Probe for Sampling of Interstitial Fluid From Bone

Janle, Elsa M.

An apparatus characterized as both a membrane probe and a bone ultrafiltration probe has been developed to enable in vivo sampling of interstitial fluid in bone. The probe makes it possible to measure the concentration of calcium and other constituents of the fluid that may be relevant to bone physiology. The probe could be especially helpful in experimental studies of microgravitational bone loss and of terrestrial bone-loss disease states, including osteoporosis. The probe can be implanted in the bone tissue of a living animal and can be used to extract samples of the interstitial bone fluid from time to time during a long-term study. The probe includes three 12-cm-long polyacrylonitrile fibers configured in a loop form and attached to polyurethane tubing [inside diameter 0.025 in. (0.64 mm), outside diameter 0.040 in. (1 mm)]; the attachment is made by use of a 1-cm-long connecting piece of polyurethane tubing [inside diameter 0.035 0.003 in. (0.89 0.08 mm), outside diameter 0.060 0.003 in. (1.52 0.08 mm)]. At the distal end, a 2-cm-long piece of polyurethane tubing of the same inner and outer diameters serves as a connector to a hub. A 1-cm long piece of expanded poly (tetrafluoroethylene) tubing over the joint between the fibers and the connecting tubing serves as a tissue-in-growth site.

Document ID

20110020339

Acquisition Source

Johnson Space Center

Document Type

Other - NASA Tech Brief

External Source(s)

http://www.techbriefs.com/component/content/121?task=view

Authors

Date Acquired

August 25, 2013

Publication Date

November 1, 2004

Publication Information

Publication: NASA Tech Briefs, November 2004

Subject Category

Report/Patent Number

Distribution Limits

Public

Public Use Permitted.

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20110020339.pdf

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NTRS

NTRS - NASA Technical Reports Server

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