Abstract
METHIONINE sulphoximine (MSO) is a toxic agent frequently used to produce experimental convulsions in various laboratory animals. These seizures are similar to human epilepsy, and several findings have pointed toward a possible biochemical mechanism of the convulsant1–3. Peters and Tower4 found a marked inhibition of glutamine synthesis in brain slices and a specific inhibition of glutamine synthetase has been observed5,6. In spite of these physiological and neurochemical changes, a morphological correlate for the action of MSO has not been found7.
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References
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DE ROBERTIS, E., RODRIGUEZ DE LORES ARNAIZ, G. & SELLINGER, O. Nerve Endings isolated from Rats convulsed by Methionine Sulphoximine. Nature 212, 537–538 (1966). https://doi.org/10.1038/212537a0
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DOI: https://doi.org/10.1038/212537a0
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