Abstract
RECENT work from our laboratory has characterized certain quantitative properties of DNA and chromatin from developing frog embryos in terms of RNA-polymerase-mediated RNA synthesis1,2. Apart from knowing how much RNA can be synthesized using chromatin or DNA as a primer, it would be of interest to know some of the qualitative properties of the RNA synthesized. The present investigation examines two questions: Can added RNA stimulate protein synthesis of intact frog embryo cells? If it can, is this stimulation due to species of tissue-specific RNA molecules directing the synthesis of the appropriate proteins? Liver RNA preparations can stimulate haemin synthesis of minced frog embryos3 or mouse ascites tumour cells4, and Niu et al.5 have claimed that liver RNA induces the synthesis of liver specific proteins in ascites tumour cells.
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ROLLINS, E., MIYAGI, M., MOSER, C. et al. Stimulation of Protein Synthesis of Frog Embryo Cells by Larval and Adult Frog Liver Ribonucleic Acid Preparations. Nature 209, 509–510 (1966). https://doi.org/10.1038/209509a0
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DOI: https://doi.org/10.1038/209509a0
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