Floods are consistently ranked as the most financially devastating natural disasters worldwide. Recent flood events in the Netherlands, Caribbean, and US have drawn attention to flood risks resulting from pluvial and fluvial sources. Despite shared experiences with flooding, these regions employ distinct approaches and flood management strategies due to differences in governance and scale—offering a three-site case study comparison. A key, yet often lacking, factor for flood risk and damage assessments at the parcel level is building elevation compared to flood elevation. First-floor elevations (FFEs) are a critical element in the vulnerability of a building flooding. US-based flood insurance policies require FFEs; however, data availability limitations exist. Drone-based FFEs were measured in all locations to assess the flood vulnerabilities of structures. Flood vulnerability profiles revealed 64% of buildings were vulnerable to a form of inundation, with 40% belonging to “moderate” or “major” inundation, and inundation elevation means (IEMs) of −0.55 m, 0.19 m, and 0.71 m within the US, Netherlands, and Puerto Rico sites, respectively. Spatial statistics revealed FFEs were more responsible for flood vulnerabilities in the US site while topography was more responsible in the Netherlands and Puerto Rico sites. Additional findings in the Puerto Rico site reveal FFEs and next highest floor elevations (NHFEs) vulnerable to future sea level rise (SLR) flood elevations. The findings within the Netherlands provide support for developing novel multi-layered flood risk reduction strategies that include building elevation. We discuss future work recommendations and how the different sites could benefit significantly from strengthening FFE requirements. Full article

Alpha-ketoglutaric acid (α-KG), as an intermediate product of the tricarboxylic acid cycle, plays a crucial role in peptide and amino acid synthesis. In order to reduce costs and improve efficiency in the oxidative production of α-ketoglutaric acid, this study successfully synthesized and expressed L-glutamate oxidase (LGOX^Str) from Streptomyces viridosporus R111 and catalase (KatG^Esc) from Escherichia coli H736. Two immobilization methods and the conditions for one-step whole-cell catalysis of α-ketoglutaric acid were investigated. α-Ketoglutaric acid has broad applications in the pharmaceutical, food, and chemical industries. The specific research results are as follows: (1) By fusing the sfGFP tag, L-glutamate oxidase (LGOX^Str r) and catalase (KatG^Esc) were successfully anchored to the outer membrane of Escherichia coli cells, achieving one-step whole-cell catalysis of α-ketoglutaric acid with a conversion efficiency of up to 75%. (2) Through the co-immobilization of LGOX^Str and KatG^Esc, optimization of the preparation parameters of immobilized cells, and exploration of the immobilization method using E.coli@ZIF-8, immobilized cells with conversion rates of over 60% were obtained even after 10 cycles of reuse. Under the optimal conditions, the production rate of α-ketoglutaric acid reached 96.7% in a 12 h reaction, which is 1.1 times that of E. coli@SA and 1.29 times that of free cells. Full article

The microstructures throughout a 696 × 1360 mm cross-section of an ISO 1.2738 prehardened steel block for a plastic mold were characterized via optical and electron microscopy and electron backscatter diffraction. The hardness, strength, and polishing performance of the steel block were also tested. The results showed that the microstructure of the steel bloom from the edge to the core consisted of tempered sorbite, tempered bainite, and pearlite microstructures. Abnormal upper bainite and coarse carbides were also found. The bloom sections with hardness values of 37.4 to 39.3 HRC comprised tempered sorbite and bainite. The hardness of the core was approximately 36.5 HRC due to the presence of pearlite. The tensile and yield strengths were the same in the edge and middle areas mainly owing to tempered sorbite. The polishing performance was affected by the microstructure. Tempered sorbite produced the best polishing performance due to its fine and uniform microstructure, whereas that of tempered bainite and pearlite, which contained large carbide particles and mixed phases, was worse. Full article

Soil salinization has a significant impact on agricultural production and ecology. There is an urgent demand to establish an effective method that monitors the spatial and temporal distribution of soil salinity. In this study, a multi-indicator soil salinity monitoring model was proposed for monitoring soil salinity in Bachu County, Kashgar Region, Xinjiang, from 2002 to 2022. The model was established by combining multiple predictors (spectral, salinity, and composite indices and topographic factors) and the accuracy of the four models (Random Forest [RF], Partial Least Squares [PLS], Classification Regression Tree [CART], and Support Vector Machine [SVM]) was compared. The results reveal the high accuracy of the optimized prediction model, and the order of the accuracy is observed as RF > PLS > CART > SVM. The most accurate model, RF, exhibited an R² of 0.723, a root mean square error (RMSE) of 2.604 g·kg⁻¹, and a mean absolute error (MAE) of 1.95 g·kg⁻¹ at a 0–20 cm depth. At a 20–40 cm depth, RF had an R² value of 0.64, an RMSE of 3.62 g·kg⁻¹, and an MAE of 2.728 g·kg⁻¹. Spatial changes in soil salinity were observed throughout the study period, particularly increased salinization from 2002 to 2012 in the agricultural and mountainous areas within the central and western regions of the country. However, salinization declined from 2012 to 2022, with a decreasing trend in salinity observed in the top 0–20 cm of soil, followed by an increasing trend in salinity at a 20–40 cm depth. The proposed method can effectively extract large-scale soil salinity and provide a practical basis for simplifying the remote sensing monitoring and management of soil salinity. This study also provides constructive suggestions for the protection of agricultural areas and farmlands. Full article

This study investigates the influence of education, professional development, and job satisfaction on the adoption of corporate social responsibility (CSR) practices among employees in the banking industry. A survey was conducted among 139 professionals employed in the banking sector in Romania to assess their engagement in CSR practices. In essence, the research explores four main objectives: the impact of demographic factors on CSR adoption, the influence of values formed during high school, the correlation between job satisfaction and CSR engagement, and the effect of professional development on CSR engagement. The findings from a hierarchical regression model indicate that job satisfaction plays a significant role in fostering stronger CSR practices within the banking sector, thereby contributing to broader social objectives. However, it is essential to conduct further research to elucidate the causal relationship between CSR adoption and job satisfaction, as the current study’s research design only establishes the existence of an association. Overall, this study holds implications for managers in the banking industry, highlighting the critical role of employee satisfaction in shaping individuals’ commitment to CSR initiatives. Full article

After exposure to cold stress, animals enhance the production of beige adipocytes and expedite thermogenesis, leading to improved metabolic health. Although brown adipose tissue in rodents is primarily induced by β3-adrenergic receptor (ADRB3) stimulation, the activation of major β-adrenergic receptors (ADRBs) in pigs has been a topic of debate. To address this, we developed overexpression vectors for ADRB1, ADRB2, and ADRB3 and silenced the expression of these receptors to observe their effects on the adipogenic differentiation stages of porcine preadipocytes. Our investigation revealed that cold stress triggers the transformation of subcutaneous white adipose tissue to beige adipose tissue in pigs by modulating adrenergic receptor levels. Meanwhile, we found that ADRB3 promotes the transformation of white adipocytes into beige adipocytes. Notably, ADRB3 enhances the expression of beige adipose tissue marker genes, consequently influencing cellular respiration and metabolism by regulating lipolysis and mitochondrial expression. Therefore, ADRB3 may serve as a pivotal gene in animal husbandry and contribute to the improvement of cold intolerance in piglets. Full article

In order to enhance the quality of thread processing by tap, a systematic analysis of its forming mechanism and factors affecting forming quality is conducted. Effects of the number of edges, the amount of shovel back, the extrusion cone, the calibration part and the extrusion cone angle on the torque and temperature are achieved by finite element analysis and experiments. From the perspective of reducing torque and temperature during the forming process, the optimal combination of tap structural parameters for machining M22×2 internal threads on 42CrMo4 high-strength steel are further obtained through orthogonal optimization. The results show that, unlike the cutting process of threads, the extrusion forming process of threads is a net forming process in which metal undergoes plastic deformation in a limited space, and the metal material continuously flows along the edge of the V-shaped groove of the tap, gradually piling up to form the thread tooth shape. This also caused a noticeable lack of flesh at the top of the extruded thread teeth. Better quality threads can be obtained by machining with optimized structural parameters. The maximum torque and temperature during the machining process are reduced by 22.86% and 20.31%, respectively. The depth of the hardened layer increased by 0.05 mm, and the root and top hardness of the teeth increased by 10 HV_0.2 and 5 HV_0.2, respectively. Full article

Haemaphysalis longicornis, a three-host tick with a wide host range, is widely distributed in different countries and regions. It stands out among ticks due to its unique feature of having both parthenogenetic and bisexual populations. Despite their morphological resemblance, the characteristics of the parthenogenetic population have been overlooked. In this comprehensive study, we systematically compared the similarities and differences between these two populations. Our investigation revealed that the parthenogenetic H. longicornis, widely distributed in China, was found in ten provinces, surpassing the previously reported distribution. Notably, individuals from the parthenogenetic population exhibited a prolonged blood-feeding duration during the larval and nymph stages compared to their bisexual counterparts. Additionally, the life cycle of the parthenogenetic population was observed to be longer. A flow cytometry analysis indicated a DNA content ratio of approximately 2:3 between the bisexual and parthenogenetic populations. A phylogenetic analysis using whole mitochondrial genome sequences resulted in the separation of the phylogenetic tree into two distinct branches. A molecular analysis unveiled a consistent single T-base deletion at nucleotide 8497 in the parthenogenetic population compared to the bisexual population. Both populations displayed high viral infection capability and significant resistance to ivermectin. Intriguingly, despite these differences, the parthenogenetic population exhibited a similar life cycle to the bisexual population, retaining the ability to transmit pathogens such as Severe fever with thrombocytopenia syndrome virus (SFTSV) and Heartland Virus (HRTV). These findings contribute to a deeper understanding of the distinct characteristics and similarities between different populations of H. longicornis, laying the foundation for future research in this field. Full article

This study proposes a form of concrete-filled steel tube column with a multiple-chamber round-ended cross-section (M-CFST). Longitudinal and transverse stiffening ribs divide the circular-ended section into different chambers, strengthening the steel tube’s confinement effect on the core concrete and improving the component’s seismic performance. A three-dimensional finite element (FE) solid model of the M-CFST is created by employing the FE software ABAQUS. Quasi-static analysis is conducted to investigate the influence of parameters, such as chamber arrangement, aspect ratio, and axial compression ratio, on flexural hysteresis performance. Moreover, the failure modes, hysteresis curves, skeleton curves, strain development, and energy dissipation of the components are analyzed. The results show the following: (1) The FE model presented in this study can simulate the quasi-static behavior of CFST columns accurately, and the calculated results are in good agreement with the measured values. (2) The seismic performance of the composite column is excellent, with a large number of chambers leading to a robust hysteresis curve for the composite columns, resulting in increased bearing capacity and energy dissipation capacity. However, the energy dissipation performance of the specimen with a two-chamber arrangement is slightly lower than that with a single-chamber arrangement. (3) The results of the finite element analysis suggest that the long and short sides of the CFST columns with a large length–width ratio should be arranged to be relatively close in length. Full article

In-stent restenosis (ISR) remains the primary cause of target lesion failure following percutaneous coronary intervention (PCI), resulting in 10-year incidences of target lesion revascularization at a rate of approximately 20%. The treatment of ISR is challenging due to its inherent propensity for recurrence and varying susceptibility to available strategies, influenced by a complex interplay between clinical and lesion-specific conditions. Given the multiple mechanisms contributing to the development of ISR, proper identification of the underlying substrate, especially by using intravascular imaging, becomes pivotal as it can indicate distinct therapeutic requirements. Among standalone treatments, drug-coated balloon (DCB) angioplasty and drug-eluting stent (DES) implantation have been the most effective. The main advantage of a DCB-based approach is the avoidance of an additional metallic layer, which may otherwise enhance neointimal hyperplasia, provide the substratum for developing neoatherosclerosis, and expose the patient to a persistently higher risk of coronary ischemic events. On the other hand, target vessel scaffolding by DES implantation confers relevant mechanical advantages over DCB angioplasty, generally resulting in larger luminal gain, while drug elution from the stent surface ensures the inhibition of neointimal hyperplasia. Nevertheless, repeat stenting with DES also implies an additional permanent metallic layer that may reiterate and promote the mechanisms leading to ISR. Against this background, the selection of either DCB or DES on a patient- and lesion-specific basis as well as the implementation of adjuvant treatments, including cutting/scoring balloons, intravascular lithotripsy, and rotational atherectomy, hold the potential to improve the effectiveness of ISR treatment over time. In this review, we comprehensively assessed the available evidence from randomized trials to define contemporary interventional treatment of ISR and provide insights for future directions. Full article

Auxin is a crucial hormone that regulates various aspects of plant growth and development. It exerts its effects through multiple signaling pathways, including the TIR1/AFB-based transcriptional regulation in the nucleus. However, the specific role of auxin receptors in determining developmental features in the strawberry (Fragaria vesca) remains unclear. Our research has identified FveAFB5, a potential auxin receptor, as a key player in the development and auxin responses of woodland strawberry diploid variety Hawaii 4. FveAFB5 positively influences lateral root development, plant height, and fruit development, while negatively regulating shoot branching. Moreover, the mutation of FveAFB5 confers strong resistance to the auxinic herbicide picloram, compared to dicamba and quinclorac. Transcriptome analysis suggests that FveAFB5 may initiate auxin and abscisic acid signaling to inhibit growth in response to picloram. Therefore, FveAFB5 likely acts as an auxin receptor involved in regulating multiple processes related to strawberry growth and development. Full article

Over the past few decades, people in Saudi Arabia have become less inclined to adopt active lifestyles and healthy eating habits due to the increasing use of digital technologies such as social media. The objective of this online-based cross-sectional study was to assess the role of social media food advertisements and physical activity on eating behaviors among the general population in Saudi Arabia (n = 471). Data were collected through a structured questionnaire, which consisted of four parts: (i) sociodemographic information, (ii) attitude towards social media, (iii) eating behaviors-related information, and (iv) exposure to and engagement with social media advertisements. The study’s outcome variable, eating behaviors (healthy vs. unhealthy), was assessed using the following question: “Are you on a healthy diet (such as a balanced diet, keto, or low carb)?” A multiple binary logistic regression analysis was performed to investigate the factors that influence unhealthy eating behaviors. Approximately 79.6% of the participants had unhealthy eating behaviors. Participants who were not involved in daily physical activity were more likely to have unhealthy eating behaviors compared to their counterparts (adjusted odds ratio, AOR = 4.86). Participants who watched food ads on social media channels 1–3 times a week (AOR = 2.58) or daily (AOR = 3.49) were more likely to have unhealthy eating behaviors than their counterparts. Participants whose appetite to try foods increases always (AOR = 1.42) or usually (AOR = 2.88) after viewing ads on social media were more likely to have unhealthy eating behaviors. These findings suggest that policymakers should take immediate action to regulate food advertising policy to promote a healthy food environment across the country. Saudis should be encouraged to engage in more physical activity, which could support the maintenance of healthy eating patterns and lifestyles. Full article

The objective of this study was to modify a protein-rich by-product, generated during β-glucan production, to render it appropriate for incorporation into meat products. Additionally, the study sought to assess the quality of a prototype meat product containing oat additives, depending on its concentration. Through hydrolyzation, its solubility was enhanced, making it suitable for broader applications in food products. With an average protein content of 52% and fat content of 6%, the pure hydrolysate exhibited a notable ferric ion reduction, as well as metal chelating properties. In meat formulations, the hydrolysate was integrated at concentrations of 1%, 2%, and 3%, relative to the meat mass. Following cooking and subsequent storage for 21 days, assessments were conducted every 7 days to evaluate colour retention, texture, and oxidation status. At concentrations of 2% to 3% (equivalent to 2–3 g/100 g), the hydrolysate significantly enhanced colour stability, while concurrently fostering oxidation. Notably, cohesiveness and resilience were augmented, with no discernible impact on hardness. The application of oat protein hydrolysate, particularly at 2–3 g/100 g, serves as a viable strategy for enhancing colour stability in meat formulations. However, its pro-oxidative effects necessitate supplementation with antioxidants to mitigate potential deterioration in the final product. Full article

Background: Scheimpflug tomography has for many years been an integral part of our pre-operative assessment in cataract extraction. We retrospectively reviewed the incidence of topographic keratoconus and keratoconus suspicion in our routine cataract surgery population over 5 years. Setting: The Laservision Clinical and Research Institute, Athens, Greece. Methods: In 1250 consecutive cataract surgery cases in otherwise naïve eyes, accounting for years 2017 to 2021, we retrospectively evaluated preoperative Pentacam HR imaging. The cases already classified as keratoconus were included in group A. The residual cases were assessed by five different experienced evaluators (two ophthalmic surgeons and three optometrists) for topographic and tomographic keratoconus suspicion based on irregular pachymetry distribution, astigmatism truncation, and/or astigmatic imaging irregularity and included in group B. Regular corneas, by this assessment, were included in group C; irregular corneas, as determined by the evaluators but unrelated to keratoconus, were included in group D. Results: Based on the above, 138 cases (11.08%) were classified by Pentacam tomography as keratoconus and by default were included in group A. Of the residual cases, 314 or 25.12% were classified as suspect keratoconus and included in group B; 725 cases (58%) were classified as normal and non-keratoconus and included in group C; and 73 cases or 5.84% were placed in group D as non-keratoconus but abnormal. There was no disagreement between the five evaluators over any of the cases in groups C and D, and little variance among them for cases included in group B (less than 5% by ANOVA). Conclusions: The incidence of keratoconus and corneas suspicious for keratoconus in Greece appears to be much higher than respective reports from other regions: one in ten Greeks appear to have topographic keratoconus, most not diagnosed even by the age of cataract surgery, and almost an additional one in four may have suspicious corneal imaging for keratoconus. These data strongly imply that routine screening for disease should be promoted among Greeks, especially during puberty, to halt possible progression; moreover, careful screening should be performed when laser vision correction is being considered. Full article

The development of monitoring and diagnostic methods for electrical machines requires the use of transient models capable of operating in real time and producing signal signatures with high precision. In this context, coupled-circuit models offer numerous advantages due to their speed of execution and accuracy. They have been successfully employed to create real-time digital twins of electrical machines. The main challenge of this modeling method lies in the preparation of the model, which involves numerous preliminary calculations and takes time to identify all its parameters. This is particularly due to the variation in inductances based on the rotor position. To determine these inductance values with great precision, the classical approach involves using finite-element field calculation software. However, the computation time quickly becomes an issue due to the large number of values to calculate and simulations to perform. This article introduces an innovative experimental approach to identify a coupled-circuit model and develop a digital twin of a wound-rotor induction machine. This method relies solely on simple electrical measurements and tests conducted at extremely low rotation speeds (1 rpm) to obtain inductance variations as a function of the rotor position. By employing this technique, the need for analytical models or finite-element field calculation simulations, which typically require precise knowledge of the machine’s geometry and materials, is circumvented. The measurement processing employs optimization methods to extract the inductances as a function of the rotor position, which are then used as input data for the coupled-circuit model. The final parameters are specific to each machine and replicate all its manufacturing imperfections such as eccentricity and geometric or winding defects. This experimental identification method significantly enhances the model’s accuracy and reduces the usually required preliminary calculation time in a finite-element-based identification process. Full article

Multi-access edge computing (MEC) enhances service quality for users and reduces computational overhead by migrating workloads and application data to the network edge. However, current solutions for task offloading and cache replacement in edge scenarios are constrained by factors such as communication bandwidth, wireless network coverage, and limited storage capacity of edge devices, making it challenging to achieve high cache reuse and lower system energy consumption. To address these issues, a framework leveraging cooperative edge servers deployed in wireless access networks across different geographical regions is designed. Specifically, we propose the Distributed Edge Service Caching and Offloading (DESCO) network architecture and design a decentralized resource-sharing algorithm based on consistent hashing, named Cache Chord. Subsequently, based on DESCO and aiming to minimize overall user energy consumption while maintaining user latency constraints, we introduce the real-time computation offloading (RCO) problem and transform RCO into a multi-player static game, prove the existence of Nash equilibrium solutions, and solve it using a multi-dimensional particle swarm optimization algorithm. Finally, simulation results demonstrate that the proposed solution reduces the average energy consumption by over 27% in the DESCO network compared to existing algorithms. Full article

The conventional Archie formula struggles with the interpretation of water saturation from resistivity well log data due to the increasing complexity of exploration targets. This challenge has prompted researchers to explore alternative physical parameters, such as acoustic characteristics, for breakthroughs. Clarifying the influencing factors of porous media acoustic characteristics is one of the most important approaches to help understanding the mechanism of acoustic characteristics of carbonate reservoirs. The article uses digital rock technology to characterize the pore structure, quantitatively identify fractures and pore structures in carbonate rocks, and establish digital models. Through conventional acoustic testing, the pressure wave (P-wave) and shear wave (S-wave) velocities of rock samples at different water saturations are obtained, and the dynamic elastic modulus is calculated. A finite element calculation model is established using the digital rock computational model to provide a basis for fluid saturation calculation methods. Based on real digital rock models, different combinations of virtual fractures are constructed, and factors affecting acoustic parameters are analyzed. The study finds that as porosity increases, the velocity difference between porous cores and fractured cores also increases. These findings provide important technical support and a theoretical basis for interpreting acoustic well logging data and evaluating carbonate reservoirs with different pore and fracture types. Full article

Circulating cell-free DNA (cfDNA) refers to small fragments of DNA molecules released after programmed cell death and necrosis in several body fluids such as blood, saliva, urine, and cerebrospinal fluid. The discovery of cfDNA has revolutionized the field of non-invasive diagnostics in the oncologic field, in prenatal testing, and in organ transplantation. Despite the potential of cfDNA and the solid results published in the recent literature, several challenges remain, represented by a low abundance, a need for highly sensitive assays, and analytical issues. In this review, the main technical advances in cfDNA analysis are presented and discussed, with a comprehensive examination of the current available methodologies applied in each field. Considering the potential advantages of cfDNA, this biomarker is increasing its consensus among clinicians, as it allows us to monitor patients’ conditions in an easy and non-invasive way, offering a more personalized care. Nevertheless, cfDNA analysis is still considered a diagnostic marker to be further validated, and very few centers are implementing its analysis in routine diagnostics. As technical improvements are enhancing the performances of cfDNA analysis, its application will transversally improve patients’ quality of life. Full article

Current regulatory documents and the scientific literature lack a theoretical framework and practical guidance for calculating centrifugally compacted reinforced concrete structures, taking into account the variatropy of their structure and the material’s characteristics across the section. A problem related to this research lies in the need to form a systematized, theoretical, and practical knowledge base about variatropic concretes, the importance of which has been proven by various scientists without, to date, the creation of a unified scientific methodological base. The importance of this study is linked to the need for the world’s construction projects and processes to transition to the most economically, materially, and resource-efficient types of building structures, which, of course, include structures made of variable-type concrete. This study’s objective is to fill these scientific and engineering gaps. The purpose of this study was to systematize the existing knowledge base about the technology, structure formation, and properties of variatropic concrete, using an analytical review of previously conducted studies by ourselves and others, both in Russia and abroad. A theoretical justification for the formation of the structure of variatropic materials is presented. An analysis of the basic physical and mechanical properties of variatropic concretes is carried out and the features of their microstructures are considered. The main structures created using centrifugation technology are considered. Variatropic concrete has an increased amount of mechanical characteristics compared to traditional concrete, on average by up to 45%. The durability of variatropic concrete is improved, on average, by up to 30% compared to conventional concrete. Full article

Driven by environmental considerations, the scientific community has directed great effort towards the synthesis of new materials derived from renewable resources. However, for photocurable resins, most commercially available building blocks still rely on petroleum-based precursors. Herein, we present a simple synthesis route for bio-based acrylate-modified polyester resins, whose viscosity is sufficiently low for processing them with vat photopolymerization 3D printing. The established synthesis route enables the gradual substitution of fossil-based raw materials with bio-based alternatives. The acid number, color and viscosity of the bio-based acrylic resins are characterized and photocurable formulations are prepared by adding a radical photoinitiator. The photopolymerization kinetics, and thermomechanical and mechanical properties of the photopolymers are investigated as a function of the resin structure and benchmarked against a commercially available petroleum-based counterpart. Finally, the processability of the new bio-based resins via digital light processing 3D printing is demonstrated and test specimens are successfully 3D printed with a resolution in the millimeter range. Full article

Graphene-based composite materials are highly sought after for space applications due to their ability to encompass various properties, such as electrical conductivity, thermal resistance, and radiation shielding. This versatility allows for the creation of multifunctional components that can serve various purposes in space. Three-dimensional (3D) printing of composite materials in space offers a versatile and efficient means of manufacturing components, tools, and structures that are tailored to the unique challenges and requirements of space missions. In this work, we aim to develop 3D-printed composites made of medium-density polyethylene (MDPE) matrix and exfoliated graphene nanoplatelets (xGnP) as filler, using fused filament fabrication (FFF). Our research focuses on the challenges associated with the FFF process for fabricating MDPE/xGnP materials, particularly by optimizing filament extrusion and assessing the resulting material properties and space environmental compatibility. Firstly, we optimize the extrusion process, and use the MDPE/xGnP filaments to fabricate 3D-printed samples after defining the FFF parameters. We employ differential scanning calorimetry (DSC) to assess the melting properties and crystallization degree of the extruded filaments and 3D-printed samples, providing insights into the relationship between these properties and the characteristics of the initial powders. Electrical and tensile tests are carried out to evaluate the material properties after successfully mitigating challenges, such as warping and inadequate adhesion, to build plates during the printing process. Finally, we subject the 3D-printed composites to outgassing tests under exposure to the AM0 solar spectrum to evaluate their space environmental suitability. The results of this work demonstrate the capability of the FFF-based process to efficiently manufacture components made of MDPE/xGnP composites, providing optimized parameters for their potential in-space fabrication. Full article

Background and Objectives. In emergency departments, chest pain is a common concern, highlighting the critical importance of distinguishing between acute coronary syndrome and other potential causes. Our research aimed to introduce and implement the HEAR score, specifically, in remote emergency outposts in Bosnia and Herzegovina. Materials and Methods. This follow-up study conducted a retrospective analysis of a prospective cohort consisting of patients who were admitted to the remote emergency medicine outposts in Canton Sarajevo and Zenica from 1 November to 31 December 2023. Results. This study comprised 103 (12.9%) patients with low-risk HEAR scores and 338 (83.8%) with high-risk HEAR scores, primarily female (221, 56.9%), with a mean age of 63.5 ± 11.2). Patients with low-risk HEAR scores were significantly younger (50.5 ± 15.6 vs. 65.9 ± 12.1), had fewer smokers (p < 0.05), and exhibited a lower incidence of cardiovascular risk factors compared to those with high-risk HEAR scores. Low-risk HEAR score for prediction of AMI had a sensitivity of 97.1% (95% CI 89.9–99.6%); specificity of 27.3% (95% CI 22.8–32.1%); PPV of 19.82% (95% CI 18.67–21.03%), and NPV of 98.08% (95% CI 92.80–99.51%). Within 30 days of the admission to the emergency department outpost, out of all 441 patients, 100 (22.7%) were diagnosed with MACE, with AMI 69 (15.6%), 3 deaths (0.7%), 6 (1.4%) had a CABG, and 22 (4.9%) underwent PCI. A low-risk HEAR score had a sensitivity of 97.0% (95% CI 91.7–99.4%) and specificity of 27.3% (95% CI 22.8–32.1%); PPV of 25.5% (95% CI 25.59–28.37%); NPV of 97.14% (95% CI 91.68–99.06%) for 30-day MACE. Conclusions. In conclusion, the outcomes of this study align with existing research, underscoring the effectiveness of the HEAR score in risk stratification for patients with chest pain. In practical terms, the implementation of the HEAR score in clinical decision-making processes holds significant promise. Full article