Abstract
BEFORE a cell is established, in a suitable environment, as a malignant one, many highly sophisticated processes presumably take place: these would include changes in DNA and aberrations in the various finely balanced phenomena of gene repression and expression. Since these events must be initiated and maintained by physico-chemical means, the part played therein by the components of cell surfaces and membranes may be important. These surfaces and membranes act not only as physical selectors in the traffic of substances in and out of the cell, but also as the essential architectural elements of intracellular metabolism and of intercellular coexistence.
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GORE, I. Sterols in Neoplastic Cells. Nature 202, 800–801 (1964). https://doi.org/10.1038/202800a0
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DOI: https://doi.org/10.1038/202800a0
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