Abstract
THERE is now considerable evidence that there are in animals tumour specific antigens of a transplantation type, that the host reacts against its own tumour and that this reaction is in some cases immunological, mediated by lymphocytes and similar to the delayed hypersensitivity reaction and homograft rejection1. The situation in man is not so clear because of the difficulty of research. We therefore decided to study the morphology and DNA synthesis of lymphocytes in Hodgkin's disease for two reasons. First, in this disease cellular immunity is depressed more than in any other human malignant disease; and second, lymphocytic and/or histiocytic proliferation is associated with localized disease and a relatively good prognosis, whereas lymphocytic depletion is associated with a poor prognosis and a generalized disease2,3.
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CROWTHER, D., FAIRLEY, G. & SEWELL, R. Lymphoid Cells in Hodgkin's Disease. Nature 215, 1086–1088 (1967). https://doi.org/10.1038/2151086a0
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DOI: https://doi.org/10.1038/2151086a0
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