Abstract
IN perfused rat heart and isolated rat diaphragm the rate of release and oxidation of fatty acids from muscle glycerides is increased by alloxan-diabetes1. These changes in diabetes involve actions of growth hormone and corticosteroids in insulin-deficient rats because they are not seen in muscles of hypophysectomized diabetic rats unless the animals are treated with growth hormone and cortisol1. As part of an investigation of the mechanisms of these changes we have investigated the effects of diabetes, hypophysectomy and treatment with growth hormone and cortisol on the concentrations of glycerides and phospholipids in rat heart and gastrocnemius (the latter as a representative skeletal muscle). The methods and procedure were as follows.
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DENTON, R., RANDLE, P. Hormonal Control of Lipid Concentration in Rat Heart and Gastrocnemius. Nature 208, 488 (1965). https://doi.org/10.1038/208488a0
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DOI: https://doi.org/10.1038/208488a0
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