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Hepatic Inactivation of Angiotensin

Nature volume 203, pages 531–532 (1964)Cite this article

Abstract

HYPERTENSION induced by renal artery stenosis can be cured in dogs by a reno-portal venous shunt, according to Aoki1. A possible explanation is that the affected kidney liberates angiotensin which is in turn inactivated when passing through the liver. The possibility of such inactivation was explored by comparing in rats the pressor response of angiotensin injected through the jugular vein and the portal system.

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Author notes

  1. ANDRÉ L. METHOT: Boursier des gouvernements de la province de Québec et du Canada.

  2. PHILIPPE MEYER: Attaché de Recherches à l'Institut National d'Hygiène.

  3. PIERRE BIRON: Fellow du Conseil de recherche Medicale du Canada.

  4. MARIE FRANÇOISE LORAIN: Aide technique à l'Institut National d'Hygiène.

  5. GILBERT LAGRUE: Maître de recherches à l'Institut National d'Hygiène.

  6. PAUL MILLIEZ: Professeur à la Faculté de Médecine de Paris

Authors and Affiliations

  1. Centre de Recherches sur l'Hypertension Arteérielle, Hôpital Broussais, rue Didot, Paris, 14°

    ANDRÉ L. METHOT, PHILIPPE MEYER, PIERRE BIRON, MARIE FRANÇOISE LORAIN, GILBERT LAGRUE & PAUL MILLIEZ

Authors
  1. ANDRÉ L. METHOT
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METHOT, A., MEYER, P., BIRON, P. et al. Hepatic Inactivation of Angiotensin. Nature 203, 531–532 (1964). https://doi.org/10.1038/203531a0

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