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Ionizing Radiation from Ex Vivo Sterilization Diminishes Fatigue but Not Static Murine Vertebral Body MechanicsFor a variety of medical and scientific reasons, human bones can be exposed to ionizing radiation. At relatively high doses (30,000±5,000 Gy), ex vivo ionizing radiation is commonly used to sterilize bone allografts. However, ionizing radiation in these applications has been shown to increase risk of fracture clinically and decrease bone quality. Previously, we observed a significant decrease in compressive static strength and fatigue life of ex vivo whole bones exposed to x-ray radiation at 17,000 Gy and above; no changes in compressive mechanical properties were observed for radiation doses of 1,000 Gy and below. The gap in doses between no mechanical change (1,000 Gy) and significant mechanical degradation (17,000 Gy) is large, and it is unclear at what dose mechanical integrity begins to diminish in whole bones, and if its effects differ in response to static versus cyclic mechanical loading. This is a major clinical concern, as trabecular and cortical bone allografts are commonly used in structural, load-bearing applications. To gain insight into the effect of ionizing radiation from 1,000-17,000 Gy, we conducted an ex vivo radiation study on the static and fatigue mechanical properties of the vertebral whole bone. Our objectives were to: (1) quantify the effect of exposure to ex vivo ionizing radiation on the mechanical integrity (compressive static and fatigue) of whole bones; and (2) evaluate, if there are observed differences in mechanics, if they differ in magnitude for static versus cyclic properties. The results of this study will give insight into the need for changes in protocols for bone allograft radiation sterilization procedures.
Document ID
20190000634
Acquisition Source
Ames Research Center
Document Type
Conference Paper
Authors
Emerzian, Shannon R. (California Univ. Berkeley, CA, United States)
Pendleton, Megan M. (California Univ. Berkeley, CA, United States)
O'Connell, Grace D. (California Univ. Berkeley, CA, United States)
Alwood, Joshua S. (NASA Ames Research Center Moffett Field, CA, United States)
Keaveny, Tony M. (California Univ. Berkeley, CA, United States)
Date Acquired
February 11, 2019
Publication Date
February 5, 2019
Subject Category
Life Sciences (General)
Report/Patent Number
ARC-E-DAA-TN63229
Meeting Information
Meeting: Orthopaedic Research Society Annual Meeting
Location: Austin, TX
Country: United States
Start Date: February 2, 2019
End Date: February 5, 2019
Sponsors: Orthopaedic Research Society
Funding Number(s)
CONTRACT_GRANT: NNX14AM56H
CONTRACT_GRANT: NSF GRFP 1752814
Distribution Limits
Public
Copyright
Public Use Permitted.
Keywords
bone mechanics

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