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The Role of Gravity Mechanotransduction in Regulating Stem Cell Tissue Regenerative Potential at the Single Cell Expressome LevelGravity is an omnipresent force on Earth, and all living organisms have evolved under the influence of constant gravity. Mechanical forces generated by gravity are potent modulators of stem cell based tissue regenerative mechanisms, inducing cell fate decisions and tissue specific commitment. A novel mechanical unloading investigation assessed the formation, morphology, and gene expression of embryoid bodies (EB), a transitory cell model of early differentiation. After 15 days of spaceflight, the mechanotransduction-null EB cells showed upregulated proliferative mechanisms while differentiation cues were silenced.
Document ID
20190027258
Acquisition Source
Ames Research Center
Document Type
Poster
Authors
Juran, Cassandra M. (Universities Space Research Association (USRA) Moffett Field, CA, United States)
Zvirblyte, Justina (Vilnius University Vilnius, Lithuania)
Coyne, Molly (NASA Ames Research Center Moffett Field, CA, United States)
Almeida, Eduardo A. C. (NASA Ames Research Center Moffett Field, CA, United States)
Date Acquired
July 12, 2019
Publication Date
February 19, 2019
Subject Category
Life Sciences (General)
Report/Patent Number
ARC-E-DAA-TN62941
Meeting Information
Meeting: ISSCR International Symposia
Location: Seoul
Country: Korea, Republic of
Start Date: September 26, 2019
End Date: September 27, 2019
Sponsors: International Society for Stem Cell Research
Funding Number(s)
CONTRACT_GRANT: NNH15CO48B
Distribution Limits
Public
Copyright
Public Use Permitted.

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