The 2023 MDPI Annual Report has
been released!
 
13 pages, 1324 KiB  
Article
Advancing in Cesium Retention: Application of Magnesium Phosphate Cement Composites
by Sana Gharsallah, Nawel Khitouni, Abdulrahman Mallah, Abdulrahman Alsawi, Abdullah H. Alluhayb, Mohamed Khitouni, Clarence Charnay and Mahmoud Chemingui
Materials 2024, 17(9), 2132; https://doi.org/10.3390/ma17092132 (registering DOI) - 01 May 2024
Abstract
A serious risk that harms the safe use of water and affects aquatic ecosystems is water pollution. This occurs when the water’s natural equilibrium is disrupted by an excessive amount of substances, both naturally occurring and as a byproduct of human activities, that [...] Read more.
A serious risk that harms the safe use of water and affects aquatic ecosystems is water pollution. This occurs when the water’s natural equilibrium is disrupted by an excessive amount of substances, both naturally occurring and as a byproduct of human activities, that have varied degrees of toxicity. Radiation from Cs isotopes, which are common components of radioactive waste and are known for their long half-lives (30 years), which are longer than the natural decay processes, is a major source of contamination. Adsorption is a commonly used technique for reducing this kind of contamination, and zeolite chabazite has been chosen as the best adsorbent for cesium in this particular situation. The purpose of this research is to investigate a composite material based on magnesium phosphate cement (MPC). Magnesium oxide (MgO), potassium dihydrogen phosphate (KH2PO4), and properly selected retarders are used to create the MPC. The optimal conditions for this composite material are investigated through the utilization of X-ray diffraction, scanning electron microscopy, BET surface area analysis, and atomic absorption spectroscopy. The principal aim is to enable innovations in the elimination of radioactive waste-contaminated water using effective cesium removal. The most promising results were obtained by using KH2PO4 as an acid, and MgO as a base, and aiming for an M/P ratio of two or four. Furthermore, we chose zeolite chabazite as a crucial component. The best adsorption abilities for Cs were found at Qads = 106.997 mg/g for S2 and Qads = 122.108 mg/g for S1. As a result, zeolite is an eco-friendly material that is a potential usage option, with many benefits, such as low prices, stability, and ease of regeneration and use. Full article
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19 pages, 1288 KiB  
Article
Composting Dairy Manure with Biochar: Compost Characteristics, Aminopyralid Residual Concentrations, and Phytotoxicity Effects
by Annesly Netthisinghe, Paul Woosley, William Strunk, Getahun Agga and Karamat Sistani
Agronomy 2024, 14(5), 952; https://doi.org/10.3390/agronomy14050952 (registering DOI) - 01 May 2024
Abstract
Aminopyralid (2-pyridine carboxylic acid, 4-amino-3, 6-dichloro-2-pyridine carboxylic acid) is an auxin herbicide that has been used widely to control broadleaf weeds in pasture and hay fields. With no post-application withdrawal time, aminopyralid absorbed into forage material can contaminate compost feed stocks such as [...] Read more.
Aminopyralid (2-pyridine carboxylic acid, 4-amino-3, 6-dichloro-2-pyridine carboxylic acid) is an auxin herbicide that has been used widely to control broadleaf weeds in pasture and hay fields. With no post-application withdrawal time, aminopyralid absorbed into forage material can contaminate compost feed stocks such as hay, grass bedding material, and manure. Composts derived from such feed stocks raises concerns about after-effect injuries to sensitive crops by residual aminopyralids. Biochar (BC) additive may affect the composting process and immobilizes organic pollutants. This study examined the effect of composting dairy manure/sawdust 1:1 mixture containing 10 ppb (wet) of aminopyralid with 0%, 2%, 4%, and 10% (w/w) BC levels on chemical and biological characteristics of compost, residual aminopyralid concentration, and intensity of plant injury to tomato (Lycopersicon esculentum L.) plants after composting in 140 L plastic rotary drum reactors for two 6-month cycles. Biochar addition decreased organic matter degradation and intensified reduction in residual aminopyralid levels in a dose-dependent manner. Composting with BC concentrated more N, P, and K, caused mild plant injuries, and increased the above ground biomass compared to the no BC incorporation. Addition of BC for composting aminopyralid-contaminated dairy manure can increase the phyto safety level of compost while enhancing the key fertilizer values. Full article
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23 pages, 11518 KiB  
Article
A Quantitative and Qualitative Experimental Framework for the Evaluation of Urban Soundscapes: Application to the City of Sidi Bou Saïd
by Mohamed Amin Hammami and Christophe Claramunt
ISPRS Int. J. Geo-Inf. 2024, 13(5), 152; https://doi.org/10.3390/ijgi13050152 (registering DOI) - 01 May 2024
Abstract
This research introduces an experimental framework based on 3D acoustic and psycho-acoustic sensors supplemented with ambisonics and sound morphological analysis, whose objective is to study urban soundscapes. A questionnaire that highlights the differences between what has been measured and what has been perceiveSd [...] Read more.
This research introduces an experimental framework based on 3D acoustic and psycho-acoustic sensors supplemented with ambisonics and sound morphological analysis, whose objective is to study urban soundscapes. A questionnaire that highlights the differences between what has been measured and what has been perceiveSd by humans complements the quantitative approach with a qualitative evaluation. The comparison of the measurements with the questionnaire provides a global vision of the perception of these soundscapes, as well as differences and similarities. The approach is experimented within the historical center of the Tunisian city of Sidi Bou Saïd, demonstrating that from a range of complementary protocols, a soundscape environment can be qualified. This framework provides an additional dimension to urban planning studies. Full article
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17 pages, 5600 KiB  
Article
Bead-Free Electrospun Nanofibrous Scaffold Made of PVOH/Keratin/Chitosan Using a Box–Behnken Experimental Design and In Vitro Studies
by Mohammad Tajul Islam, Afsana Al Sharmin, Raechel Laing, Michelle McConnell and M. Azam Ali
Polysaccharides 2024, 5(2), 112-128; https://doi.org/10.3390/polysaccharides5020009 (registering DOI) - 01 May 2024
Abstract
Bead-free nanofibrous scaffolds composed of PVOH/keratin/chitosan were prepared using electrospinning after optimising the process parameters using a Box–Behnken experimental design. Two quadratic models were developed to optimise the fibre diameter and the diameter of fibre beads considering the voltage, flow rate, spinning distance, [...] Read more.
Bead-free nanofibrous scaffolds composed of PVOH/keratin/chitosan were prepared using electrospinning after optimising the process parameters using a Box–Behnken experimental design. Two quadratic models were developed to optimise the fibre diameter and the diameter of fibre beads considering the voltage, flow rate, spinning distance, and amount of biopolymer as independent variables. All independent variables were found to be significant in determining responses, although not all interactions among these were significant. The models were highly effective in describing responses, with an R2 of 98.58 and 99.67%. The optimum conditions were determined to be 15.82 kV voltage, 0.25 mL/h flow rate, 105 mm spinning distance, and 30% biopolymers. The accuracy of the models was verified and found to be within an acceptable range. The bead-free nanofibrous scaffold exhibited no cytotoxicity to Human Aneuploid Immortal Keratinocyte (HaCaT) and Normal Human Dermal Fibroblast (NHDF) cell lines, enabling cell adhesion and proliferation. Both cell lines remained attached with perfect cell morphology when co-cultured on the scaffold for 30 days, indicating the scaffold’s potential for biomedical applications. Full article
(This article belongs to the Special Issue Latest Research on Polysaccharides: Structure and Applications)
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19 pages, 2761 KiB  
Article
Optimization of Cyanocobalamin (Vitamin B12) Sorption onto Mesoporous Superparamagnetic Iron Oxide Nanoparticles
by Jolanta Flieger, Natalia Żuk, Sylwia Pasieczna-Patkowska, Michał Flieger, Rafał Panek, Tomasz Klepka and Wojciech Franus
Molecules 2024, 29(9), 2094; https://doi.org/10.3390/molecules29092094 (registering DOI) - 01 May 2024
Abstract
The techniques used to detect and quantify cyanocobalamin (vitamin B12) vary considerably in terms of detection sensitivity, from the most sensitive, based on radioisotopes and mass spectrometry (MS) with limits of detection (LOD) in fg mL−1, to fluorescence (FL) and surface [...] Read more.
The techniques used to detect and quantify cyanocobalamin (vitamin B12) vary considerably in terms of detection sensitivity, from the most sensitive, based on radioisotopes and mass spectrometry (MS) with limits of detection (LOD) in fg mL−1, to fluorescence (FL) and surface plasmon resonance (SPR) biosensors with LOD values in the range of a few µg mL−1. For accurate quantification of an analyte present at trace levels in complex biological matrices, a selective separation and enrichment step is required to overcome matrix interferences and ensure sufficient detection sensitivity. In this study, iron oxide magnetic nanoparticles (IONPs) were used for the extraction and initial preconcentration of cyanocobalamin (vitamin B12). In the dependence of the magnetization on the H-field (hysteresis loop), no coercivity and remanence values were found at 300 K, indicating the superparamagnetic properties of the tested IONPs. Perfluorinated acids were used as amphiphilic agents to allow the sorption of cyanocobalamin onto the IONPs. FT-IR/ATR spectroscopy was used to confirm the sorption of cyanocobalamin on the IONPs. The influence of the addition of a homologous series of perfluorinated acids such as trifluoroacetic acid (TFAA), heptafluorobutyric acid (HFBA), and trichloroacetic acid (TCAA) to the extraction mixture was tested considering their type, mass, and time required for effective sorption. The adsorption kinetics and isotherm, described by the Freundlich and Langmuir equations, were analyzed. The maximum adsorption capacity (qm) exceeded 6 mg g−1 and was 8.9 mg g−1 and 7.7 mg g−1 for HFBA and TCAA, respectively, as the most efficient additives. After the desorption process using aqueous KH2PO4 solution, the sample was finally analyzed spectrophotometrically and chromatographically. The IONP-based method was successfully applied for the isolation of cyanocobalamin from human urine samples. The results showed that the developed approach is simple, cheap, accurate, and efficient for the determination of traces of cyanocobalamin in biological matrices. Full article
(This article belongs to the Section Nanochemistry)
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16 pages, 323 KiB  
Article
A New Nonlinear Integral Inequality with a Tempered Ψ–Hilfer Fractional Integral and Its Application to a Class of Tempered Ψ–Caputo Fractional Differential Equations
by Milan Medved’, Michal Pospíšil and Eva Brestovanská
Axioms 2024, 13(5), 301; https://doi.org/10.3390/axioms13050301 (registering DOI) - 01 May 2024
Abstract
In this paper, the tempered Ψ–Riemann–Liouville fractional derivative and the tempered Ψ–Caputo fractional derivative of order n1<α<nN are introduced for Cn1–functions. A nonlinear version of the second Henry–Gronwall inequality [...] Read more.
In this paper, the tempered Ψ–Riemann–Liouville fractional derivative and the tempered Ψ–Caputo fractional derivative of order n1<α<nN are introduced for Cn1–functions. A nonlinear version of the second Henry–Gronwall inequality for integral inequalities with the tempered Ψ–Hilfer fractional integral is derived. By using this inequality, an existence and uniqueness result and a sufficient condition for the non-existence of blow-up solutions of nonlinear tempered Ψ–Caputo fractional differential equations are proved. Illustrative examples are given. Full article
(This article belongs to the Special Issue Recent Advances in Fractional Differential Equations and Inequalities)
25 pages, 6941 KiB  
Article
Bat2Web: A Framework for Real-Time Classification of Bat Species Echolocation Signals Using Audio Sensor Data
by Taslim Mahbub, Azadan Bhagwagar, Priyanka Chand, Imran Zualkernan, Jacky Judas and Dana Dghaym
Sensors 2024, 24(9), 2899; https://doi.org/10.3390/s24092899 (registering DOI) - 01 May 2024
Abstract
Bats play a pivotal role in maintaining ecological balance, and studying their behaviors offers vital insights into environmental health and aids in conservation efforts. Determining the presence of various bat species in an environment is essential for many bat studies. Specialized audio sensors [...] Read more.
Bats play a pivotal role in maintaining ecological balance, and studying their behaviors offers vital insights into environmental health and aids in conservation efforts. Determining the presence of various bat species in an environment is essential for many bat studies. Specialized audio sensors can be used to record bat echolocation calls that can then be used to identify bat species. However, the complexity of bat calls presents a significant challenge, necessitating expert analysis and extensive time for accurate interpretation. Recent advances in neural networks can help identify bat species automatically from their echolocation calls. Such neural networks can be integrated into a complete end-to-end system that leverages recent internet of things (IoT) technologies with long-range, low-powered communication protocols to implement automated acoustical monitoring. This paper presents the design and implementation of such a system that uses a tiny neural network for interpreting sensor data derived from bat echolocation signals. A highly compact convolutional neural network (CNN) model was developed that demonstrated excellent performance in bat species identification, achieving an F1-score of 0.9578 and an accuracy rate of 97.5%. The neural network was deployed, and its performance was evaluated on various alternative edge devices, including the NVIDIA Jetson Nano and Google Coral. Full article
(This article belongs to the Section Environmental Sensing)
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17 pages, 19155 KiB  
Article
Enhancing Urban Resilience: Strategic Management and Action Plans for Cyclonic Events through Socially Constructed Risk Processes
by Raúl Pérez-Arévalo, Juan Jiménez-Caldera, José Luis Serrano-Montes, Jesús Rodrigo-Comino, Kevin Therán-Nieto and Andrés Caballero-Calvo
Urban Sci. 2024, 8(2), 43; https://doi.org/10.3390/urbansci8020043 (registering DOI) - 01 May 2024
Abstract
Cities will face increasing challenges due to the impacts of global climate change, particularly in the form of cyclonic events, necessitating a deeper understanding and the establishment of effective response mechanisms at both institutional and citizen levels. In this research, we tested the [...] Read more.
Cities will face increasing challenges due to the impacts of global climate change, particularly in the form of cyclonic events, necessitating a deeper understanding and the establishment of effective response mechanisms at both institutional and citizen levels. In this research, we tested the efficiency of crowdsourcing in fostering participatory resilience and improving urban management. The main aim was to design novel and accurate proactive response strategies and mitigate the adverse effects of cyclonic wind events through volunteerism, citizen science, and urban science. To achieve this goal, as a case study, the municipality of Soledad, Colombia was used. This research employed a two-phase methodological approach: (i) initially evaluating the spatial distribution of emergency response resources, and (ii) developing a geo-referenced survey to map, systematize, and categorize data and outcomes. A total of three hundred and seventy-eight residents across five neighborhoods in Soledad, which have experienced a high frequency of atmospheric wind phenomena over the past two decades, were surveyed. The results indicate that the crowdsourcing mechanism effectively enhanced the empirical understanding of atmospheric wind events in Soledad, facilitating the establishment of a geo-referenced volunteer network for real-time responses. Additionally, this study shed light on previously undocumented challenges, in terms of reducing the number of people affected, and the actions that would lead to improved urban development to reduce the impacts of cyclonic events, emphasizing the significance of citizen science in the social construction of risk and disaster risk reduction (DDR) efforts. Full article
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32 pages, 3303 KiB  
Review
Extraction, Modification, Biofunctionality, and Food Applications of Chickpea (Cicer arietinum) Protein: An Up-to-Date Review
by Nikhil Dnyaneshwar Patil, Aarti Bains, Kandi Sridhar, Maharshi Bhaswant, Sawinder Kaur, Manikant Tripathi, Déborah Lanterbecq, Prince Chawla and Minaxi Sharma
Foods 2024, 13(9), 1398; https://doi.org/10.3390/foods13091398 (registering DOI) - 01 May 2024
Abstract
Plant-based proteins have gained popularity in the food industry as a good protein source. Among these, chickpea protein has gained significant attention in recent times due to its high yields, high nutritional content, and health benefits. With an abundance of essential amino acids, [...] Read more.
Plant-based proteins have gained popularity in the food industry as a good protein source. Among these, chickpea protein has gained significant attention in recent times due to its high yields, high nutritional content, and health benefits. With an abundance of essential amino acids, particularly lysine, and a highly digestible indispensable amino acid score of 76 (DIAAS), chickpea protein is considered a substitute for animal proteins. However, the application of chickpea protein in food products is limited due to its poor functional properties, such as solubility, water-holding capacity, and emulsifying and gelling properties. To overcome these limitations, various modification methods, including physical, biological, chemical, and a combination of these, have been applied to enhance the functional properties of chickpea protein and expand its applications in healthy food products. Therefore, this review aims to comprehensively examine recent advances in Cicer arietinum (chickpea) protein extraction techniques, characterizing its properties, exploring post-modification strategies, and assessing its diverse applications in the food industry. Moreover, we reviewed the nutritional benefits and sustainability implications, along with addressing regulatory considerations. This review intends to provide insights into maximizing the potential of Cicer arietinum protein in diverse applications while ensuring sustainability and compliance with regulations. Full article
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14 pages, 9282 KiB  
Communication
Nickel–Iron-Layered Double Hydroxide Electrocatalyst with Nanosheets Array for High Performance of Water Splitting
by Zhi Lu, Shilin Li, Laiyuan Ning, Kun Tang, Yifan Guo, Long You, Chong Chen and Guangxin Wang
Molecules 2024, 29(9), 2092; https://doi.org/10.3390/molecules29092092 (registering DOI) - 01 May 2024
Abstract
Developing high-performance and cost-competitive electrocatalysts have great significance for the massive commercial production of water-splitting hydrogen. Ni-based electrocatalysts display tremendous potential for electrocatalytic water splitting. Herein, we synthesize a novel NiFe-layered double hydroxide (LDH) electrocatalyst in nanosheets array on high-purity Ni foam. By [...] Read more.
Developing high-performance and cost-competitive electrocatalysts have great significance for the massive commercial production of water-splitting hydrogen. Ni-based electrocatalysts display tremendous potential for electrocatalytic water splitting. Herein, we synthesize a novel NiFe-layered double hydroxide (LDH) electrocatalyst in nanosheets array on high-purity Ni foam. By adjusting the Ni/Fe ratio, the microstructure, and even the behavior of the electrocatalyst in the oxygen evolution reaction (OER), changes significantly. The as-obtained material shows a small overpotential of 223 mV at 10 mAcm−2 as well as a low Tafel slope of 48.9 mV·dec−1 in the 1 M KOH electrolyte. In addition, it can deliver good stability for at least 24 h of continuous working at 10 mAcm−2. This work proposes a strategy for engineering catalysts and provides a method for the development of other Ni-based catalysts with excellent performance. Full article
(This article belongs to the Special Issue Current Development Prospects of Electrocatalysis Today)
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14 pages, 1172 KiB  
Article
Phospholipid Membrane Interactions of Model Ac-WL-X-LL-OH Peptides Investigated by Solid-State Nuclear Magnetic Resonance
by Nicolai Etwin Alsaker, Øyvind Halskau, Bengt Erik Haug, Nathalie Reuter and Willy Nerdal
Membranes 2024, 14(5), 105; https://doi.org/10.3390/membranes14050105 (registering DOI) - 01 May 2024
Abstract
The role of aromatic amino acids in peripheral protein membrane binding has been reported to involve cation–π interactions with choline lipids. In this study, we have investigated the interactions of the model pentapeptide Ac-WL-X-LL-OH (where X = L, Y, F, or W) with [...] Read more.
The role of aromatic amino acids in peripheral protein membrane binding has been reported to involve cation–π interactions with choline lipids. In this study, we have investigated the interactions of the model pentapeptide Ac-WL-X-LL-OH (where X = L, Y, F, or W) with the phospholipid membrane using solid-state NMR. The effect of guest residue X on the peptide-lipid interactome was complementary to the seminal report on the interfacial hydrophobicity scale by Wimley and White. We found that the phospholipids retained a lamellar phase in the presence of each of the peptides with an aromatic X residue, whereas the Leu peptide perturbed the bilayer to an extent where an additional isotropic phase was observed. The solid-state NMR 13C and 31P data provide additional information on the influence of these short peptides on the membrane that has not been previously reported. The magnitude of membrane perturbation was in the order of guest residue X = L > Y~F > W, which is consistent with the relative amino acid interfacial affinity reported by Wimley and White. Further work is, however, required to uncover the behavior of the peptide and localization in the membrane domain due to ambiguity of the 13C NMR data. We have launched efforts in this regard for the objective of better understanding the role of aromatic amino acids in peripheral membrane protein binding. Full article
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14 pages, 3398 KiB  
Article
Maize/Peanut Intercropping Affects Legume Nodulation in Semi-Arid Conditions
by Chen Feng, Guijuan Du, Yue Zhang, Liangshan Feng, Lili Zhang, Qi Wang, Wuyan Xiang, Wei Bai, Qian Cai, Tianran Sun, Zhanxiang Sun and Lizhen Zhang
Agronomy 2024, 14(5), 951; https://doi.org/10.3390/agronomy14050951 (registering DOI) - 01 May 2024
Abstract
Maize/peanut intercropping is practiced widely to increase land productivity and considered a sustainable way for using and saving resources through peanut’s complementary N source via biological N2 fixation. Our study aims to understand how maize/peanut intercropping affects the nodulation of peanuts under [...] Read more.
Maize/peanut intercropping is practiced widely to increase land productivity and considered a sustainable way for using and saving resources through peanut’s complementary N source via biological N2 fixation. Our study aims to understand how maize/peanut intercropping affects the nodulation of peanuts under water-limiting conditions and different nitrogen inputs. A two-year micro-plot experiment in 2015–2016 and a two-year field experiment in 2017–2018 were conducted to quantify nodulation in maize/peanut intercropping and sole peanut cropping under four N fertilization rates (N-free, low, medium, and high N) in rain-fed water-limited conditions. In the micro-plot experiment, intercropped peanuts increased nodule biomass compared to sole peanuts. The nodule number of intercropped peanuts was 51.6% (p = 0.001) higher than that of sole cropped peanuts, while nodule weights did not differ at high N fertilization rates and were lower in the no-N fertilization control. However, the results were different in the field experiment. Both the nodule number and single weight of the sole cropped peanut were 48.7% (p = 0.020) and 58.9% (p = 0.014) higher than that of the intercropped peanut. The ratio of the nodule weight to aboveground dry matter at the beginning peg in the dry year of 2017 was lower in intercropping than sole cropping, especially at low N fertilization rates. The potential increase in nodulation found in a well-controlled micro-plot environment might be limited by strong water and light competitions in field conditions. The results could contribute to the understanding of interspecific interactions in cereal/legume intercropping. Full article
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16 pages, 744 KiB  
Article
Causal Inference and Prefix Prompt Engineering Based on Text Generation Models for Financial Argument Analysis
by Fei Ding, Xin Kang, Linhuang Wang, Yunong Wu, Satoshi Nakagawa and Fuji Ren
Electronics 2024, 13(9), 1746; https://doi.org/10.3390/electronics13091746 (registering DOI) - 01 May 2024
Abstract
The field of argument analysis has become a crucial component in the advancement of natural language processing, which holds the potential to reveal unprecedented insights from complex data and enable more efficient, cost-effective solutions for enhancing human initiatives. Despite its importance, current technologies [...] Read more.
The field of argument analysis has become a crucial component in the advancement of natural language processing, which holds the potential to reveal unprecedented insights from complex data and enable more efficient, cost-effective solutions for enhancing human initiatives. Despite its importance, current technologies face significant challenges, including (1) low interpretability, (2) lack of precision and robustness, particularly in specialized fields like finance, and (3) the inability to deploy effectively on lightweight devices. To address these challenges, we introduce a framework uniquely designed to process and analyze massive volumes of argument data efficiently and accurately. This framework employs a text-to-text Transformer generation model as its backbone, utilizing multiple prompt engineering methods to fine-tune the model. These methods include Causal Inference from ChatGPT, which addresses the interpretability problem, and Prefix Instruction Fine-tuning as well as in-domain further pre-training, which tackle the issues of low robustness and accuracy. Ultimately, the proposed framework generates conditional outputs for specific tasks using different decoders, enabling deployment on consumer-grade devices. After conducting extensive experiments, our method achieves high accuracy, robustness, and interpretability across various tasks, including the highest F1 scores in the NTCIR-17 FinArg-1 tasks. Full article
(This article belongs to the Section Artificial Intelligence)
14 pages, 2607 KiB  
Article
Lysophosphatidylcholine Acetyltransferase 2 (LPCAT2) Influences the Gene Expression of the Lipopolysaccharide Receptor Complex in Infected RAW264.7 Macrophages, Depending on the E. coli Lipopolysaccharide Serotype
by Victory Ibigo Poloamina, Hanaa Alrammah, Wondwossen Abate, Neil D. Avent, Gyorgy Fejer and Simon K. Jackson
Biology 2024, 13(5), 314; https://doi.org/10.3390/biology13050314 (registering DOI) - 01 May 2024
Abstract
Escherichia coli (E. coli) is a frequent gram-negative bacterium that causes nosocomial infections, affecting more than 100 million patients annually worldwide. Bacterial lipopolysaccharide (LPS) from E. coli binds to toll-like receptor 4 (TLR4) and its co-receptor’s cluster of differentiation protein 14 [...] Read more.
Escherichia coli (E. coli) is a frequent gram-negative bacterium that causes nosocomial infections, affecting more than 100 million patients annually worldwide. Bacterial lipopolysaccharide (LPS) from E. coli binds to toll-like receptor 4 (TLR4) and its co-receptor’s cluster of differentiation protein 14 (CD14) and myeloid differentiation factor 2 (MD2), collectively known as the LPS receptor complex. LPCAT2 participates in lipid-raft assembly by phospholipid remodelling. Previous research has proven that LPCAT2 co-localises in lipid rafts with TLR4 and regulates macrophage inflammatory response. However, no published evidence exists of the influence of LPCAT2 on the gene expression of the LPS receptor complex induced by smooth or rough bacterial serotypes. We used RAW264.7—a commonly used experimental murine macrophage model—to study the effects of LPCAT2 on the LPS receptor complex by transiently silencing the LPCAT2 gene, infecting the macrophages with either smooth or rough LPS, and quantifying gene expression. LPCAT2 only significantly affected the gene expression of the LPS receptor complex in macrophages infected with smooth LPS. This study provides novel evidence that the influence of LPCAT2 on macrophage inflammatory response to bacterial infection depends on the LPS serotype, and it supports previous evidence that LPCAT2 regulates inflammatory response by modulating protein translocation to lipid rafts. Full article
(This article belongs to the Special Issue Macrophages and Antimicrobial Immune Response)
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15 pages, 747 KiB  
Article
Multi-Channel Audio Completion Algorithm Based on Tensor Nuclear Norm
by Lin Zhu, Lidong Yang, Yong Guo, Dawei Niu and Dandan Zhang
Electronics 2024, 13(9), 1745; https://doi.org/10.3390/electronics13091745 (registering DOI) - 01 May 2024
Abstract
Multi-channel audio signals provide a better auditory sensation to the audience. However, missing data may occur in the collection, transmission, compression, or other processes of audio signals, resulting in audio quality degradation and affecting the auditory experience. As a result, the completeness of [...] Read more.
Multi-channel audio signals provide a better auditory sensation to the audience. However, missing data may occur in the collection, transmission, compression, or other processes of audio signals, resulting in audio quality degradation and affecting the auditory experience. As a result, the completeness of the audio signal has become a popular research topic in the field of signal processing. In this paper, the tensor nuclear norm is introduced into the audio signal completion algorithm, and the multi-channel audio signals with missing data are restored by using the completion algorithm based on the tensor nuclear norm. First of all, the multi-channel audio signals are preprocessed and are then transformed from the time domain to the frequency domain. Afterwards, the multi-channel audio with missing data is modeled to construct a third-order multi-channel audio tensor. In the next part, the tensor completion algorithm is used to complete the third-order tensor. The optimal solution of the convex optimization model of the tensor completion is obtained by using the convex relaxation technique and, ultimately, the data recovery of the multi-channel audio with data loss is accomplished. The experimental results of the tensor completion algorithm and the traditional matrix completion algorithm are compared using both objective and subjective indicators. The final result shows that the high-order tensor completion algorithm has a better completion ability and can restore the audio signal better. Full article
(This article belongs to the Section Circuit and Signal Processing)
19 pages, 488 KiB  
Review
Conceptualisation and Role of Market Access in Pharmaceutical Industry: A Scoping Review
by Clara Fatoye, Gillian Yeowell, Eula Miller, Isaac Odeyemi and Chidozie Mbada
J. Mark. Access Health Policy 2024, 12(2), 81-99; https://doi.org/10.3390/jmahp12020007 (registering DOI) - 01 May 2024
Abstract
Background: Understanding the concept and dynamic process of the evolution of professional identity and roles of market access (MA) in the pharmaceutical industry (pharma) is critical to personal, interpersonal, and professional levels of development and impact. Objective: The aim was to carry out [...] Read more.
Background: Understanding the concept and dynamic process of the evolution of professional identity and roles of market access (MA) in the pharmaceutical industry (pharma) is critical to personal, interpersonal, and professional levels of development and impact. Objective: The aim was to carry out a scoping review of the conceptualisation of MA within pharma. Data Sources: BioMed Central, WorldCat.org, and Directory of Open Access Journals were searched from 2003 to 2023. Study Selection: All articles on concepts or definitions and other surrogate terms on MA in pharma were selected. Data Extraction: Keywords generated from an initial cursory literature search on MA in pharma were used in conjunction with AND/OR as search terms. Using the data charting method, key findings were mapped and summarised descriptively. inductive analysis was performed, allowing codes/themes that are relevant to the concept to emerge. Data Synthesis: Arskey and O’Malley’s six-stage framework and the PRISMA extension for scoping reviews extension checklist were used as the review and reporting templates. The databases search yielded 222 results. Following title and abstract screening, a total of 146 papers were screened, and 127 of them were excluded. Full-text review was conducted for 19 papers that were deemed by two reviewers to meet the eligibility criteria. One of the authors arbitrated on disputed papers for inclusion. Only 14 of the included papers were found to meet the criteria for the final analysis. Five conceptual dimensions of MA in pharma were identified as “right products”, “right patient”, “right price”, “right point” (time), and “right place” (setting). Conclusions: Market access in pharma is a process that commences with the development and availability of the right products that are proven to be efficacious and disease/condition-specific (including medications, medical devices, and vaccines); specifically produced for the right patients or end users who will maximise best clinical outcomes and economic value; delivered at the right point in a timely, sustained, and efficient manner, given at the right price (commercially viable or reimbursed price that represents good value); and conducted within the economic, policy, societal, and technological contexts, with the overarching goal of achieving the best patient outcomes and ensuring product profitability. Full article
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21 pages, 7766 KiB  
Article
Tool Wear Prediction Based on Residual Connection and Temporal Networks
by Ziteng Li, Xinnan Lei, Zhichao You, Tao Huang, Kai Guo, Duo Li and Huan Liu
Machines 2024, 12(5), 306; https://doi.org/10.3390/machines12050306 (registering DOI) - 01 May 2024
Abstract
Since tool wear accumulates in the cutting process, the condition of the cutting tool shows a degradation trend, which ultimately affects the surface quality. Tool wear monitoring and prediction are of significant importance in intelligent manufacturing. The cutting signal shows short-term randomness due [...] Read more.
Since tool wear accumulates in the cutting process, the condition of the cutting tool shows a degradation trend, which ultimately affects the surface quality. Tool wear monitoring and prediction are of significant importance in intelligent manufacturing. The cutting signal shows short-term randomness due to non-uniform materials in the workpiece, making it difficult to accurately monitor tool condition by relying on instantaneous signals. To reduce the impact of transient fluctuations, this paper proposes a novel network based on deep learning to monitor and predict tool wear. Firstly, a CNN model based on residual connection was designed to extract deep features from multi-sensor signals. After that, a temporal model based on an encoder and decoder was built for short-term monitoring and long-term prediction. It captured the instantaneous features and long-term trend features by mining the temporal dependence of the signals. In addition, an encoder and decoder-based temporal model is proposed for smoothing correction to improve the estimation accuracy of the temporal model. To validate the performance of the proposed model, the PHM dataset was used for wear monitoring and prediction and compared with other deep learning models. In addition, CFRP milling experiments were conducted to verify the stability and generalization of the model under different machining conditions. The experimental results show that the model outperformed other deep learning models in terms of MAE, MAPE, and RMSE. Full article
(This article belongs to the Special Issue Machinery Condition Monitoring and Intelligent Fault Diagnosis)
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20 pages, 1467 KiB  
Review
Common Beverage Consumption and Benign Gynecological Conditions
by Rachel Michel, Dana Hazimeh, Eslam E. Saad, Sydney L. Olson, Kelsey Musselman, Eman Elgindy and Mostafa A. Borahay
Beverages 2024, 10(2), 33; https://doi.org/10.3390/beverages10020033 (registering DOI) - 01 May 2024
Abstract
The purpose of this article is to review the effects of four commonly consumed beverage types—sugar-sweetened beverages (SSBs), caffeinated beverages, green tea, and alcohol—on five common benign gynecological conditions: uterine fibroids, endometriosis, polycystic ovary syndrome (PCOS), anovulatory infertility, and primary dysmenorrhea (PD). Here [...] Read more.
The purpose of this article is to review the effects of four commonly consumed beverage types—sugar-sweetened beverages (SSBs), caffeinated beverages, green tea, and alcohol—on five common benign gynecological conditions: uterine fibroids, endometriosis, polycystic ovary syndrome (PCOS), anovulatory infertility, and primary dysmenorrhea (PD). Here we outline a plethora of research, highlighting studies that demonstrate possible associations between beverage intake and increased risk of certain gynecological conditions—such as SSBs and dysmenorrhea—as well as studies that demonstrate a possible protective effect of beverage against risk of gynecological condition—such as green tea and uterine fibroids. This review aims to help inform the diet choices of those with the aforementioned conditions and give those with uteruses autonomy over their lifestyle decisions. Full article
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12 pages, 996 KiB  
Article
Impact of Photosynthetic Efficiency on Watermelon Cultivation in the Face of Drought
by Dayane Mércia Ribeiro Silva, Allan Cunha Barros, Ricardo Barros Silva, Wesley de Oliveira Galdino, José Wilker Germano de Souza, Isabelly Cristina da Silva Marques, Jadielson Inácio de Sousa, Viviane da Silva Lira, Alan Fontes Melo, Lucas da Silva de Abreu, Elias de Oliveira Albuquerque Júnior, Luana do Nascimento Silva Barbosa, Antônio Lucrécio dos Santos Neto, Valdevan Rosendo dos Santos, Francisco Gilvan Borges Ferreira Freitas Júnior, Fernanda Nery Vargens, João Henrique Silva da Luz, Elizabeth Orika Ono and João Domingos Rodrigues
Agronomy 2024, 14(5), 950; https://doi.org/10.3390/agronomy14050950 (registering DOI) - 01 May 2024
Abstract
Water availability is a limiting factor for plant production, especially in Brazilian semi-arid regions. The main aim of the study was to investigate the physiological effects of drought during the fruiting stage of watermelon cultivation. A completely randomized block design with four replications [...] Read more.
Water availability is a limiting factor for plant production, especially in Brazilian semi-arid regions. The main aim of the study was to investigate the physiological effects of drought during the fruiting stage of watermelon cultivation. A completely randomized block design with four replications and six treatments varied by the number of lateral drip tapes (1 or 2) and the duration of drought stress (0, 4, and 8 days) was used. The following parameters were evaluated: relative chlorophyll content, relative leaf water content, electrolyte leakage, CO2 assimilation (A), stomatal conductance (gs), internal CO2 concentration, leaf temperature, transpiration (E), water use efficiency (WUE), carboxylation efficiency (CE), yield, thickness, diameter, length, and fruit °brix, at 4 and 8 days of drought. Drought negatively affected photosynthesis, particularly in treatments with a single dripper and 4 days of drought, resulting in reductions of up to 60% in A, 68% in gs, 44% in E, 58% in WUE, and 59% in CE, but did not have a significant effect on watermelon yield after 4 or 8 days of irrigation. It was concluded that drought influences the physiological responses of watermelon plants, mainly in reducing photosynthesis, but does not drastically affect fruit productivity in short periods of stress. Full article
(This article belongs to the Special Issue Crop and Vegetable Physiology under Environmental Stresses)
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20 pages, 8322 KiB  
Article
Ultrasonic-Assisted Extraction of Xanthorrhizol from Curcuma xanthorrhiza Roxb. Rhizomes by Natural Deep Eutectic Solvents: Optimization, Antioxidant Activity, and Toxicity Profiles
by Adelina Simamora, Kris Herawan Timotius, Heri Setiawan, Febrina Amelia Saputri, Chinthia Rahadi Putri, Dewi Aryani, Ratih Asmana Ningrum and Abdul Mun’im
Molecules 2024, 29(9), 2093; https://doi.org/10.3390/molecules29092093 (registering DOI) - 01 May 2024
Abstract
Xanthorrhizol, an important marker of Curcuma xanthorrhiza, has been recognized for its different pharmacological activities. A green strategy for selective xanthorrhizol extraction is required. Herein, natural deep eutectic solvents (NADESs) based on glucose and organic acids (lactic acid, malic acid, and citric [...] Read more.
Xanthorrhizol, an important marker of Curcuma xanthorrhiza, has been recognized for its different pharmacological activities. A green strategy for selective xanthorrhizol extraction is required. Herein, natural deep eutectic solvents (NADESs) based on glucose and organic acids (lactic acid, malic acid, and citric acid) were screened for the extraction of xanthorrhizol from Curcuma xanthorrhiza. Ultrasound-assisted extraction using glucose/lactic acid (1:3) (GluLA) gave the best yield of xanthorrhizol. The response surface methodology with a Box–Behnken Design was used to optimize the interacting variables of water content, solid-to-liquid (S/L) ratio, and extraction to optimize the extraction. The optimum conditions of 30% water content in GluLA, 1/15 g/mL (S/L), and a 20 min extraction time yielded selective xanthorrhizol extraction (17.62 mg/g) over curcuminoids (6.64 mg/g). This study indicates the protective effect of GluLA and GluLA extracts against oxidation-induced DNA damage, which was comparable with those obtained for ethanol extract. In addition, the stability of the xanthorrhizol extract over 90 days was revealed when stored at −20 and 4 °C. The FTIR and NMR spectra confirmed the hydrogen bond formation in GluLA. Our study reported, for the first time, the feasibility of using glucose/lactic acid (1:3, 30% water v/v) for the sustainable extraction of xanthorrhizol. Full article
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30 pages, 1283 KiB  
Article
Hybrid Approach for Detection and Diagnosis of Short-Circuit Faults in Power Transmission Lines
by Luís Brito Palma
Energies 2024, 17(9), 2169; https://doi.org/10.3390/en17092169 (registering DOI) - 01 May 2024
Abstract
In this article, the main problem under investigation is the detection and diagnosis of short-circuit faults in power transmission lines. The proposed fault detection (FDD) approach is mainly based on principal component analysis (PCA). The proposed fault diagnosis/identification (FAI) approach is mainly based [...] Read more.
In this article, the main problem under investigation is the detection and diagnosis of short-circuit faults in power transmission lines. The proposed fault detection (FDD) approach is mainly based on principal component analysis (PCA). The proposed fault diagnosis/identification (FAI) approach is mainly based on sliding-window versions of the discrete Fourier transform (DFT) and discrete Hilbert transform (DHT). The main contributions of this article are (a) a fault detection approach based on principal component analysis in the two-dimensional scores space; and (b) a rule-based fault identification approach based on human expert knowledge, combined with a probabilistic decision system, which detects variations in the amplitudes and frequencies of current and voltage signals, using DFT and DHT, respectively. Simulation results of power transmission lines in Portugal are presented in order to show the robust and high performance of the proposed FDD approach for different signal-to-noise ratios. The proposed FDD approach, implemented in Python, that can be executed online or offline, can be used to evaluate the stress to which circuit breakers (CBs) are subjected, providing information to supervision- and condition-based monitoring systems in order to improve predictive and preventive maintenance strategies, and it can be applied to high-/medium-voltage power transmission lines as well as to low-voltage electronic transmission systems. Full article
(This article belongs to the Section F: Electrical Engineering)
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12 pages, 1749 KiB  
Review
Nodular/Keloidal Scleroderma with No Systemic Involvement—A Case Report and a Review of the Literature
by Ioana Irina Trufin, Loredana Ungureanu, Salomea-Ruth Halmágyi, Adina Patricia Apostu and Simona Corina Șenilă
J. Clin. Med. 2024, 13(9), 2662; https://doi.org/10.3390/jcm13092662 (registering DOI) - 01 May 2024
Abstract
Nodular or keloidal scleroderma is a rare condition with unclear cause and sporadic mentions in the medical literature. It was first recognized in the 19th century, yet its classification is still debated due to the limited number of reported cases. This rare variant [...] Read more.
Nodular or keloidal scleroderma is a rare condition with unclear cause and sporadic mentions in the medical literature. It was first recognized in the 19th century, yet its classification is still debated due to the limited number of reported cases. This rare variant of scleroderma is associated with either progressive systemic sclerosis or localized morphea. Clinically, it presents with asymptomatic nodules or plaques, resembling spontaneous keloid formation, often found on the trunk and proximal extremities. Recent literature reviews show a predominance of women with a mean age of 44 years. Diagnosis relies on clinical and histopathological findings, which usually show overlapping features of both scleroderma and true keloids, secondarily to an excessive fibrosing reaction attributed to collagen formation. We present an unusual case of a 70-year-old female patient who displayed the coexistence of two distinct subtypes of morphea (nodular/keloidal and linear), and exclusive skin involvement, which contrasts with the typical presentation of nodular/keloidal scleroderma, often associated with organ-specific disease. However, recent publications have diverged from previous ones regarding systemic sclerosis, with no systemic involvement reported between 2018 and 2024, which we evaluated in our descriptive literature review. With less than 50 cases reported in total, our case underlines the importance of recognizing this rare disease, ensuring appropriate evaluation, treatment, and follow-up. Full article
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11 pages, 279 KiB  
Article
Seroprevalence and Associated Risk Factors of Toxoplasma gondii in Patients Diagnosed with Schizophrenia: A Case–Control Cross Sectional Study
by Sebastian Grada, Alin Gabriel Mihu, Daniela Adriana Oatis, Constantin Catalin Marc, Liana Maria Chicea, Cristina Petrescu, Alina Maria Lupu and Tudor Rares Olariu
Biomedicines 2024, 12(5), 998; https://doi.org/10.3390/biomedicines12050998 (registering DOI) - 01 May 2024
Abstract
The protozoan parasite, Toxoplasma gondii, has been linked to several psychiatric disorders, including schizophrenia. The aim of this study was to assess the prevalence of T. gondii IgG antibodies and risk factors associated with seroprevalence in patients diagnosed with schizophrenia. This seroepidemiological [...] Read more.
The protozoan parasite, Toxoplasma gondii, has been linked to several psychiatric disorders, including schizophrenia. The aim of this study was to assess the prevalence of T. gondii IgG antibodies and risk factors associated with seroprevalence in patients diagnosed with schizophrenia. This seroepidemiological study assessed 196 participants, divided into two groups. The study group consisted of 98 schizophrenic patients and was matched with 98 healthy blood donors. A questionnaire was used to gather information regarding potential risk factors associated with T. gondii seroprevalence. Results revealed a higher seroprevalence of T. gondii IgG antibodies in schizophrenic patients (69.39%, 68/98) when compared to healthy controls (51.02%, 50/98) (OR: 2.18; 95% CI: 1.21–3.9; p = 0.01). Patients with schizophrenia who consumed raw or undercooked meat (80.65%, 25/31) (OR: 3.75; 95% CI: 1.25–11.21, p = 0.02) and those with a lower educational level (77.59%, 45/58) (OR: 3.5; 95% CI: 1.59–7.54, p = 0.002) presented increased T. gondii seropositivity rates versus their control counterparts. Our findings indicate a high T. gondii IgG seroprevalence in patients diagnosed with schizophrenia compared to healthy blood donors. Factors associated with T. gondii seroprevalence were consumption of raw or uncooked meat and a lower educational attainment. This study provided the first data regarding the potential risk factors for toxoplasmosis in Romanian patients diagnosed with schizophrenia and may serve as a foundation for future research and the development of preventive strategies. Full article
(This article belongs to the Special Issue Pathogenesis, Prophylaxis and Treatment of Infectious Diseases)

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