Abstract
THE suggestion has been made by various authors1 that anions as well as various non-electrolytes cross the membrane of erythrocytes by a special mechanism. An investigation of the permeability of human and rabbit erythrocytes to ammonium chloride was carried out which suggested that the anion exchange in the erythrocyte of these two species involved facilitated diffusion (Hunter, F. R., and Ospina, B., unpublished results). The disadvantage of using ammonium chloride was that in addition to the movement of anions, ammonia also crosses the membrane2. Consequently, a less complicated system which involved only anion exchange was sought to test the conclusions reached with the ammonium chloride system.
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HUNTER, F. Evidence for Facilitated Diffusion of Anion in Erythrocytes. Nature 213, 816–817 (1967). https://doi.org/10.1038/213816a0
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DOI: https://doi.org/10.1038/213816a0
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