factor in assessing the vulnerability of a specific area to forest fires. The conventional FMC estimation method, which relies on look-up tables and loss functions, cannot to elucidate the relationship between FMC and simulated
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Forest canopy fuel moisture content (FMC) is a critical factor in assessing the vulnerability of a specific area to forest fires. The conventional FMC estimation method, which relies on look-up tables and loss functions, cannot to elucidate the relationship between FMC and simulated data from look-up tables. This study proposes a novel approach for estimating FMC by combining enhanced vegetation index (EVI) and normalized difference moisture index (NDMI). The method employs the PROSAIL + PROGeoSAIL two-layer coupled radiation transfer model to simulate the vegetation index, the water index, and the FMC value, targeting the prevalent double-layer structure in the study area’s vegetation distribution. Additionally, a look-up table is constructed through numerical analysis to investigate the relationships among vegetation indices, water indices, and FMC. The results reveal that the polynomial equations incorporating vegetation and water indices as independent variables exhibit a strong correlation with FMC. Utilizing the EVI–NDMI joint FMC estimation method enables the direct estimation of FMC. The collected samples from Dali were compared with the estimated values, revealing that the proposed method exhibits superior accuracy (R2 = 0.79) in comparison with conventional FMC estimation methods. In addition, we applied this method to estimate the FMC in the Chongqing region one week before the 2022 forest fire event, revealing a significant decreasing trend in regional FMC leading up to the fire outbreak, highlighting its effectiveness in facilitating pre-disaster warnings.
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In the debate over the theory and practice of the Spanish empire at the beginning of the sixteenth century, political, religious, and legal discourses differentiated conquered peoples and recent converts to Christianity from so-called “old Christians”, thereby creating distinct categories of Spanish subjects.
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In the debate over the theory and practice of the Spanish empire at the beginning of the sixteenth century, political, religious, and legal discourses differentiated conquered peoples and recent converts to Christianity from so-called “old Christians”, thereby creating distinct categories of Spanish subjects. In Spain itself, cultural markers like language, dress, and diet became the foundations of fiscal and legal differences, while normative codes were promulgated and negotiated across a range of documents, e.g., legal instruments, civic and ecclesiastical records, university debates, and juridical theory. Concomitant with this process, a set of Christian catechisms was produced in Spain, both before and after the promulgation of Tridentine reforms, that were directed especially at the converted morisco populations in Granada and Valencia. These catechisms were produced in Iberian Arabic and Romance languages and included instructions about how new converts from Islam should behave, as well as what they should believe in order to participate in liturgical activities and to be recognized as full members of the Christian community. This article examines the morisco catechisms produced in Spain between 1496 and 1566, as these documents are representative of a unique period in both the history of Latin Christianity and the burgeoning Spanish empire. Through the emergence of this corpus and against the backdrop of targeted legislation and new policies aimed at Arabic-speaking moriscos, first in Granada and later in Valencia, the ideological foundations constraining the morisco experience were forged.
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Acute mastoiditis, a complication of otitis media, poses significant challenges in diagnosis and treatment, particularly in pediatric populations. This study aims to comprehensively evaluate the demographic characteristics, clinical features, and prognostic factors associated with acute mastoiditis in pediatric patients in Saudi Arabia. Analysis
[...] Read more.
Acute mastoiditis, a complication of otitis media, poses significant challenges in diagnosis and treatment, particularly in pediatric populations. This study aims to comprehensively evaluate the demographic characteristics, clinical features, and prognostic factors associated with acute mastoiditis in pediatric patients in Saudi Arabia. Analysis of a multicenter dataset was conducted to assess demographic variables, symptomatology, disease course, and predictors of acute mastoiditis in pediatric patients. Significant associations were found between demographic variables (age group, gender, nationality) and acute mastoiditis risk. Symptomatology analysis revealed consistent frequencies of otalgia across age groups and genders. Disease course analysis highlighted a mean duration from symptom onset to diagnosis of 14.11 days, with frequent complications like mastoid abscess and meningitis. Predictor identification identified symptoms (otalgia, fever, otorrhea), duration of illness, and complications as significant predictors of disease severity. These findings contribute valuable insights into the epidemiology and clinical management of acute mastoiditis, informing targeted interventions to improve patient outcomes.
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Pathogenic ASH1L variants have been reported in probands with broad phenotypic presentations, including intellectual disability, autism spectrum disorder, attention deficit hyperactivity disorder, seizures, congenital anomalies, and other skeletal, muscular, and sleep differences. Here, we review previously published individuals with pathogenic ASH1L variants and
[...] Read more.
Pathogenic ASH1L variants have been reported in probands with broad phenotypic presentations, including intellectual disability, autism spectrum disorder, attention deficit hyperactivity disorder, seizures, congenital anomalies, and other skeletal, muscular, and sleep differences. Here, we review previously published individuals with pathogenic ASH1L variants and report three further probands with novel ASH1L variants and previously unreported phenotypic features, including mixed receptive language disorder and gait disturbances. These novel data from the Brain Gene Registry, an accessible repository of clinically derived genotypic and phenotypic data, have allowed for the expansion of the phenotypic and genotypic spectrum of this condition.
Full article
Currently, power trains based on an Open-End Winding Induction Machine fed by a Dual Inverter (DI-OEWIM) are attracting a great deal of interest in various modern industrial applications. However, applying symmetrical control to this system (DI-OEWIM), which is symmetrical in nature, will lead
[...] Read more.
Currently, power trains based on an Open-End Winding Induction Machine fed by a Dual Inverter (DI-OEWIM) are attracting a great deal of interest in various modern industrial applications. However, applying symmetrical control to this system (DI-OEWIM), which is symmetrical in nature, will lead to malfunction. Therefore, the objective of this paper is to explore the influence of asymmetric control on the performance of this system. The principle of this study is to create an asymmetrical control by integrating a phase-shift angle in the Space Vector Pulse Width Modulation (SVPWM) strategy. We then evaluate the impact of these angles on various performances, such as the Total Harmonic Distortion (THD), power losses, Common Mode Voltage (CMV), Zero-Sequence Voltage (ZSV), rotation speed and torque ripple of this system. This study was carried out in the Matlab/Simulink environment and was validated experimentally using the dSPACE 1104 board. The results show that the different angles have significant effects on the overall performance of this system.
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Microalgae are being recognized as valuable sources of bioactive chemicals with important medical properties, attracting interest from multiple industries, such as food, feed, cosmetics, and medicines. This review study explores the extensive research on identifying important bioactive chemicals from microalgae, and choosing the
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Microalgae are being recognized as valuable sources of bioactive chemicals with important medical properties, attracting interest from multiple industries, such as food, feed, cosmetics, and medicines. This review study explores the extensive research on identifying important bioactive chemicals from microalgae, and choosing the best strains for nutraceutical manufacturing. It explores the most recent developments in recovery and formulation strategies for creating stable, high-purity, and quality end products for various industrial uses. This paper stresses the significance of using Life Cycle Analysis (LCA) as a strategic tool with which to improve the entire process. By incorporating LCA into decision-making processes, researchers and industry stakeholders can assess the environmental impact, cost-effectiveness, and sustainability of raw materials of several approaches. This comprehensive strategy will allow for the choosing of the most effective techniques, which in turn will promote sustainable practices for developing microalgae-based products. This review offers a detailed analysis of the bioactive compounds, strain selection methods, advanced processing techniques, and the incorporation of LCA. It will serve as a valuable resource for researchers and industry experts interested in utilizing microalgae for producing bioactive products with medicinal properties.
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The study aimed to explore the relationship between the presence of hypertension or dyslipidemia and the recognition of early symptoms of cardiovascular diseases (CVD), particularly acute myocardial infarction (AMI) and stroke. It is crucial for individuals with hypertension or dyslipidemia to recognize early
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The study aimed to explore the relationship between the presence of hypertension or dyslipidemia and the recognition of early symptoms of cardiovascular diseases (CVD), particularly acute myocardial infarction (AMI) and stroke. It is crucial for individuals with hypertension or dyslipidemia to recognize early symptoms of AMI and stroke, as timely and appropriate intervention can lead to favorable health outcomes. The study enrolled 104 participants aged 19 and above who are current residents of the Icheon region, Gyeonggi, Korea. The assessment of early symptoms of AMI and stroke utilized adapted items from the Korea Community Health Survey. In consideration of health literacy and education attainment, logistic regression analyses were conducted. While there was no significant association between hypertension and awareness of AMI or stoke symptoms, individuals with dyslipidemia demonstrated enhanced recognition of specific AMI symptoms, such as ‘sudden chest pain or pressure’ and ‘sudden feeling of breathlessness’. No significant associations were observed between hypertension or dyslipidemia and awareness of stroke symptoms. The study emphasized the significance of targeted health education programs for individuals with chronic conditions to enhance their awareness of early symptoms of AMI and stroke.
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Inland water level and its dynamics are key components in the global water cycle and land surface hydrology, significantly influencing climate variability and water resource management. Satellite observations, in particular altimetry missions, provide inland water level time series for nearly three decades. Space-based
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Inland water level and its dynamics are key components in the global water cycle and land surface hydrology, significantly influencing climate variability and water resource management. Satellite observations, in particular altimetry missions, provide inland water level time series for nearly three decades. Space-based remote sensing is regarded as a cost-effective technique that provides measurements of global coverage and homogeneous accuracy in contrast to in-situ sensors. The advent of Open-Loop Tracking Command (OLTC), and Synthetic Aperture Radar (SAR) mode strengthened the use of altimetry missions for inland water level monitoring. However, it is still very challenging to obtain accurate measurements of water level over narrow rivers and small lakes. This scoping systematic literature review summarizes and disseminates the research findings, highlights major results, and presents the limitations regarding inland water level monitoring from satellite observations between 2018 and 2022. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline and through a double screening process, 48 scientific publications were selected meeting the eligibility criteria. To summarize the achievements of the previous 5 years, we present fundamental statistical results of the publications, such as the annual number of publications, scientific journals, keywords, and study regions per continent and type of inland water body. Also, publications associated with specific satellite missions were analyzed. The findings show that Sentinel-3 is the dominant satellite mission, while the ICESat-2 laser altimetry mission has exhibited a high growth trend. Furthermore, publications including radar altimetry missions were charted based on the retracking algorithms, presenting the novel and improved methods of the last five years. Moreover, this review confirms that there is a lack of research on the collaboration of altimetry data with machine learning techniques.
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BAHD acyltransferases are involved in catalyzing and regulating the secondary metabolism in plants. Despite this, the members of BAHD family and their functions have not been reported in the Taxus species. In this study, a total of 123 TwBAHD acyltransferases from Taxus wallichiana [...] Read more.
BAHD acyltransferases are involved in catalyzing and regulating the secondary metabolism in plants. Despite this, the members of BAHD family and their functions have not been reported in the Taxus species. In this study, a total of 123 TwBAHD acyltransferases from Taxus wallichiana var. mairei genome were identified and divided into six clades based on phylogenetic analysis, of which Clade VI contained a Taxus-specific branch of 52 members potentially involved in taxol biosynthesis. Most TwBAHDs from the same clade shared similar conserved motifs and gene structures. Besides the typical conserved motifs within the BAHD family, the YPLAGR motif was also conserved in multiple clades of T. mairei. Moreover, only one pair of tandem duplicate genes was found on chromosome 1, with a Ka/Ks ratio < 1, indicating that the function of duplicate genes did not differentiate significantly. RNA-seq analysis revealed different expression patterns of TwBAHDs in MeJA induction and tissue-specific expression experiments. Several TwBAHD genes in the Taxus-specific branch were highly expressed in different tissues of T. mairei, suggesting an important role in the taxol pathway. This study provides comprehensive information for the TwBAHD gene family and sets up a basis for its potential functions.
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Tessier No. 7 cleft, known as lateral facial cleft, is a rare and understudied entity with an incidence of 1/80,000–1/300,000 live births. Besides perioral tissue abnormalities manifesting as macrostomia, Tessier 7 cleft also involves anomalies of the underlying bony structures. It can appear
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Tessier No. 7 cleft, known as lateral facial cleft, is a rare and understudied entity with an incidence of 1/80,000–1/300,000 live births. Besides perioral tissue abnormalities manifesting as macrostomia, Tessier 7 cleft also involves anomalies of the underlying bony structures. It can appear as part of a syndrome, such as Treacher-Collins syndrome or Goldenhar/Orbito-Auriculo-Vestibular Spectrum, or as an isolated form (unilateral or bilateral) with variable expressions. Bilateral maxillary duplication in Tessier 7 cleft is considered extremely rare, accounting for only two previously presented cases. Given that the cases presented in the literature mainly focus on clinical appearance and surgical treatment, without providing sufficient imaging, we aim to present key radiological features of Tessier 7 cleft in terms of evaluating the involved structures, which is essential for the therapeutic approach and final outcome. A 17-year-old male with incompetent lips and orthodontic abnormalities was referred to our Radiology Department for orthopantomography (OPG) and CT examinations. Hetero-anamnestic data revealed a history of surgical treatment of the commissural cleft conducted 2 months after the birth to enable feeding. Intraoral examination showed a maxillary cleft and supernumerary teeth. Since the given clinical presentation was inconclusive, radiological diagnostics took precedence in elucidating this complex entity.
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Achieving successful hematopoietic stem cell transplantation (HSCT) relies on two fundamental pillars: effective mobilization and efficient collection through apheresis to attain the optimal graft dose. These cornerstones pave the way for enhanced patient outcomes. The primary challenges encountered by the clinical unit and
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Achieving successful hematopoietic stem cell transplantation (HSCT) relies on two fundamental pillars: effective mobilization and efficient collection through apheresis to attain the optimal graft dose. These cornerstones pave the way for enhanced patient outcomes. The primary challenges encountered by the clinical unit and collection facility within a transplant program encompass augmenting mobilization efficiency to optimize the harvest of target cell populations, implementing robust monitoring and predictive strategies for mobilization, streamlining the apheresis procedure to minimize collection duration while ensuring adequate yield, prioritizing patient comfort by reducing the overall collection time, guaranteeing the quality and purity of stem cell products to optimize graft function and transplant success, and facilitating seamless coordination between diverse entities involved in the HSCT process. In this review, we aim to address key questions and provide insights into the critical aspects of mobilizing and collecting hematopoietic stem cells for transplantation purposes.
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Introduction: Augmentation rhinoplasty traditionally represents a serious challenge for plastic surgeons. The association with centrofacial lipofilling is a great approach to achieve harmonious, aesthetic results. The aim of this article is to describe our personal association between Augmentation Rhinoplasty and Centrofacial Lipofilling (ARCL)
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Introduction: Augmentation rhinoplasty traditionally represents a serious challenge for plastic surgeons. The association with centrofacial lipofilling is a great approach to achieve harmonious, aesthetic results. The aim of this article is to describe our personal association between Augmentation Rhinoplasty and Centrofacial Lipofilling (ARCL) in non-Caucasian patients. Materials and Methods: In this study, we retrospectively reviewed patients treated with ARCL at our institution between January 2019 and December 2023. We described our personal approach and technique. At a minimum follow-up time of one year, post-operative pictures were taken, and patients were reassessed, evaluating aspects such as global symmetry, shape and contour of the nose, and facial harmony and rejuvenation; finally, patients’ satisfaction was investigated according to the ROE questionnaire and the modified S-GAIS. Results: A total of 307 patients were included in the study. They reported a significant satisfactory aesthetic result in nasal image and facial harmony, as the mean postoperative ROE and S-GAIS score show. None of the grafts extruded or collapsed. Wounds healed without reported major infection. Conclusions: This study has demonstrated that ARCL is a safe approach that contributes to improve functional and aesthetic outcomes, has a high patient satisfaction rate, and limited post-operative complications.
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In conventional hot stamping, an Al-Si-coated blank is first heated above the austenitization temperature and then soaked for a period of time within a furnace, prior to the stamping operation. In this work, the impacts of furnace heating rate, soaking temperature, and soaking
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In conventional hot stamping, an Al-Si-coated blank is first heated above the austenitization temperature and then soaked for a period of time within a furnace, prior to the stamping operation. In this work, the impacts of furnace heating rate, soaking temperature, and soaking time on the Al-Si coating evolution were investigated for two commercial coating weights, 80 and 150 g/. These heat treatment parameters during heating and soaking affect the coating microstructure and the thickness of the interdiffusion layer, which affect the properties of the as-formed coatings. The transformation and growth of binary Fe-Al and ternary Fe-Al-Si intermetallic layers were characterized and quantified for soak times up to 240 s. The results show that the effect of the heating rate on the Al-Si intermetallic distribution and ternary phase morphology was more severe than the soaking time and soaking temperature. The (η) phase was the dominant layer at the beginning of the soaking stage with a () layer formed within it, and then the layer transformed into ( as the soaking time increased due to the interdiffusion of Fe and Al. The transformation of to occurred at a higher rate for elevated soaking temperatures due to the greater diffusivity of Al and Fe. The interdiffusion layer (IDL) consisted of ( and . Higher soaking temperatures of 1000 °C resulted in a thicker IDL for the same soak time when compared with 900 °C and 950 °C, but when the heating rate was lower, the IDL was thicker than that at the higher heating rate since a longer heating time was required to reach the soaking temperature of 900 °C, which prolonged the diffusion time during the heating stage. The findings were similar for AS80.
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A local area configures a socio-economic system in which several institutions interact. As stakeholders hold different values and perhaps conflicting interests, managing local area performance is a dynamic and complex issue. In these inter-institutional settings, performance management may help address such complexity. Traditional
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A local area configures a socio-economic system in which several institutions interact. As stakeholders hold different values and perhaps conflicting interests, managing local area performance is a dynamic and complex issue. In these inter-institutional settings, performance management may help address such complexity. Traditional performance management approaches, mostly based on static and linear analysis, fail to capture the dynamic complexity of local-area performance, bounding decision-makers’ mindsets to an organizational view of performance. Overcoming such limitations requires methods oriented to grasp a better understanding of the social reality in which their institutions operate. This contribution aims to illustrate how the Dynamic Performance Management (DPM) approach may foster a “performative” (We are indebted to Maria Cleofe Giorgino and Federico Barnabè, who illustrated the “performative” potential of “calculative practices” at the Workshop “Le sfide della sostenibilità. Profili aziendali e giuridici” organized by the Department of Business and Law Studies at the University of Siena, 11 October 2023. Such a perspective on the “performativity” of performance information use has remarkably enriched the conceptual positioning of our paper) use of performance information by decision-makers in inter-institutional settings. To this end, the article highlights the importance of designing conducive learning settings (i.e., action research enhanced by a system dynamics-based interactive learning environment) to support decision-makers make such a cognitive leap. Drawing from empirical evidence on destination governance studies, the article shows that enriching performance management with system dynamics modeling may help decision-makers to reflect on key issues impacting local area development, sparking a discussion on potential actions to balance economic, social, and competitive dimensions of performance. Findings reveal that DPM insight modeling holds explanatory and communicative potential in real forums by providing decision-makers with an understanding of the means-end relationships linking strategic resources to outcomes through value drivers. The use of such performance information can help local area stakeholders to (re)conceptualize the social reality in which their institutions operate. By acting as a “maieutic machine”, DPM fosters a shift from an organizational and static to an inter-organizational and dynamic view of local area performance. Implications of the study include the opportunity to provide training to strengthen the active use of performance information by decision-makers in inter-institutional settings.
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Purpose: Low doses of systemic doxycycline (LD-SD) inhibit angiogenesis and the expression of matrix metalloproteases, which are determinants of pterygium progression. This study aimed to compare the recurrence rate and visual outcome of pterygium excision in patients undergoing chronic treatment with LD-SD for
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Purpose: Low doses of systemic doxycycline (LD-SD) inhibit angiogenesis and the expression of matrix metalloproteases, which are determinants of pterygium progression. This study aimed to compare the recurrence rate and visual outcome of pterygium excision in patients undergoing chronic treatment with LD-SD for chronic refractory blepharitis and LD-SD-naive patients. Methods: A retrospective analysis of patients that underwent surgical excision and conjunctival graft apposition was conducted. Patients were divided in a TETRA group (under LD-SD treatment at the moment of surgery) and a control group. The main outcome was the rate of recurrence at 1 year postoperatively. Secondary outcomes were the comparisons of surface regularity, visual quality, and dry-eye symptoms at 6-week, 6-month, and 1-year follow-up in the two groups. Results: The TETRA group showed a significantly lower rate of 1-year recurrence both in primary (p = 0.034) and recurrent (p < 0.001) pterygia. The best corrected visual acuity (BCVA), astigmatic error, corneal total root mean square (RMS), and ocular surface disease index (OSDI) significantly reduced during the follow-up in both groups. The surface asymmetry index and high-order aberrations (HOAs) significantly reduced only in the TETRA group. The final BCVA was significantly higher, while the OSDI score and total RMS and HOAs were significantly lower in the TETRA group compared to the control. Conclusions: Patients under treatment with LD-SD showed a lower rate of recurrence at 1-year follow-up compared to controls. These patients also experienced higher BCVA and surface regularity and less dry-eye symptoms.
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This paper presents an analysis of the effect of the geometry of the end-coil transition zone on the material stress state of a machined compression spring with a rectangular wire cross-section. The literature relationships for determining the stresses in rectangular wire compression springs
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This paper presents an analysis of the effect of the geometry of the end-coil transition zone on the material stress state of a machined compression spring with a rectangular wire cross-section. The literature relationships for determining the stresses in rectangular wire compression springs neglect the effects associated with the geometry of this zone. A series of non-linear numerical analyses were carried out for models of machined compression springs with a wide range of variation in geometrical parameters. The results of these analyses were used to develop a computational model to estimate the minimum value of the rounding radius ρmin, which ensures that the stresses in this zone are reduced to the level of the maximum coil stresses. The model is simple to apply, and allows the radius ρmin to be estimated for springs with a spring index between 2.5 and 10, a helix angle between 1° and 15°, and a proportion of the sides of the wire section between 0.4 and 5.
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Research has shown that people with an intellectual disability have higher rates of certain preventable health conditions and a higher rate of avoidable mortality relative to the general population. With respect to health behaviours, they also have lower levels of physical activity and
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Research has shown that people with an intellectual disability have higher rates of certain preventable health conditions and a higher rate of avoidable mortality relative to the general population. With respect to health behaviours, they also have lower levels of physical activity and poorer nutrition. Despite the increased health needs, this population cohort is less likely to have the opportunity to participate in health promotion programs. The interventions that have been delivered are programmatic and individual in focus and have lacked a broader ecological and settings focus, which makes them very difficult to scale. Health promotion programs designed for the general population, such as lifestyle campaigns, rarely reach people with an intellectual disability. This increases the importance of ensuring that the settings in which they live and engage with are as health promoting as possible. Interventions have been particularly absent in the workplace for people with an intellectual disability. This paper highlights gaps in a settings-and-systems-based approach to promoting the health and wellbeing of people with an intellectual disability, particularly with respect to workplace health promotion. The paper concludes with recommendations for a systems approach that integrates approaches across multiple settings to better promote the health of this population cohort.
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Recently, immunotherapy has arisen as a novel treatment approach for patients with colorectal cancer (CRC), but the effectiveness of immunotherapy varies in these patients. We hypothesized that immune checkpoint molecules (ICMs), which are the targets of immunotherapy, are often exhibited concomitantly. Our objective
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Recently, immunotherapy has arisen as a novel treatment approach for patients with colorectal cancer (CRC), but the effectiveness of immunotherapy varies in these patients. We hypothesized that immune checkpoint molecules (ICMs), which are the targets of immunotherapy, are often exhibited concomitantly. Our objective was to investigate the patterns of ICM expression in patients with CRC and the differences in ICM expression based on microsatellite instability status. The immunohistochemical expression of programmed cell death protein 1 (PD-1), programmed cell death ligand 1 (PD-L1), T cell immunoglobulin and mucin-domain containing-3 (TIM-3), and lymphocyte-activation gene 3 (LAG-3) in the tumor center and periphery was assessed in patients with non-metastatic colorectal cancer. We enrolled 83 patients with CRC: a total of 40 microsatellite-stable (MSS) and 43 microsatellite-instability-high (MSI-H) cancer patients. PD-L1 was more frequently expressed in the tumor center in the MSI-H patients with than that in the MSS patients (18 [41.9%] vs. 3 [7.5%], respectively; p < 0.001), and the same trend was observed for TIM-3 expression (30 [69.8%] vs. 19 [47.5%], respectively; p = 0.047). The concomitant expression of two or more ICMs was more frequently observed than no expression or the expression of a single molecule in both the MSS and MSI-H groups; a total of 34 (79.7%) patients with MSI-H cancer and 23 (57.5%) with MSS cancer showed ICM expression at the tumor center, whereas 34 (79.7%) patients with MSI-H cancer and 22 (55%) with MSS cancer showed expression at the tumor periphery. Patients with the genetic characteristics of MSI-H cancer showed higher expression levels of ICMs than those in patients with MSS cancer, and predominantly, two or more ICMs were concurrently expressed. Our findings highlight the potential efficacy of the dual-blockade approach in immunotherapy, particularly in patients with MSI-H CRC.
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Colorectal cancer (CRC) stands as a major cause of cancer-related mortality globally, accounting for approximately 881,000 deaths each year. Traditional approaches such as chemotherapy and surgery have been the primary treatment modalities, yet the outcomes for patients with metastatic CRC are often unsatisfactory.
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Colorectal cancer (CRC) stands as a major cause of cancer-related mortality globally, accounting for approximately 881,000 deaths each year. Traditional approaches such as chemotherapy and surgery have been the primary treatment modalities, yet the outcomes for patients with metastatic CRC are often unsatisfactory. Recent research has focused on targeting the pathways involved in oxidative stress, inflammation, and metastasis to enhance the survival of CRC patients. Within this context, sulforaphane (SFN), a notable phytochemical found predominantly in cruciferous vegetables, has been recognized as a potential anticancer agent. However, the specific mechanisms through which SFN may exert its chemopreventive effects in CRC remain unclear. This study explores the impact of SFN on IL-1β-induced IL-6 activation and MAPK and AP-1 signaling in HT-29 cells. Our findings reveal that SFN treatment not only diminishes IL-1β-stimulated IL-6 expression but also reduces oxidative stress by curtailing reactive oxygen species (ROS) production. Furthermore, it hinders the proliferation and invasiveness of HT-29 cells through the modulation of MAPK/AP-1 and STAT3 signaling pathways. These results indicate that SFN mitigates IL-1β-induced IL-6 expression in CRC cells by attenuating ROS production and disrupting MAPK/AP-1 signaling. This suggests that SFN holds significant potential as a chemotherapeutic agent for both treating and preventing CRC.
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by
Kateryna Davydenko, Natalia Łukaszewska-Skrzypniak, Katarzyna Sadowska, Justyna Anna Nowakowska, Kristina Raitelaitytė, Svetlana Markovskaja, Daiva Burokienė, Olena Shcherbak, Jorge Martín-García, Julio Javier Diez Casero, Tom Hsiang and Tomasz Oszako
Forests2024, 15(4), 613; https://doi.org/10.3390/f15040613 (registering DOI) - 28 Mar 2024
Pine pitch canker, caused by the ascomycete Fusarium circinatum, poses a substantial threat to pine trees and Douglas firs (Pseudotsuga menziesii), and has been identified as a pervasive issue in forests and nurseries worldwide, particularly in regions where susceptible conifers
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Pine pitch canker, caused by the ascomycete Fusarium circinatum, poses a substantial threat to pine trees and Douglas firs (Pseudotsuga menziesii), and has been identified as a pervasive issue in forests and nurseries worldwide, particularly in regions where susceptible conifers are cultivated. Given its prevalence in the Iberian Peninsula, assessments of the susceptibility of diverse European provenances of Scots pine (Pinus sylvestris)—specifically those from Poland, Lithuania, and Ukraine—have been conducted. Preliminary evaluations of Polish provenances have raised concerns about the potential threat to Scots pine stands in Poland posed by pitch canker. Under controlled conditions, we examined the impact of F. circinatum inoculation on the survival of seeds and seedlings from ten provenances of Scots pine. In response, the initial assessment of F. circinatum pathogenicity was undertaken in a controlled greenhouse environment. This evaluation uncovered a heightened susceptibility of pine seedlings to pitch canker among the tested provenances. Notably, one Lithuanian provenance demonstrated superior resistance to pitch canker, while two Polish provenances exhibited a higher prevalence of symptomless seedlings. These findings underscore the need for further exploration and identification of resilient individuals within these provenances, offering valuable insights for developing strategies to mitigate the impact of pitch canker on Scots pine in Europe.
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This paper delves into the application of digital twin monitoring techniques for enhancing offshore floating wind turbine performance, with a detailed case study that uses open-source digital twin software. We explore the practical implementation of digital twins and their efficacy in optimizing operations
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This paper delves into the application of digital twin monitoring techniques for enhancing offshore floating wind turbine performance, with a detailed case study that uses open-source digital twin software. We explore the practical implementation of digital twins and their efficacy in optimizing operations and predictive maintenance, focusing on controlling the real-time structural state of composite wind turbine structures and forecasting the remaining useful life by tracking the fatigue state in the structure. Our findings emphasize digital twins’ potential as a valuable tool for renewable energy, driving efficiency and sustainability in offshore floating wind installations. These aspects, along with the aforementioned simulations, whether in real-time or forecasted, reduce costly and unnecessary inspections and scheduled maintenance.
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