The 2023 MDPI Annual Report has
been released!
 
12 pages, 278 KiB  
Article
Pediatric Oral Health Online Education for Rural and Migrant Head Start Programs in the United States
by Francisco Ramos-Gomez, Stephanie Parkinson, Victor Garcia de Jesus, Jose A. Rios and Janni J. Kinsler
Int. J. Environ. Res. Public Health 2024, 21(5), 544; https://doi.org/10.3390/ijerph21050544 (registering DOI) - 25 Apr 2024
Abstract
Children living in rural and migrant areas in the United States disproportionately suffer from poor oral health. Additionally, there continues to be a shortage of pediatric dentists practicing in rural/migrant areas. The purpose of this formative research study was to assess whether staff, [...] Read more.
Children living in rural and migrant areas in the United States disproportionately suffer from poor oral health. Additionally, there continues to be a shortage of pediatric dentists practicing in rural/migrant areas. The purpose of this formative research study was to assess whether staff, teachers and families from rural/migrant Head Start/Early Head Start (HS/EHS) programs in California were receptive to oral health online education workshops conducted by pediatric dental residents who were assisted by bilingual (English and Spanish) community oral health workers (COHWs). Our findings suggest that partnering pediatric dental residents with bilingual COHWs to educate HS/EHS teachers, staff and parents on oral health care in rural/migrant areas could result in a rewarding experience for pediatric dentists that might lead them to practice in these communities upon graduation from their residency program. Furthermore, the positive feedback received from the teachers, staff and parents who participated in the workshops indicates they were receptive to receiving oral health information related to oral health literacy from the dental providers and COHWs. COHWs can help increase access to oral health care by serving as a bridge between families and providers by relaying information in a cultural, linguistic and sensitive manner. Full article
(This article belongs to the Special Issue Caries Management)
15 pages, 1166 KiB  
Article
Exploring Motor Network Connectivity in State-Dependent Transcranial Magnetic Stimulation: A Proof-of-Concept Study
by Laura Marzetti, Alessio Basti, Roberto Guidotti, Antonello Baldassarre, Johanna Metsomaa, Christoph Zrenner, Antea D’Andrea, Saeed Makkinayeri, Giulia Pieramico, Risto J. Ilmoniemi, Ulf Ziemann, Gian Luca Romani and Vittorio Pizzella
Biomedicines 2024, 12(5), 955; https://doi.org/10.3390/biomedicines12050955 (registering DOI) - 25 Apr 2024
Abstract
State-dependent non-invasive brain stimulation (NIBS) informed by electroencephalography (EEG) has contributed to the understanding of NIBS inter-subject and inter-session variability. While these approaches focus on local EEG characteristics, it is acknowledged that the brain exhibits an intrinsic long-range dynamic organization in networks. This [...] Read more.
State-dependent non-invasive brain stimulation (NIBS) informed by electroencephalography (EEG) has contributed to the understanding of NIBS inter-subject and inter-session variability. While these approaches focus on local EEG characteristics, it is acknowledged that the brain exhibits an intrinsic long-range dynamic organization in networks. This proof-of-concept study explores whether EEG connectivity of the primary motor cortex (M1) in the pre-stimulation period aligns with the Motor Network (MN) and how the MN state affects responses to the transcranial magnetic stimulation (TMS) of M1. One thousand suprathreshold TMS pulses were delivered to the left M1 in eight subjects at rest, with simultaneous EEG. Motor-evoked potentials (MEPs) were measured from the right hand. The source space functional connectivity of the left M1 to the whole brain was assessed using the imaginary part of the phase locking value at the frequency of the sensorimotor μ-rhythm in a 1 s window before the pulse. Group-level connectivity revealed functional links between the left M1, left supplementary motor area, and right M1. Also, pulses delivered at high MN connectivity states result in a greater MEP amplitude compared to low connectivity states. At the single-subject level, this relation is more highly expressed in subjects that feature an overall high cortico-spinal excitability. In conclusion, this study paves the way for MN connectivity-based NIBS. Full article
(This article belongs to the Special Issue Emerging Trends in Brain Stimulation)
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66 pages, 4594 KiB  
Article
Conformal and Non-Minimal Couplings in Fractional Cosmology
by Kevin Marroquín, Genly Leon, Alfredo D. Millano, Claudio Michea and Andronikos Paliathanasis
Fractal Fract. 2024, 8(5), 253; https://doi.org/10.3390/fractalfract8050253 (registering DOI) - 25 Apr 2024
Abstract
Fractional differential calculus is a mathematical tool that has found applications in the study of social and physical behaviors considered “anomalous”. It is often used when traditional integer derivatives models fail to represent cases where the power law is observed accurately. Fractional calculus [...] Read more.
Fractional differential calculus is a mathematical tool that has found applications in the study of social and physical behaviors considered “anomalous”. It is often used when traditional integer derivatives models fail to represent cases where the power law is observed accurately. Fractional calculus must reflect non-local, frequency- and history-dependent properties of power-law phenomena. This tool has various important applications, such as fractional mass conservation, electrochemical analysis, groundwater flow problems, and fractional spatiotemporal diffusion equations. It can also be used in cosmology to explain late-time cosmic acceleration without the need for dark energy. We review some models using fractional differential equations. We look at the Einstein–Hilbert action, which is based on a fractional derivative action, and add a scalar field, ϕ, to create a non-minimal interaction theory with the coupling, ξRϕ2, between gravity and the scalar field, where ξ is the interaction constant. By employing various mathematical approaches, we can offer precise schemes to find analytical and numerical approximations of the solutions. Moreover, we comprehensively study the modified cosmological equations and analyze the solution space using the theory of dynamical systems and asymptotic expansion methods. This enables us to provide a qualitative description of cosmologies with a scalar field based on fractional calculus formalism. Full article
(This article belongs to the Special Issue Advances in Fractional Modeling and Computation)
14 pages, 8017 KiB  
Article
Study of the Possibility of Using Virtual Reality Application in Rehabilitation Among Elderly Post-Stroke Patients
by Katarzyna Matys-Popielska, Krzysztof Popielski and Anna Sibilska-Mroziewicz
Sensors 2024, 24(9), 2745; https://doi.org/10.3390/s24092745 (registering DOI) - 25 Apr 2024
Abstract
Thanks to medical advances, life expectancy is increasing. With it comes an increased incidence of diseases, of which age is a risk factor. Stroke is among these diseases, and is one of the causes of long-term disability. The opportunity to treat these patients [...] Read more.
Thanks to medical advances, life expectancy is increasing. With it comes an increased incidence of diseases, of which age is a risk factor. Stroke is among these diseases, and is one of the causes of long-term disability. The opportunity to treat these patients is via rehabilitation. A promising new technology that can enhance rehabilitation is virtual reality (VR). However, this technology is not widely used by elderly patients, and, moreover, the elderly often do not use modern technology at all. It therefore becomes a legitimate question whether elderly people will be able to use virtual reality in rehabilitation. This article presents a rehabilitation application dedicated to patients with upper limb paresis and unilateral spatial neglect (USN). The application was tested on a group of 60 individuals including 30 post-stroke patients with an average age of 72.83 years. The results of the conducted study include a self-assessment by the patients, the physiotherapist’s evaluation, as well as the patients’ performance of the exercise in VR. The study showed that elderly post-stroke patients are able to use virtual reality applications, but the ability to correctly and fully perform an exercise in VR depends on several factors. One of them is the ability to make logical contact (p = 0.0001 < 0.05). However, the study presented here shows that the ability to use VR applications does not depend on age but on mental and physical condition, which gives hope that virtual reality applications can be used in post-stroke rehabilitation among patients of all ages. Full article
15 pages, 885 KiB  
Article
Event-Triggered Disturbance Estimation and Output Feedback Control Design for Inner-Formation Systems
by Liwei Hao and Yingchun Zhang
Appl. Sci. 2024, 14(9), 3656; https://doi.org/10.3390/app14093656 (registering DOI) - 25 Apr 2024
Abstract
This study investigates an event-triggered disturbance estimation approach for the inner-formation system. An extended state observer is designed using an event-based sampling scheme, which offers advantages over traditional estimation methods by reducing information transmission and unnecessary output information exchange while ensuring accurate system [...] Read more.
This study investigates an event-triggered disturbance estimation approach for the inner-formation system. An extended state observer is designed using an event-based sampling scheme, which offers advantages over traditional estimation methods by reducing information transmission and unnecessary output information exchange while ensuring accurate system estimation performance. Additionally, a method for designing output-feedback control is proposed. The separation of feedback control and event-based observation in the design of output feedback allows us to apply existing optimal control algorithms to the targeted plant without compromising our established event-triggered sampling methods. A numerical simulation is presented, and we demonstrate the effectiveness of our proposed approach for the inner-formation system. Full article
(This article belongs to the Section Aerospace Science and Engineering)
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12 pages, 3101 KiB  
Article
Protecting the Quantum Coherence of Two Atoms Inside an Optical Cavity by Quantum Feedback Control Combined with Noise-Assisted Preparation
by Chang-Xiao Li
Photonics 2024, 11(5), 400; https://doi.org/10.3390/photonics11050400 (registering DOI) - 25 Apr 2024
Abstract
We propose a theoretical scheme to enhance quantum coherence and obtain steady-state coherence by combining quantum feedback control and noise-assisted preparation. We investigate the effects of quantum-jump-based feedback control and noise field on the quantum coherence and excited-state population between two atoms inside [...] Read more.
We propose a theoretical scheme to enhance quantum coherence and obtain steady-state coherence by combining quantum feedback control and noise-assisted preparation. We investigate the effects of quantum-jump-based feedback control and noise field on the quantum coherence and excited-state population between two atoms inside an optical cavity where a noise field drives one, and the other is under quantum feedback control. It is found that steady quantum coherence can be achieved by adding an external noise field, and the quantum feedback can prolong the coherence time with partial suppression of the spontaneous emission of atoms. In addition, we study the influence of the joint action of quantum feedback and noise-assisted preparation on quantum coherence and show that the combined action of feedback control and noise-assisted preparation is more effective in enhancing steady coherence. The findings of our research offer some general guidelines for improving the steady-state coherence of coupled qubit systems and have the potential to be applied in the realm of quantum information technology. Full article
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17 pages, 3752 KiB  
Article
Short-Wavelength Infrared Characteristics and Indications of Exploration of the Jiawula Silver–Lead–Zinc Deposit in Inner Mongolia
by Lei Wang, Zian Yang, Weixuan Fang, Dewen Wu, Zhiqiang Liu and Gao Guan
Appl. Sci. 2024, 14(9), 3658; https://doi.org/10.3390/app14093658 (registering DOI) - 25 Apr 2024
Abstract
For the Jiawula lead–zinc deposit, as easily accessible resources become depleted, mines are becoming deeper to replenish ore reserves. Identifying large, continuous, and high-grade ore bodies in deep areas has become a daunting problem. Moreover, separating lead–zinc-bearing complex ore bodies from waste material [...] Read more.
For the Jiawula lead–zinc deposit, as easily accessible resources become depleted, mines are becoming deeper to replenish ore reserves. Identifying large, continuous, and high-grade ore bodies in deep areas has become a daunting problem. Moreover, separating lead–zinc-bearing complex ore bodies from waste material and extracting them from associated minerals are also difficult. Thus, pioneering exploratory strategies and technological methodologies are required to make breakthroughs in mineral discovery. Based on extensive-scale structural lithofacies mapping, this paper uses short-wave infrared (SWIR) spectroscopy technology to investigate hydrothermal alteration minerals in the mining area. It has identified a total of 16 hydroxyl-bearing alteration minerals, including chlorite, muscovite, illite, calcite, ankerite, kaolinite, and smectite. These minerals establish zoning characteristics around the ore bodies and on their flanks. They comprise a segmented assemblage that follows the pattern of comb-textured quartz–illite–chlorite–carbonate → muscovite–illite–chlorite–ankerite → illite–smectite–chlorite → chlorite–kaolinite–calcite. Deep-zone illitization with a lower Al–OH absorbance peak wavelength (<2206 nm) and higher crystallinity indices (>1.1) and chloritization with higher Fe–OH absorbance peak wavelengths (>2254) and higher crystallinity indices (>3.0) are indicators of potential hydrothermal centers in the deeper regions. By finding hydrothermal centers and connecting their spatial distribution with existing ore bodies, a pertinent relationship between diabase + andesite, Fe-chlorite + illite, and high-grade mineralization has been established. They correspond well with the lithology-alteration mineralization. This research provides a basis for predicting the positioning of concealed ore bodies deep inside a mine or at the periphery. Full article
(This article belongs to the Special Issue State-of-the-Art Earth Sciences and Geography in China)
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16 pages, 26476 KiB  
Article
Beyond Preservation: Heritage as an Educational Practice Process at 141 Neil Road, Singapore
by Xintong Wei, Haoming Zhou, Nikhil Joshi and Muyuan Tang
Buildings 2024, 14(5), 1225; https://doi.org/10.3390/buildings14051225 (registering DOI) - 25 Apr 2024
Abstract
Over the past two decades, the concept of heritage has been significantly broadened, with an increasing number of scholars viewing it not as a set of static objects with fixed meanings but as a social process consciously endowed with commemorative functions through human [...] Read more.
Over the past two decades, the concept of heritage has been significantly broadened, with an increasing number of scholars viewing it not as a set of static objects with fixed meanings but as a social process consciously endowed with commemorative functions through human creation. This research illustrates and empirically supports this perspective through a case study. Initially, the paper reviews the development of the heritage concept through the literature review and elaborates on the idea of “heritage as process”. Subsequently, it examines Singapore’s enriching exploration and successful implementation of heritage conservation, particularly since 2000, when the local government shifted from preserving historical buildings to a comprehensive conservation strategy that embraces a sense of place, identity, and memory and encourages a bottom-up participatory approach. Finally, this paper takes the transformation of the century-old townhouse at 141 Neil Road in Singapore as its focus. After being renovated into an urban architectural heritage conservation laboratory, the house has gradually become a place of heritage on Neil Road by training professionals’ construction skills, transforming its function, introducing technological explorations, and enhancing public interaction. This process has developed the abilities of heritage conservation professionals in desktop research, reuse design, and practical construction skills while simultaneously promoting community participation and heightening awareness of heritage conservation among local residents. Through daily practices, this historical townhouse gradually became a place of heritage on Neil Road, exemplifying the research theme that “heritage is a comprehensive and dynamic practice encompassing social, cultural, and technological dimensions”. From being preserved for renovation in 2020 to being approved as a “Heritage Show House” by the Urban Redevelopment Authority (URA) in 2023, the case of 141 Neil Road offers a new perspective in the heritage conservation field that “heritage is always in the process of becoming, rather than a constant given”. Full article
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17 pages, 6005 KiB  
Article
Enzymatic Activity of Soil on the Occurrence of the Endangered Beetle Cheilotoma musciformis (Coleoptera: Chrysomelidae) in Xerothermic Grasslands
by Barbara Futa, Mariusz Kulik, Łukasz Kajtoch, Miłosz A. Mazur, Małgorzata Jaźwa, Radosław Ścibior and Justyna Wielgos
Insects 2024, 15(5), 307; https://doi.org/10.3390/insects15050307 (registering DOI) - 25 Apr 2024
Abstract
This work attempts to find the reasons for the rather limited range of occurrence of Cheilotoma musciformis in Poland, based on soil properties, which affects both the plant cover and the entomofauna. The aim of the study was to assess the influence of [...] Read more.
This work attempts to find the reasons for the rather limited range of occurrence of Cheilotoma musciformis in Poland, based on soil properties, which affects both the plant cover and the entomofauna. The aim of the study was to assess the influence of soil enzyme activity on the occurrence of Ch. musciformis in xerothermic grasslands in Southern Poland. The sites inhabited by the beetle were most often extensively grazed by farm animals or had recently been cleared of bushes. The control plots were in wasteland. The soils of most sites with Ch. musciformis were characterized by significantly higher activity of the tested enzymes and higher content of total organic carbon and total nitrogen, as well as lower pHKCl compared to the control sites. The higher enzymatic activity of soils in sites with the beetle than in the control sites may indicate the dependence of the occurrence of this beetle on the presence of patches of extensively grazed xerothermic grasslands. Grazing influences the behavior of preferred host plant species. Therefore, when planning active protection of xerothermic grasslands inhabited by Ch. musciformis, changes in the biochemical properties of the soil and vegetation structure should be taken into account. Full article
(This article belongs to the Section Insect Ecology, Diversity and Conservation)
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39 pages, 16952 KiB  
Article
Ensemble Learning Approach for Developing Performance Models of Flexible Pavement
by Ali Taheri and John Sobanjo
Infrastructures 2024, 9(5), 78; https://doi.org/10.3390/infrastructures9050078 (registering DOI) - 25 Apr 2024
Abstract
This research utilizes the Long-Term Pavement Performance database, focusing on devel-oping a predictive model for flexible pavement performance in the Southern United States. Analyzing 367 pavement sections, this study investigates crucial factors influencing asphaltic concrete (AC) pavement deterioration, such as structural and material [...] Read more.
This research utilizes the Long-Term Pavement Performance database, focusing on devel-oping a predictive model for flexible pavement performance in the Southern United States. Analyzing 367 pavement sections, this study investigates crucial factors influencing asphaltic concrete (AC) pavement deterioration, such as structural and material components, air voids, compaction density, temperature at laydown, traffic load, precipitation, and freeze–thaw cycles. The objective of this study is to develop a predictive machine learning model for AC pavement wheel path cracking (WpCrAr) and the age at which cracking initiates (WpCrAr) as performance indicators. This study thoroughly investigated three ensemble machine learning models, including random forest, extremely randomized trees (ETR), and extreme gradient boosting (XGBoost). It was observed that XGBoost, optimized using Bayesian methods, emerged as the most effective among the evaluated models, demonstrating good predictive accuracy, with an R2 of 0.79 for WpCrAr and 0.92 for AgeCrack and mean absolute errors of 1.07 and 0.74, respectively. The most important features influencing crack initiation and progression were identified, including equivalent single axle load (ESAL), pavement age, number of layers, precipitation, and freeze–thaw cycles. This paper also showed the impact of pavement material combinations for base and subgrade layers on the delay of crack initiation. Full article
(This article belongs to the Section Infrastructures and Structural Engineering)
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37 pages, 460 KiB  
Article
Representations of Solutions of Time-Fractional Multi-Order Systems of Differential-Operator Equations
by Sabir Umarov
Fractal Fract. 2024, 8(5), 254; https://doi.org/10.3390/fractalfract8050254 (registering DOI) - 25 Apr 2024
Abstract
This paper is devoted to the general theory of systems of linear time-fractional differential-operator equations. The representation formulas for solutions of systems of ordinary differential equations with single (commensurate) fractional order is known through the matrix-valued Mittag-Leffler function. Multi-order (incommensurate) systems with rational [...] Read more.
This paper is devoted to the general theory of systems of linear time-fractional differential-operator equations. The representation formulas for solutions of systems of ordinary differential equations with single (commensurate) fractional order is known through the matrix-valued Mittag-Leffler function. Multi-order (incommensurate) systems with rational components can be reduced to single-order systems, and, hence, representation formulas are also known. However, for arbitrary fractional multi-order (not necessarily with rational components) systems of differential equations, the representation formulas are still unknown, even in the case of fractional-order ordinary differential equations. In this paper, we obtain representation formulas for the solutions of arbitrary fractional multi-order systems of differential-operator equations. The existence and uniqueness theorems in appropriate topological vector spaces are also provided. Moreover, we introduce vector-indexed Mittag-Leffler functions and prove some of their properties. Full article
(This article belongs to the Section General Mathematics, Analysis)
18 pages, 904 KiB  
Article
In Vitro Digestion and Intestinal Absorption of Mycotoxins Due to Exposure from Breakfast Cereals: Implications for Children’s Health
by Soraia V. M. de Sá, Miguel A. Faria, José O. Fernandes and Sara C. Cunha
Toxins 2024, 16(5), 205; https://doi.org/10.3390/toxins16050205 (registering DOI) - 25 Apr 2024
Abstract
Breakfast cereals play a crucial role in children’s diets, providing essential nutrients that are vital for their growth and development. Children are known to be more susceptible than adults to the harmful effects of food contaminants, with mycotoxins being a common concern in [...] Read more.
Breakfast cereals play a crucial role in children’s diets, providing essential nutrients that are vital for their growth and development. Children are known to be more susceptible than adults to the harmful effects of food contaminants, with mycotoxins being a common concern in cereals. This study specifically investigated aflatoxin B1 (AFB1), enniatin B (ENNB), and sterigmatocystin (STG), three well-characterized mycotoxins found in cereals. The research aimed to address existing knowledge gaps by comprehensively evaluating the bioaccessibility and intestinal absorption of these three mycotoxins, both individually and in combination, when consumed with breakfast cereals and milk. The in vitro gastrointestinal method revealed patterns in the bioaccessibility of AFB1, ENNB, and STG. Overall, bioaccessibility increased as the food progressed from the stomach to the intestinal compartment, with the exception of ENNB, whose behavior differed depending on the type of milk. The ranking of overall bioaccessibility in different matrices was as follows: digested cereal > cereal with semi-skimmed milk > cereal with lactose-free milk > cereal with soy beverage. Bioaccessibility percentages varied considerably, ranging from 3.1% to 86.2% for AFB1, 1.5% to 59.3% for STG, and 0.6% to 98.2% for ENNB. Overall, the inclusion of milk in the ingested mixture had a greater impact on bioaccessibility compared to consuming the mycotoxins as a single compound or in combination. During intestinal transport, ENNB and STG exhibited the highest absorption rates when ingested together. This study highlights the importance of investigating the combined ingestion and transport of these mycotoxins to comprehensively assess their absorption and potential toxicity in humans, considering their frequent co-occurrence and the possibility of simultaneous exposure. Full article
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21 pages, 5345 KiB  
Review
The Effectiveness Mechanisms of Carbon Nanotubes (CNTs) as Reinforcements for Magnesium-Based Composites for Biomedical Applications: A Review
by Abbas Saberi, Madalina Simona Baltatu and Petrica Vizureanu
Nanomaterials 2024, 14(9), 756; https://doi.org/10.3390/nano14090756 (registering DOI) - 25 Apr 2024
Abstract
As a smart implant, magnesium (Mg) is highly biocompatible and non-toxic. In addition, the elastic modulus of Mg relative to other biodegradable metals (iron and zinc) is close to the elastic modulus of natural bone, making Mg an attractive alternative to hard tissues. [...] Read more.
As a smart implant, magnesium (Mg) is highly biocompatible and non-toxic. In addition, the elastic modulus of Mg relative to other biodegradable metals (iron and zinc) is close to the elastic modulus of natural bone, making Mg an attractive alternative to hard tissues. However, high corrosion rates and low strength under load relative to bone are some challenges for the widespread use of Mg in orthopedics. Composite fabrication has proven to be an excellent way to improve the mechanical performance and corrosion control of Mg. As a result, their composites emerge as an innovative biodegradable material. Carbon nanotubes (CNTs) have superb properties like low density, high tensile strength, high strength-to-volume ratio, high thermal conductivity, and relatively good antibacterial properties. Therefore, using CNTs as reinforcements for the Mg matrix has been proposed as an essential option. However, the lack of understanding of the mechanisms of effectiveness in mechanical, corrosion, antibacterial, and cellular fields through the presence of CNTs as Mg matrix reinforcements is a challenge for their application. This review focuses on recent findings on Mg/CNT composites fabricated for biological applications. The literature mentions effective mechanisms for mechanical, corrosion, antimicrobial, and cellular domains with the presence of CNTs as reinforcements for Mg-based nanobiocomposites. Full article
33 pages, 3695 KiB  
Review
Biominerals and Bioinspired Materials in Biosensing: Recent Advancements and Applications
by Mohamed A. A. Abdelhamid, Mi-Ran Ki and Seung Pil Pack
Int. J. Mol. Sci. 2024, 25(9), 4678; https://doi.org/10.3390/ijms25094678 (registering DOI) - 25 Apr 2024
Abstract
Inspired by nature’s remarkable ability to form intricate minerals, researchers have unlocked transformative strategies for creating next-generation biosensors with exceptional sensitivity, selectivity, and biocompatibility. By mimicking how organisms orchestrate mineral growth, biomimetic and bioinspired materials are significantly impacting biosensor design. Engineered bioinspired materials [...] Read more.
Inspired by nature’s remarkable ability to form intricate minerals, researchers have unlocked transformative strategies for creating next-generation biosensors with exceptional sensitivity, selectivity, and biocompatibility. By mimicking how organisms orchestrate mineral growth, biomimetic and bioinspired materials are significantly impacting biosensor design. Engineered bioinspired materials offer distinct advantages over their natural counterparts, boasting superior tunability, precise controllability, and the ability to integrate specific functionalities for enhanced sensing capabilities. This remarkable versatility enables the construction of various biosensing platforms, including optical sensors, electrochemical sensors, magnetic biosensors, and nucleic acid detection platforms, for diverse applications. Additionally, bioinspired materials facilitate the development of smartphone-assisted biosensing platforms, offering user-friendly and portable diagnostic tools for point-of-care applications. This review comprehensively explores the utilization of naturally occurring and engineered biominerals and materials for diverse biosensing applications. We highlight the fabrication and design strategies that tailor their functionalities to address specific biosensing needs. This in-depth exploration underscores the transformative potential of biominerals and materials in revolutionizing biosensing, paving the way for advancements in healthcare, environmental monitoring, and other critical fields. Full article
(This article belongs to the Special Issue New Trends in Molecular Biosensors)
33 pages, 1251 KiB  
Review
Interaction of Trypanosoma cruzi, Triatomines and the Microbiota of the Vectors—A Review
by Günter A. Schaub
Microorganisms 2024, 12(5), 855; https://doi.org/10.3390/microorganisms12050855 (registering DOI) - 25 Apr 2024
Abstract
This review summarizes the interactions between Trypanosoma cruzi, the etiologic agent of Chagas disease, its vectors, triatomines, and the diverse intestinal microbiota of triatomines, which includes mutualistic symbionts, and highlights open questions. T. cruzi strains show great biological heterogeneity in their development [...] Read more.
This review summarizes the interactions between Trypanosoma cruzi, the etiologic agent of Chagas disease, its vectors, triatomines, and the diverse intestinal microbiota of triatomines, which includes mutualistic symbionts, and highlights open questions. T. cruzi strains show great biological heterogeneity in their development and their interactions. Triatomines differ from other important vectors of diseases in their ontogeny and the enzymes used to digest blood. Many different bacteria colonize the intestinal tract of triatomines, but only Actinomycetales have been identified as mutualistic symbionts. Effects of the vector on T. cruzi are indicated by differences in the ability of T. cruzi to establish in the triatomines and in colonization peculiarities, i.e., proliferation mainly in the posterior midgut and rectum and preferential transformation into infectious metacyclic trypomastigotes in the rectum. In addition, certain forms of T. cruzi develop after feeding and during starvation of triatomines. Negative effects of T. cruzi on the triatomine vectors appear to be particularly evident when the triatomines are stressed and depend on the T. cruzi strain. Effects on the intestinal immunity of the triatomines are induced by ingested blood-stage trypomastigotes of T. cruzi and affect the populations of many non-symbiotic intestinal bacteria, but not all and not the mutualistic symbionts. After the knockdown of antimicrobial peptides, the number of non-symbiotic bacteria increases and the number of T. cruzi decreases. Presumably, in long-term infections, intestinal immunity is suppressed, which supports the growth of specific bacteria, depending on the strain of T. cruzi. These interactions may provide an approach to disrupt T. cruzi transmission. Full article
(This article belongs to the Section Parasitology)
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9 pages, 818 KiB  
Article
Abietane Diterpenoids from the Bark of Cryptomeria japonica and Their Antifungal Activities against Wood Decay Fungi
by Chi-I Chang, Cheng-Chi Chen, Sheng-Yang Wang and Yueh-Hsiung Kuo
Plants 2024, 13(9), 1197; https://doi.org/10.3390/plants13091197 (registering DOI) - 25 Apr 2024
Abstract
Phytochemical investigation of the bark of Cryptomeria japonica led to the isolation of five new abietane diterpenoids, 5-epi-12-hydroxy-6-nor-5,6-secoabieta-8,11,13-trien-7,5-olide (1), 12-hydroxy-6β-methoxy-6,7-secoabieta-8,11,13-trien-7,6-olide (2), 6β,12-dihydroxy-7,8-secoabieta-8,11,13-trien-7,8-olide (4), 5,12-dihydroxy-7,8-secoabieta-8,11,13-trien-7,8-olide (5), and 5α,8-epoxy-12-hydroxy-7,8-secoabieta-8,11,13-trien-7-al (6), together [...] Read more.
Phytochemical investigation of the bark of Cryptomeria japonica led to the isolation of five new abietane diterpenoids, 5-epi-12-hydroxy-6-nor-5,6-secoabieta-8,11,13-trien-7,5-olide (1), 12-hydroxy-6β-methoxy-6,7-secoabieta-8,11,13-trien-7,6-olide (2), 6β,12-dihydroxy-7,8-secoabieta-8,11,13-trien-7,8-olide (4), 5,12-dihydroxy-7,8-secoabieta-8,11,13-trien-7,8-olide (5), and 5α,8-epoxy-12-hydroxy-7,8-secoabieta-8,11,13-trien-7-al (6), together with one known abietane diterpenoid, obtuanhydride (3). Their structures were elucidated by analysis of spectroscopic data and comparison with the spectral data of known analogs. At the concentration of 100 μg/mL, compounds 4, 5, and 6 inhibited antifungal activities against wood decay fungi activity by 18.7, 37.2, and 46.7%, respectively. Full article
(This article belongs to the Section Phytochemistry)
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18 pages, 2958 KiB  
Article
Deciphering the Diversity in Bacterial Transporters That Salvage Queuosine Precursors
by Samia Quaiyum, Yifeng Yuan, Paul J. Kuipers, Maria Martinelli, Marshall Jaroch and Valérie de Crécy-Lagard
Epigenomes 2024, 8(2), 16; https://doi.org/10.3390/epigenomes8020016 (registering DOI) - 25 Apr 2024
Abstract
Queuosine (Q) is a modification of the wobble base of tRNA harboring GUN anticodons with roles in decoding accuracy and efficiency. Its synthesis is complex with multiple enzymatic steps, and several pathway intermediates can be salvaged. The only two transporter families known to [...] Read more.
Queuosine (Q) is a modification of the wobble base of tRNA harboring GUN anticodons with roles in decoding accuracy and efficiency. Its synthesis is complex with multiple enzymatic steps, and several pathway intermediates can be salvaged. The only two transporter families known to salvage Q precursors are QPTR/COG1738 and QrtT/QueT. Analyses of the distribution of known Q synthesis and salvage genes in human gut and oral microbiota genomes have suggested that more transporter families remain to be found and that Q precursor exchanges must occur within the structured microenvironments of the mammalian host. Using physical clustering and fusion-based association with Q salvage genes, candidate genes for missing transporters were identified and five were tested experimentally by complementation assays in Escherichia coli. Three genes encoding transporters from three different Pfam families, a ureide permease (PF07168) from Acidobacteriota bacterium, a hemolysin III family protein (PF03006) from Bifidobacterium breve, and a Major Facilitator Superfamily protein (PF07690) from Bartonella henselae, were found to allow the transport of both preQ0 and preQ1 in this heterologous system. This work suggests that many transporter families can evolve to transport Q precursors, reinforcing the concept of transporter plasticity. Full article
10 pages, 873 KiB  
Article
In Vitro Anti-Rotaviral Activity of Bavachin Isolated from Psoralea corylifolia L. (Fabaceae)
by Jinseok Jung, Jaehoon Bae, Ji Sun Park, Seung Woong Lee, Jae-Ho Jeong and Su-Jin Park
Vet. Sci. 2024, 11(5), 188; https://doi.org/10.3390/vetsci11050188 (registering DOI) - 25 Apr 2024
Abstract
Rotavirus is the main causative agent of viral gastroenteritis among young animals worldwide. Currently, no clinically approved or effective antiviral drugs are available to combat rotavirus infections. Herein, we evaluated the anti-rotaviral activities of extracts and bavachin isolated from Psoralea corylifolia L. ( [...] Read more.
Rotavirus is the main causative agent of viral gastroenteritis among young animals worldwide. Currently, no clinically approved or effective antiviral drugs are available to combat rotavirus infections. Herein, we evaluated the anti-rotaviral activities of extracts and bavachin isolated from Psoralea corylifolia L. (Fabaceae) (P. corylifolia) against the bovine rotavirus G8P[7] and porcine rotavirus G5P[7] in vitro. Two assay strategies were performed: (1) a virucidal assay to reduce viral infectivity by virus neutralization and (2) a post-treatment assay to assess viral replication suppression. The results from the virucidal assay showed that the extracts and bavachin did not exert anti-rotaviral activities. In the follow-up analysis after treatment, bavachin exhibited robust antiviral efficacy, with 50% effective concentration (EC50) values of 10.6 μM (selectivity index [SI] = 2.38) against bovine rotavirus G8P[7] and 13.0 μM (SI = 1.94) against porcine rotavirus G5P[7]. Bavachin strongly suppressed viral RNA synthesis in the early (6 h) and late stages (18 h) after rotaviral infection. These findings strongly suggest that bavachin may have hindered the virions by effectively inhibiting the early stages of the virus replication cycle after rotaviral infection. Furthermore, confocal imaging showed that bavachin suppressed viral protein synthesis, notably that of the rotaviral protein (VP6). These results suggest that bavachin has strong antiviral activity against rotaviruses, inhibits viral replication, and is a candidate natural therapeutic drug targeting rotaviral infection. The utilization of bavachin isolated from P. corylifolia may contribute to decreased mortality rates, lower medication expenses, and enhanced economic viability in domestic farms. Full article
(This article belongs to the Section Veterinary Microbiology, Parasitology and Immunology)
24 pages, 1748 KiB  
Article
Experimental Research on the Anti-Reflection Crack Performance of Basalt Fiber Modified Rubber Asphalt Stress-Absorbing Layer
by Cheng Shen, Zhengguang Wu, Peng Xiao, Aihong Kang and Yangbo Wang
Materials 2024, 17(9), 2013; https://doi.org/10.3390/ma17092013 (registering DOI) - 25 Apr 2024
Abstract
Reflection cracks are one of the most common problems in semi-rigid base pavement. Setting a stress absorption layer can effectively delay the occurrence of reflection cracks, but further improvement is still needed in its interlayer bonding performance and anti-reflection crack performance. Considering the [...] Read more.
Reflection cracks are one of the most common problems in semi-rigid base pavement. Setting a stress absorption layer can effectively delay the occurrence of reflection cracks, but further improvement is still needed in its interlayer bonding performance and anti-reflection crack performance. Considering the excellent crack resistance of basalt fibers and the good elastic recovery ability of rubber asphalt, it is considered worthwhile to incorporate them into traditional stress absorption layers to improve performance. To simulate the actual pavement layer effect, composite specimens consisting of a cement-stabilized macadam base + basalt fiber rubber asphalt stress-absorbing layer + AC-20 asphalt mixture surface layer were prepared to evaluate their performance through interlayer direct shear tests, interlayer tensile tests, three-point bending tests, and overlay tests (OTs). To determine the optimal fiber blending combination, four fiber lengths (3 cm, 6 cm, 9 cm, 12 cm) and four fiber proportions (120 g/m2, 140 g/m2, 160 g/m2, 180 g/m2) were selected respectively. The specific effects of basalt fibers with different lengths and dosages were analyzed. The results show that compared with the absence of fibers, the improvement of interlayer bonding performance of rubber asphalt with basalt fibers is not significant, and it has certain limitations; however, the improvement of anti-reflective crack performance is significant, with an increase of up to 305.5%. This indicates that the network structure formed by basalt fibers and rubber asphalt stress absorption layer can effectively absorb and disperse external loads, causing an excellent crack resistance effect. Meanwhile, the results indicate that the main factor affecting its interlayer bonding strength and anti-reflective crack performance is the fiber content. Based on the comprehensive analysis of the performance and economy of the stress absorption layer of basalt fiber rubber asphalt, the optimal fiber parameter combination recommended is as fiber length 9 cm and fiber content 160 g/m2.These results can provide a reference for the design and performance evaluation of basalt fiber rubber asphalt stress absorption layer, and have certain application value. Full article
(This article belongs to the Special Issue Mechanical Property Research of Advanced Asphalt-Based Materials)
32 pages, 977 KiB  
Review
The Future Design of Smart Energy Systems with Energy Flexumers: A Constructive Literature Review
by Jin-Li Hu and Nhi Ha Bao Bui
Energies 2024, 17(9), 2039; https://doi.org/10.3390/en17092039 (registering DOI) - 25 Apr 2024
Abstract
From powering our homes to driving our economies, energy lies at the heart of humanity’s complex challenges in the modern era. This paper reviews the evolution of smart energy systems, examining their technological advancements and societal implications while proposing a future design framework [...] Read more.
From powering our homes to driving our economies, energy lies at the heart of humanity’s complex challenges in the modern era. This paper reviews the evolution of smart energy systems, examining their technological advancements and societal implications while proposing a future design framework emphasizing four key pillars: holistic resource optimization, adaptive intelligence, environmental harmony, and human-centered design. While they offer numerous benefits, such as enhanced energy efficiency and reduced carbon emissions, smart energy systems also face challenges. These include cybersecurity risks, the complexity of integrating diverse energy sources seamlessly, high upfront costs, and potential compatibility issues arising from evolving technologies. Overcoming these challenges will be crucial for unleashing the full potential of smart energy systems and facilitating their global adoption. Abundant opportunities for further research and development exist in this domain, awaiting exploration and advancement. Full article
(This article belongs to the Section C: Energy Economics and Policy)
14 pages, 1565 KiB  
Article
Synthesis of Propylene Glycol Methyl Ether Acetate: Reaction Kinetics and Process Simulation Using Heterogeneous Catalyst
by Yui Rak Son, Jong Kee Park, Eun Woo Shin, Seok Pyong Moon and Heon E. Park
Processes 2024, 12(5), 865; https://doi.org/10.3390/pr12050865 (registering DOI) - 25 Apr 2024
Abstract
Propylene glycol methyl ether acetate (PGMEA) serves as a crucial solvent in semiconductor and display material processes, demanding high purity and low acidity. Despite its significance, its conventional synthesis method using homogeneous catalysts requires extensive purification. Our study explores the use of Amberlyst-15, [...] Read more.
Propylene glycol methyl ether acetate (PGMEA) serves as a crucial solvent in semiconductor and display material processes, demanding high purity and low acidity. Despite its significance, its conventional synthesis method using homogeneous catalysts requires extensive purification. Our study explores the use of Amberlyst-15, a stable solid catalyst, to streamline this process. Through batch reactions with a 1:1 reactant ratio at various temperatures and modeling using an integrated reaction rate equation, we obtained kinetic parameters. These parameters were used to predict the kinetics under different reactant ratios and different catalyst amounts, and the predictions match well with experimental results, especially when we used the catalyst amount scaled by the amount of the limiting reactant (PGME) rather than the total amount of the reactants. This highlights the importance of reporting kinetic parameters with proper scaling for catalyst used. Furthermore, we integrated these parameters into process simulations to determine the length of a plug flow reactor (PFR), constructed a PFR system, and confirmed that the simulation results matched well with experimental data obtained from the PFR system. Our findings suggest Amberlyst-15’s potential in simplifying PGMEA synthesis, promising advancements in industrial applications. Full article
(This article belongs to the Special Issue Heterogeneous Catalysis in Chemical and Petrochemical Processes)
19 pages, 642 KiB  
Article
Study of Random Walk Invariants for Spiro-Ring Network Based on Laplacian Matrices
by Yasir Ahmad, Umar Ali, Daniele Ettore Otera and Xiang-Feng Pan
Mathematics 2024, 12(9), 1309; https://doi.org/10.3390/math12091309 (registering DOI) - 25 Apr 2024
Abstract
The use of the global mean first-passage time (GMFPT) in random walks on networks has been widely explored in the field of statistical physics, both in theory and practical applications. The GMFPT is the estimated interval of time needed to reach a state [...] Read more.
The use of the global mean first-passage time (GMFPT) in random walks on networks has been widely explored in the field of statistical physics, both in theory and practical applications. The GMFPT is the estimated interval of time needed to reach a state j in a system from a starting state i. In contrast, there exists an intrinsic measure for a stochastic process, known as Kemeny’s constant, which is independent of the initial state. In the literature, it has been used as a measure of network efficiency. This article deals with a graph-spectrum-based method for finding both the GMFPT and Kemeny’s constant of random walks on spiro-ring networks (that are organic compounds with a particular graph structure). Furthermore, we calculate the Laplacian matrix for some specific spiro-ring networks using the decomposition theorem of Laplacian polynomials. Moreover, using the coefficients and roots of the resulting matrices, we establish some formulae for both GMFPT and Kemeny’s constant in these spiro-ring networks. Full article
(This article belongs to the Special Issue Geometry and Topology with Applications)
18 pages, 4855 KiB  
Article
A Reentry Trajectory Planning Algorithm via Pseudo-Spectral Convexification and Method of Multipliers
by Haizhao Liang, Yunhao Luo, Haohui Che, Jingxian Zhu and Jianying Wang
Mathematics 2024, 12(9), 1306; https://doi.org/10.3390/math12091306 (registering DOI) - 25 Apr 2024
Abstract
The reentry trajectory planning problem of hypersonic vehicles is generally a continuous and nonconvex optimization problem, and it constitutes a critical challenge within the field of aerospace engineering. In this paper, an improved sequential convexification algorithm is proposed to solve it and achieve [...] Read more.
The reentry trajectory planning problem of hypersonic vehicles is generally a continuous and nonconvex optimization problem, and it constitutes a critical challenge within the field of aerospace engineering. In this paper, an improved sequential convexification algorithm is proposed to solve it and achieve online trajectory planning. In the proposed algorithm, the Chebyshev pseudo-spectral method with high-accuracy approximation performance is first employed to discretize the continuous dynamic equations. Subsequently, based on the multipliers and linearization methods, the original nonconvex trajectory planning problem is transformed into a series of relaxed convex subproblems in the form of an augmented Lagrange function. Then, the interior point method is utilized to iteratively solve the relaxed convex subproblem until the expected convergence precision is achieved. The convex-optimization-based and multipliers methods guarantee the promotion of fast convergence precision, making it suitable for online trajectory planning applications. Finally, numerical simulations are conducted to verify the performance of the proposed algorithm. The simulation results show that the algorithm possesses better convergence performance, and the solution time can reach the level of seconds, which is more than 97% less than nonlinear programming algorithms, such as the sequential quadratic programming algorithm. Full article

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