The 2023 MDPI Annual Report has
been released!
 
13 pages, 1047 KiB  
Article
Evaluation of Clinical Remission in Best-Performing Severe Asthmatic Patients Treated for Three Years with Mepolizumab
by Diego Bagnasco, Benedetta Bondi, Marco Caminati, Stefania Nicola, Laura Pini, Manlio Milanese, Luisa Brussino, Gianenrico Senna, Giorgio Walter Canonica and Fulvio Braido
Biomedicines 2024, 12(5), 960; https://doi.org/10.3390/biomedicines12050960 (registering DOI) - 26 Apr 2024
Abstract
Background: In its severe form, where possible, asthma is treated using biological drugs in order to reduce, as much as possible, the use of systemic steroids. Mepolizumab is effective for severe asthma based on key outcomes such as exacerbation and steroid dependence. Its [...] Read more.
Background: In its severe form, where possible, asthma is treated using biological drugs in order to reduce, as much as possible, the use of systemic steroids. Mepolizumab is effective for severe asthma based on key outcomes such as exacerbation and steroid dependence. Its efficacy in terms of the criteria for clinical remission in the short and long term has become of interest. Objective: We aimed to evaluate the effect of mepolizumab in the achievement of clinical remission after 3 years of administration. Methods: In this study, 71 patients who continued mepolizumab for 3 years were assessed for clinical remission according to six different published sets of remission criteria. Results: According to the criteria, 39–52% of patients experienced complete remission in the first year, increasing to 51–73% at 3 years. By classifying patients according to partial and complete remission criteria, proposed by the SANI, we observe 22% of patients in partial remission at one year, achieving complete remission after three years. The baseline factors associated with earlier remission were a higher FEV1, if we consider classifications requiring an FEV1 ≥ 80%, a low OCS dose, and low FeNO levels, in the patients requiring FEV1 stabilization. Conclusions: Clinical remission is possible for patients treated with mepolizumab. The observations at three years compared with the first year indicated that the factors negatively affecting remission delayed rather than prevented it. Earlier treatment could increase the chances of remission. Full article
(This article belongs to the Special Issue Recent Advances in Chronic Rhinosinusitis and Asthma)
Show Figures

Figure 1

18 pages, 3646 KiB  
Article
Multimodal Environmental Sensing Using AI & IoT Solutions: A Cognitive Sound Analysis Perspective
by Alexandros Emvoliadis, Nikolaos Vryzas, Marina-Eirini Stamatiadou, Lazaros Vrysis and Charalampos Dimoulas
Sensors 2024, 24(9), 2755; https://doi.org/10.3390/s24092755 (registering DOI) - 26 Apr 2024
Abstract
This study presents a novel audio compression technique, tailored for environmental monitoring within multi-modal data processing pipelines. Considering the crucial role that audio data play in environmental evaluations, particularly in contexts with extreme resource limitations, our strategy substantially decreases bit rates to facilitate [...] Read more.
This study presents a novel audio compression technique, tailored for environmental monitoring within multi-modal data processing pipelines. Considering the crucial role that audio data play in environmental evaluations, particularly in contexts with extreme resource limitations, our strategy substantially decreases bit rates to facilitate efficient data transfer and storage. This is accomplished without undermining the accuracy necessary for trustworthy air pollution analysis while simultaneously minimizing processing expenses. More specifically, our approach fuses a Deep-Learning-based model, optimized for edge devices, along with a conventional coding schema for audio compression. Once transmitted to the cloud, the compressed data undergo a decoding process, leveraging vast cloud computing resources for accurate reconstruction and classification. The experimental results indicate that our approach leads to a relatively minor decrease in accuracy, even at notably low bit rates, and demonstrates strong robustness in identifying data from labels not included in our training dataset. Full article
(This article belongs to the Special Issue Multimodal Sensing Technologies for IoT and AI-Enabled Systems)
Show Figures

Figure 1

20 pages, 4604 KiB  
Article
Full-Process Adaptive Encoding and Decoding Framework for Remote Sensing Images Based on Compression Sensing
by Huiling Hu, Chunyu Liu, Shuai Liu, Shipeng Ying, Chen Wang and Yi Ding
Remote Sens. 2024, 16(9), 1529; https://doi.org/10.3390/rs16091529 (registering DOI) - 26 Apr 2024
Abstract
Faced with the problem of incompatibility between traditional information acquisition mode and spaceborne earth observation tasks, starting from the general mathematical model of compressed sensing, a theoretical model of block compressed sensing was established, and a full-process adaptive coding and decoding compressed sensing [...] Read more.
Faced with the problem of incompatibility between traditional information acquisition mode and spaceborne earth observation tasks, starting from the general mathematical model of compressed sensing, a theoretical model of block compressed sensing was established, and a full-process adaptive coding and decoding compressed sensing framework for remote sensing images was proposed, which includes five parts: mode selection, feature factor extraction, adaptive shape segmentation, adaptive sampling rate allocation and image reconstruction. Unlike previous semi-adaptive or local adaptive methods, the advantages of the adaptive encoding and decoding method proposed in this paper are mainly reflected in four aspects: (1) Ability to select encoding modes based on image content, and maximizing the use of the richness of the image to select appropriate sampling methods; (2) Capable of utilizing image texture details for adaptive segmentation, effectively separating complex and smooth regions; (3) Being able to detect the sparsity of encoding blocks and adaptively allocate sampling rates to fully explore the compressibility of images; (4) The reconstruction matrix can be adaptively selected based on the size of the encoding block to alleviate block artifacts caused by non-stationary characteristics of the image. Experimental results show that the method proposed in this article has good stability for remote sensing images with complex edge textures, with the peak signal-to-noise ratio and structural similarity remaining above 35 dB and 0.8. Moreover, especially for ocean images with relatively simple image content, when the sampling rate is 0.26, the peak signal-to-noise ratio reaches 50.8 dB, and the structural similarity is 0.99. In addition, the recovered images have the smallest BRISQUE value, with better clarity and less distortion. In the subjective aspect, the reconstructed image has clear edge details and good reconstruction effect, while the block effect is effectively suppressed. The framework designed in this paper is superior to similar algorithms in both subjective visual and objective evaluation indexes, which is of great significance for alleviating the incompatibility between traditional information acquisition methods and satellite-borne earth observation missions. Full article
Show Figures

Figure 1

11 pages, 4068 KiB  
Article
Synthesis, Structure and Antibacterial Activity of Two Novel Coordination Polymers Based on N,N′-bis(4-carbozvlbenzvl)-4-aminotoluene and Heterocyclic Ligand against S. aureus
by Ziyun Wang, Lun Zhao, Hongwei Jing, Guanying Song and Jiayu Li
Molecules 2024, 29(9), 1990; https://doi.org/10.3390/molecules29091990 (registering DOI) - 26 Apr 2024
Abstract
As the use of antibiotics increases, the increasing resistance of bacteria is the main reason for the reduced efficiency of antibacterial drugs, making the research of new antibacterial materials become new hot spot. In this article, two novel coordination polymers (CPs), namely, [Cd [...] Read more.
As the use of antibiotics increases, the increasing resistance of bacteria is the main reason for the reduced efficiency of antibacterial drugs, making the research of new antibacterial materials become new hot spot. In this article, two novel coordination polymers (CPs), namely, [Cd2(L)2(bibp)2]n (1) and [Ni(L)(bib)]n (2), where H2L = N,N′-bis(4-carbozvlbenzvl)-4-aminotoluene, bibp = 4,4′-bis(imidazol-1-yl)biphenyl, and bib = 1,3-bis(1-imidazoly)benzene, have been synthesized under solvothermal and hydrothermal condition. Structural clarification was performed through infrared spectrum and single-crystal X-ray diffraction analysis, while thermal analysis and XRD technology were used for the performance assessment of compounds 1 and 2. In addition, antibacterial performance experiments showed that compounds 1 and 2 have certain selectivity in their antibacterial properties and have good antibacterial properties against S. aureus. As the concentration of the compound increases, the inhibitory effect gradually strengthens, and when the concentration of the compound reaches 500 μg/mL and 400 μg/mL, the concentration of the S. aureus solution no longer increases and has been completely inhibited. Full article
Show Figures

Graphical abstract

16 pages, 3039 KiB  
Article
Immune-Related Gene Profiles and Differential Expression in the Grey Garden Slug Deroceras reticulatum Infected with the Parasitic Nematode Phasmarhabditis hermaphrodita
by Muhammad Hafeez, Rory Mc Donnell, Andrew Colton, Dana Howe, Dee Denver, Ruth C. Martin and Man-Yeon Choi
Insects 2024, 15(5), 311; https://doi.org/10.3390/insects15050311 (registering DOI) - 26 Apr 2024
Abstract
The grey garden slug (Deroceras reticulatum), a common terrestrial slug native to Europe with a global distribution including North America, is commonly considered the most severe slug pest in agriculture. The nematode Phasmarhabditis hermaphrodita, which has been used in the [...] Read more.
The grey garden slug (Deroceras reticulatum), a common terrestrial slug native to Europe with a global distribution including North America, is commonly considered the most severe slug pest in agriculture. The nematode Phasmarhabditis hermaphrodita, which has been used in the U.K. and Europe as a commercial biocontrol agent since 1994, has also recently been collected in Oregon and California and has long been considered a candidate biocontrol agent for slug management in the U.S. In this study, we report differential gene expressions in nematode-infected slugs using RNA-seq to identify slug immune-related genes against nematodes. Comparison of gene expression levels between the whole bodies of a nematode-infected slug (N-S) and an uninfected control slug (C-S) revealed that there were a total of 39,380 regulated unigenes, of which 3084 (3%) were upregulated and 6761 (6%) were downregulated at greater than 2-fold change (FC > 2) in the nematode-infected slug. To further investigate the biological functions of differentially expressed genes (DEGs), gene ontology (GO) and functional enrichment analysis were performed to map the DEGs to terms in the GO, eukaryotic ortholog groups of proteins (KOG) and Kyoto Encyclopedia of Genes and Genome Pathway (KEGG) databases. Among these DEGs, approximately 228 genes associated with immunity or immune-related pathways were upregulated 2-fold or more in the N-S compared to C-S. These genes include toll, Imd, JNK, scavenger receptors (SCRs), C-type lectins (CTLs), immunoglobulin-like domains, and JAK/STAT63 signaling pathways. From the RNA-seq results, we selected 18 genes and confirmed their expression levels by qRT-PCR. Our findings provide insights into the immune response of slugs during nematode infection. These studies provide fundamental information that will be valuable for the development of new methods of pest slug control using pathogenic nematodes in the field. Full article
(This article belongs to the Section Insect Molecular Biology and Genomics)
Show Figures

Figure 1

21 pages, 551 KiB  
Article
An Analytical Model of IaaS Architecture for Determining Resource Utilization
by Slawomir Hanczewski, Maciej Stasiak and Michal Weissenberg
Sensors 2024, 24(9), 2758; https://doi.org/10.3390/s24092758 (registering DOI) - 26 Apr 2024
Abstract
Cloud computing has become a major component of the modern IT ecosystem. A key contributor to this has been the development of Infrastructure as a Service (IaaS) architecture, in which users’ virtual machines (VMs) are run on the service provider’s physical infrastructure, making [...] Read more.
Cloud computing has become a major component of the modern IT ecosystem. A key contributor to this has been the development of Infrastructure as a Service (IaaS) architecture, in which users’ virtual machines (VMs) are run on the service provider’s physical infrastructure, making it possible to become independent of the need to purchase one’s own physical machines (PMs). One of the main aspects to consider when designing such systems is achieving the optimal utilization of individual resources, such as processor, RAM, disk, and available bandwidth. In response to these challenges, the authors developed an analytical model (the ARU method) to determine the average utilization levels of the aforementioned resources. The effectiveness of the proposed analytical model was evaluated by comparing the results obtained by utilizing the model with those obtained by conducting a digital simulation of the operation of a cloud system according to the IaaS paradigm. The results show the effectiveness of the model regardless of the structure of the emerging requests, the variability of the capacity of individual resources, and the number of physical machines in the system. This translates into the applicability of the model in the design process of cloud systems. Full article
(This article belongs to the Special Issue Recent Trends and Advances in Telecommunications and Sensing)
Show Figures

Figure 1

24 pages, 23162 KiB  
Article
An Experimental Procedure to Study the High-Speed Orthogonal Cutting of Unidirectional GFRP
by Martina Panico, Luca Boccarusso, Antonio Formisano, Giuseppe Villani and Antonio Langella
J. Manuf. Mater. Process. 2024, 8(3), 87; https://doi.org/10.3390/jmmp8030087 (registering DOI) - 26 Apr 2024
Abstract
The aim of this paper is to establish a valid procedure for better understanding all of the phenomena associated with the high-speed machining of glass fiber-reinforced plastic (GFRP) composites. Both rectangular and circular specimens were machined at high cutting speeds (up to 50 [...] Read more.
The aim of this paper is to establish a valid procedure for better understanding all of the phenomena associated with the high-speed machining of glass fiber-reinforced plastic (GFRP) composites. Both rectangular and circular specimens were machined at high cutting speeds (up to 50 m/min) in order to understand what occurred for all values of fiber orientation angles during machining operations. An innovative testing methodology was proposed and studied to investigate the phenomenon of burr formation and thus understand how to avoid it during machining operations. To this end, the forces arising during the machining process and the roughness of the resulting surface were carefully studied and correlated with the cutting angle. Additionally, the cutting surface and chip morphology formed during cutting tests were examined using a high-speed camera. Close correlations were found between the variations in the cutting forces’ signals and the trends of the surface roughness and the morphology of the machined surface. Full article
Show Figures

Figure 1

9 pages, 287 KiB  
Article
Investigating the Barriers and Facilitators to Using Antiretroviral Therapy among Women Living with HIV in Plateau State, Nigeria
by Emmanuel O. Osayi, Sarah C. Blake, Tolulope Afolaranmi, Oluseye Ajayi, John Onyeji, Atiene S. Sagay, Albert Anderson and Taiwo J. Obindo
Int. J. Environ. Res. Public Health 2024, 21(5), 546; https://doi.org/10.3390/ijerph21050546 (registering DOI) - 26 Apr 2024
Abstract
Background: Women and girls account for more than 50% of the global HIV population. In Nigeria, the proportion of women living with HIV on long-term antiretroviral therapy (ART) has been on the rise. Despite this, little research exists on their experiences regarding antiretroviral [...] Read more.
Background: Women and girls account for more than 50% of the global HIV population. In Nigeria, the proportion of women living with HIV on long-term antiretroviral therapy (ART) has been on the rise. Despite this, little research exists on their experiences regarding antiretroviral therapy use, especially for women living with HIV (WLHIV) in Plateau State, Nigeria. This study investigates the barriers and facilitators influencing antiretroviral therapy use among women living with HIV. Methods: This study employed a qualitative research design, using focus groups, and included women (female sex workers, pregnant and non-pregnant women living with HIV) and the male partners of serodiscordant couples. Eligibility criteria were being 18 years of age or older, on antiretroviral therapy for more than one year/on pre-exposure prophylaxis (PrEP) for more than one month, and speaking English, Hausa, or both. Data coding utilized both inductive and deductive approaches, and standard content analysis was applied to develop emerging themes. Results: Of the 106 participants, 88 were women living with HIV, and 18 were men in serodiscordant couples. The first facilitator shared by the participants was feeling healthier and stronger due to the antiretroviral therapy, which was also expressed by the male participants on PrEP as feeling good while taking the drug. Additional facilitators shared by the participants included weight gain and having a more positive outlook on life. Participants also disproportionately described barriers to using antiretroviral therapy, including experiences with emotional challenges, physical discomfort, and side effects of ART. Such barriers were linked to feelings of past regret, frustration, and disappointment. Conclusion: This study underscores the significance of maintaining a positive perspective on ART use, demonstrated by the connection between a positive outlook and weight gain, and highlights the hurdles that Plateau State’s women living with HIV face in adhering to antiretroviral therapy. Policymakers and healthcare providers can utilize these findings to formulate targeted strategies aimed at minimizing identified barriers and enhancing antiretroviral therapy utilization among this population via peer- support groups, economic empowerment, and psychosocial support. Full article
(This article belongs to the Special Issue Women Living with HIV)
15 pages, 3067 KiB  
Article
Electrochemical Behavior of Natural Manganese Oxides: Transforming Mining Waste into Energy Storage Materials
by George Soulamidis, Maria Kourmousi, Christiana A. Mitsopoulou and Christina Stouraiti
Minerals 2024, 14(5), 455; https://doi.org/10.3390/min14050455 (registering DOI) - 26 Apr 2024
Abstract
The present research explores the potential of manganese oxide waste ore in energy storage applications, focusing on supercapacitors. The investigation assesses the electrochemical capabilities of natural manganese oxides obtained from the Drama region, which has been the main mining center of Greece for [...] Read more.
The present research explores the potential of manganese oxide waste ore in energy storage applications, focusing on supercapacitors. The investigation assesses the electrochemical capabilities of natural manganese oxides obtained from the Drama region, which has been the main mining center of Greece for manganese ore, especially that of battery-grade quality. Samples were collected from abandoned mining sites in the Kato Nevrokopi area, Drama. The structure and composition of the manganese minerals were determined by X-ray diffraction (XRD) and transmission electron microscopy (TEM). Electrochemical tests involved the preparation of electrodes using natural nsutite and heat-treated nsutite (hausmannite). Then, the designed electrodes were subjected to cyclic voltammetry tests and charge–discharge measurements. The hausmannite electrode exhibited a higher specific capacitance of 667 F/g at a current density of 0.2 A/g, and the electrode material retained 98.3% of its initial capacitance after 1000 cycles. This study provides new perspectives on simple and efficient methods for transforming natural nsutite material from mining waste to hausmannite with greater structural homogeneity and better electrochemical behavior. Full article
Show Figures

Graphical abstract

28 pages, 1921 KiB  
Article
Efficient Modeling of Distributed Energy Resources’ Impact on Electric Grid Technical Losses: A Dynamic Regression Approach
by Alain Aoun, Mehdi Adda, Adrian Ilinca, Mazen Ghandour, Hussein Ibrahim and Saba Salloum
Energies 2024, 17(9), 2053; https://doi.org/10.3390/en17092053 (registering DOI) - 26 Apr 2024
Abstract
Technical losses in electrical grids are inherent inefficiencies induced by the transmission and distribution of electricity, resulting in energy losses that can reach up to 40% of the generated energy. These losses pose significant challenges to grid operators regarding energy sustainability, reliability, and [...] Read more.
Technical losses in electrical grids are inherent inefficiencies induced by the transmission and distribution of electricity, resulting in energy losses that can reach up to 40% of the generated energy. These losses pose significant challenges to grid operators regarding energy sustainability, reliability, and economic viability. Distributed Energy Resources (DERs) offer promising solutions to lower technical losses by decentralizing energy generation and consumption, reducing the need for long-distance transmission and optimizing grid operation. Hence, estimating the impact of DERs on grid technical losses becomes paramount for grid operators and planners. In response, this article proposes the application of regression modeling and nonlinear curve fitting algorithms to provide a more nuanced understanding and better characterize the intricate interplay between DER deployment and technical losses. Through a comprehensive case study based on more than 1080 computer simulations, we demonstrate the effectiveness of our proposed dynamic polynomial varying coefficient regression model in estimating the impact of DERs on technical losses within electrical grids. The proposed model offers a simple and effective methodology that allows grid operators to gain insights into the nonlinear dynamics of DER integration and make quicker and more informed decisions regarding grid management strategies, infrastructure investments, and policy interventions. Also, this research contributes to advancing the field of grid optimization by offering a simple equation that enhances our ability and haste to assess and mitigate technical losses in the context of an evolving energy landscape characterized by increasing DER adoption. Full article
(This article belongs to the Special Issue The Future of Renewable Energy: 2nd Edition)
Show Figures

Figure 1

10 pages, 258 KiB  
Review
Assisted Reproductive Technologies: A New Player in the Foetal Programming of Childhood and Adult Diseases?
by Gavino Faa, Mirko Manchia and Vassilios Fanos
Pediatr. Rep. 2024, 16(2), 329-338; https://doi.org/10.3390/pediatric16020029 (registering DOI) - 26 Apr 2024
Abstract
Assisted reproductive technology (ART) is an emerging field in medicine that incorporates complex procedures and has profound ethical, moral, social, religious, and economic implications not just for the individuals who have access to this method but also for society. In this narrative review, [...] Read more.
Assisted reproductive technology (ART) is an emerging field in medicine that incorporates complex procedures and has profound ethical, moral, social, religious, and economic implications not just for the individuals who have access to this method but also for society. In this narrative review, we summarise multiple aspects of ART procedures and the possible consequences on the mother and newborn. Moreover, we provide an overview of the possible long-term consequences of ART procedures on the health of newborns, although longitudinal evidence is particularly scant. Users should be informed that ART procedures are not risk-free to prepare them for the possible negative outcomes that may occur in the perinatal period or even in childhood and adulthood. Indeed, risk estimates point to increased liability for major nonchromosomal birth defects; cardiovascular, musculoskeletal, and urogenital (in male newborns) defects; and any other birth defects. Less certainty is present for the risk of neuropsychiatric sequelae in children conceived through ART. Thus, its application should be accompanied by adequate counselling and psychological support, possibly integrated into specific multidisciplinary clinical programmes. Full article
(This article belongs to the Section Inborn Errors and Neonatal Screening)
18 pages, 763 KiB  
Article
Can Cooperatives Enhance the Income-Generating Effect of Eco-Industries for Farmers?—Empirical Evidence from the Crested Ibis National Nature Reserve, China
by Li Ma, Zimeng Chen, Kaiwen Su, Han Zhang, Yali Wen and Yilei Hou
Forests 2024, 15(5), 757; https://doi.org/10.3390/f15050757 (registering DOI) - 26 Apr 2024
Abstract
Promoting the development of eco-industries plays a significant role in achieving the harmonious symbiosis between economic growth and environmental protection as well as enhancing the comprehensive effectiveness of ecological and economic benefits. Due to their unique nature, cooperatives may play a crucial role [...] Read more.
Promoting the development of eco-industries plays a significant role in achieving the harmonious symbiosis between economic growth and environmental protection as well as enhancing the comprehensive effectiveness of ecological and economic benefits. Due to their unique nature, cooperatives may play a crucial role in facilitating the integration between farmers and the development of eco-industries. To investigate whether cooperatives possess the capacity to enhance the income-generating effects for farmers involved in eco-industries, this study selected the Crested Ibis National Nature Reserve (CINNR), a representative area for eco-industry development, as the research site. Data were gathered through face-to-face interviews, and this research empirically analyzed the impact of cooperatives on the income-generating effect of farmers using endogenous switching regression (ESR). The findings are threefold. First, cooperatives indeed enhance the income-generating effects for farmers engaged in eco-industries. Second, variables such as the distribution of agroforestry materials, premium capacity, soil quality, and status of village cadres have a positive impact on farmers joining cooperatives, whereas punishment initiatives discourage their participation. Third, for farmers who have joined cooperatives, factors such as the distribution of agroforestry materials, premium capacity, low-cost conservation initiatives, land area, status of village cadres, the proportion of labor force, technical training, soil quality, and land area positively affect their income from eco-industries. Conversely, punishment initiatives, age, and land location negatively impact their income. The results of this study provide new ideas for farmers to participate in the development of eco-industries, new evidence showing co-operatives can improve farmers’ income, and new directions for coordinating conflicts between conservation and development in protected areas. Full article
14 pages, 3319 KiB  
Article
The Application of Optical Sensors with Built-in Anchor-like Cavities in the Detection of Hemoglobin Concentration
by Wen Jiang, Shubin Yan, Yiru Su, Chong Wang, Taiquan Wu, Yang Cui, Chuanhui Zhu, Yi Zhang, Xiangyang Mu and Guowang Gao
Photonics 2024, 11(5), 402; https://doi.org/10.3390/photonics11050402 (registering DOI) - 26 Apr 2024
Abstract
This paper introduces a refractive index sensor based on Fano resonance, utilizing a metal–insulator–metal (MIM) waveguide structure with an Anchor-like cavity. This study utilizes the finite element method (FEM) for analyzing the propagation characteristics of the structure. The evaluation concentrated on assessing how [...] Read more.
This paper introduces a refractive index sensor based on Fano resonance, utilizing a metal–insulator–metal (MIM) waveguide structure with an Anchor-like cavity. This study utilizes the finite element method (FEM) for analyzing the propagation characteristics of the structure. The evaluation concentrated on assessing how the refractive index and the structure’s geometric parameters affect its sensing characteristics. The designed structure demonstrates optimum performance, achieving a maximum sensitivity of 2440 nm/RIU and an FOM of 63. Given its high sensitivity, this nanoscale refractive index sensor is ideal for detecting hemoglobin concentrations in blood, and the sensor’s sensitivity is 0.6 nm·g/L, aiding in clinical prevention and treatment. Full article
(This article belongs to the Special Issue New Perspectives in Optical Design)
Show Figures

Figure 1

19 pages, 2748 KiB  
Article
Correction Control Model of L-Index Based on VSC-OPF and BLS Method
by Yude Yang, Jingru Long, Lizhen Yang, Shuqin Mo and Xuesong Wu
Sustainability 2024, 16(9), 3621; https://doi.org/10.3390/su16093621 (registering DOI) - 26 Apr 2024
Abstract
With the advancement of artificial intelligence (AI) technology, the real-time measurement and control technology of power systems has also progressed. This paper proposes a correction control model for L-indexes based on voltage stability constrained optimal power flow (VSC-OPF) and a broad learning system [...] Read more.
With the advancement of artificial intelligence (AI) technology, the real-time measurement and control technology of power systems has also progressed. This paper proposes a correction control model for L-indexes based on voltage stability constrained optimal power flow (VSC-OPF) and a broad learning system (BLS) (BLS-VSC-OPF). This model aims to quickly assess the system’s voltage stability and accurately correct the operation mode when the voltage stability indexes are out of the security range. Firstly, the BLS is used to predict the L-index and to analyze the voltage stability of the power system. Secondly, the approximate first-order sensitivity of the L-index is calculated by the combination of the BLS and the perturbation method. This method solves the problem of the complex sensitivity derivation process in the modeling process of the VSC-OPF model. Meanwhile, when the L-index exceeds the threshold, the BLS and VSC-OPF models are combined to correct this operation mode. The feasibility of the proposed method is verified by the simulation of IEEE-30, IEEE-118, and 1047 bus systems. Finally, the BLS-VSC-OPF model is compared with the linear programming correction model based on BLS (BLS-LPC). The results show that the BLS-VSC-OPF model provides a better correction and control performance. Full article
Show Figures

Figure 1

11 pages, 2559 KiB  
Article
The Human Phospholipase B-II Precursor (HPLBII-P) in Urine as a Novel Biomarker of Glomerular Activity in COVID-19 and Diabetes Mellitus
by Shengyuan Xu, Michael Hultström, Anders Larsson, Miklos Lipcsey, Cecilia Lindskog, Sara Bülow, Robert Frithiof and Per Venge
J. Clin. Med. 2024, 13(9), 2540; https://doi.org/10.3390/jcm13092540 (registering DOI) - 26 Apr 2024
Abstract
Background: The human phospholipase B-II precursor (HPLBII-P) was originally purified from white blood cells but is also found in other cellular structures, such as kidney glomeruli and tubuli. The objective of this report was to investigate the relationship of HPLBII-P in urine to [...] Read more.
Background: The human phospholipase B-II precursor (HPLBII-P) was originally purified from white blood cells but is also found in other cellular structures, such as kidney glomeruli and tubuli. The objective of this report was to investigate the relationship of HPLBII-P in urine to acute kidney injury in patients with COVID-19. Methods: Urine was collected at admission from 132 patients with COVID-19 admitted to the intensive care units (ICUs) because of respiratory failure. HPLBII-P was measured using a sensitive ELISA. For comparison, human neutrophil lipocalin (HNL) was measured in urine, using the ELISA configured with the monoclonal antibody 763/8F, as a sign of tubular affection in addition to routine biomarkers of kidney disease. Results: Overall, the concentrations of urinary HPLBII-P were almost 3-fold higher in patients with COVID-19 compared to healthy controls (p < 0.0001) and with significantly higher concentrations even in patients with COVID-19 without signs of acute kidney injury (AKI) (p < 0.001). HPLBII-P was further increased in patients with AKI (p < 0.02). HPLBII-P was significantly increased in patients with diabetes mellitus (p = 0.0008) and correlated to plasma glucose (r = 0.29, p = 0.001) and urine albumin concentrations (r = 0.55, p < 0.001). Conclusions: Urine concentrations of HPLBII-P are highly raised in the urine of patients with COVID-19 and relate to AKI and diabetes mellitus. HPLBII-P may reflect glomerular injury and/or increased glomerular cell activity in SARS-CoV-2 infections. Full article
(This article belongs to the Topic Nephrology and Dialysis: From Bench to Bedside)
Show Figures

Figure 1

16 pages, 1048 KiB  
Article
Exploring TSLP and IL-33 Serum Levels and Genetic Variants: Unveiling Their Limited Potential as Biomarkers for Mild Asthma in Children
by Joanna Połomska, Hanna Sikorska-Szaflik, Anna Drabik-Chamerska, Barbara Sozańska and Anna Dębińska
J. Clin. Med. 2024, 13(9), 2542; https://doi.org/10.3390/jcm13092542 (registering DOI) - 26 Apr 2024
Abstract
As the burden of mild asthma is not well understood, the significance of expanding research in the group of patients with mild asthma is emphasized. Thymic stromal lymphopoietin (TSLP) and interleukin 33 (IL-33) are involved in the pathogenesis of atopy and the immune [...] Read more.
As the burden of mild asthma is not well understood, the significance of expanding research in the group of patients with mild asthma is emphasized. Thymic stromal lymphopoietin (TSLP) and interleukin 33 (IL-33) are involved in the pathogenesis of atopy and the immune response to inhaled environmental insults, such as allergens, in asthmatic patients. Objectives: The objective of this study was to explore the correlation between specific polymorphisms within the genes encoding TSLP and IL-33, as well as the concentrations of TSLP and IL-33 in the serum, and the occurrence of pediatric mild asthma. Methods: The analysis encompassed 52 pediatric patients diagnosed with mild bronchial asthma, including both atopic and non-atopic cases, and a control group of 26 non-asthmatic children. Recruitment was conducted through a comprehensive questionnaire. Parameters such as allergic sensitization, serum levels of circulating TSLP and IL-33, and the identification of single-nucleotide polymorphisms in TSLP (rs11466750 and rs2289277) and IL-33 (rs992969 and rs1888909) were assessed for all participants. Results: Significantly lower mean serum TSLP concentrations were observed in asthmatic subjects compared to the control group, with atopic asthma patients showing even lower TSLP levels than non-atopic counterparts. No significant differences were found in mean serum IL-33 concentrations between the two groups. Considering the allele model, for both tested SNPs of IL-33, we observed that patients with asthma, atopic asthma, and atopy statistically less frequently possess the risk allele. Conclusions: Our study findings suggest that IL-33 and TSLP do not serve as ideal biomarkers for mild asthma in children. Their effectiveness as biomarkers might be more relevant for assessing disease severity rather than identifying asthma in pediatric patients. Further research focusing on the association between TSLP and IL-33 gene polymorphisms and asthma is expected to significantly advance disease management. Full article
(This article belongs to the Special Issue New Clinical Advances in Pediatric Allergic Diseases)
Show Figures

Figure 1

16 pages, 1691 KiB  
Article
Comprehensive Two-Dimensional Gas Chromatography with a TOF MS Detector—An Effective Tool to Trace the Signature of Grape Varieties
by Daniela Fonseca, Nuno Martins, Raquel Garcia and Maria João Cabrita
Molecules 2024, 29(9), 1989; https://doi.org/10.3390/molecules29091989 (registering DOI) - 26 Apr 2024
Abstract
Varietal volatile compounds are characteristic of each variety of grapes and come from the skins of the grapes. This work focuses on the development of a methodology for the analysis of free compounds in grapes from Trincadeira, Cabernet Sauvignon, Syrah, Castelão and Tinta [...] Read more.
Varietal volatile compounds are characteristic of each variety of grapes and come from the skins of the grapes. This work focuses on the development of a methodology for the analysis of free compounds in grapes from Trincadeira, Cabernet Sauvignon, Syrah, Castelão and Tinta Barroca from the 2021 and 2022 harvests, using HS-SPME-GC × GC-TOFMS. To achieve this purpose, a previous optimization step of sample preparation was implemented, with the optimized conditions being 4 g of grapes, 2 g of NaCl, and 2 mL of H2O. The extraction conditions were also optimized, and it was observed that performing the extraction for 40 min at 60 °C was the best for identifying more varietal compounds. The fiber used was a triple fiber of carboxen/divinylbenzene/polydimethylsiloxane (CAR/DVB/PDMS). In addition to the sample preparation, the analytical conditions were also optimized, enabling the adequate separation of analytes. Using the optimized methodology, it was possible to identify fifty-two free volatile compounds, including seventeen monoterpenes, twenty-eight sesquiterpenes, and seven C13-norisoprenoids. It was observed that in 2021, more free varietal volatile compounds were identifiable compared to 2022. According to the results obtained through a linear discriminant analysis (LDA), the differences in volatile varietal signature are observed both among different grape varieties and across different years. Full article
(This article belongs to the Special Issue Advances in Wine Chemistry)
Show Figures

Figure 1

17 pages, 2876 KiB  
Article
Numerical Analysis for Shear Behavior of Binary Interfaces under Different Bonded Conditions
by Haijun Lv, Lu Han, Xing Zhang and Hang Lin
Appl. Sci. 2024, 14(9), 3686; https://doi.org/10.3390/app14093686 (registering DOI) - 26 Apr 2024
Abstract
The shear performance of the binary interface formed by mortar and rock cementation is a key factor influencing the stability and safety of basic engineering projects related to livelihood and economy since concrete has become one of the most widely used materials in [...] Read more.
The shear performance of the binary interface formed by mortar and rock cementation is a key factor influencing the stability and safety of basic engineering projects related to livelihood and economy since concrete has become one of the most widely used materials in engineering. Therefore, it is an urgent practical problem to further explore and clarify the shear failure mechanism of the mortar–rock binary interface. In response to the current research objective focused on fully bonded interfaces, this paper constructed binary interface models with different bonded conditions to perform direct shear experiments using numerical simulation methods, and the effect of bonded conditions on the shear behavior of the mortar–rock binary interface was analyzed. The results indicate that the bonded conditions have a significant influence on the shear mechanical behavior of the mortar–rock binary interface, which is mainly reflected in the stress-displacement curve characteristics, the shear strength, the fracture development and the stress distribution state. The research findings are of great theoretical significance for the further study of shear mechanics at the mortar–rock binary interface and of great practical significance for safe construction, resource conservation and disaster warning. Full article
Show Figures

Figure 1

11 pages, 7752 KiB  
Case Report
Obscure Bleeding from a Metastatic Small Bowel Tumor Diagnosed Using Motorized Spiral Enteroscopy: A Case Study and a Literature Review
by Christian Banciu, Andreea Munteanu, Adrian Aprotosoaie, Ramona Fabian, Amadeus Dobrescu, Adrian Vaduva, Antonio Fabian, Irina Soica, Viviana Ivan and Laurentiu Sima
Diagnostics 2024, 14(9), 904; https://doi.org/10.3390/diagnostics14090904 (registering DOI) - 26 Apr 2024
Abstract
Small bowel tumors are relatively rare, representing only around 5% of all gastrointestinal neoplasms, with a progressively increasing incidence. Currently, there are no established guidelines for diagnostic approaches, screening procedures, or management strategies for small bowel tumors. We present here the case of [...] Read more.
Small bowel tumors are relatively rare, representing only around 5% of all gastrointestinal neoplasms, with a progressively increasing incidence. Currently, there are no established guidelines for diagnostic approaches, screening procedures, or management strategies for small bowel tumors. We present here the case of a patient with a rare type of metastatic tumor of the small bowel originating from primary lung adenocarcinoma who presented with abdominal pain, severe iron-deficiency anemia, and melena. The initial investigations, gastroscopy and colonoscopy, failed to identify the bleeding source. The obscure bleeding source and diagnosis were achieved through power motorized spiral enteroscopy (MSE), which allowed the visualization and biopsy of the tumor. Histopathological examination established the presence of a poorly differentiated non-mucinous adenocarcinoma originating from the lung. This case is reported to provide evidence of the efficiency of MSE in the diagnosis of small bowel tumors, with the method providing higher insertion depth in a reduced amount of time. Full article
(This article belongs to the Section Pathology and Molecular Diagnostics)
Show Figures

Figure 1

15 pages, 2629 KiB  
Article
Mission Planning of UAVs and UGV for Building Inspection in Rural Area
by Xiao Chen, Yu Wu and Shuting Xu
Algorithms 2024, 17(5), 177; https://doi.org/10.3390/a17050177 (registering DOI) - 26 Apr 2024
Abstract
Unmanned aerial vehicles (UAVs) have become increasingly popular in the civil field, and building inspection is one of the most promising applications. In a rural area, the UAVs are assigned to inspect the surface of buildings, and an unmanned ground vehicle (UGV) is [...] Read more.
Unmanned aerial vehicles (UAVs) have become increasingly popular in the civil field, and building inspection is one of the most promising applications. In a rural area, the UAVs are assigned to inspect the surface of buildings, and an unmanned ground vehicle (UGV) is introduced to carry the UAVs to reach the rural area and also serve as a charging station. In this paper, the mission planning problem for UAVs and UGV systems is focused on, and the goal is to realize an efficient inspection of buildings in a specific rural area. Firstly, the mission planning problem (MPP) involving UGVs and UAVs is described, and an optimization model is established with the objective of minimizing the total UAV operation time, fully considering the impact of UAV operation time and its cruising capability. Subsequently, the locations of parking points are determined based on the information about task points. Finally, a hybrid ant colony optimization-genetic algorithm (ACO-GA) is designed to solve the problem. The update mechanism of ACO is incorporated into the selection operation of GA. At the same time, the GA is improved and the defects that make GA easy to fall into local optimal and ACO have insufficient searching ability are solved. Simulation results demonstrate that the ACO-GA algorithm can obtain reasonable solutions for MPP, and the search capability of the algorithm is enhanced, presenting significant advantages over the original GA and ACO. Full article
(This article belongs to the Section Evolutionary Algorithms and Machine Learning)
Show Figures

Figure 1

15 pages, 545 KiB  
Article
Home Language Experience Shapes Which Skills Are Used during Unfamiliar Speech Processing
by Susannah V. Levi
Languages 2024, 9(5), 159; https://doi.org/10.3390/languages9050159 (registering DOI) - 26 Apr 2024
Abstract
Speech mixed with noise and speech that is of an unfamiliar variety both make the task of understanding more difficult. Children are often more negatively affected by these situations than adults. Numerous studies have examined the cognitive and linguistic skills that support spoken [...] Read more.
Speech mixed with noise and speech that is of an unfamiliar variety both make the task of understanding more difficult. Children are often more negatively affected by these situations than adults. Numerous studies have examined the cognitive and linguistic skills that support spoken language processing. In the current study, we examine the contribution of linguistic exposure and various cognitive and linguistic skills for spoken word recognition of an unfamiliar variety of speech (German-accented English). The Ease of Language Understanding model predicts that working memory skills are needed in the most difficult listening situations. Two groups of school-age children were drawn from a larger sample: those with exposure to multiple languages in the home and those exposed to only English in the home. As predicted, working memory skills predicted performance for children with less varied linguistic experience (those only exposed to English in the home), but not for children with varied linguistic exposure. In contrast, linguistic skills predicted performance for children with more varied linguistic experience, even though the two groups did not differ overall in any of the assessed skills. These findings support the Ease of Language Understanding model of language processing. Full article
Show Figures

Figure 1

5 pages, 197 KiB  
Editorial
Introduction to Special Issue on “The System of Rice Intensification (SRI)—Contributions to Agricultural Sustainability”
by Norman Uphoff
Agronomy 2024, 14(5), 909; https://doi.org/10.3390/agronomy14050909 (registering DOI) - 26 Apr 2024
Abstract
The ideas and methods that constitute the System of Rice Intensification (SRI) were first synthesized in Madagascar by Henri de Laulanié in the early 1980s [...] Full article
16 pages, 6121 KiB  
Article
15-Year Experience in Maxillofacial Surgical Navigation with Tracked Instruments
by Giorgio Novelli, Filippo Santamato, Alejandro Juan Piza Moragues, Andrea Filippi, Federico Valsecchi, Gabriele Canzi and Davide Sozzi
Surg. Tech. Dev. 2024, 13(2), 162-177; https://doi.org/10.3390/std13020010 (registering DOI) - 26 Apr 2024
Abstract
(1) Introduction and Aim: Surgical navigation has evolved as a vital tool in maxillofacial surgery, offering precise and patient-specific data. This study explores the clinical applications and accuracy of intraoperative tool tracking in maxillofacial surgery. (2) Materials and Methods: The research includes 42 [...] Read more.
(1) Introduction and Aim: Surgical navigation has evolved as a vital tool in maxillofacial surgery, offering precise and patient-specific data. This study explores the clinical applications and accuracy of intraoperative tool tracking in maxillofacial surgery. (2) Materials and Methods: The research includes 42 patients with various pathologies who underwent surgeries assisted by a surgical navigation system using tracked instruments. Four representative cases are exhibited in the study: the first case involving coronoid hyperplasia with mouth opening deficit, the second case addressing naso-orbital-ethmoidal-frontal ossifying fibroma resection, the third case showcasing a subapical osteotomy (Köle) for a class III dentoskeletal malocclusion, and the fourth one exposing the treatment of a recurrent ameloblastoma. (3) Results: The results indicate that surgical navigation with tracked instruments provides high precision (<1.5 mm error), reduced surgical time, and a less invasive approach. (4) Conclusions: This study highlights the potential for reproducible outcomes and increased safety, especially in complex cases. Despite some limitations, the synergy between surgical navigation and tracked instruments offers a promising approach in maxillofacial surgery, expanding its applications beyond current practices. Full article
Show Figures

Figure 1

Open Access Journals

Browse by Indexing Browse by Subject Selected Journals
Back to TopTop