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19 pages, 5819 KiB  
Article
VvJAZ13 Positively Regulates Cold Tolerance in Arabidopsis and Grape
by Lili Che, Shixiong Lu, Huimin Gou, Min Li, Lili Guo, Juanbo Yang and Juan Mao
Int. J. Mol. Sci. 2024, 25(8), 4458; https://doi.org/10.3390/ijms25084458 (registering DOI) - 18 Apr 2024
Abstract
Cold stress adversely impacts grape growth, development, and yield. Therefore, improving the cold tolerance of grape is an urgent task of grape breeding. The Jasmonic acid (JA) pathway responsive gene JAZ plays a key role in plant response to cold stress. However, the [...] Read more.
Cold stress adversely impacts grape growth, development, and yield. Therefore, improving the cold tolerance of grape is an urgent task of grape breeding. The Jasmonic acid (JA) pathway responsive gene JAZ plays a key role in plant response to cold stress. However, the role of JAZ in response to low temperatures in grape is unclear. In this study, VvJAZ13 was cloned from the ‘Pinot Noir’ (Vitis vinefera cv. ‘Pinot Noir’) grape, and the potential interacting protein of VvJAZ13 was screened by yeast two-hybrid (Y2H). The function of VvJAZ13 under low temperature stress was verified by genetic transformation. Subcellular localization showed that the gene was mainly expressed in cytoplasm and the nucleus. Y2H indicated that VvF-box, VvTIFY5A, VvTIFY9, Vvbch1, and VvAGD13 may be potential interacting proteins of VvJAZ13. The results of transient transformation of grape leaves showed that VvJAZ13 improved photosynthetic capacity and reduced cell damage by increasing maximum photosynthetic efficiency of photosystem II (Fv/Fm), reducing relative electrolyte leakage (REL) and malondialdehyde (MDA), and increasing proline content in overexpressed lines (OEs), which played an active role in cold resistance. Through the overexpression of VvJAZ13 in Arabidopsis thaliana and grape calli, the results showed that compared with wild type (WT), transgenic lines had higher antioxidant enzyme activity and proline content, lower REL, MDA, and hydrogen peroxide (H2O2) content, and an improved ability of scavenging reactive oxygen species. In addition, the expression levels of CBF1-2 and ICE1 genes related to cold response were up-regulated in transgenic lines. To sum up, VvJAZ13 is actively involved in the cold tolerance of Arabidopsis and grape, and has the potential to be a candidate gene for improving plant cold tolerance. Full article
(This article belongs to the Section Molecular Plant Sciences)
27 pages, 4291 KiB  
Article
Evaluation of Deep Coalbed Methane Potential and Prediction of Favorable Areas within the Yulin Area, Ordos Basin, Based on a Multi-Level Fuzzy Comprehensive Evaluation Method
by Keyu Zhou, Fengrui Sun, Chao Yang, Feng Qiu, Zihao Wang, Shaobo Xu and Jiaming Chen
Processes 2024, 12(4), 820; https://doi.org/10.3390/pr12040820 (registering DOI) - 18 Apr 2024
Abstract
The research on the deep coalbed methane (CBM) in the Ordos Basin is mostly concentrated on the eastern margin of the basin. The geological resources of the Benxi Formation in the Yulin area, located in the central-eastern part, cover 15,000 × 108 [...] Read more.
The research on the deep coalbed methane (CBM) in the Ordos Basin is mostly concentrated on the eastern margin of the basin. The geological resources of the Benxi Formation in the Yulin area, located in the central-eastern part, cover 15,000 × 108 m3, indicating enormous resource potential. However, the characteristics of the reservoir distribution and the favorable areas are not yet clear. This research comprehensively performed data logging, coal rock experiments, and core observations to identify the geological characteristics of the #8 coal seam, using a multi-level fuzzy mathematics method to evaluate the favorable area. The results indicate the following: (1) The thickness of the #8 coal in the Yulin Block ranges from 2.20 m to 11.37 m, with depths of between 2285.72 m and 3282.98 m, and it is mainly underlain by mudstone; the gas content ranges from 9.74 m3/t to 23.38 m3/t, showing a northwest–low and southeast–high trend. The overall area contains low-permeability reservoirs, with a prevalence of primary structural coal. (2) A multi-level evaluation system for deep CBM was established, dividing the Yulin Block into three types of favorable areas. This block features a wide range of Type I favorable areas, concentrated in the central-eastern, northern, and southwestern parts; Type II areas are closely distributed around the edges of Type I areas. The subsequent development process should prioritize the central-eastern part of the study area. The evaluation system established provides a reference for selecting favorable areas for deep CBM and offers theoretical guidance for targeted exploration and development in the Yulin area. Full article
(This article belongs to the Special Issue Shale Gas and Coalbed Methane Exploration and Practice)
12 pages, 597 KiB  
Article
Machine Learning Prediction of Tongue Pressure in Elderly Patients with Head and Neck Tumor: A Cross-Sectional Study
by Xuewei Han, Ziyi Bai, Kaoru Mogushi, Takeshi Hase, Katsuyuki Takeuchi, Yoritsugu Iida, Yuka I. Sumita and Noriyuki Wakabayashi
J. Clin. Med. 2024, 13(8), 2363; https://doi.org/10.3390/jcm13082363 (registering DOI) - 18 Apr 2024
Abstract
Background: This investigation sought to cross validate the predictors of tongue pressure recovery in elderly patients’ post-treatment for head and neck tumors, leveraging advanced machine learning techniques. Methods: By employing logistic regression, support vector regression, random forest, and extreme gradient boosting, the [...] Read more.
Background: This investigation sought to cross validate the predictors of tongue pressure recovery in elderly patients’ post-treatment for head and neck tumors, leveraging advanced machine learning techniques. Methods: By employing logistic regression, support vector regression, random forest, and extreme gradient boosting, the study analyzed an array of variables including patient demographics, surgery types, dental health status, and age, drawn from comprehensive medical records and direct tongue pressure assessments. Results: Among the models, logistic regression emerged as the most effective, demonstrating an accuracy of 0.630 [95% confidence interval (CI): 0.370–0.778], F1 score of 0.688 [95% confidence interval (CI): 0.435–0.853], precision of 0.611 [95% confidence interval (CI): 0.313–0.801], recall of 0.786 [95% confidence interval (CI): 0.413–0.938] and an area under the receiver operating characteristic curve of 0.626 [95% confidence interval (CI): 0.409–0.806]. This model distinctly highlighted the significance of glossectomy (p = 0.039), the presence of functional teeth (p = 0.043), and the patient’s age (p = 0.044) as pivotal factors influencing tongue pressure, setting the threshold for statistical significance at p < 0.05. Conclusions: The analysis underscored the critical role of glossectomy, the presence of functional natural teeth, and age as determinants of tongue pressure in logistics regression, with the presence of natural teeth and the tumor site located in the tongue consistently emerging as the key predictors across all computational models employed in this study. Full article
(This article belongs to the Special Issue State of the Art of Oral Health in Japan and Other Aging Countries)
17 pages, 1514 KiB  
Article
Nanocrystalline Cubic Phase Scandium-Stabilized Zirconia Thin Films
by Victor Danchuk, Mykola Shatalov, Michael Zinigrad, Alexey Kossenko, Tamara Brider, Luc Le, Dustin Johnson, Yuri M. Strzhemechny and Albina Musin
Nanomaterials 2024, 14(8), 708; https://doi.org/10.3390/nano14080708 (registering DOI) - 18 Apr 2024
Abstract
The cubic zirconia (ZrO2) is attractive for a broad range of applications. However, at room temperature, the cubic phase needs to be stabilized. The most studied stabilization method is the addition of the oxides of trivalent metals, such as Sc2 [...] Read more.
The cubic zirconia (ZrO2) is attractive for a broad range of applications. However, at room temperature, the cubic phase needs to be stabilized. The most studied stabilization method is the addition of the oxides of trivalent metals, such as Sc2O3. Another method is the stabilization of the cubic phase in nanostructures—nanopowders or nanocrystallites of pure zirconia. We studied the relationship between the size factor and the dopant concentration range for the formation and stabilization of the cubic phase in scandium-stabilized zirconia (ScSZ) films. The thin films of (ZrO2)1−x(Sc2O3)x, with x from 0 to 0.2, were deposited on room-temperature substrates by reactive direct current magnetron co-sputtering. The crystal structure of films with an average crystallite size of 85 Å was cubic at Sc2O3 content from 6.5 to 17.5 mol%, which is much broader than the range of 8–12 mol.% of the conventional deposition methods. The sputtering of ScSZ films on hot substrates resulted in a doubling of crystallite size and a decrease in the cubic phase range to 7.4–11 mol% of Sc2O3 content. This confirmed that the size of crystallites is one of the determining factors for expanding the concentration range for forming and stabilizing the cubic phase of ScSZ films. Full article
(This article belongs to the Special Issue Advanced Nanoscale Materials and (Flexible) Devices)
4 pages, 656 KiB  
Short Note
1-(3-Chlorophenyl)-3-(6-((1,7,7-trimethylbicyclo[2.2.1]heptan-2-ylidene)amino)hexyl)thiourea
by Daria Zapravdina and Vladimir Burmistrov
Molbank 2024, 2024(2), M1809; https://doi.org/10.3390/M1809 (registering DOI) - 18 Apr 2024
Abstract
The compound 1-(3-chlorophenyl)-3-(6-((1,7,7-trimethylbicyclo[2.2.1]heptan-2-ylidene)amino)hexyl)thiourea was synthesized for the first time from 6-((1,7,7-trimethylbicyclo[2.2.1]heptan-2-ylidene)amino)hexan-1-amine and 3-chlorophenylisothiocyanate in DMF with a 60% yield. It was characterized by 1H, 13C{1H} NMR, FT-IR, MS, and elemental analysis. Full article
(This article belongs to the Section Organic Synthesis)
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23 pages, 4128 KiB  
Article
Genomic Insights into Cyanide Biodegradation in the Pseudomonas Genus
by Lara P. Sáez, Gema Rodríguez-Caballero, Alfonso Olaya-Abril, Purificación Cabello, Conrado Moreno-Vivián, María Dolores Roldán and Víctor M. Luque-Almagro
Int. J. Mol. Sci. 2024, 25(8), 4456; https://doi.org/10.3390/ijms25084456 (registering DOI) - 18 Apr 2024
Abstract
Molecular studies about cyanide biodegradation have been mainly focused on the hydrolytic pathways catalyzed by the cyanide dihydratase CynD or the nitrilase NitC. In some Pseudomonas strains, the assimilation of cyanide has been linked to NitC, such as the cyanotrophic model strain Pseudomonas [...] Read more.
Molecular studies about cyanide biodegradation have been mainly focused on the hydrolytic pathways catalyzed by the cyanide dihydratase CynD or the nitrilase NitC. In some Pseudomonas strains, the assimilation of cyanide has been linked to NitC, such as the cyanotrophic model strain Pseudomonas pseudoalcaligenes CECT 5344, which has been recently reclassified as Pseudomonas oleovorans CECT 5344. In this work, a phylogenomic approach established a more precise taxonomic position of the strain CECT 5344 within the species P. oleovorans. Furthermore, a pan-genomic analysis of P. oleovorans and other species with cyanotrophic strains, such as P. fluorescens and P. monteilii, allowed for the comparison and identification of the cioAB and mqoAB genes involved in cyanide resistance, and the nitC and cynS genes required for the assimilation of cyanide or cyanate, respectively. While cyanide resistance genes presented a high frequency among the analyzed genomes, genes responsible for cyanide or cyanate assimilation were identified in a considerably lower proportion. According to the results obtained in this work, an in silico approach based on a comparative genomic approach can be considered as an agile strategy for the bioprospection of putative cyanotrophic bacteria and for the identification of new genes putatively involved in cyanide biodegradation. Full article
(This article belongs to the Special Issue Current Research on Omics of Microorganisms)
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19 pages, 4493 KiB  
Article
Ensemble Empirical Mode Decomposition Granger Causality Test Dynamic Graph Attention Transformer Network: Integrating Transformer and Graph Neural Network Models for Multi-Sensor Cross-Temporal Granularity Water Demand Forecasting
by Wenhong Wu and Yunkai Kang
Appl. Sci. 2024, 14(8), 3428; https://doi.org/10.3390/app14083428 (registering DOI) - 18 Apr 2024
Abstract
Accurate water demand forecasting is crucial for optimizing the strategies across multiple water sources. This paper proposes the Ensemble Empirical Mode Decomposition Granger causality test Dynamic Graph Attention Transformer Network (EG-DGATN) for multi-sensor cross-temporal granularity water demand forecasting, which combines the Transformer and [...] Read more.
Accurate water demand forecasting is crucial for optimizing the strategies across multiple water sources. This paper proposes the Ensemble Empirical Mode Decomposition Granger causality test Dynamic Graph Attention Transformer Network (EG-DGATN) for multi-sensor cross-temporal granularity water demand forecasting, which combines the Transformer and Graph Neural Networks. It employs the EEMD‒Granger test to delineate the interconnections among sensors and extracts the spatiotemporal features within the causal domain by stacking dynamical graph spatiotemporal attention layers. The experimental results demonstrate that compared to baseline models, the EG-DGATN improves the MAPE metrics by 2.12%, 4.33%, and 6.32% in forecasting intervals of 15 min, 45 min, and 90 min, respectively. The model achieves an R2 score of 0.97, indicating outstanding predictive accuracy and exceptional explanatory power for the target variable. This research highlights significant potential applications in predictive tasks within smart water management systems. Full article
31 pages, 385 KiB  
Article
The Vertex Gutman Index and Gutman Index of the Union of Two Cycles
by Yinzhen Mei and Hongli Miao
Axioms 2024, 13(4), 269; https://doi.org/10.3390/axioms13040269 (registering DOI) - 18 Apr 2024
Abstract
The Wiener index is one of the most classic and widely used indicators in topology. It reflects the average distance of any node pair in the graph. It not only makes the boundaries of given graphs clearer but also continuously generates topological indices [...] Read more.
The Wiener index is one of the most classic and widely used indicators in topology. It reflects the average distance of any node pair in the graph. It not only makes the boundaries of given graphs clearer but also continuously generates topological indices that are more suitable for new fields, such as the Gutman index. The Wiener index and Gutman index are two important topological indices, which are commonly used to describe the characteristics of molecular structure. They are closely related to the physical and chemical properties of molecular compounds. And they are widely used to predict the physical and chemical properties and biological activity of molecular compounds. In this paper, we study the vertex Gutman index and Gutman index and describe the structural characteristics of all cases of two simple cycles intersecting. We comprehensively analyze the Gutman index and vertex Gutman index in these cases in detail by means of classification discussion and analogical reasoning and characterize their maximum and minimum accordingly. Full article
(This article belongs to the Special Issue Advances in Convex Geometry and Analysis)
15 pages, 1539 KiB  
Article
Variability in Mechanical Properties and Cracking Behavior of Frozen Sandstone Containing En Echelon Flaws under Compression
by Weimin Liu, Li Han, Di Wu, Hailiang Jia and Liyun Tang
Appl. Sci. 2024, 14(8), 3427; https://doi.org/10.3390/app14083427 (registering DOI) - 18 Apr 2024
Abstract
The mechanical properties of frozen fissured rock masses are crucial considerations for engineering in frozen earth. However, there has been little research on the mechanical properties of frozen fissured sandstone, including its strength, deformation, and geometric parameters. In this study, sandstone samples with [...] Read more.
The mechanical properties of frozen fissured rock masses are crucial considerations for engineering in frozen earth. However, there has been little research on the mechanical properties of frozen fissured sandstone, including its strength, deformation, and geometric parameters. In this study, sandstone samples with three open en echelon fissures were observed using high-speed photography and acoustic emissions during uniaxial compression tests. The aim was to investigate sandstone’s strength, deformability, and failure process in order to elucidate the effects of freezing on its mechanical properties. In the frozen-saturated and dried states, the uniaxial compression strength (UCS) initially decreases and then increases with an increase in fissure inclination angle. Conversely, the UCS of samples in the saturated state continuously increases. The UCS follows a decreasing trend, as follows: frozen-saturated state > dried state > saturated state. The initial crack angle decreases as the fissure inclination increases in all states, irrespective of temperature and moisture conditions. However, the initial crack stress and time show an increasing trend. The uniaxial compression strength (UCS) of frozen fissured sandstone is influenced by four mechanisms: (1) ice provides support to the rock under compression, (2) ice fills microcracks, (3) unfrozen water films act as a cementing agent under tension or shearing loads, and (4) frost damage leads to softening of the rock. Full article
26 pages, 2158 KiB  
Article
Linear Parameter Varying Observer-Based Adaptive Dynamic Surface Sliding Mode Control for PMSM
by Tongtong Li, Liang Tao and Binzi Xu
Mathematics 2024, 12(8), 1219; https://doi.org/10.3390/math12081219 (registering DOI) - 18 Apr 2024
Abstract
This paper presents an adaptive dynamic surface sliding mode control technique to address the issue of system parameter changes in permanent magnet synchronous motor (PMSM) position servo systems. The proposed method involves adopting a linear parameter varying (LPV) observer-based parameter identification algorithm and [...] Read more.
This paper presents an adaptive dynamic surface sliding mode control technique to address the issue of system parameter changes in permanent magnet synchronous motor (PMSM) position servo systems. The proposed method involves adopting a linear parameter varying (LPV) observer-based parameter identification algorithm and adaptive control technique. Initially, a mathematical model of the PMSM is established, and the system parameters are divided into nominal and perturbation values. This allows for the reconstruction of the system model into a state space equation that incorporates the unknown perturbation parameters. To accurately estimate these unknown parameters, an LPV observer is designed based on the reconstructed model. Additionally, an adaptive dynamic surface sliding mode control technique is explored to achieve the desired tracking performance. Meanwhile, an exponential reaching law is introduced to expedite the dynamic behavior of the system and mitigate chattering. Finally, a suitable Lyapunov function is selected to ensure the overall stability of the system. The simulation results demonstrate the effectiveness of the parameter identification and control algorithm in achieving good identification and tracking control ability for PMSM systems. Full article
21 pages, 13440 KiB  
Article
Stingray Sensor System for Persistent Survey of the GEO Belt
by Tanner Campbell, Adam Battle, Dan Gray, Om Chabra, Scott Tucker, Vishnu Reddy and Roberto Furfaro
Sensors 2024, 24(8), 2596; https://doi.org/10.3390/s24082596 (registering DOI) - 18 Apr 2024
Abstract
The Stingray sensor system is a 15-camera optical array dedicated to the nightly astrometric and photometric survey of the geosynchronous Earth orbit (GEO) belt visible above Tucson, Arizona. The primary scientific goal is to characterize GEO and near-GEO satellites based on their observable [...] Read more.
The Stingray sensor system is a 15-camera optical array dedicated to the nightly astrometric and photometric survey of the geosynchronous Earth orbit (GEO) belt visible above Tucson, Arizona. The primary scientific goal is to characterize GEO and near-GEO satellites based on their observable properties. This system is completely autonomous in both data acquisition and processing, with human oversight reserved for data quality assurance and system maintenance. The 15 ZWO ASI1600MM Pro cameras are mated to Sigma 135 mm f/1.8 lenses and are controlled simultaneously by four separate computers. Each camera is fixed in position and observes a 7.6-by-5.8-degree portion of the GEO belt, for a total of a 114-by-5.8-degree field of regard. The GAIA DR2 star catalog is used for image astrometric plate solution and photometric calibration to GAIA G magnitudes. There are approximately 200 near-GEO satellites on any given night that fall within the Stingray field of regard, and all those with a GAIA G magnitude brighter than approximately 15.5 are measured by the automated data reduction pipeline. Results from an initial one-month survey show an aggregate photometric uncertainty of 0.062 ± 0.008 magnitudes and astrometric accuracy consistent with theoretical sub-pixel centroid limits. Provided in this work is a discussion of the design and function of the system, along with verification of the initial survey results. Full article
(This article belongs to the Special Issue Optical Sensors for Space Situational Awareness)
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21 pages, 17397 KiB  
Article
Considerations on the Failure Mechanisms at Fatigue Loading of 1018 Steel Samples Coated with Wip-C1 by Cold Spray
by Layth Alkisswani, Viorel Goanta, Corneliu Munteanu, Fayez Samara, Roxana Elena Cosau and Bogdan Istrate
Materials 2024, 17(8), 1868; https://doi.org/10.3390/ma17081868 (registering DOI) - 18 Apr 2024
Abstract
There are some important advantages presented by metal specimens coated with WIP-C1 (Ni/CrC)-type materials. However, given the coating methods and the stress under dynamic loads, there are issues that need to be taken into account, particularly in terms of the behavior at the [...] Read more.
There are some important advantages presented by metal specimens coated with WIP-C1 (Ni/CrC)-type materials. However, given the coating methods and the stress under dynamic loads, there are issues that need to be taken into account, particularly in terms of the behavior at the interface between the two materials. Using standardized cylindrical 1018 steel specimens uniformly coated with WIP-C1 (Ni/CrC) by cold spraying, this study investigated the fatigue behavior of the specimen as a whole, focusing on the interface areas of the two materials. The fatigue life diagram is given, to a large extent, by the behavior of the base material. As a result, in this work, we have focused not so much on the fatigue behavior of the assembly as on the integrity of the coating material and the defects, failures, etc., that may occur at the interface after a certain number of cycles. The applied load was cyclic fatigue through alternating–symmetric cycles. Scanning optical microscopy was used to observe plastic deformations and crack propagation during the breakage process. It was found that both the base material zone and the cover material zone presented good performance when the maximum stresses were at low values. A fatigue durability curve was also plotted, showing a conventional appearance for a metallic material, slightly influenced by the destruction of the base material interface. At higher maximum stress and, consequently, to large strains, a series of destructions at the interface of the two materials, of different types, were observed and will be highlighted in the paper. Full article
(This article belongs to the Special Issue Advanced Materials for Multifunctional Applications, 2nd Edition)
17 pages, 6954 KiB  
Article
Smart Textile Flexible MnCo2O4 Electrodes: Urea Surface Modification for Improved Electrochemical Functionality
by Manesh A. Yewale, Aviraj M. Teli, Sonali A. Beknalkar, Vineet Kumar and Dong-Kil Shin
Materials 2024, 17(8), 1866; https://doi.org/10.3390/ma17081866 (registering DOI) - 18 Apr 2024
Abstract
Surface microstructure modification of metal oxides also improves the electrochemical performance of metal oxide nanoparticles. The present investigation demonstrates how varying the urea molar content during the hydrothermal process altered the surfaces of MnCo2O4 nanoparticles. Successive increases of 0.1 M [...] Read more.
Surface microstructure modification of metal oxides also improves the electrochemical performance of metal oxide nanoparticles. The present investigation demonstrates how varying the urea molar content during the hydrothermal process altered the surfaces of MnCo2O4 nanoparticles. Successive increases of 0.1 M in urea concentration transformed the surface shape of MnCo2O4 nanoparticles from flower-like to sheet-like microstructures. Excellent electrochemical performance of MnCo2O4 nanoparticles was demonstrated in an aqueous 1 M KOH electrolyte. The improved MnCo2O4 nanoparticles have been employed to develop an asymmetric supercapacitor (ASC). The ASC device exhibits an energy density of 13 Wh/kg at a power density of 553 W/kg and a specific capacitance of 29 F g−1 at a current density of 4 mA/cm2. The MnCo2O4 nanoparticle electrode demonstrates remarkable electrocatalytic activity in both HER and OER. The MnCo2O4 electrode shows overpotential for HER and OER at 356 mV and 1.46 V, respectively. The Tafel slopes for HER and OER of the MnCo2O4 electrode are 356 mV/dec and 187 mV/dec, respectively. Full article
(This article belongs to the Special Issue Flexible Electrode for Energy Harvesting and Storage Applications)
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11 pages, 1842 KiB  
Article
Peritoneal Flap Following Lymph Node Dissection in Robotic Radical Prostatectomy: A Novel “Bunching” Technique
by Ahmed Gamal, Marcio Covas Moschovas, Abdel Rahman Jaber, Shady Saikali, Marco Sandri, Ela Patel, Evan Patel, Travis Rogers and Vipul Patel
Cancers 2024, 16(8), 1547; https://doi.org/10.3390/cancers16081547 (registering DOI) - 18 Apr 2024
Abstract
Background: Pelvic lymph node dissection (PLND) is recommended while performing robot-assisted radical prostatectomy (RARP) for patients with localized intermediate or high-risk prostate cancer. However, symptomatic lymphoceles can occur after surgery, adding significant morbidity to patients. Our objective is to describe a novel Peritoneal [...] Read more.
Background: Pelvic lymph node dissection (PLND) is recommended while performing robot-assisted radical prostatectomy (RARP) for patients with localized intermediate or high-risk prostate cancer. However, symptomatic lymphoceles can occur after surgery, adding significant morbidity to patients. Our objective is to describe a novel Peritoneal Bladder Flap Bunching technique (PBFB) to reduce the risk of clinically significant lymphoceles in patients undergoing RARP and PLND. Methods: We evaluated 2267 patients who underwent RARP with PLND, dividing them into two groups: Group 1, comprising 567 patients who had the peritoneal flap (PBFB), and Group 2, comprising 1700 patients without the flap; propensity score matching carried out at a 1:3 ratio. Variables analyzed included estimated blood loss (EBL), operative time, postoperative complications, lymphocele formation, and the development of symptomatic lymphocele. Results: The two groups exhibited similar preoperative characteristics after matching. There was no statistically significant difference in the occurrence of lymphoceles between the flap group and the non-flap group, with rates of 24% and 20.9%, respectively (p = 0.14). However, none of the patients in the flap group (0%) developed symptomatic lymphoceles, whereas 2.2% of patients in the non-flap group experienced symptomatic lymphoceles (p = 0.01). Conclusion: We have demonstrated a modified technique for a peritoneal flap (PBFB) with the initial elimination of postoperative symptomatic lymphoceles and promising short-term outcomes. Full article
(This article belongs to the Special Issue Advances in the Management of Pelvic Tumors)
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25 pages, 6608 KiB  
Article
Integrating Proteomics and Transcriptomics Reveals The Potential Pathways of Hippocampal Neuron Apoptosis in Dravet Syndrome Model Mice
by Xuerui Kong, Gaohe Dai, Zhong Zeng, Yi Zhang, Jiarong Gu, Teng Ma, Nina Wang, Jinhai Gu and Yin Wang
Int. J. Mol. Sci. 2024, 25(8), 4457; https://doi.org/10.3390/ijms25084457 (registering DOI) - 18 Apr 2024
Abstract
An important component contributing to the onset of epilepsy is the death of hippocampal neurons. Several studies have shown that Dravet syndrome model mice: Scn1a KO mice have a high number of apoptotic neurons following seizures, but the precise mechanism underlying this remains [...] Read more.
An important component contributing to the onset of epilepsy is the death of hippocampal neurons. Several studies have shown that Dravet syndrome model mice: Scn1a KO mice have a high number of apoptotic neurons following seizures, but the precise mechanism underlying this remains unclear. The aim of this research was to elucidate the potential molecular mechanism of neuronal apoptosis in Scn1a KO mice by integrating proteomics and transcriptomics, with the ultimate goal of offering better neuroprotection. We found that apoptotic processes were enriched in both proteomic and transcriptomic GO analyses, and KEGG results also indicated that differential proteins and genes play a role in neurotransmission, the cell cycle, apoptosis, and neuroinflammation. Then, we examined the upstream and downstream KGML interactions of the pathways to determine the relationship between the two omics, and we found that the HIF-1 signaling pathway plays a significant role in the onset and apoptosis of epilepsy. Meanwhile, the expression of the apoptosis-related protein VHL decreased in this pathway, and the expression of p21 was upregulated. Therefore, this study suggests that VHL/HIF-1α/p21 might be involved in the apoptosis of hippocampal neurons in Scn1a KO mice. Full article
(This article belongs to the Section Molecular Neurobiology)
16 pages, 925 KiB  
Article
The Evolution of Cooperation and Diversity under Integrated Indirect Reciprocity
by Tatsuya Sasaki, Satoshi Uchida, Isamu Okada and Hitoshi Yamamoto
Games 2024, 15(2), 15; https://doi.org/10.3390/g15020015 (registering DOI) - 18 Apr 2024
Abstract
Indirect reciprocity is one of the major mechanisms driving the evolution of cooperation in human societies. There are two types of indirect reciprocity: upstream and downstream reciprocity. Cooperation in downstream reciprocity follows the pattern ‘You helped someone, and I will help you’, while [...] Read more.
Indirect reciprocity is one of the major mechanisms driving the evolution of cooperation in human societies. There are two types of indirect reciprocity: upstream and downstream reciprocity. Cooperation in downstream reciprocity follows the pattern ‘You helped someone, and I will help you’, while the direction of cooperation is reversed in upstream reciprocity, which follows the pattern ‘You helped me, and I will help someone else’. These two types of indirect reciprocity often occur in combination. However, upstream and downstream reciprocity have mostly been theoretically studied in isolation. In this study, we propose a new model that integrates both types of reciprocity. In particular, we apply the standard giving-game framework of indirect reciprocity and analyze the three-strategy model including reciprocal altruists, indiscriminate altruists, and free riders using evolutionary game theory. We show that the model allows reciprocal altruists and free riders to coexist stably in well-mixed populations. We also find that by accounting for inattention in the assessment rule, the stability of this mixed equilibrium can be strengthened to prevent the invasion of infamous indiscriminate altruists and can even be made globally stable. Full article
(This article belongs to the Section Cooperative Game Theory and Bargaining)
23 pages, 700 KiB  
Article
Harnessing Test-Oriented Knowledge Graphs for Enhanced Test Function Recommendation
by Kaiqi Liu, Ji Wu, Qing Sun, Haiyan Yang and Ruiyuan Wan
Electronics 2024, 13(8), 1547; https://doi.org/10.3390/electronics13081547 (registering DOI) - 18 Apr 2024
Abstract
Application Programming Interfaces (APIs) have become common in contemporary software development. Many automated API recommendation methods have been proposed. However, these methods suffer from a deficit of using domain knowledge, giving rise to challenges like the “cold start” and “semantic gap” problems. Consequently, [...] Read more.
Application Programming Interfaces (APIs) have become common in contemporary software development. Many automated API recommendation methods have been proposed. However, these methods suffer from a deficit of using domain knowledge, giving rise to challenges like the “cold start” and “semantic gap” problems. Consequently, they are unsuitable for test function recommendation, which recommends test functions for test engineers to implement test cases formed with various test steps. This paper introduces an approach named TOKTER, which recommends test functions leveraging test-oriented knowledge graphs. Such a graph contains domain concepts and their relationships related to the system under test and the test harness, which is constructed from the corpus data of the concerned test project. TOKTER harnesses the semantic associations between test steps (or queries) and test functions by considering literal descriptions, test function parameters, and historical data. We evaluated TOKTER with an industrial dataset and compared it with three state-of-the-art approaches. Results show that TOKTER significantly outperformed the baseline by margins of at least 36.6% in mean average precision (MAP), 19.6% in mean reciprocal rank (MRR), and 1.9% in mean recall (MR) for the top-10 recommendations. Full article
(This article belongs to the Section Computer Science & Engineering)
21 pages, 885 KiB  
Article
Resistance Feedback of a Ni-Ti Alloy Actuator at Room Temperature in Still Air
by Francesco Durante, Terenziano Raparelli and Pierluigi Beomonte Zobel
Micromachines 2024, 15(4), 545; https://doi.org/10.3390/mi15040545 (registering DOI) - 18 Apr 2024
Abstract
This paper illustrates an experimental activity for the closed-loop position control of an actuator made using shape memory alloy (SMA) wire. A solution with the self-sensing effect was implemented to miniaturize the systems, i.e., without external sensors. A proportional control algorithm was initially [...] Read more.
This paper illustrates an experimental activity for the closed-loop position control of an actuator made using shape memory alloy (SMA) wire. A solution with the self-sensing effect was implemented to miniaturize the systems, i.e., without external sensors. A proportional control algorithm was initially used, demonstrating the idea’s feasibility; the wire can behave simultaneously as an actuator and sensor. An experimental investigation was subsequently conducted for the optimization of the developed actuator. As for the material, a Flexinol wire, Ni-Ti alloy, with a diameter of 0.150 mm and a length of 200 mm, was used. Preliminarily, characterization of the SMA wire at constant and variable loads was carried out; the characteristics detected were elongation vs. electric current and elongation vs. electrical resistance. The control system is PC based with a data acquisition card (DAQ). A drive board was designed and built to read the wire’s electrical resistance and power it by pulse width modulation (PWM). A notable result is that the actuator works with good precision and in dynamic conditions, even when it is called to support a load up to 65% different from that for which the electrical resistance–length correlation has previously been experimentally obtained, on which the control is based. This opens up the possibility of using the actuator in a counteracting configuration with a spring, which makes hardware implementation and control management simple. Full article
(This article belongs to the Special Issue Smart Material-Based Micromechatronics in Soft Robotics)
17 pages, 1169 KiB  
Article
Research on the Stability Control Strategy of High-Speed Steering Intelligent Vehicle Platooning
by Guangbing Xiao, Zhicheng Li, Ning Sun and Yong Zhang
World Electr. Veh. J. 2024, 15(4), 169; https://doi.org/10.3390/wevj15040169 (registering DOI) - 18 Apr 2024
Abstract
Based on an investigation of how vehicle structural characteristics and system parameters influence the motion stability of high-speed steering intelligent vehicle platooning, a control strategy for ensuring motion stability is proposed. This strategy is based on a virtual articulated concept and is validated [...] Read more.
Based on an investigation of how vehicle structural characteristics and system parameters influence the motion stability of high-speed steering intelligent vehicle platooning, a control strategy for ensuring motion stability is proposed. This strategy is based on a virtual articulated concept and is validated using both characteristic equation analysis and time domain analysis methods. To create a system, any two adjacent front and rear vehicles in the intelligent vehicle platooning are connected using a virtual articulated model constructed through the virtual structure method. A ten-degrees-of-freedom model of the intelligent vehicle platooning system is established, taking into account the nonlinearities of the tire and steering systems, utilizing the principles of the second Lagrange equation theory. The system damping ratio is determined through characteristic equation analysis, and the system’s dynamic critical speed is assessed by examining the relationship between the damping ratio and the motion stability of the intelligent vehicle platooning, serving as an indicator of system stability. By applying sensitivity analysis, control variable analysis, and time domain analysis methods, the influence of vehicle structural characteristics and system parameters on the system’s dynamic critical speed and motion stability under lateral disturbances within the intelligent vehicle platooning is thoroughly investigated, thereby validating the soundness of the proposed control strategy. Full article
(This article belongs to the Special Issue Design Theory, Method and Control of Intelligent and Safe Vehicles)
17 pages, 2140 KiB  
Article
Changes in Surface and Terrestrial Waters in the China–Pakistan Economic Corridor Due to Climate Change and Human Activities
by Jiayu Bao, Yanfeng Wu, Xiaoran Huang, Peng Qi, Ye Yuan, Tao Li, Tao Yu, Ting Wang, Pengfei Zhang, Vincent Nzabarinda, Sulei Naibi, Jingyu Jin, Gang Long and Shuya Yang
Remote Sens. 2024, 16(8), 1437; https://doi.org/10.3390/rs16081437 (registering DOI) - 18 Apr 2024
Abstract
The surface water area (SWA) and terrestrial water storage (TWS) are both essential metrics for assessing regional water resources. However, the combined effects of climate change and human activities on the dynamics of the SWA and TWS have not been extensively researched within [...] Read more.
The surface water area (SWA) and terrestrial water storage (TWS) are both essential metrics for assessing regional water resources. However, the combined effects of climate change and human activities on the dynamics of the SWA and TWS have not been extensively researched within the context of the CPEC. To fill this gap, we first analyzed the annual changes in the SWA and TWS in the China–Pakistan Economic Corridor (CPEC) region in recent decades using the methods of correlation analysis and Geodetector. Our findings indicate that Sindh exhibited the highest increase in the SWA at 8.68 ha/km2, whereas FATA showed the least increase at 0.2 ha/km2 from 2002 to 2018. Punjab exhibited a significant decrease in TWS, with a slope of −0.48 cm/year. Azad Kashmir followed with a decrease in TWS at a rate of −0.36 cm/year. Khyber Pakhtunkhwa and FATA exhibited an insignificant increase in TWS, with values of 0.02 cm/year and 0.11 cm/year, respectively. TWS was significantly positively correlated with the SWA in Balochistan and Khyber Pakhtunkhwa. However, other regions showed inconsistent changes; in particular, a decline was observed in Gilgit–Baltistan. The changes in TWS in Balochistan were primarily influenced by the SWA and climate change, while TWS changes in FATA were mainly affected by climate change. In addition, human activities had a primary impact on the TWS changes in Azad Kashmir, Punjab, and Sindh. The influencing factors of TWS changes in different regions of the CPEC mainly involved a dual-factor enhancement and the nonlinear weakening of single factors. These results highlight that under the effect of climate change and human activities, TWS may not increase as surface water area increases. This study contributes to a better understanding of water resource dynamics and can aid in the development of strategies for the efficient and sustainable use of water resources in the CPEC. Full article
21 pages, 9709 KiB  
Article
Research on Two Improved High–Voltage–Transfer–Ratio Space–Vector Pulse–Width–Modulation Strategies Applied to Five–Phase Inverter
by Mingchen Jing, Yihui Xia and Bin Zhang
Electronics 2024, 13(8), 1546; https://doi.org/10.3390/electronics13081546 (registering DOI) - 18 Apr 2024
Abstract
Considering that the defects of traditional nearest–two–vector SVPWM (NTV–SVPWM) have a low voltage transfer ratio (VTR) and those of nearest–four–vector SVPWM (NFV–SVPWM) have a high output current harmonic, two improved space–voltage pulse–width–modulation (SVPWM) strategies are proposed in this paper, based on analyzing the [...] Read more.
Considering that the defects of traditional nearest–two–vector SVPWM (NTV–SVPWM) have a low voltage transfer ratio (VTR) and those of nearest–four–vector SVPWM (NFV–SVPWM) have a high output current harmonic, two improved space–voltage pulse–width–modulation (SVPWM) strategies are proposed in this paper, based on analyzing the harmonic characteristics of traditional NTV–SVPWM and NFV–SVPWM. The first strategy is to synthesize the referenced voltage vector according to the different weight factors by NTV–SVPWM and NFV–SVPWM. The second strategy is to synthesize the referenced voltage vector according to the different weight factors of NFV–SVPWM and the large vector. Compared to NTV–SVPWM, the simulation results show that the two proposed SVPWM strategies have lower output voltage errors and THDs. Compared to NFV–SVPWM, the simulation results show that the two proposed SVPWM strategies have higher VTRs and THDs. Compared to the two proposed SVPWM strategies, proposed SVPWM strategy one has a lower output voltage error and THD. The experimental results verify that the proposed modulation strategy is correct and feasible. Full article
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16 pages, 1375 KiB  
Systematic Review
Oral Mucositis Management in Children under Cancer Treatment: A Systematic Review
by Ricardo Braguês, Maria Francisca Marvão, Patrícia Correia and Raquel M. Silva
Cancers 2024, 16(8), 1548; https://doi.org/10.3390/cancers16081548 (registering DOI) - 18 Apr 2024
Abstract
Children undergoing antineoplastic treatment often present severe side effects due to the dosage and duration of treatments, with oral mucositis emerging as one of the most prevalent and painful inflammatory conditions. There is a growing body of evidence on therapeutic interventions such as [...] Read more.
Children undergoing antineoplastic treatment often present severe side effects due to the dosage and duration of treatments, with oral mucositis emerging as one of the most prevalent and painful inflammatory conditions. There is a growing body of evidence on therapeutic interventions such as cryotherapy, low-level laser therapy, and natural compounds for this condition. The aim of this systematic review was to identify and compare therapies for the management of cancer treatment-induced oral mucositis in pediatric patients. From 2655 articles obtained in initial searches, 39 articles were considered in this systematic review, after applying inclusion/exclusion criteria. Low-level laser therapy, palifermin, honey, and zinc demonstrated reductions in oral mucositis incidence, duration, severity, and pain reported by the patient. Although there are several therapies in place for the prevention and treatment of oral mucositis in children, evidence of their efficacy is still inconclusive to establish accurate clinical protocols. Full article
(This article belongs to the Special Issue Supportive Care for Patients with Cancer)
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11 pages, 802 KiB  
Article
Effectiveness of Non-Pharmacological Interventions for Dementia among the Elderly: A Randomized Controlled Trial
by Huong Thu Vu, Hung Trong Nguyen and Anh Trung Nguyen
Geriatrics 2024, 9(2), 52; https://doi.org/10.3390/geriatrics9020052 (registering DOI) - 18 Apr 2024
Abstract
(1) Background: Up until now, there is still no medicine that can cure dementia, but there are some that can only help slow down the progression of the disease and reduce some symptoms. Pharmacological interventions for dementia have many side effects and are [...] Read more.
(1) Background: Up until now, there is still no medicine that can cure dementia, but there are some that can only help slow down the progression of the disease and reduce some symptoms. Pharmacological interventions for dementia have many side effects and are expensive, so non-pharmacological treatments for dementia become more urgent. This study aimed to evaluate the effectiveness of multifactorial non-pharmacological interventions in dementia patients; (2) Methods: This is a randomized controlled trial conducted in Hai Duong from July 2021 to December 2022. Selected subjects included 88 patients diagnosed with very mild, mild, and moderate dementia, of whom 44 patients were assigned to the intervention group and 44 patients to the control group; (3) Results: For the effectiveness of the non-pharmacological multifactorial intervention on depression severity: in the intervention group, the GDS 15 depression score decreased from 4.8 to 2.9, while, in the control group, the GDS 15 depression score increased by 1.3 points after six months of no intervention. For the effect of the non-pharmacological multifactorial intervention on the level of sleep disturbance, in the intervention group, the PSQI sleep disturbance score decreased by nearly half (from 10.2 to 5.6), while, in the control group, this trend was not clear. For the effect of the non-pharmacological multifactorial intervention on daily functioning: in the intervention group, the ADL and IADL scores improved (1.02 ± 1.32 and 1.23 ± 1.75), while, in the control group, the ADL and IADL scores decreased (0.93 ± 1.2 and 0.98 ± 2.19). For the effect of the non-pharmacological multifactorial intervention on quality of life: in the intervention group, the EQ-5D-5L scores improved (0.17 ± 0.19), while, in the control group, the EQ-5D-5L scores decreased (0.20 ± 0.30); (4) Conclusions: Non-pharmacological multifactorial interventions, including physical activity, cognitive training, listening to educational lectures, and organizing miniature social models, have been shown to improve mental health, self-control, and quality of life. Full article
(This article belongs to the Section Geriatric Public Health)

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