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Tremorine-induced Tremor Versus Extra-pyramidal Disease

Abstract

TREMORINE (1-4 dipyrrolidino-2-butyne) has induced short-lived tremor and remarkable salivation in small laboratory animals. These manifestations have been considered as constituting a laboratory model for studying extrapyramidal syndromes of man1. Indeed, such animals have been used to screen possible therapeutic agents prior to clinical trial on patients suffering from Parkinson's disease.

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Thomas Welton, Francisco Cardoso, … Eng-King Tan

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PATTEN, B., SAKAMOTO, A., VAN WOERT, M. et al. Tremorine-induced Tremor Versus Extra-pyramidal Disease. Nature 201, 929–930 (1964). https://doi.org/10.1038/201929a0

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