Abstract
Metal ions may play a part in the control of enzyme and metabolic activities. The feedback inhibition of glycolysis, for example, may take place as a result of the inhibition of the pyruvate kinase reaction by calcium ions. This reaction could be only one of a number of enzyme-catalysed reactions controlled by the concentration of metal ions.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Pardee, A. B., and Wilson, A. C., Cancer Res., 23, 1483 (1963).
Pitot, H. C., and Heidelberger, C., Cancer Res., 23, 1694 (1963).
Monod, J., Changeux, J. P., and Jacob, F., J. Mol. Biol., 6, 306 (1963).
Umbarger, H. E., Science, 145, 674 (1964).
Atkinson, D. E., Science, 150, 851 (1965).
Wyatt, H. V., J. Theoret. Biol., 6, 441 (1964).
Brown, A. D., Bact. Rev., 28, 296 (1964).
Dixon, M., and Webb, E. C., Enzymes, 420 (Academic Press, Inc., New York, 1964).
Lehninger, A. L., Physiol. Rev., 30, 393 (1950).
Kuby, S. A., and Noltmann, E. A., in The Enzymes (edit. by Boyer, P. D., Lardy, H. A., and Myrback, K.), 6, 515 (Academic Press, Inc., New York, 1962).
Nordlie, R., and Lardy, H. A., in The Enzymes (edit. by Boyer, P. D., Lardy, H. A., and Myrback, K.), 6, 3 (Academic Press, Inc., New York, 1962).
Mildvan, A. S., and Cohn, M., J. Biol. Chem., 240, 238 (1965).
Mildvan, A. S., and Cohn, M., J. Biol. Chem., 241, 1178 (1966).
Lehninger, A. L., Bioenergetics, 51 (W. A. Benjamin, Inc., New York, 1965).
Kachmar, J. F., and Boyer, P. D., J. Biol. Chem., 200, 669 (1953).
Bygrave, F. L., Biochem. J., 101, 480 (1966).
Bygrave, F. L., Biochem. J., 101, 488 (1966).
Harrison, W. H., Boyer, P. D., and Falcone, A. B., J. Biol. Chem., 215, 303 (1955).
Mildvan, A. S., and Cohn, M., Abstr. Sixth Intern. Cong. Biochem., 32, 322 (1964).
Parks, R. E., Ben-Gershom, E., and Lardy, H. A., J. Biol. Chem., 227, 231 (1957).
Hers, H. G., Biochim. Biophys. Acta, 8, 416 (1952).
Atkinson, D. E., and Walton, G. M., J. Biol. Chem., 240, 757 (1965).
Hanlon, D. P., and Westhead, E. W., Biochim. Biophys. Acta, 96, 537 (1965).
Koshland, D. E., Science, 142, 1533 (1964).
Bygrave, F. L., and Macdonald, K., Austral. J. Sci., 26, 21 (1963).
Bygrave, F. L., thesis, Univ. Queensland (1964).
Cowdry, E. V., Adv. Cancer Res., 1, 57 (1953).
Abercrombie, M., and Ambrose, E. J., Cancer Res., 22, 525 (1962).
Coman, D. R., Cancer Res., 13, 397 (1953).
Thomason, D., and Schofield, R., Exp. Cell Res., 16, 324 (1959).
Warburg, O., Science, 123, 309 (1956).
Kit, S., and Griffin, A. C., Cancer Res., 18, 621 (1958).
Underwood, A., and Newsholme, E., cited in ref. 49.
Malmström, B. G., Arch. Biochem. Biophys., 58, 381 (1955).
Boszormenyi-Nagy, I., J. Biol. Chem., 212, 495 (1955).
Utter, M. F., and Werkman, C. H., J. Biol. Chem., 146, 289 (1942).
Krebs, H. A., and Eggleston, L. V., Biochem. J., 94, 36 (1965).
Reynard, A. M., Hass, L. F., Jacobson, D. D., and Boyer, P. D., J. Biol. Chem., 236, 2277 (1961).
Kimberg, D. V., and Yielding, K. L., J. Biol. Chem., 237, 3233 (1962).
Weber, G., Stamm, N. B., and Fisher, E. A., Science, 149, 65 (1965).
Bygrave, F. L., Canad. J. Biochem., 44, 1061 (1966).
Dische, Z., Bull. Soc. Biochem. France, 23, 1140 (1941).
Uydea, K., and Racker, E., J. Biol. Chem., 240, 4682 (1966).
Bygrave, F. L., unpublished observations (1963).
Lehninger, A. L., The Mitochondrion, 157 (W. A. Benjamin, Inc., New York, 1964).
Drahota, Z., Carafoli, E., Rossi, C. S., Gamble, R. L., and Lehninger, A. L., J. Biol. Chem., 240, 2712 (1965).
Carafoli, E., J. Gen. Physiol. (submitted for publication).
Thiers, R. E., and Vallee, B. L., J. Biol. Chem., 226, 911 (1957).
Epstein, F. H., and Whittam, R., Biochem. J., 99, 232 (1966).
Gevers, W., and Krebs, H. A., Biochem. J., 98, 720 (1966).
Chance, B., Proc. Third Intern. Gong. Biochem., Brussels, 1955, 300 (Academic Press, Inc., New York, 1956).
Lehninger, A. L., Physiol. Revs., 42, 467 (1962).
Raaflaub, J., Helv. Physiol. Pharmacol. Acta, 11, 142, 157 (1953).
Whittam, R., Biochem. J., 82, 205 (1962).
McIlwain, H., Chemical Exploration of the Brain (Elsevier Publishing Co., Amsterdam, 1963).
Katz, A. B. M., Biochim. Biophys. Acta, 71, 397 (1963).
Davies, R. E., Nature, 199, 1068 (1963).
Huxley, A. F., Ann. Revs. Physiol., 26, 131 (1964).
Hasselbach, W., and Makinose, M., Biochem. Z., 339, 94 (1963).
Podolsky, R. J., and Constantin, L. L., Fed. Proc., 23, 933 (1964).
Sandow, A., Pharmacol. Revs., 17, 265 (1965).
Weber, A., Herz, R., and Reiss, I., Fed. Proc., 23, 896 (1964).
Hasselbach, W., Fed. Proc., 23, 909 (1964).
Ebashi, S., and Lipmann, F., J. Cell. Biol., 14, 389 (1962).
Webb, J. L., Enzyme and Metabolic Inhibitors, 649 (Academic Press, Inc., New York, 1963).
Perrin, D. D., Nature, 206, 170 (1965).
Martell, A. E., and Calvin, M., Chemistry of the Metal Chelate Compounds (Prentice-Hall, Inc., New York, 1952).
Trivedi, B., and Danforth, W. H., J. Biol. Chem., 241, 4110 (1966).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BYGRAVE, F. The Ionic Environment and Metabolic Control. Nature 214, 667–671 (1967). https://doi.org/10.1038/214667a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/214667a0
This article is cited by
-
Heat flows in rock cracks naturally optimize salt compositions for ribozymes
Nature Chemistry (2021)
-
Potassium transport in the maturing kidney
Pediatric Nephrology (2007)
-
Evaluation of glucose tolerance, insulin secretion, and insulin action in patients with primary hyperparathyroidism before and after surgery
Calcified Tissue International (1990)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.