Phytochemical investigation of the bark of
Cryptomeria japonica led to the isolation of five new abietane diterpenoids, 5-
epi-12-hydroxy-6-
nor-5,6-secoabieta-8,11,13-trien-7,5-olide (
1), 12-hydroxy-6β-methoxy-6,7-secoabieta-8,11,13-trien-7,6-olide (
2), 6β,12-dihydroxy-7,8-secoabieta-8,11,13-trien-7,8-olide (
4), 5,12-dihydroxy-7,8-secoabieta-8,11,13-trien-7,8-olide (
5), and 5α,8-epoxy-12-hydroxy-7,8-secoabieta-8,11,13-trien-7-al (
6), together
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Phytochemical investigation of the bark of
Cryptomeria japonica led to the isolation of five new abietane diterpenoids, 5-
epi-12-hydroxy-6-
nor-5,6-secoabieta-8,11,13-trien-7,5-olide (
1), 12-hydroxy-6β-methoxy-6,7-secoabieta-8,11,13-trien-7,6-olide (
2), 6β,12-dihydroxy-7,8-secoabieta-8,11,13-trien-7,8-olide (
4), 5,12-dihydroxy-7,8-secoabieta-8,11,13-trien-7,8-olide (
5), and 5α,8-epoxy-12-hydroxy-7,8-secoabieta-8,11,13-trien-7-al (
6), together with one known abietane diterpenoid, obtuanhydride (
3). Their structures were elucidated by analysis of spectroscopic data and comparison with the spectral data of known analogs. At the concentration of 100 μg/mL, compounds
4,
5, and
6 inhibited antifungal activities against wood decay fungi activity by 18.7, 37.2, and 46.7%, respectively.
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