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Genetic evidence that a Y-linked gene in man is homologous to a gene on the X chromosome

Nature volume 302, pages 346–349 (1983)Cite this article

Abstract

The mammalian sex chromosomes are thought to be related to each other by sharing a common origin. That is, the X and Y chromosomes originally evolved from a pair of chromosomes that only differed at the locus determining sexual differentiation1,2. For example, this evolutionary relationship is reflected during meiosis3 in chromosomal pairing between the tip of the human X chromosome short arm and the Y chromosome which presumably implies sequence homology4. However, compelling genetic evidence for functional homology between the mammalian X and Y chromosome is lacking. We describe here the localization of a gene to the tip of the short arm of the human X chromosome and evidence for a related gene on the Y chromosome.

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Authors and Affiliations

  1. Imperial Cancer Research Fund, Lincoln's Inn Fields, London, WC2A 3PX, UK

    P. Goodfellow, G. Banting & D. Sheer

  2. Institute für Humangenetik and Antropologie, Albert-Ludwigs-Universität, Freiburg, FRG

    H. H. Ropers

  3. Duncan Guthrie Institute of Medical Genetics, University of Glasgow, Glasgow, G3 4SJ, UK

    A. Caine & M. A. Ferguson-Smith

  4. MRC Human Biochemical Genetics Unit, Galton Laboratories, University of London, London, NW1 2HE, UK

    S. Povey

  5. Department of Human Genetics, Hadassah Medical Centre, Ein Karem, Jerusalem, Israel

    R. Voss

Authors
  1. P. Goodfellow
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  2. G. Banting
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  3. D. Sheer
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  4. H. H. Ropers
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  5. A. Caine
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  6. M. A. Ferguson-Smith
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  7. S. Povey
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  8. R. Voss
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Goodfellow, P., Banting, G., Sheer, D. et al. Genetic evidence that a Y-linked gene in man is homologous to a gene on the X chromosome. Nature 302, 346–349 (1983). https://doi.org/10.1038/302346a0

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