Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Organic chemistry

Fast reactions ‘on water’

Nature volume 435, pages 746–747 (2005)Cite this article

Efficient reactions in aqueous organic chemistry do not require soluble reactants, as had been thought. A newly developed ‘on-water’ protocol is characterized by short reaction times, and the products are easy to isolate.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The ‘on water’ protocol, as developed by Sharpless and colleagues2.
Figure 2: Rapid reaction.

References

  1. Daniel, R. M., Finney, J. L. & Stoneham, M. (eds) Phil. Trans. R. Soc. Lond. B 359, 1141–1328 (2004).

  2. Narayan, S. et al. Angew. Chem. Int. Edn 44, 3275–3279 (2005).

    Article  CAS  Google Scholar 

  3. Breslow, R. & Rideout, D. C. J. Am. Chem. Soc. 102, 7816–7817 (1980).

    Article  Google Scholar 

  4. Grieco, P. A. (ed.) Organic Synthesis in Water (Blackie, London, 1998).

Download references

Author information

Authors and Affiliations

  1. the Physical Organic Chemistry Unit, Stratingh Institute, University of Groningen, Groningen, 9747 AG, The Netherlands

    Jaap E. Klijn & Jan B. F. N. Engberts

Authors
  1. Jaap E. Klijn
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jan B. F. N. Engberts
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Klijn, J., Engberts, J. Fast reactions ‘on water’. Nature 435, 746–747 (2005). https://doi.org/10.1038/435746a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/435746a

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing