ExLibris header image
SFX Logo
Title: Discovery of a Highly Potent, Nonabsorbable Apical Sodium-Dependent Bile Acid Transporter Inhibitor (GSK2330672) for Treatment of Type 2 Diabetes
Source:

Journal of Medicinal Chemistry [0022-2623] yr:2013


Collapse list of basic services Basic
Full text
Full text available via American Chemical Society Journals
GO
Document delivery
Request document via Library/Bibliothek GO
Users interested in this article also expressed an interest in the following:
1. Hegade, V S. "P1323 : A study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of repeat doses of GSK2330672 administration in subjects with primary biliary cirrhosis and symptoms of pruritus." Journal of hepatology 62 (2015). Link to SFX for this item
2. Martin, Rainer E. "2-Phenoxy-nicotinamides are Potent Agonists at the Bile Acid Receptor GPBAR1 (TGR5)." ChemMedChem 8.4 (2013): 569-576. Link to Full Text for this item Link to SFX for this item
3. Floreani, A. "New Therapies for Primary Biliary Cirrhosis." Clinical reviews in allergy & immunology 48.2-3 (2015): 263-272. Link to SFX for this item
4. Dutia, R. "Temporal changes in bile acid levels and 12α-hydroxylation after Roux-en-Y gastric bypass surgery in type 2 diabetes." International journal of obesity 39.5 (2015): 806-13. Link to Full Text for this item Link to SFX for this item
5. Zhang, Y. "Letter: probiotics vs. lactulose for minimal hepatic encephalopathy therapy." Alimentary pharmacology & therapeutics 39.9 (2014): 1000-1000. Link to Full Text for this item Link to SFX for this item
6. Venier, O. "Pyrrolidine-pyrazole ureas as potent and selective inhibitors of 11β-hydroxysteroid-dehydrogenase type 1." Bioorganic and medicinal chemistry letters 21.8 (2011): 2244-2251. Link to SFX for this item
7. Herbert, Mark R. "Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5." Bioorganic and medicinal chemistry letters 20.19 (2010): 5718-21. Link to SFX for this item
8. Hughes, R. "Investigation of aminopyridopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system." Bioorganic & medicinal chemistry letters 19.15 (2009): 4092-4096. Link to SFX for this item
9. Sekhar, Gabriel S. "Synbiotic formulation of probiotic and lactulose combination for hepatic encephalopathy treatment: A realistic hope?" Medical hypotheses 81.2 (2013): 167-168. Link to SFX for this item
10. Phongsamran, Paula V. "Pharmacotherapy for hepatic encephalopathy." Drugs 70.9 (2010): 1131-1148. Link to SFX for this item
11. Whitlock, Gavin A. "Novel 2-imidazoles as potent and selective α1A adrenoceptor partial agonists." Bioorganic & medicinal chemistry letters 18.9 (2008): 2930-6440. Link to SFX for this item
12. Trabelsi, M. "Intestinal bile acid receptors are key regulators of glucose homeostasis." The Proceedings of the Nutrition Society 76.3 (2016): 1-11. Link to SFX for this item
13. Huang, M. "Multifunctional coumarin derivatives: Monoamine oxidase B (MAO-B) inhibition, anti-β-amyloid (Aβ) aggregation and metal chelation properties against Alzheimer's disease." Bioorganic and medicinal chemistry letters 25.3 (2015): 508-513. Link to SFX for this item
14. Mithieux, G. "Bile Routing Modification Reproduces Key Features of Gastric Bypass in Rat." Annals of surgery 262.6 (2015): 1-15. Link to SFX for this item
15. van Avesaat, M. "Ileal brake activation: macronutrient-specific effects on eating behavior?" International journal of obesity 39.2 (2014): 235-43. Link to Full Text for this item Link to SFX for this item
16. Dirksen, C. "Gut hormones, early dumping and resting energy expenditure in patients with good and poor weight loss response after Roux-en-Y gastric bypass." International journal of obesity 37.11 (2013): 1452-9. Link to Full Text for this item Link to SFX for this item
17. Popova, M. "Beneficial effects of probiotics in upper respiratory tract infections and their mechanical actions to antagonize pathogens." Journal of applied microbiology 113.6 (2012): 1305-1318. Link to Full Text for this item Link to SFX for this item
18. Sharma, P. "Lactulose for minimal hepatic encephalopathy in patients with extrahepatic portal vein obstruction." Saudi journal of gastroenterology 13.3 (2012): 168-172. Link to Full Text for this item Link to SFX for this item
19. Keating, N. "Bile acids in regulation of intestinal physiology." Current Gastroenterology Reports 11.5 (2009): 375-382. Link to SFX for this item
20. Firouzabadi, H. "Solid trichlorotitanium(IV) trifluoromethanesulfonate TiCl3(OTf) catalyzed efficient acylation of -OH and -SH: Direct esterification of alcohols with carboxylic acids and transesterification of alcohols with esters under neat conditions." Journal of molecular catalysis. A, Chemical 289.1 (2008): 61-68. Link to SFX for this item
View More...
View Less...
Select All Clear All

Expand list of advanced services Advanced